{"entity": "researcher", "timestamp": "2026-08-21T22:26:26.704Z", "family": "Tixier-Boichard", "given": "Mich\u00e8le", "initials": "M", "orcid": "0000-0001-5944-7884", "affiliations": ["GABI, AgroParisTech, INRA, Universit\u00e9 Paris-Saclay, Jouy-en-Josas, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd3617c930c54aa490318c8f2c2a2320.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd3617c930c54aa490318c8f2c2a2320"}}, "publications": [{"entity": "publication", "iuid": "f05bbec67b264103a6c780cf2d6f7cb4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f05bbec67b264103a6c780cf2d6f7cb4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f05bbec67b264103a6c780cf2d6f7cb4"}}, "title": "The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus.", "authors": [{"family": "Schwochow", "given": "Doreen", "initials": "D", "orcid": "0000-0002-0090-4355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e44e74c556442b196f4ec880525813d.json"}}, {"family": "Bornel\u00f6v", "given": "Susanne", "initials": "S"}, {"family": "Jiang", "given": "Tingxing", "initials": "T", "orcid": "0000-0003-1972-8985", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49a01b8cf7f6435b93ad571176a8e5bc.json"}}, {"family": "Li", "given": "Jingyi", "initials": "J", "orcid": "0000-0001-6775-5190", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5425c2a0fe7b48a8865bce6b7f137ade.json"}}, {"family": "Gourichon", "given": "David", "initials": "D"}, {"family": "Bed'Hom", "given": "Bertrand", "initials": "B", "orcid": "0000-0002-0825-0886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/852272555fbf475da45d338fad9ccf3a.json"}}, {"family": "Dorshorst", "given": "Ben J", "initials": "BJ"}, {"family": "Chuong", "given": "Cheng-Ming", "initials": "CM", "orcid": "0000-0001-9673-3994", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fb0ccfcf57604e49a3e0f0c606b3a381.json"}}, {"family": "Tixier-Boichard", "given": "Mich\u00e8le", "initials": "M", "orcid": "0000-0001-5944-7884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd3617c930c54aa490318c8f2c2a2320.json"}}, {"family": "Andersson", "given": "Leif", "initials": "L", "orcid": "0000-0002-4085-6968", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c8202937eda401fa0d07f583589359d.json"}}], "type": "journal article", "published": "2021-11-00", "journal": {"title": "Pigment Cell Melanoma Res", "issn": "1755-148X", "volume": "34", "issue": "6", "pages": "1015-1028", "issn-l": "1755-1471"}, "abstract": "Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.", "doi": "10.1111/pcmr.12975", "pmid": "33793042", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1723557"}, {"db": "pmc", "key": "PMC8484376"}], "notes": [], "created": "2026-08-20T11:19:15.870Z", "modified": "2026-08-20T11:19:16.084Z"}, {"entity": "publication", "iuid": "3a773e39bf9d4ae08e8fbb3544446227", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3a773e39bf9d4ae08e8fbb3544446227.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3a773e39bf9d4ae08e8fbb3544446227"}}, "title": "A missense mutation in TYRP1 causes the chocolate plumage color in chicken and alters melanosome structure.", "authors": [{"family": "Li", "given": "Jingyi", "initials": "J"}, {"family": "Bed'hom", "given": "Bertrand", "initials": "B"}, {"family": "Marthey", "given": "Sylvain", "initials": "S"}, {"family": "Valade", "given": "Mathieu", "initials": "M"}, {"family": "Dureux", "given": "Audrey", "initials": "A"}, {"family": "Moroldo", "given": "Marco", "initials": "M"}, {"family": "P\u00e9choux", "given": "Christine", "initials": "C"}, {"family": "Coville", "given": "Jean-Luc", "initials": "JL"}, {"family": "Gourichon", "given": "David", "initials": "D"}, {"family": "Vieaud", "given": "Agathe", "initials": "A"}, {"family": "Dorshorst", "given": "Ben", "initials": "B"}, {"family": "Andersson", "given": "Leif", "initials": "L"}, {"family": "Tixier-Boichard", "given": "Mich\u00e8le", "initials": "M", "orcid": "0000-0001-5944-7884", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd3617c930c54aa490318c8f2c2a2320.json"}}], "type": "journal article", "published": "2019-05-00", "journal": {"title": "Pigment Cell Melanoma Res", "issn": "1755-148X", "volume": "32", "issue": "3", "pages": "381-390", "issn-l": "1755-1471"}, "abstract": "The chocolate plumage color in chickens is due to a sex-linked recessive mutation, choc, which dilutes eumelanin pigmentation. Because TYRP1 is sex-linked in chickens, and TYRP1 mutations determine brown coat color in mammals, TYRP1 appeared as the obvious candidate gene for the choc mutation. By combining gene mapping with gene capture, a complete association was identified between the chocolate phenotype and a missense mutation leading to a His214Asn change in the ZnA zinc-binding domain of the protein. A diagnostic test confirmed complete association by screening 428 non-chocolate chickens of various origins. This is the first TYRP1 mutation described in the chicken. Electron microscopy analysis showed that melanosomes were more numerous in feather follicles of chocolate chickens but exhibited an abnormal structure characterized by a granular content and an irregular shape. A similar altered morphology was observed on melanosomes of another TYRP1 mutant in birds, the roux mutation of the quail.", "doi": "10.1111/pcmr.12753", "pmid": "30457703", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:19:09.698Z", "modified": "2026-08-20T11:19:09.805Z"}]}