{"entity": "researcher", "timestamp": "2026-08-20T21:45:57.946Z", "family": "Vinding", "given": "Mikkel C", "initials": "MC", "orcid": "0000-0002-7954-2886", "affiliations": ["NatMEG, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. mikkelcv@drcmr.dk.", "Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark. mikkelcv@drcmr.dk."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaff4ee9c23497ba518325c7997701b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaff4ee9c23497ba518325c7997701b"}}, "publications": [{"entity": "publication", "iuid": "93bba24e1e8247789d1eca1dc8e97bb8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/93bba24e1e8247789d1eca1dc8e97bb8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/93bba24e1e8247789d1eca1dc8e97bb8"}}, "title": "Cortex-wide topography of 1/f-exponent in Parkinson's disease.", "authors": [{"family": "Helson", "given": "Pascal", "initials": "P", "orcid": "0000-0002-2877-3705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ee66ee661c64a4a89df82afceff2e11.json"}}, {"family": "Lundqvist", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1593-2559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06fbc4c5ba644ef4b6ebeb1cc39c7f08.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Vinding", "given": "Mikkel C", "initials": "MC", "orcid": "0000-0002-7954-2886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaff4ee9c23497ba518325c7997701b.json"}}, {"family": "Kumar", "given": "Arvind", "initials": "A"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "NPJ Parkinsons Dis", "issn": "2373-8057", "volume": "9", "issue": "1", "pages": "109", "issn-l": null}, "abstract": "Parkinson's disease (PD) is a progressive and debilitating brain disorder. Besides the characteristic movement-related symptoms, the disease also causes decline in sensory and cognitive processing. The extent of symptoms and brain-wide projections of neuromodulators such as dopamine suggest that many brain regions are simultaneously affected in PD. To characterise brain-wide disease-related changes in neuronal function, we analysed resting state magnetoencephalogram (MEG) from two groups: PD patients and healthy controls. Besides standard spectral analysis, we quantified the aperiodic components (\u03ba, \u03bb) of the neural activity by fitting a power law \u03ba/f\u03bb - f is the frequency, \u03ba and \u03bb are the fitting parameters-to the MEG power spectrum and studied its relationship with age and Unified Parkinson's Disease Rating Scale (UPDRS). Consistent with previous results, the most significant spectral changes were observed in the high theta/low-alpha band (7-10 Hz) in all brain regions. Furthermore, analysis of the aperiodic part of the spectrum showed that in all but frontal regions \u03bb was significantly larger in PD patients than in control subjects. Our results indicate that PD is associated with significant changes in aperiodic activity across the whole neocortex. Surprisingly, even early sensory areas showed a significantly larger \u03bb in patients than in healthy controls. Moreover, \u03bb was not affected by the Levodopa medication. Finally, \u03bb was positively correlated with patient age but not with UPDRS-III. Because \u03bb is closely associated with excitation-inhibition balance, our results propose new hypotheses about neural correlates of PD in cortical networks.", "doi": "10.1038/s41531-023-00553-6", "pmid": "37438362", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10338503"}, {"db": "pii", "key": "10.1038/s41531-023-00553-6"}], "notes": [], "created": "2026-08-20T08:54:37.789Z", "modified": "2026-08-20T08:54:37.957Z"}, {"entity": "publication", "iuid": "fd2dcf41e7b849259a479369ec513c93", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fd2dcf41e7b849259a479369ec513c93.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fd2dcf41e7b849259a479369ec513c93"}}, "title": "Cortex-wide topography of 1/f-exponent in Parkinson\u2019s disease", "authors": [{"family": "Helson", "given": "Pascal", "initials": "P", "orcid": "0000-0002-2877-3705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ee66ee661c64a4a89df82afceff2e11.json"}}, {"family": "Lundqvist", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1593-2559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06fbc4c5ba644ef4b6ebeb1cc39c7f08.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Vinding", "given": "Mikkel C", "initials": "MC", "orcid": "0000-0002-7954-2886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaff4ee9c23497ba518325c7997701b.json"}}, {"family": "Kumar", "given": "Arvind", "initials": "A", "orcid": "0000-0002-8044-9195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2fe30252074acb8d09f88f6c9b55f3.json"}}], "type": "posted-content", "published": "2023-01-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.01.19.524792", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:43:31.079Z", "modified": "2026-08-20T10:43:31.221Z"}]}