{"entity": "researcher", "timestamp": "2026-10-13T19:27:15.505Z", "family": "Hansen", "given": "Justine Y", "initials": "JY", "orcid": "0000-0003-3142-7480", "affiliations": ["McConnell Brain Imaging Centre, Montr\u00e9al Neurological Institute, McGill University, Montr\u00e9al, QC, Canada."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb0fa058a43d40329e061d621d305b06.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb0fa058a43d40329e061d621d305b06"}}, "publications": [{"entity": "publication", "iuid": "0c2cac650bae4d76b8be915a0ddc508f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0c2cac650bae4d76b8be915a0ddc508f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0c2cac650bae4d76b8be915a0ddc508f"}}, "title": "Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer\u2019s disease", "authors": [{"family": "Xiao", "given": "Yu", "initials": "Y", "orcid": "0009-0006-6760-4134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49c14c0be1f2486bb835dd3090785268.json"}}, {"family": "Spotorno", "given": "Nicola", "initials": "N", "orcid": "0000-0001-5404-8788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4851c8ec84264207bdf67c2fd04643da.json"}}, {"family": "An", "given": "Lijun", "initials": "L", "orcid": "0000-0003-1030-4625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06744ec5a4ad4223b88038071e7b1dbf.json"}}, {"family": "Bazinet", "given": "Vincent", "initials": "V", "orcid": "0000-0001-6693-9641", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf7315c0afaa444dab889dc98142cfc1.json"}}, {"family": "Hansen", "given": "Justine Y", "initials": "JY", "orcid": "0000-0003-3142-7480", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb0fa058a43d40329e061d621d305b06.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Shafiei", "given": "Golia", "initials": "G", "orcid": "0000-0002-2036-5571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a248c7067e0487e90ef72448bb7fd1c.json"}}, {"family": "Behjat", "given": "Harry H", "initials": "HH", "orcid": "0000-0001-6729-6801", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5d1b40c4a8342eb841754961f1b3593.json"}}, {"family": "Funck", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8925-9830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0069b039d56940928b8785a6a68d5eda.json"}}, {"family": "Salvad\u00f3", "given": "Gemma", "initials": "G", "orcid": "0000-0002-5210-9230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3b7599000404d618d84b389ba47f19a.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E", "orcid": "0000-0002-0841-5580", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac36a615800c40b98d64369cb029497c.json"}}, {"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Palomero-Gallagher", "given": "Nicola", "initials": "N", "orcid": "0000-0003-4463-8578", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb2e20b61c594a2cbb69ebac77b193cc.json"}}, {"family": "Dagher", "given": "Alain", "initials": "A", "orcid": "0000-0002-0945-5779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/642c0c268b8a447784b84ad589d0ba7f.json"}}, {"family": "Misic", "given": "Bratislav", "initials": "B", "orcid": "0000-0003-0307-2862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6cba1b095bd43b2b9a44cbd57fac573.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}], "type": "posted-content", "published": "2025-04-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.04.17.648358", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-10-01T08:31:00.151Z", "modified": "2026-10-01T08:31:00.421Z"}, {"entity": "publication", "iuid": "954616d8454e4935bf4fcccbbc3db5ab", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/954616d8454e4935bf4fcccbbc3db5ab.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/954616d8454e4935bf4fcccbbc3db5ab"}}, "title": "Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain.", "authors": [{"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Alexander-Bloch", "given": "Aaron F", "initials": "AF", "orcid": "0000-0001-6554-1893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d96b7bb3399c4a0f8cd66be01f00b02c.json"}}, {"family": "Wagstyl", "given": "Konrad", "initials": "K", "orcid": "0000-0003-3439-5808", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b68b976fde44ed283ae3a7e703c5a1a.json"}}, {"family": "Bertolero", "given": "Maxwell A", "initials": "MA"}, {"family": "Markello", "given": "Ross D", "initials": "RD"}, {"family": "Pines", "given": "Adam", "initials": "A"}, {"family": "Sydnor", "given": "Valerie J", "initials": "VJ"}, {"family": "Diaz-Papkovich", "given": "Alex", "initials": "A", "orcid": "0000-0002-2867-5494", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c08d7bc6bc94ebb80179f50d8e38685.json"}}, {"family": "Hansen", "given": "Justine Y", "initials": "JY", "orcid": "0000-0003-3142-7480", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb0fa058a43d40329e061d621d305b06.json"}}, {"family": "Evans", "given": "Alan C", "initials": "AC", "orcid": "0000-0003-3841-6098", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fa91d38d5224aae83e537a417c0c3ae.json"}}, {"family": "Bernhardt", "given": "Boris", "initials": "B", "orcid": "0000-0001-9256-6041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/997776eeb20044efbeb3b6bbe03ed50d.json"}}, {"family": "Misic", "given": "Bratislav", "initials": "B", "orcid": "0000-0003-0307-2862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6cba1b095bd43b2b9a44cbd57fac573.json"}}, {"family": "Satterthwaite", "given": "Theodore D", "initials": "TD", "orcid": "0000-0001-7072-9399", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/461c3637946f4ed8956764658711fca7.json"}}, {"family": "Seidlitz", "given": "Jakob", "initials": "J"}], "type": "journal article", "published": "2024-06-18", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "121", "issue": "25", "pages": "e2219137121", "issn-l": "0027-8424"}, "abstract": "Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain remains unknown. Here, we uncover three axes of topographic variation in gene expression in the adult human brain that specifically capture previously identified rostral-caudal, dorsal-ventral, and medial-lateral axes of early developmental patterning. The interaction of these spatiomolecular gradients i) accurately reconstructs the position of brain tissue samples, ii) delineates known functional territories, and iii) can model the topographical variation of diverse cortical features. The spatiomolecular gradients are distinct from canonical cortical axes differentiating the primary sensory cortex from the association cortex, but radiate in parallel with the axes traversed by local field potentials along the cortex. We replicate all three molecular gradients in three independent human datasets as well as two nonhuman primate datasets and find that each gradient shows a distinct developmental trajectory across the lifespan. The gradients are composed of several well-known transcription factors (e.g., PAX6 and SIX3), and a small set of genes shared across gradients are strongly enriched for multiple diseases. Together, these results provide insight into the developmental sculpting of functionally distinct brain regions, governed by three robust transcriptomic axes embedded within brain parenchyma.", "doi": "10.1073/pnas.2219137121", "pmid": "38861593", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11194492"}], "notes": [], "created": "2025-03-19T11:17:05.048Z", "modified": "2026-09-23T09:05:21.153Z"}, {"entity": "publication", "iuid": "da88b1480524423180d0c9690442bf3a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/da88b1480524423180d0c9690442bf3a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/da88b1480524423180d0c9690442bf3a"}}, "title": "Local molecular and global connectomic contributions to cross-disorder cortical abnormalities.", "authors": [{"family": "Hansen", "given": "Justine Y", "initials": "JY", "orcid": "0000-0003-3142-7480", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb0fa058a43d40329e061d621d305b06.json"}}, {"family": "Shafiei", "given": "Golia", "initials": "G", "orcid": "0000-0002-2036-5571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a248c7067e0487e90ef72448bb7fd1c.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Smart", "given": "Kelly", "initials": "K", "orcid": "0000-0002-4775-6943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fcc8495ae5c34c0f8b5be2b2e36ca5c0.json"}}, {"family": "Bearden", "given": "Carrie E", "initials": "CE", "orcid": "0000-0002-8516-923X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/747391903b0148f39f23a2a106995a1c.json"}}, {"family": "Hoogman", "given": "Martine", "initials": "M"}, {"family": "Franke", "given": "Barbara", "initials": "B"}, {"family": "van Rooij", "given": "Daan", "initials": "D"}, {"family": "Buitelaar", "given": "Jan", "initials": "J", "orcid": "0000-0001-8288-7757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8abc7e5901ea43ccb4f02dd516fab810.json"}}, {"family": "McDonald", "given": "Carrie R", "initials": "CR"}, {"family": "Sisodiya", "given": "Sanjay M", "initials": "SM"}, {"family": "Schmaal", "given": "Lianne", "initials": "L", "orcid": "0000-0001-9822-048X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/601a457b9ac94b1eadefc9e611e0dbc2.json"}}, {"family": "Veltman", "given": "Dick J", "initials": "DJ"}, {"family": "van den Heuvel", "given": "Odile A", "initials": "OA"}, {"family": "Stein", "given": "Dan J", "initials": "DJ", "orcid": "0000-0001-7218-7810", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/25e779a8905d45518b4440bfbb1e8050.json"}}, {"family": "van Erp", "given": "Theo G M", "initials": "TGM", "orcid": "0000-0002-2465-2797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/496d84f2b39f425aa01f9b68c6cdeacd.json"}}, {"family": "Ching", "given": "Christopher R K", "initials": "CRK"}, {"family": "Andreassen", "given": "Ole A", "initials": "OA"}, {"family": "Hajek", "given": "Tomas", "initials": "T"}, {"family": "Opel", "given": "Nils", "initials": "N"}, {"family": "Modinos", "given": "Gemma", "initials": "G"}, {"family": "Aleman", "given": "Andr\u00e9", "initials": "A"}, {"family": "van der Werf", "given": "Ysbrand", "initials": "Y", "orcid": "0000-0003-2370-9584", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1eb787a7390646228564dfdf834a2f53.json"}}, {"family": "Jahanshad", "given": "Neda", "initials": "N"}, {"family": "Thomopoulos", "given": "Sophia I", "initials": "SI"}, {"family": "Thompson", "given": "Paul M", "initials": "PM"}, {"family": "Carson", "given": "Richard E", "initials": "RE", "orcid": "0000-0002-9338-7966", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ce09a469dbc42feb9631e513a23c19d.json"}}, {"family": "Dagher", "given": "Alain", "initials": "A", "orcid": "0000-0002-0945-5779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/642c0c268b8a447784b84ad589d0ba7f.json"}}, {"family": "Misic", "given": "Bratislav", "initials": "B", "orcid": "0000-0003-0307-2862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6cba1b095bd43b2b9a44cbd57fac573.json"}}], "type": "journal article", "published": "2022-08-10", "journal": {"title": "Nat Commun", "issn": "2041-1723", "issn-l": "2041-1723", "volume": "13", "issue": "1", "pages": "4682"}, "abstract": "Numerous brain disorders demonstrate structural brain abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these molecular and connectomic vulnerabilities to brain disorders remain unknown, and has yet to be studied in a single multi-disorder framework. Using MRI morphometry from the ENIGMA consortium, we construct maps of cortical abnormalities for thirteen neurodevelopmental, neurological, and psychiatric disorders from N = 21,000 participants and N = 26,000 controls, collected using a harmonised processing protocol. We systematically compare cortical maps to multiple micro-architectural measures, including gene expression, neurotransmitter density, metabolism, and myelination (molecular vulnerability), as well as global connectomic measures including number of connections, centrality, and connection diversity (connectomic vulnerability). We find a relationship between molecular vulnerability and white-matter architecture that drives cortical disorder profiles. Local attributes, particularly neurotransmitter receptor profiles, constitute the best predictors of both disorder-specific cortical morphology and cross-disorder similarity. Finally, we find that cross-disorder abnormalities are consistently subtended by a small subset of network epicentres in bilateral sensory-motor, inferior temporal lobe, precuneus, and superior parietal cortex. Collectively, our results highlight how local molecular attributes and global connectivity jointly shape cross-disorder cortical abnormalities.", "doi": "10.1038/s41467-022-32420-y", "pmid": "35948562", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC9365855"}, {"db": "pii", "key": "10.1038/s41467-022-32420-y"}], "notes": [], "created": "2023-05-28T17:54:14.361Z", "modified": "2023-11-29T06:39:44.700Z"}]}