{"entity": "researcher", "timestamp": "2026-08-20T21:02:57.051Z", "family": "Butler", "given": "Lynn Marie", "initials": "LM", "orcid": "0000-0002-2352-8217", "affiliations": ["Science for Life Laboratory, Department of Protein Science, CBH, KTH Royal Institute of Technology, SE-171 21, Stockholm, Sweden.", "Translational Vascular Research, Department of Clinical Medicine, UiT The Arctic University of Norway, 9019, Troms\u00f8, Norway.", "Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.", "Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a"}}, "publications": [{"entity": "publication", "iuid": "03f98235d6314f8f8966034a7e51ed65", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/03f98235d6314f8f8966034a7e51ed65.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/03f98235d6314f8f8966034a7e51ed65"}}, "title": "Factor XII-driven coagulation traps bacterial infections.", "authors": [{"family": "Nickel", "given": "Katrin F", "initials": "KF", "orcid": "0000-0003-1287-6766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/482416cc32564e4980f996de9b3de984.json"}}, {"family": "J\u00e4ms\u00e4", "given": "Anne", "initials": "A", "orcid": "0009-0009-7663-5700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f56b24c8baa045be95193ce608ec0081.json"}}, {"family": "Konrath", "given": "Sandra", "initials": "S", "orcid": "0009-0007-2336-8982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2fd5bf1c58d5482382218c59b5348a18.json"}}, {"family": "Papareddy", "given": "Praveen", "initials": "P", "orcid": "0000-0002-3872-478X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e792ecc29554294a087324dc8801447.json"}}, {"family": "Butler", "given": "Lynn M", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Stavrou", "given": "Evi X", "initials": "EX", "orcid": "0000-0002-6075-7609", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be1e7e09fffc4a14960e7d0d0212d6be.json"}}, {"family": "Frye", "given": "Maike", "initials": "M", "orcid": "0000-0002-6257-7636", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8484d63bbba4163a7642d14bcf42bf3.json"}}, {"family": "Gelderblom", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4254-3439", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d4756de195ef4097aba06331228b9e34.json"}}, {"family": "Nieswandt", "given": "Bernhard", "initials": "B", "orcid": "0000-0003-1454-7413", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/029fabbfec9e4a0b96c829a9767454f3.json"}}, {"family": "Hammerschmidt", "given": "Sven", "initials": "S", "orcid": "0000-0002-6382-6681", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c25ea9a2059c465b941a4ffc55bd8e09.json"}}, {"family": "Herwald", "given": "Heiko", "initials": "H", "orcid": "0000-0002-8111-2842", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cf2d138f75140f68de333390b1c3adc.json"}}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T", "orcid": "0000-0003-4594-5975", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c1703d52e6c4a3f9832eb469ca19167.json"}}], "type": "journal article", "published": "2025-07-07", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "222", "issue": "7", "issn-l": "0022-1007"}, "abstract": "Blood coagulation is essential for stopping bleeding but also drives thromboembolic disorders. Factor XII (FXII)-triggered coagulation promotes thrombosis while being dispensable for hemostasis, making it a potential anticoagulant target. However, its physiological role remains unclear. Here, we demonstrate that FXII-driven coagulation enhances innate immunity by trapping pathogens and restricting bacterial infection in mice. Streptococcus pneumoniae infection was more severe in FXII-deficient (F12-/-) mice, with increased pulmonary bacterial burden, systemic spread, and mortality. Similarly, Staphylococcus aureus skin infections and systemic dissemination were exacerbated in F12-/- mice. Reconstitution with human FXII restored bacterial containment. Plasma kallikrein amplifies FXII activation, and its deficiency aggravated S. aureus skin infections, similarly to F12-/- mice. FXII deficiency impaired fibrin deposition in abscess walls, leading to leaky capsules and bacterial escape. Bacterial long-chain polyphosphate activated FXII, triggering fibrin formation. Deficiency in FXII substrate factor XI or FXII/factor XI co-deficiency similarly exacerbated S. aureus infection. The data reveal a protective role for FXII-driven coagulation in host defense, urging caution in developing therapeutic strategies targeting this pathway.", "doi": "10.1084/jem.20250049", "pmid": "40261297", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12013512"}, {"db": "pii", "key": "277405"}], "notes": [], "created": "2026-08-20T09:38:18.221Z", "modified": "2026-08-20T09:38:18.685Z"}, {"entity": "publication", "iuid": "8e547e0b7a9f480084b5613828d59617", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e547e0b7a9f480084b5613828d59617.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e547e0b7a9f480084b5613828d59617"}}, "title": "A human stomach cell type transcriptome atlas.", "authors": [{"family": "\u00d6ling", "given": "S", "initials": "S"}, {"family": "Struck", "given": "E", "initials": "E"}, {"family": "Noreen-Thorsen", "given": "M", "initials": "M"}, {"family": "Zwahlen", "given": "M", "initials": "M"}, {"family": "von Feilitzen", "given": "K", "initials": "K"}, {"family": "Odeberg", "given": "J", "initials": "J"}, {"family": "Pont\u00e9n", "given": "F", "initials": "F"}, {"family": "Lindskog", "given": "C", "initials": "C"}, {"family": "Uhl\u00e9n", "given": "M", "initials": "M"}, {"family": "Dusart", "given": "P", "initials": "P"}, {"family": "Butler", "given": "L M", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}], "type": "journal article", "published": "2024-02-14", "journal": {"title": "BMC Biol.", "issn": "1741-7007", "volume": "22", "issue": "1", "pages": "36", "issn-l": "1741-7007"}, "abstract": "The identification of cell type-specific genes and their modification under different conditions is central to our understanding of human health and disease. The stomach, a hollow organ in the upper gastrointestinal tract, provides an acidic environment that contributes to microbial defence and facilitates the activity of secreted digestive enzymes to process food and nutrients into chyme. In contrast to other sections of the gastrointestinal tract, detailed descriptions of cell type gene enrichment profiles in the stomach are absent from the major single-cell sequencing-based atlases.\n\nHere, we use an integrative correlation analysis method to predict human stomach cell type transcriptome signatures using unfractionated stomach RNAseq data from 359 individuals. We profile parietal, chief, gastric mucous, gastric enteroendocrine, mitotic, endothelial, fibroblast, macrophage, neutrophil, T-cell, and plasma cells, identifying over 1600 cell type-enriched genes.\n\nWe uncover the cell type expression profile of several non-coding genes strongly associated with the progression of gastric cancer and, using a sex-based subset analysis, uncover a panel of male-only chief cell-enriched genes. This study provides a roadmap to further understand human stomach biology.", "doi": "10.1186/s12915-024-01812-5", "pmid": "38355543", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10865703"}, {"db": "pii", "key": "10.1186/s12915-024-01812-5"}], "notes": [], "created": "2026-08-20T12:20:21.104Z", "modified": "2026-08-20T12:20:21.166Z"}, {"entity": "publication", "iuid": "88d46598d38049e49334326bc3a3c0bc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/88d46598d38049e49334326bc3a3c0bc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/88d46598d38049e49334326bc3a3c0bc"}}, "title": "Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.", "authors": [{"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Sanchez-Rivera", "given": "Laura", "initials": "L"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Naudin", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0002-6777-9587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f89e25cd7fcc4617ab5299c72fd17e0c.json"}}, {"family": "Munsch", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0003-1564-9825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed62bf6aa35643f283511d68d2aa4b01.json"}}, {"family": "Goumidi", "given": "Louisa", "initials": "L", "orcid": "0000-0003-4164-8471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d3df066e5e54e32bb99110289ab8a45.json"}}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Smith", "given": "Philip M", "initials": "PM"}, {"family": "Thibord", "given": "Florian", "initials": "F"}, {"family": "Kral-Pointner", "given": "Julia Barbara", "initials": "JB"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Germain", "given": "Marine", "initials": "M"}, {"family": "Schrottmaier", "given": "Waltraud", "initials": "W", "orcid": "0000-0003-0550-4120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ab65a615b9e477aa6206677e57025b0.json"}}, {"family": "Dusart", "given": "Philip", "initials": "P", "orcid": "0000-0003-2747-3214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cf50c230954da190746c16b5ac2b7d.json"}}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Kotol", "given": "David", "initials": "D", "orcid": "0000-0002-5388-3826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41f8f491c474e6bba2047b5d04b4af5.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Koprulu", "given": "Mine", "initials": "M", "orcid": "0000-0001-6870-4539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8fa2ddd2cfa4bbeb9c0b043513a6701.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f35b78d4384d41f2bfae2639b23b1e82.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Klarin", "given": "Derek M", "initials": "DM", "orcid": "0000-0002-4636-5780", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b81fbf037ec4b4b8ac0013544539f00.json"}}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Silveira", "given": "Angela", "initials": "A", "orcid": "0000-0003-2063-4935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8cbafcc7f04ac3adda984af7d85a16.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T"}, {"family": "Martinez-Perez", "given": "Angel", "initials": "A", "orcid": "0000-0002-5934-1454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fa8f32fb99f46dcb16d3a64643dbbfa.json"}}, {"family": "Emmerich", "given": "Joseph", "initials": "J"}, {"family": "Deleuze", "given": "Jean-Francois", "initials": "JF", "orcid": "0000-0002-5358-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33bb50dc6b8045bd9dbbde4423f66129.json"}}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soria Fernandez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Assinger", "given": "Alice", "initials": "A", "orcid": "0000-0002-5670-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccb6bb03693c4c799f4cbb53e6ff7049.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Souto Andres", "given": "Joan Carles", "initials": "JC", "orcid": "0000-0003-2092-5142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164af41db2204f2591c719a8b024d32a.json"}}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE", "orcid": "0000-0002-9065-722X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50bca11c313740c299901843e86e5d48.json"}}, {"family": "Butler", "given": "Lynn Marie", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "DA", "orcid": "0000-0001-9084-7800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74ca463a0d804b1ab97dac4750563220.json"}}, {"family": "Odeberg", "given": "Jacob", "initials": "J", "orcid": "0000-0003-0996-1644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6abb3fc822a4cacbf1d45224f2442f5.json"}}], "type": "published erratum", "published": "2023-11-27", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "7752", "issn-l": "2041-1723"}, "abstract": null, "doi": "10.1038/s41467-023-43764-4", "pmid": "38012230", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10682365"}, {"db": "pii", "key": "10.1038/s41467-023-43764-4"}], "notes": [], "created": "2026-08-20T08:53:02.011Z", "modified": "2026-08-20T08:53:02.187Z"}, {"entity": "publication", "iuid": "3eab6f40adba4a1eaa807ee583bf2a28", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3eab6f40adba4a1eaa807ee583bf2a28.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3eab6f40adba4a1eaa807ee583bf2a28"}}, "title": "Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.", "authors": [{"family": "Iglesias", "given": "Maria Jesus", "initials": "MJ"}, {"family": "Sanchez-Rivera", "given": "Laura", "initials": "L"}, {"family": "Ibrahim-Kosta", "given": "Manal", "initials": "M"}, {"family": "Naudin", "given": "Cl\u00e9ment", "initials": "C", "orcid": "0000-0002-6777-9587", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f89e25cd7fcc4617ab5299c72fd17e0c.json"}}, {"family": "Munsch", "given": "Ga\u00eblle", "initials": "G", "orcid": "0000-0003-1564-9825", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed62bf6aa35643f283511d68d2aa4b01.json"}}, {"family": "Goumidi", "given": "Louisa", "initials": "L", "orcid": "0000-0003-4164-8471", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7d3df066e5e54e32bb99110289ab8a45.json"}}, {"family": "Farm", "given": "Maria", "initials": "M"}, {"family": "Smith", "given": "Philip M", "initials": "PM"}, {"family": "Thibord", "given": "Florian", "initials": "F"}, {"family": "Kral-Pointner", "given": "Julia Barbara", "initials": "JB"}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Suchon", "given": "Pierre", "initials": "P"}, {"family": "Germain", "given": "Marine", "initials": "M"}, {"family": "Schrottmaier", "given": "Waltraud", "initials": "W", "orcid": "0000-0003-0550-4120", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ab65a615b9e477aa6206677e57025b0.json"}}, {"family": "Dusart", "given": "Philip", "initials": "P", "orcid": "0000-0003-2747-3214", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/26cf50c230954da190746c16b5ac2b7d.json"}}, {"family": "Boland", "given": "Anne", "initials": "A"}, {"family": "Kotol", "given": "David", "initials": "D", "orcid": "0000-0002-5388-3826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c41f8f491c474e6bba2047b5d04b4af5.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Koprulu", "given": "Mine", "initials": "M", "orcid": "0000-0001-6870-4539", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8fa2ddd2cfa4bbeb9c0b043513a6701.json"}}, {"family": "Pietzner", "given": "Maik", "initials": "M", "orcid": "0000-0003-3437-9963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3304844cece945168cbec0b5e3d9a9cf.json"}}, {"family": "Langenberg", "given": "Claudia", "initials": "C", "orcid": "0000-0002-5017-7344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f287f3248cc24c6cbfc100c249b87418.json"}}, {"family": "Damrauer", "given": "Scott M", "initials": "SM", "orcid": "0000-0001-8009-1632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f35b78d4384d41f2bfae2639b23b1e82.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Klarin", "given": "Derek M", "initials": "DM", "orcid": "0000-0002-4636-5780", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0b81fbf037ec4b4b8ac0013544539f00.json"}}, {"family": "Smith", "given": "Nicholas L", "initials": "NL"}, {"family": "Smadja", "given": "David M", "initials": "DM"}, {"family": "Holmstr\u00f6m", "given": "Margareta", "initials": "M"}, {"family": "Magnusson", "given": "Maria", "initials": "M"}, {"family": "Silveira", "given": "Angela", "initials": "A", "orcid": "0000-0003-2063-4935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8cbafcc7f04ac3adda984af7d85a16.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Renn\u00e9", "given": "Thomas", "initials": "T"}, {"family": "Martinez-Perez", "given": "Angel", "initials": "A", "orcid": "0000-0002-5934-1454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0fa8f32fb99f46dcb16d3a64643dbbfa.json"}}, {"family": "Emmerich", "given": "Joseph", "initials": "J"}, {"family": "Deleuze", "given": "Jean-Francois", "initials": "JF", "orcid": "0000-0002-5358-4463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33bb50dc6b8045bd9dbbde4423f66129.json"}}, {"family": "Antovic", "given": "Jovan", "initials": "J"}, {"family": "Soria Fernandez", "given": "Jose Manuel", "initials": "JM"}, {"family": "Assinger", "given": "Alice", "initials": "A", "orcid": "0000-0002-5670-5910", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccb6bb03693c4c799f4cbb53e6ff7049.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Souto Andres", "given": "Joan Carles", "initials": "JC", "orcid": "0000-0003-2092-5142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/164af41db2204f2591c719a8b024d32a.json"}}, {"family": "Morange", "given": "Pierre-Emmanuel", "initials": "PE", "orcid": "0000-0002-9065-722X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/50bca11c313740c299901843e86e5d48.json"}}, {"family": "Butler", "given": "Lynn Marie", "initials": "LM", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Tr\u00e9gou\u00ebt", "given": "David-Alexandre", "initials": "DA", "orcid": "0000-0001-9084-7800", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74ca463a0d804b1ab97dac4750563220.json"}}, {"family": "Odeberg", "given": "Jacob", "initials": "J", "orcid": "0000-0003-0996-1644", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6abb3fc822a4cacbf1d45224f2442f5.json"}}], "type": "journal article", "published": "2023-06-07", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "3280", "issn-l": "2041-1723"}, "abstract": "Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction. Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. In plasma, higher CFHR5 levels are associated with increased thrombin generation potential and recombinant CFHR5 enhanced platelet activation in vitro. GWAS analysis of ~52,000 participants identifies six loci associated with CFHR5 plasma levels, but Mendelian randomization do not demonstrate causality between CFHR5 and VTE. Our results indicate an important role for the regulation of the alternative pathway of complement activation in VTE and that CFHR5 represents a potential diagnostic and/or risk predictive plasma biomarker.", "doi": "10.1038/s41467-023-38383-y", "pmid": "37286573", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10247781"}, {"db": "pii", "key": "10.1038/s41467-023-38383-y"}], "notes": [], "created": "2026-08-20T08:52:37.351Z", "modified": "2026-08-20T08:52:38.261Z"}, {"entity": "publication", "iuid": "5f5c21f7e3234bf48653afca410eb85f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5f5c21f7e3234bf48653afca410eb85f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5f5c21f7e3234bf48653afca410eb85f"}}, "title": "Genome-wide single cell annotation of the human protein-coding genes", "authors": [{"family": "Karlsson", "given": "Max", "initials": "M", "orcid": "0000-0002-7000-4416", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b93284f942e44f1086616357d77267c3.json"}}, {"family": "\u00c1lvez", "given": "Mar\u00eda Bueno", "initials": "MB", "orcid": "0000-0002-2669-7796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7d09e4780a445b9b432d494c76d07e8.json"}}, {"family": "Shi", "given": "Mengnan", "initials": "M", "orcid": "0000-0001-8643-5846", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/642e9296ea7645848f1a28f619447231.json"}}, {"family": "M\u00e9ar", "given": "Loren", "initials": "L", "orcid": "0000-0001-9333-0110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0dcfbca8ff5446ef9d6d219f23480e0c.json"}}, {"family": "Schutten", "given": "Rutger", "initials": "R", "orcid": "0000-0001-8787-8868", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/770756518b8d49d58ce15957b07c8b46.json"}}, {"family": "Hikmet", "given": "Feria", "initials": "F", "orcid": "0000-0002-3750-9308", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0193c8f793be4446827f92db9871e2a7.json"}}, {"family": "Digre", "given": "Andreas", "initials": "A", "orcid": "0000-0003-1145-6700", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3deb03dd3c21410282f4a414d6c394be.json"}}, {"family": "Katona", "given": "Borbala", "initials": "B", "orcid": "0000-0003-2431-5288", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19828108d9bf441ba5ba99e3e00327c1.json"}}, {"family": "Vuu", "given": "Jimmy", "initials": "J"}, {"family": "Bosic", "given": "Martina", "initials": "M", "orcid": "0000-0001-7113-2834", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d1642462dcc43469933afe00c81305b.json"}}, {"family": "Sj\u00f6stedt", "given": "Evelina", "initials": "E", "orcid": "0000-0002-0327-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6fb5a1c88b44798144fd2de255fb00.json"}}, {"family": "Edfors", "given": "Fredrik", "initials": "F", "orcid": "0000-0002-0017-7987", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e213b04f8984c8eb00c68f5bc2f6a36.json"}}, {"family": "Oksvold", "given": "Per", "initials": "P", "orcid": "0000-0003-3014-5502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/16beca5822c747128300910b5c74dbfc.json"}}, {"family": "von Feilitzen", "given": "Kalle", "initials": "K", "orcid": "0000-0002-0257-7554", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4c4545bd2324b7d9b6696dab5bcb7dd.json"}}, {"family": "Zwahlen", "given": "Martin", "initials": "M", "orcid": "0000-0002-0064-4776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/456805fa3f4f47328f3923b78bf66996.json"}}, {"family": "Forsberg", "given": "Mattias", "initials": "M"}, {"family": "Johansson", "given": "Fredric", "initials": "F", "orcid": "0000-0001-5160-9543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88e81d055b6f4c23852dfa7768e62c99.json"}}, {"family": "Mulder", "given": "Jan", "initials": "J", "orcid": "0000-0003-3717-5018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40ed8170792444b491519e499d51c434.json"}}, {"family": "H\u00f6kfelt", "given": "Tomas", "initials": "T", "orcid": "0000-0002-3587-0116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c3a72e637e24e79abaf263ce5a23821.json"}}, {"family": "Luo", "given": "Younglun", "initials": "Y", "orcid": "0000-0002-0007-7759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0283cb6c284428f906b0d03fda62a1e.json"}}, {"family": "Butler", "given": "Lynn", "initials": "L", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}, {"family": "Zhong", "given": "Wen", "initials": "W", "orcid": "0000-0002-7422-6104", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6ffb1140aaa42c5ac63fe76653fc63b.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5", "orcid": "0000-0001-8800-8469", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9397c6e626b1457e8dcd47f037c4cf9d.json"}}, {"family": "Ponten", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0703-3940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f5294424542413c9ba4432c839c2b63.json"}}, {"family": "Zhang", "given": "Cheng", "initials": "C", "orcid": "0000-0002-3721-8586", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46e4161be08458994efddb75ed75874.json"}}, {"family": "Lindskog", "given": "Cecilia", "initials": "C", "orcid": "0000-0001-5611-1015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21610a810a87459c962d6da3f2ad38ad.json"}}, {"family": "Fagerberg", "given": "Linn", "initials": "L", "orcid": "0000-0003-0198-7137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/abbbf8193d5a4376a5c726768d039439.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}], "type": "posted-content", "published": "2022-08-04", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.08.03.502627", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:12:50.664Z", "modified": "2026-08-20T10:12:50.936Z"}, {"entity": "publication", "iuid": "9aacb8663e4347f3b847332747a50c1b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9aacb8663e4347f3b847332747a50c1b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9aacb8663e4347f3b847332747a50c1b"}}, "title": "Identification of endothelial-derived proteins in plasma associated with cardiovascular risk factors", "authors": [{"family": "Iglesias", "given": "MJ", "initials": "M"}, {"family": "Kruse", "given": "LD", "initials": "L"}, {"family": "Sanchez-Rivera", "given": "L", "initials": "L"}, {"family": "Enge", "given": "L", "initials": "L"}, {"family": "Dusart", "given": "P", "initials": "P"}, {"family": "Hong", "given": "MG", "initials": "M"}, {"family": "Uhl\u00e9n", "given": "M", "initials": "M"}, {"family": "Renn\u00e9", "given": "T", "initials": "T"}, {"family": "Schwenk", "given": "JM", "initials": "J", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Bergstrom", "given": "G", "initials": "G"}, {"family": "Odeberg", "given": "J", "initials": "J"}, {"family": "Butler", "given": "LM", "initials": "L", "orcid": "0000-0002-2352-8217", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca98647aea15499485d755977bd0869a.json"}}], "type": "posted-content", "published": "2021-02-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2021.02.08.21251209", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:02:34.926Z", "modified": "2026-08-20T10:02:34.950Z"}]}