{"entity": "researcher", "timestamp": "2026-08-23T09:24:56.044Z", "family": "Kiasat", "given": "Ali", "initials": "A", "orcid": "0000-0001-5568-3265", "affiliations": ["Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.", "Colorectal Surgery Unit, Department of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca2eaafcd72745f98b66e1640e99378a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca2eaafcd72745f98b66e1640e99378a"}}, "publications": [{"entity": "publication", "iuid": "5c6a516882004156abe90c4c899745a3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5c6a516882004156abe90c4c899745a3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5c6a516882004156abe90c4c899745a3"}}, "title": "Plasma bile acids in association with Crohn's disease.", "authors": [{"family": "Kiasat", "given": "Ali", "initials": "A", "orcid": "0000-0001-5568-3265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca2eaafcd72745f98b66e1640e99378a.json"}}, {"family": "Prast-Nielsen", "given": "Stefanie", "initials": "S"}, {"family": "Rautiainen", "given": "Susanne", "initials": "S"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Andersson", "given": "Fredrik", "initials": "F"}, {"family": "Lindberg", "given": "Johan", "initials": "J"}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I"}, {"family": "L\u00f6f Granstr\u00f6m", "given": "Anna", "initials": "A"}, {"family": "Gustafsson", "given": "Ulf O", "initials": "UO"}], "type": "journal article", "published": "2024-06-00", "journal": {"title": "Scand. J. Gastroenterol.", "issn": "1502-7708", "volume": "59", "issue": "6", "pages": "674-682", "issn-l": "0036-5521"}, "abstract": "In addition to facilitating lipid digestions, bile acids (BA) are signalling molecules acting on receptors on immune cells and along the gastrointestinal (GI) tract. The aim of this study was to assess if altered bile acid profiles in plasma are associated with Crohn's disease (CD).\n\nThis cross-sectional study included individuals (aged \u226518 years) referred for colonoscopy at a tertiary centre in Stockholm between 2016 and 2019. All participants received bowel preparation, completed a lifestyle questionnaire and provided blood samples for analysis. During colonoscopy, severity of disease was graded, and biopsies were taken from colonic mucosa. In the current substudy, 88 individuals with CD and 88 age-matched controls were selected for analysis of BA in plasma with ultra performance liquid chromatography (UPLC). Linear regression models were then used to compare mean bile acid concentrations and concentration ratios between CD and controls.\n\nIndividuals with CD had lower plasma concentrations of the majority of secondary BA compared to controls, in total CD/CC ratio 0.60 (SE 0.12), p = 0.001. The most prominent observations were lower levels of deoxycolic acid derivates and lithocolic acid derivates among participants with CD. Moreover, plasma concentration for secondary BA among participants with active CD was significantly lower compared to those with CD in remission, CD active/CD remission ratio 0.65 (SE 0.11), p < 0.002.\n\nCrohn's disease may be associated with altered plasma bile acid composition. The significance of colonic bacterial diversity in this context needs to be investigated in further studies.", "doi": "10.1080/00365521.2024.2328592", "pmid": "38505982", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:04:21.713Z", "modified": "2026-08-21T12:04:21.755Z"}, {"entity": "publication", "iuid": "ef93c02c465b4879babdad0fe1aff7a8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ef93c02c465b4879babdad0fe1aff7a8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ef93c02c465b4879babdad0fe1aff7a8"}}, "title": "Evaluation of plasma Short chain fatty acid levels as markers for Inflammatory bowel disease.", "authors": [{"family": "Kiasat", "given": "Ali", "initials": "A", "orcid": "0000-0001-5568-3265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca2eaafcd72745f98b66e1640e99378a.json"}}, {"family": "Rautiainen", "given": "Susanne", "initials": "S"}, {"family": "Prast-Nielsen", "given": "Stefanie", "initials": "S"}, {"family": "Engstrand", "given": "Lars", "initials": "L"}, {"family": "Schuppe-Koistinen", "given": "Ina", "initials": "I"}, {"family": "Gustafsson", "given": "Ulf O", "initials": "UO"}, {"family": "L\u00f6f Granstr\u00f6m", "given": "Anna", "initials": "A"}], "type": "journal article", "published": "2023-06-05", "journal": {"title": "Scand. J. Gastroenterol.", "issn": "1502-7708", "volume": "58", "issue": "11", "pages": "1246-1252", "issn-l": "0036-5521"}, "abstract": "Specific variations of short chain fatty acids in fecal samples have been shown for patients with inflammatory bowel disease. The aim of this study was to assess if Crohn's disease and ulcerative colitis are associated with altered concentrations of short chain fatty acids also in blood plasma.\n\nBetween 2016-2019, Swedish adults referred to a tertiary center for colonoscopy were asked to participate in a cross-sectional study. Individuals with Crohn's disease or ulcerative colitis as well as individuals with no findings on the colonoscopy (defined as clean colon) were included in the study. Data on colonoscopy findings, blood samples (including haemoglobin, C-reactive protein and short chain fatty acid analysis) as well as a validated lifestyle questionnaire including 277 questions were collected from all participants. Linear regression was used to compare mean concentrations of short chain fatty acids between Crohn's disease, ulcerative colitis and clean colon.\n\nThe cohort consisted of 132 individuals with Crohn's disease, 119 with ulcerative colitis and 205 with clean colon. In the crude model, succinic acid was significantly lower (p < 0.05) among patients with Crohn's disease (mean 3.00 \u00b5M SE 0.10) and ulcerative colitis (mean 3.13 \u00b5M SE 0.10) in comparison to clean colon (mean 3.41 \u00b5M SE 0.08), however when adjusting for sex, age and diet the results did not remain statistically significant. No differences in plasma concentration of the other measured short chain fatty acids were detected.\n\nCrohn's disease and ulcerative colitis are not associated with altered short chain fatty acid concentrations in plasma. Further research is needed to confirm or refute our findings.", "doi": "10.1080/00365521.2023.2219357", "pmid": "37272725", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T12:04:19.821Z", "modified": "2026-08-21T12:04:19.912Z"}]}