{"entity": "researcher", "timestamp": "2026-09-28T13:02:16.620Z", "family": "Classon", "given": "Johanna", "initials": "J", "orcid": "0000-0003-0392-7605", "affiliations": ["Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9f51e78f4e04793abac00c22d972363.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9f51e78f4e04793abac00c22d972363"}}, "publications": [{"entity": "publication", "iuid": "2be4c0bb8c4d4b1ebadf5f42ae2ab3d4", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2be4c0bb8c4d4b1ebadf5f42ae2ab3d4.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2be4c0bb8c4d4b1ebadf5f42ae2ab3d4"}}, "title": "Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity.", "authors": [{"family": "Classon", "given": "Johanna", "initials": "J", "orcid": "0000-0003-0392-7605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9f51e78f4e04793abac00c22d972363.json"}}, {"family": "Zamboni", "given": "Margherita", "initials": "M"}, {"family": "Engblom", "given": "Camilla", "initials": "C"}, {"family": "Alkass", "given": "Kanar", "initials": "K"}, {"family": "Mantovani", "given": "Giulia", "initials": "G", "orcid": "0000-0002-5307-165X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9497b224930b4459aa8915e51c47e919.json"}}, {"family": "Pou", "given": "Christian", "initials": "C"}, {"family": "Nkulikiyimfura", "given": "Dieudonn\u00e9", "initials": "D"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Druid", "given": "Henrik", "initials": "H"}, {"family": "Mold", "given": "Jeff", "initials": "J"}, {"family": "Fris\u00e9n", "given": "Jonas", "initials": "J"}], "type": "journal article", "published": "2022-10-00", "journal": {"title": "Mol Oncol", "issn": "1878-0261", "volume": "16", "issue": "19", "pages": "3452-3464", "issn-l": "1574-7891"}, "abstract": "Prostate cancer is a heterogeneous disease with a need for new prognostic biomarkers. Human leukocyte antigen (HLA) genes are highly polymorphic genes central to antigen presentation to T-cells. Two alleles, HLA-A*02:01 and HLA-A*24:02, have been associated with prognosis in patients diagnosed with de novo metastatic prostate cancer. We leveraged the next-generation sequenced cohorts CPC-GENE and TCGA-PRAD to examine HLA alleles, antiviral T-cell receptors and prostate cancer disease recurrence after prostatectomy. Carrying HLA-A*02:01 (111/229; 48% of patients) was independently associated with disease recurrence in patients with low-intermediate risk prostate cancer. HLA-A*11 (carried by 42/441; 10% of patients) was independently associated with rapid disease recurrence in patients with high-risk prostate cancer. Moreover, HLA-A*02:01 carriers in which anti-cytomegalovirus T-cell receptors (CMV-TCR) were identified in tumors (13/144; 10% of all patients in the cohort) had a higher risk of disease recurrence than CMV-TCR-negative patients. These findings suggest that HLA-type and CMV immunity may be valuable biomarkers for prostate cancer progression.", "doi": "10.1002/1878-0261.13273", "pmid": "35712787", "labels": {"SciLifeLab Fellow": "", "Camilla Engblom": ""}, "xrefs": [{"db": "pmc", "key": "PMC9533687"}, {"db": "RefSeq", "key": "NC_006273.2"}], "notes": [], "created": "2026-09-23T12:11:25.234Z", "modified": "2026-09-23T12:11:25.332Z"}]}