{"entity": "researcher", "timestamp": "2026-08-20T20:39:16.410Z", "family": "Aransay", "given": "Ana M", "initials": "AM", "orcid": "0000-0002-8271-612X", "affiliations": ["Genome Analysis Platform, Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance (BRTA), Mendaro, Spain.", "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas Y Digestivas (CIBERehd), Madrid, Spain."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8a11379529b4769a5f8b5a989e99330.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8a11379529b4769a5f8b5a989e99330"}}, "publications": [{"entity": "publication", "iuid": "ea277b458a2b4444aef52213bc5d355e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ea277b458a2b4444aef52213bc5d355e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ea277b458a2b4444aef52213bc5d355e"}}, "title": "A dual genetic constraint underlies the conservation of early brains in vertebrates", "authors": [{"family": "Senovilla-Ganzo", "given": "Rodrigo", "initials": "R", "orcid": "0000-0001-6615-0923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9378f3be005344eab9287605a6cc8352.json"}}, {"family": "Bekiari", "given": "Christina", "initials": "C"}, {"family": "Rueda-Ala\u00f1a", "given": "Eneritz", "initials": "E", "orcid": "0000-0003-3045-4970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53052de34774443d922c19887a8aa0f5.json"}}, {"family": "Yamada", "given": "Tetsuya", "initials": "T", "orcid": "0000-0001-8601-737X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1abdce0223ba4e2baf064c88a10161e1.json"}}, {"family": "Zaremba", "given": "Bastienne", "initials": "B", "orcid": "0000-0002-2195-5135", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b49f1217d7524fc78fdf70856dcb9868.json"}}, {"family": "Aransay", "given": "Ana Mar\u00eda", "initials": "AM", "orcid": "0000-0002-8271-612X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8a11379529b4769a5f8b5a989e99330.json"}}, {"family": "Escobar", "given": "Laura", "initials": "L", "orcid": "0000-0003-0955-2015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0de21df1c024eca98c19c758f61e93e.json"}}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3311155f09a64b4f88d673da2a40627b.json"}}, {"family": "Grillo", "given": "Marco", "initials": "M", "orcid": "0000-0003-2155-0645", "researcher": {"href": 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"https://publications-affiliated.scilifelab.se/publication/a1e8842df8314e1fab9d332f761d6b8c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a1e8842df8314e1fab9d332f761d6b8c"}}, "title": "Beyond basic characterization and omics: Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing.", "authors": [{"family": "Palviainen", "given": "Mari", "initials": "M", "orcid": "0000-0002-7105-3543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bc89cf67f1842fdb3dd0d4fdf80a328.json"}}, {"family": "Puutio", "given": "Johanna", "initials": "J", "orcid": "0000-0002-5519-7053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4301cceee9f34549b7a6fef5393670bc.json"}}, {"family": "\u00d8stergaard", "given": "Rikke Halse", "initials": "RH", "orcid": "0000-0001-6341-3871", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f06d9129e024ccfb508779f65409be5.json"}}, {"family": "Eble", "given": "Johannes A", "initials": "JA"}, {"family": "Maaninka", "given": "Katariina", "initials": "K", "orcid": "0000-0003-1211-3267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/069c55d42f5942918124cd1c45dc8a3e.json"}}, {"family": "Butt", "given": "Umar", "initials": "U", "orcid": "0000-0002-0696-9520", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3556274862cd4eba8a4829c467f39322.json"}}, {"family": "Ndika", "given": "Joseph", "initials": "J", "orcid": "0000-0003-2326-5821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee4cfe2ca7a9427797157a50650d66b2.json"}}, {"family": "Kari", "given": "Otto K", "initials": "OK", "orcid": "0000-0003-3133-0670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5b8dc4904a146028699385aa0c144ea.json"}}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Kjaer-Sorensen", "given": "Kasper", "initials": "K"}, {"family": "Oxvig", "given": "Claus", "initials": "C"}, {"family": "Aransay", "given": "Ana M", "initials": "AM", "orcid": "0000-0002-8271-612X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8a11379529b4769a5f8b5a989e99330.json"}}, {"family": "Falcon-Perez", "given": "Juan M", "initials": "JM"}, {"family": "Federico", "given": "Antonio", "initials": "A"}, {"family": "Greco", "given": "Dario", "initials": "D"}, {"family": "Laitinen", "given": "Saara", "initials": "S"}, {"family": "Hayashi", "given": "Yuya", "initials": "Y"}, {"family": "Siljander", "given": "Pia R-M", "initials": "PR"}], "type": "journal article", "published": "2024-10-00", "journal": {"title": "J Extracell Vesicles", "issn": "2001-3078", "volume": "13", "issue": "10", "pages": "e12513", "issn-l": null}, "abstract": "Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases. Platelets express a wide range of receptors, which allows them to reach a variety of activation endpoints and grants them immunomodulatory functions. Activated platelets release extracellular vesicles (PEVs), whose formation and molecular cargo has been shown to depend on receptor-mediated activation and environmental cues. This study compared the immunomodulatory profiles of PEVs generated via activation of platelets by different receptors, glycoprotein VI, C-type lectin-like receptor 2 and combining all thrombin-collagen receptors. Functional assays in vivo in zebrafish and in vitro in human macrophages highlighted distinct homing and secretory responses triggered by the PEVs. In contrast, omics analyses of protein and miRNA cargo combined with physicochemical particle characterization found only subtle differences between the activated PEV types, which were insufficient to predict their different immunomodulatory functions. In contrast, constitutively released PEVs, formed in the absence of an exogenous activator, displayed a distinct immunomodulatory profile from the receptor-induced PEVs. Our findings underscore that PEVs are tunable through receptor-mediated activation. To truly comprehend their role(s) in mediating platelet functions among immune cells, conducting functional assays is imperative.", "doi": "10.1002/jev2.12513", "pmid": "39330919", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11428872"}], "notes": [], "created": "2026-08-20T06:34:07.974Z", "modified": "2026-08-20T06:34:08.354Z"}, {"entity": "publication", "iuid": "246fcd077319479589b289496d57efea", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/246fcd077319479589b289496d57efea.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/246fcd077319479589b289496d57efea"}}, "title": "Evolutionary convergence of sensory circuits in the pallium of amniotes", "authors": [{"family": "Rueda-Ala\u00f1a", "given": "Eneritz", "initials": "E", "orcid": "0000-0003-3045-4970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/53052de34774443d922c19887a8aa0f5.json"}}, {"family": "Senovilla-Ganzo", "given": "Rodrigo", "initials": "R", "orcid": "0000-0001-6615-0923", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9378f3be005344eab9287605a6cc8352.json"}}, {"family": "Grillo", "given": "Marco", "initials": "M", "orcid": "0000-0003-2155-0645", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e82de1e6bb4c738b8e9868419e59bf.json"}}, {"family": "V\u00e1zquez", "given": "Enrique", "initials": "E", "orcid": "0000-0003-1157-2592", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41d23e391fd043a4abd3e5abea84c6fa.json"}}, {"family": "Marco-Salas", "given": "Sergio", "initials": "S", "orcid": "0000-0002-4636-0322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/68b3baa22ffe41c0aa352075c6ea70b9.json"}}, {"family": "Gallego-Flores", "given": "Tatiana", "initials": "T", "orcid": "0000-0003-0773-0578", "researcher": {"href": 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"https://publications-affiliated.scilifelab.se/researcher/d2f4723a7eb6457e8ec319488bc58212.json"}}, {"family": "R\u00e1bano", "given": "Miriam", "initials": "M"}, {"family": "dM Vivanco", "given": "Mar\u00eda", "initials": "M", "orcid": "0000-0002-9540-247X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05fb5b75e416414ca45b7da92de74adb.json"}}, {"family": "Aransay", "given": "Ana Mar\u00eda", "initials": "AM", "orcid": "0000-0002-8271-612X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8a11379529b4769a5f8b5a989e99330.json"}}, {"family": "Garrigos", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1337-1321", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ce27eb565fd48f69102f78a8970e3f7.json"}}, {"family": "Toval", "given": "\u00c1ngel", "initials": "\u00c1", "orcid": "0000-0003-4798-1216", "researcher": {"href": 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"Garc\u00eda-Moreno", "given": "Fernando", "initials": "F", "orcid": "0000-0001-9048-4237", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/829813abf875418a8aa1d59c47e41355.json"}}], "type": "posted-content", "published": "2024-05-02", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.04.30.591819", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:54:06.339Z", "modified": "2026-08-20T10:54:06.995Z"}, {"entity": "publication", "iuid": "1918cf0682d54c08b565a08624f89ea5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1918cf0682d54c08b565a08624f89ea5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1918cf0682d54c08b565a08624f89ea5"}}, "title": "Beyond Basic Characterization and Omics: Immunomodulatory Roles of Platelet-Derived Extracellular Vesicles Unveiled by Functional Testing", "authors": [{"family": "Palviainen", "given": "Mari", "initials": "M", "orcid": "0000-0002-7105-3543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3bc89cf67f1842fdb3dd0d4fdf80a328.json"}}, {"family": "Puutio", "given": "Johanna", "initials": "J", "orcid": "0000-0002-5519-7053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4301cceee9f34549b7a6fef5393670bc.json"}}, {"family": "\u00d8stergaard", "given": "Rikke Halse", "initials": "RH"}, {"family": "Eble", "given": "Johannes A", "initials": "JA", "orcid": "0000-0001-9156-2137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c69127263fbb42d3acd6c2b36b079cff.json"}}, {"family": "Maaninka", "given": "Katariina", "initials": "K", "orcid": "0000-0001-6341-3871", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f06d9129e024ccfb508779f65409be5.json"}}, {"family": "Ndika", "given": "Joseph", "initials": "J", "orcid": "0000-0003-0669-1300", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddb225ee16ef486aaf41ce67d262c442.json"}}, {"family": "Kari", "given": "Otto K", "initials": "OK", "orcid": "0000-0002-1201-5010", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5af5a47a2e2d44209c92fc321bacbbd4.json"}}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M", "orcid": "0000-0002-1303-2218", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/70fceb2370d74e39a8c26d17963981cc.json"}}, {"family": "Kjaer-Sorensen", "given": "Kasper", "initials": "K", "orcid": "0000-0003-1211-3267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/069c55d42f5942918124cd1c45dc8a3e.json"}}, {"family": "Oxvig", "given": "Claus", "initials": "C", "orcid": "0000-0002-4715-9719", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81978ac366f346f4a0e596c354d98410.json"}}, {"family": "Aransay", "given": "Ana M", "initials": "AM", "orcid": "0000-0002-8271-612X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8a11379529b4769a5f8b5a989e99330.json"}}, {"family": "Falcon-Perez", "given": "Juan", "initials": "J", "orcid": "0000-0003-3133-0670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5b8dc4904a146028699385aa0c144ea.json"}}, {"family": "Federico", "given": "Antonio", "initials": "A", "orcid": "0000-0003-2554-9879", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecbdc2f5f6b84cdc86d591aa07bf3c95.json"}}, {"family": "Greco", "given": "Dario", "initials": "D", "orcid": "0000-0001-9195-9003", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db0acb9d0db7478fbd9c6a3719511918.json"}}, {"family": "Laitinen", "given": "Saara", "initials": "S", "orcid": "0000-0002-3482-1304", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d630dbebd2b041969213c09d16a5a799.json"}}, {"family": "Hayashi", "given": "Yuya", "initials": "Y", "orcid": "0000-0002-7090-0990", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9da7dae6d58346c3afb8766d32ff321c.json"}}, {"family": "Siljander", "given": "Pia RM", "initials": "PR", "orcid": "0000-0003-2326-5821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee4cfe2ca7a9427797157a50650d66b2.json"}}], "type": "posted-content", "published": "2024-01-01", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.31.570750", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:51:21.062Z", "modified": "2026-08-20T10:51:21.446Z"}]}