{"entity": "researcher", "timestamp": "2026-08-20T20:45:45.712Z", "family": "Malmstr\u00f6m", "given": "J", "initials": "J", "orcid": "0000-0002-2889-7169", "affiliations": ["Division of Infection Medicine, Department of Clinical Sciences, Lund University, SE-221 84, Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7"}}, "publications": [{"entity": "publication", "iuid": "f451b8d900d749338eb9298e0b94d701", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f451b8d900d749338eb9298e0b94d701.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f451b8d900d749338eb9298e0b94d701"}}, "title": "Streptolysin O Accelerates the Conversion of Plasminogen to Plasmin", "authors": [{"family": "Tang", "given": "Di", "initials": "D", "orcid": "0000-0001-6323-9375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ab26121ccb4cbcb99161cea8aca0cd.json"}}, {"family": "Khakzad", "given": "Hamed", "initials": "H", "orcid": "0000-0002-8556-0650", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f180aac313b4c58821bf706a242d345.json"}}, {"family": "Hjortswang", "given": "Elisabeth", "initials": "E", "orcid": "0009-0003-9932-1751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e15db3610334564ac7fd4dfb2948dda.json"}}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L", "orcid": "0000-0001-9885-9312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0310c5c750a4357af859999d705cfad.json"}}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S", "orcid": "0000-0002-7694-285X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/277129edad3b4b77b645be7353cec439.json"}}, {"family": "Happonen", "given": "Lotta", "initials": "L", "orcid": "0000-0002-5922-4549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/687cf1ac5c8e4c52add689341b2d61e8.json"}}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7.json"}}], "type": "posted-content", "published": "2024-05-16", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.05.15.594458", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:54:54.063Z", "modified": "2026-08-20T10:54:54.171Z"}, {"entity": "publication", "iuid": "49da3b71ec69483381e3b61be2ff23d8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/49da3b71ec69483381e3b61be2ff23d8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/49da3b71ec69483381e3b61be2ff23d8"}}, "title": "Multi-Modal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O", "authors": [{"family": "Tang", "given": "Di", "initials": "D", "orcid": "0000-0001-6323-9375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ab26121ccb4cbcb99161cea8aca0cd.json"}}, {"family": "Gueto-Tettay", "given": "Carlos", "initials": "C", "orcid": "0000-0002-8496-6341", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0953c0491dd44d80a4acbec2d4884bbb.json"}}, {"family": "Hjortswang", "given": "Elisabeth", "initials": "E", "orcid": "0009-0003-9932-1751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3e15db3610334564ac7fd4dfb2948dda.json"}}, {"family": "Str\u00f6baek", "given": "Joel", "initials": "J", "orcid": "0000-0003-1231-0420", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e55a29a34b9747948646ea4b5f5fd9ca.json"}}, {"family": "Ekstr\u00f6m", "given": "Simon", "initials": "S"}, {"family": "Happonen", "given": "Lotta", "initials": "L", "orcid": "0000-0002-5922-4549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/687cf1ac5c8e4c52add689341b2d61e8.json"}}, {"family": "Malmstr\u00f6m", "given": "Lars", "initials": "L", "orcid": "0000-0001-9885-9312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f0310c5c750a4357af859999d705cfad.json"}}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7.json"}}], "type": "posted-content", "published": "2023-12-02", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.02.569700", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:50:38.431Z", "modified": "2026-08-20T10:50:38.642Z"}, {"entity": "publication", "iuid": "9093be9d25304416ae8c5998d9551ac6", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9093be9d25304416ae8c5998d9551ac6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9093be9d25304416ae8c5998d9551ac6"}}, "title": "Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model.", "authors": [{"family": "Tanner", "given": "L", "initials": "L", "orcid": "0000-0003-0626-9820", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/981640c7635b47b2aca0380e88fb307f.json"}}, {"family": "Single", "given": "A B", "initials": "AB"}, {"family": "Bhongir", "given": "R K V", "initials": "RKV", "orcid": "0000-0001-6648-1781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a31b3b22ce2a439e9185e10e23824d96.json"}}, {"family": "Heusel", "given": "M", "initials": "M", "orcid": "0000-0002-8506-530X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1be58c525be846cdb4ec2c66f5c8e2e1.json"}}, {"family": "Mohanty", "given": "T", "initials": "T", "orcid": "0000-0003-4593-9612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aebc0056f7634624a1d9b49349ecdd83.json"}}, {"family": "Karlsson", "given": "C A Q", "initials": "CAQ"}, {"family": "Pan", "given": "L", "initials": "L", "orcid": "0000-0003-2324-2144", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/125298170cc54ff1b710b0c13d3b1c95.json"}}, {"family": "Clausson", "given": "C-M", "initials": "CM"}, {"family": "Bergwik", "given": "J", "initials": "J"}, {"family": "Wang", "given": "K", "initials": "K"}, {"family": "Andersson", "given": "C K", "initials": "CK"}, {"family": "Oommen", "given": "R M", "initials": "RM"}, {"family": "Erjef\u00e4lt", "given": "J S", "initials": "JS"}, {"family": "Malmstr\u00f6m", "given": "J", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7.json"}}, {"family": "Wallner", "given": "O", "initials": "O"}, {"family": "Boldogh", "given": "I", "initials": "I"}, {"family": "Helleday", "given": "T", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/385586c159494955a9a72c3381e3ad47.json"}}, {"family": "Kalder\u00e9n", "given": "C", "initials": "C"}, {"family": "Egesten", "given": "A", "initials": "A", "orcid": "0000-0001-5269-3433", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63e0e8feadd341789778f04cd07cf020.json"}}], "type": "journal article", "published": "2023-02-06", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "14", "issue": "1", "pages": "643", "issn-l": "2041-1723"}, "abstract": "Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedanib, compounds which slow the rate of disease progression but fail to target underlying pathophysiological mechanisms. The DNA repair protein 8-oxoguanine DNA glycosylase-1 (OGG1) has significant roles in the modulation of inflammation and metabolic syndromes. Currently, no pharmaceutical solutions targeting OGG1 have been utilized in the treatment of IPF. In this study we show Ogg1-targeting siRNA mitigates bleomycin-induced pulmonary fibrosis in male mice, highlighting OGG1 as a tractable target in lung fibrosis. The small molecule OGG1 inhibitor, TH5487, decreases myofibroblast transition and associated pro-fibrotic gene expressions in fibroblast cells. In addition, TH5487 decreases levels of pro-inflammatory mediators, inflammatory cell infiltration, and lung remodeling in a murine model of bleomycin-induced pulmonary fibrosis conducted in male C57BL6/J mice. OGG1 and SMAD7 interact to induce fibroblast proliferation and differentiation and display roles in fibrotic murine and IPF patient lung tissue. Taken together, these data suggest that TH5487 is a potentially clinically relevant treatment for IPF but further study in human trials is required.", "doi": "10.1038/s41467-023-36314-5", "pmid": "36746968", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9902543"}, {"db": "pii", "key": "10.1038/s41467-023-36314-5"}], "notes": [], "created": "2026-08-20T08:52:35.313Z", "modified": "2026-08-20T08:52:35.614Z"}, {"entity": "publication", "iuid": "3e361ab03510479f99e72aeadd8afd37", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3e361ab03510479f99e72aeadd8afd37.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3e361ab03510479f99e72aeadd8afd37"}}, "title": "Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization.", "authors": [{"family": "Governa", "given": "Valeria", "initials": "V"}, {"family": "Talbot", "given": "Hugo", "initials": "H", "orcid": "0000-0001-9774-8573", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28e1c9cf68e6408dbcf4ac2c031fb468.json"}}, {"family": "Gon\u00e7alves de Oliveira", "given": "Kelin", "initials": "K", "orcid": "0000-0003-1646-5657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f774f99247314765b97114edc82199f1.json"}}, {"family": "Cerezo-Maga\u00f1a", "given": "Myriam", "initials": "M", "orcid": "0000-0001-9752-8917", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c8019362baf45b394e839c00f7ac1d5.json"}}, {"family": "B\u00e5ng-Rudenstam", "given": "Anna", "initials": "A", "orcid": "0000-0003-2706-9502", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fea3b51f73f4175b859cde49e99e5e7.json"}}, {"family": "Johansson", "given": "Maria C", "initials": "MC", "orcid": "0000-0003-0075-3187", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ce5f12cf2e24399b8b1a2f90a647e6e.json"}}, {"family": "M\u00e5nsson", "given": "Ann-Sofie", "initials": "AS", "orcid": "0000-0002-5984-3470", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b3c8e6d27ad4029be4738d5816e0234.json"}}, {"family": "Forsberg-Nilsson", "given": "Karin", "initials": "K"}, {"family": "Marko-Varga", "given": "Gy\u00f6rgy", "initials": "G"}, {"family": "Enr\u00edquez P\u00e9rez", "given": "Julio", "initials": "J", "orcid": "0000-0002-6361-3272", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/836f9e769c34462ea7d6d9ac64345beb.json"}}, {"family": "Darabi", "given": "Anna", "initials": "A", "orcid": "0000-0003-4326-8149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb9f19a0c8694ee79ca515a79976d146.json"}}, {"family": "Malmstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0002-2889-7169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c89da9268a4f47a8a99fd62de451aaa7.json"}}, {"family": "Bengzon", "given": "Johan", "initials": "J"}, {"family": "Welinder", "given": "Charlotte", "initials": "C", "orcid": "0000-0001-9626-0576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5715a70ce8df4a5d84ad88709791772a.json"}}, {"family": "Belting", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1585-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9763a47486d410fb5034fb2603f3a02.json"}}], "type": "journal article", "published": "2022-03-01", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "119", "issue": "9", "issn-l": "0027-8424"}, "abstract": "Therapeutic strategies directed at the tumor surfaceome (TS), including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have developed a platform (tumor surfaceome mapping [TS-MAP]) integrated with a newly curated TS classifier (SURFME) that allows profiling of primary 3D cultures and intact patient glioma tumors with preserved tissue architecture. Moreover, TS-MAP specifically identifies proteins capable of endocytosis as tractable targets for ADCs and other modalities requiring toxic payload internalization. In high-grade gliomas that remain among the most aggressive forms of cancer, we show that cellular spatial organization (2D vs. 3D) fundamentally transforms the surfaceome and endocytome (e.g., integrins, proteoglycans, semaphorins, and cancer stem cell markers) with general implications for target screening approaches, as exemplified by an ADC targeting EGFR. The TS-MAP platform was further applied to profile the surfaceome and endocytome landscape in a cohort of freshly resected gliomas. We found a highly diverse TS repertoire between patient tumors, not directly associated with grade and histology, which highlights the need for individualized approaches. Our data provide additional layers of understanding fundamental to the future development of immunotherapy strategies, as well as procedures for proteomics-based target identification and selection. The TS-MAP platform should be widely applicable in efforts aiming at a better understanding of how to harness the TS for personalized immunotherapy.", "doi": "10.1073/pnas.2114456119", "pmid": "35217608", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8892282"}, {"db": "pii", "key": "2114456119"}], "notes": [], "created": "2026-08-20T09:31:01.542Z", "modified": "2026-08-20T09:31:01.946Z"}]}