{"entity": "researcher", "timestamp": "2026-08-22T07:48:09.202Z", "family": "Linge", "given": "Petrus", "initials": "P", "orcid": "0000-0001-8906-2715", "affiliations": ["Department of Clinical Sciences Lund, Section of Rheumatology, Lunds University Faculty of Medicine, Lund, Skane, Sweden petrus.linge@med.lu.se."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9"}}, "publications": [{"entity": "publication", "iuid": "6538516184c34387bbd73b670be1f443", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443"}}, "title": "NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.", "authors": [{"family": "Linge", "given": "Petrus", "initials": "P", "orcid": "0000-0001-8906-2715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9.json"}}, {"family": "Arve", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3347-5550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d063b42c4af42efbba4afb26b9a9fd3.json"}}, {"family": "Olsson", "given": "Lina M", "initials": "LM"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Tyd\u00e9n", "given": "Helena", "initials": "H"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Ann. Rheum. Dis.", "issn": "1468-2060", "volume": "79", "issue": "2", "pages": "254-261", "issn-l": "0003-4967"}, "abstract": "\u200bOBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). This study aimed at characterising NCF1-339 effects on neutrophil extracellular trap (NET) formation, type I interferon activity and antibody profile in patients with SLE. \u200bMETHODS: Neutrophil NET-release pathways (n=31), serum interferon (n=141) and finally antibody profiles (n=305) were investigated in SLE subjects from Lund, genotyped for NCF1-339. Then, 1087 SLE subjects from the rheumatology departments of four Swedish SLE centres, genotyped for NCF1-339, were clinically characterised to validate these findings. \u200bRESULTS: Compared with patients with normal-ROS NCF1-339 genotypes, neutrophils from patients with SLE with low-ROS NCF1-339 genotypes displayed impaired NET formation (p<0.01) and increased dependence on mitochondrial ROS (p<0.05). Low-ROS patients also had increased frequency of high serum interferon activity (80% vs 21.4%, p<0.05) and positivity for anti-\u03b22 glycoprotein I (p<0.01) and anticardiolipin antibodies (p<0.05) but were not associated with other antibodies. We confirmed an over-representation of having any antiphospholipid antibody, OR 1.40 (95% CI 1.01 to 1.95), anti-\u03b22 glycoprotein I, OR 1.82 (95% CI 1.02 to 3.24) and the antiphospholipid syndrome (APS), OR 1.74 (95% CI 1.19 to 2.55) in all four cohorts (n=1087). \u200bCONCLUSIONS: The NCF1-339 SNP mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of NETs in SLE, allowing dependence on mitochondrial ROS. Unexpectedly, we revealed a striking connection between the ROS deficient NCF1-339 genotypes and the presence of phospholipid antibodies and APS.", "doi": "10.1136/annrheumdis-2019-215820", "pmid": "31704719", "labels": [], "xrefs": [{"db": "pii", "key": "S0003-4967(24)01509-7"}], "notes": [], "created": "2026-08-21T12:25:45.018Z", "modified": "2026-08-21T12:25:45.336Z"}]}