{"entity": "researcher", "timestamp": "2026-08-23T22:11:21.166Z", "family": "Aaseb\u00f8", "given": "Kristine", "initials": "K", "orcid": "0000-0003-3575-5588", "affiliations": ["Department of Clinical Science, University of Bergen, Bergen, Norway."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c33b6dea17eb4502aae023058a58e48a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c33b6dea17eb4502aae023058a58e48a"}}, "publications": [{"entity": "publication", "iuid": "fa5fef700c74416f8234c9de7f58cec5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fa5fef700c74416f8234c9de7f58cec5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fa5fef700c74416f8234c9de7f58cec5"}}, "title": "Molecular characterization of a large unselected cohort of metastatic colorectal cancers in relation to primary tumor location, rare metastatic sites and prognosis.", "authors": [{"family": "Nunes", "given": "Lu\u00eds", "initials": "L", "orcid": "0000-0002-3391-1607", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7aa31ccf1801456bb57744978bd605fd.json"}}, {"family": "Aaseb\u00f8", "given": "Kristine", "initials": "K", "orcid": "0000-0003-3575-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c33b6dea17eb4502aae023058a58e48a.json"}}, {"family": "Mathot", "given": "Lucy", "initials": "L", "orcid": "0000-0002-2990-2038", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/458c07a1748d4ce0ac5cff3d6836f350.json"}}, {"family": "Ljungstr\u00f6m", "given": "Viktor", "initials": "V"}, {"family": "Edqvist", "given": "Per-Henrik", "initials": "PH"}, {"family": "Sundstr\u00f6m", "given": "Magnus", "initials": "M"}, {"family": "Dragomir", "given": "Anca", "initials": "A", "orcid": "0000-0003-2777-8114", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0097cdbab8cf450688184aef60a6f8b3.json"}}, {"family": "Pfeiffer", "given": "Per", "initials": "P"}, {"family": "Ameur", "given": "Adam", "initials": "A", "orcid": "0000-0001-6085-6749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a8b8ce05cf7f49aeb3199b5938b9f160.json"}}, {"family": "Ponten", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0703-3940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f5294424542413c9ba4432c839c2b63.json"}}, {"family": "Mezheyeuski", "given": "Artur", "initials": "A", "orcid": "0000-0002-4394-2634", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/227a0142881848f4a1635d66cf52e673.json"}}, {"family": "Sorbye", "given": "Halfdan", "initials": "H"}, {"family": "Sj\u00f6blom", "given": "Tobias", "initials": "T", "orcid": "0000-0001-6668-4140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/851b95a56b3244fb9bc7cec8294e7ae7.json"}}, {"family": "Glimelius", "given": "Bengt", "initials": "B", "orcid": "0000-0002-5440-791X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a4a4dfe9cc6478baaaae4672181691c.json"}}], "type": "journal article", "published": "2020-04-00", "journal": {"title": "Acta Oncol", "issn": "1651-226X", "volume": "59", "issue": "4", "pages": "417-426", "issn-l": "0284-186X"}, "abstract": "Background: We have reported that BRAF V600E mutations and microsatellite instability-high (MSI-H) are more prevalent in a population-based cohort of metastatic colorectal cancer (mCRC) patients than has been reported from clinical trials or hospital-based patient groups. The aim was to explore if other mutations in mCRC differ in prevalence between these cohorts in relation to mismatch repair status and primary tumor location and if presence of bone or brain metastases is associated with any mutations.Material and methods: A population-based cohort of 798 mCRC patients from three regions in Scandinavia was used. Forty-four cancer related genes were investigated in a custom designed Ampliseq hotspot panel. Differences in survival were analyzed using the Kaplan-Meier estimator and the Cox regression analysis.Results: Determination of mutations was possible in 449/501 patients for 40/44 genes. Besides BRAF V600E, seen in 19% of the tumors, none of the other mutations appeared more prevalent than in trial cohorts. BRAF V600E and MSI-H, seen in 8%, were associated with poor prognosis as was right-sided primary tumor location (39%) when compared to left-sided and rectum together; however, in a multivariable regression, only the BRAF mutation retained its statistical significance. No other mutations were associated with poor prognosis. ERBB2 alterations were more common if bone metastases were present at diagnosis (17% vs. 4%, p = .011). No association was found for brain metastases. Fifty-two percent had an alteration that is treatable with an FDA-approved targeted therapy, chiefly by EGFR-inhibitor for RAS wild-type and a check-point inhibitor for MSI-H tumors.Conclusions: Right-sided tumor location, BRAF V600E mutations, but no other investigated mutation, and MSI-H are more commonly seen in an unselected cohort than is reported from clinical patient cohorts, likely because they indicate poor prognosis. Half of the patients have a tumor that is treatable with an already FDA-approved targeted drug for mCRC.", "doi": "10.1080/0284186X.2019.1711169", "pmid": "31924107", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-21T09:28:00.960Z", "modified": "2026-08-21T09:28:01.022Z"}, {"entity": "publication", "iuid": "8d8ce4237a5a4c84a238c86dd4afb65b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8d8ce4237a5a4c84a238c86dd4afb65b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8d8ce4237a5a4c84a238c86dd4afb65b"}}, "title": "Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients.", "authors": [{"family": "Aaseb\u00f8", "given": "Kristine \u00d8", "initials": "K\u00d8", "orcid": "0000-0003-3575-5588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c33b6dea17eb4502aae023058a58e48a.json"}}, {"family": "Dragomir", "given": "Anca", "initials": "A"}, {"family": "Sundstr\u00f6m", "given": "Magnus", "initials": "M"}, {"family": "Mezheyeuski", "given": "Artur", "initials": "A"}, {"family": "Edqvist", "given": "Per-Henrik", "initials": "PH"}, {"family": "Eide", "given": "Geir Egil", "initials": "GE"}, {"family": "Ponten", "given": "Fredrik", "initials": "F"}, {"family": "Pfeiffer", "given": "Per", "initials": "P"}, {"family": "Glimelius", "given": "Bengt", "initials": "B"}, {"family": "Sorbye", "given": "Halfdan", "initials": "H"}], "type": "journal article", "published": "2019-07-00", "journal": {"title": "Cancer Med", "issn": "2045-7634", "volume": "8", "issue": "7", "pages": "3623-3635", "issn-l": "2045-7634"}, "abstract": "Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the frequency of these molecular changes in trial patients are low. Unselected population-based studies of these molecular changes are warranted.\n\nA population-based cohort of 798 mCRC patients in Scandinavia was studied. Patient and molecular tumor characteristics, overall survival (OS) and progression-free survival (PFS) were estimated.\n\nHere, 40/583 (7%) tumor samples were MSI-H and 120/591 (20%) were mutBRAF; 87% of MSI-H tumors were mutBRAF (non-Lynch). Elderly (>75 years) had more often MSI-H (10% vs 6%) and MSI-H/mutBRAF (9% vs 4%) tumors. Response rate (5% vs 44%), PFS (4 vs 8 months), and OS (9 vs 18 months) after first-line chemotherapy was all significantly lower in patients with MSI-H compared to patients with microsatellite stable tumors. MSI-H and mutBRAF were both independent poor prognostic predictors for OS (P = 0.049, P < 0.001) and PFS (P = 0.045, P = 0.005) after first-line chemotherapy. Patients with MSI-H tumors received less second-line chemotherapy (15% vs 37%, P = 0.005).\n\nIn unselected mCRC patients, MSI-H and mutBRAF cases were more common than previously reported. Patients with MSI-H tumors had worse survival, less benefit from chemotherapy, and they differed considerably from recent third-line immunotherapy trial patients as they were older and most had mutBRAF tumor (non-Lynch).", "doi": "10.1002/cam4.2205", "pmid": "31070306", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6601706"}], "notes": [], "created": "2026-08-21T11:00:41.700Z", "modified": "2026-08-21T11:00:41.746Z"}]}