{"entity": "researcher", "timestamp": "2026-08-23T09:27:11.538Z", "family": "Valentino", "given": "Mariaelena", "initials": "M", "orcid": "0000-0003-1925-1005", "affiliations": ["IFOM ETS - The AIRC Institute of Molecular Oncology, Milan, 20139, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3218fe59b894a73936c790d60c377cd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3218fe59b894a73936c790d60c377cd"}}, "publications": [{"entity": "publication", "iuid": "8e264d56f32f463c828559c875b7f636", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e264d56f32f463c828559c875b7f636.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e264d56f32f463c828559c875b7f636"}}, "title": "Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations.", "authors": [{"family": "Pham", "given": "Van-Cuong", "initials": "VC", "orcid": "0000-0003-4787-7013", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fbb2a4fb4e74050aa30104ffc2ab51a.json"}}, {"family": "R\u00f6del", "given": "Claudia Jasmin", "initials": "CJ", "orcid": "0000-0002-2384-1537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/267c4897525945feb15fdd2903304e39.json"}}, {"family": "Valentino", "given": "Mariaelena", "initials": "M", "orcid": "0000-0003-1925-1005", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3218fe59b894a73936c790d60c377cd.json"}}, {"family": "Malinverno", "given": "Matteo", "initials": "M"}, {"family": "Paolini", "given": "Alessio", "initials": "A", "orcid": "0000-0001-7002-7303", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/026e36344354415bbcba8e9d5977fdfa.json"}}, {"family": "M\u00fcnch", "given": "Juliane", "initials": "J", "orcid": "0000-0002-5910-6569", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/964ce00c6e124680a6111812c906fd82.json"}}, {"family": "Pasquier", "given": "Candice", "initials": "C", "orcid": "0009-0007-9731-1559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27de08eb88b7496d998b741ec9b0740b.json"}}, {"family": "Onyeogaziri", "given": "Favour C", "initials": "FC", "orcid": "0000-0002-5742-0474", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8aae5b71f73f44d5ab210e2eb2865b3c.json"}}, {"family": "Lazovic", "given": "Bojana", "initials": "B"}, {"family": "Girard", "given": "Romuald", "initials": "R"}, {"family": "Koskim\u00e4ki", "given": "Janne", "initials": "J", "orcid": "0000-0002-2311-6327", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eea751c8956243528e149f759279a74e.json"}}, {"family": "Hu\u00dfmann", "given": "Melina", "initials": "M", "orcid": "0000-0003-4798-7503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a59fcc7d06d4f7fb277457a41bb6ce1.json"}}, {"family": "Keith", "given": "Benjamin", "initials": "B"}, {"family": "Jachimowicz", "given": "Daniel", "initials": "D"}, {"family": "Kohl", "given": "Franziska", "initials": "F"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A", "orcid": "0000-0003-3015-4038", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4b00dea21d446c0af4c0cd542d24907.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2a049a261eb46c79066a817f5cd4d5b.json"}}, {"family": "Schulte-Merker", "given": "Stefan", "initials": "S", "orcid": "0000-0003-3617-8807", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dbeddeebdec64023be70b835575fb4f6.json"}}, {"family": "Awad", "given": "Issam A", "initials": "IA"}, {"family": "Hicks", "given": "Ryan", "initials": "R"}, {"family": "Magnusson", "given": "Peetra U", "initials": "PU", "orcid": "0000-0003-1142-854X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/386c2465430546df9a9231e99d588a28.json"}}, {"family": "Faurobert", "given": "Eva", "initials": "E", "orcid": "0000-0002-2714-8537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12c8f7c0f5554824a2b3e37eda2934be.json"}}, {"family": "Pagani", "given": "Massimiliano", "initials": "M", "orcid": "0000-0002-7017-9304", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/02c8e9fba29947078938a102a9e96dc2.json"}}, {"family": "Abdelilah-Seyfried", "given": "Salim", "initials": "S", "orcid": "0000-0003-3183-3841", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/37eb2266764c4ac1b4a8617aaf07fad7.json"}}], "type": "journal article", "published": "2024-11-00", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "16", "issue": "11", "pages": "2827-2855", "issn-l": "1757-4676"}, "abstract": "Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Kr\u00fcppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological pattern of gene expression. The downstream target genes that are activated by KLF2 are mostly unknown. Here we show that Chromobox Protein Homolog 7 (CBX7), component of the Polycomb Repressive Complex 1, contributes to pathophysiological KLF2 signaling during zebrafish cardiovascular development. CBX7/cbx7a mRNA is strongly upregulated in lesions of CCM patients, and in human, mouse, and zebrafish CCM-deficient endothelial cells. The silencing or pharmacological inhibition of CBX7/Cbx7a suppresses pathological CCM phenotypes in ccm2 zebrafish, CCM2-deficient HUVECs, and in a pre-clinical murine CCM3 disease model. Whole-transcriptome datasets from zebrafish cardiovascular tissues and human endothelial cells reveal a role of CBX7/Cbx7a in the activation of KLF2 target genes including TEK, ANGPT1, WNT9, and endoMT-associated genes. Our findings uncover an intricate interplay in the regulation of Klf2-dependent biomechanical signaling by CBX7 in CCM. This work also provides insights for therapeutic strategies in the pathogenesis of CCM.", "doi": "10.1038/s44321-024-00152-9", "pmid": "39402138", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11555420"}, {"db": "pii", "key": "10.1038/s44321-024-00152-9"}], "notes": [], "created": "2026-08-20T09:26:56.373Z", "modified": "2026-08-20T09:26:56.956Z"}]}