{"entity": "researcher", "timestamp": "2026-09-23T15:24:57.576Z", "family": "Rasmusson", "given": "Annica", "initials": "A", "orcid": "0000-0002-7228-7755", "affiliations": ["Department of Medical Sciences, Psychiatry, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2f3b6ac5c4e40f484add0f1fbfa17fa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2f3b6ac5c4e40f484add0f1fbfa17fa"}}, "publications": [{"entity": "publication", "iuid": "3153fe66a9d94bb8bfce7c800b37a4e9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3153fe66a9d94bb8bfce7c800b37a4e9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3153fe66a9d94bb8bfce7c800b37a4e9"}}, "title": "Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19.", "authors": [{"family": "Jernbom", "given": "August F", "initials": "AF", "orcid": "0000-0002-7773-1851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36e1c0cae02d4307be2b4bae725d122d.json"}}, {"family": "Skoglund", "given": "Lovisa", "initials": "L", "orcid": "0009-0002-7863-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/091d25512b5f491087dd0d3415ff7800.json"}}, {"family": "Pin", "given": "Elisa", "initials": "E", "orcid": "0000-0002-2158-2674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1533d567ad31481fae15627d3b316382.json"}}, {"family": "Sj\u00f6berg", "given": "Ronald", "initials": "R", "orcid": "0000-0003-1363-5796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d78ebc1fe5f140dd8a8011d8f7f4d05c.json"}}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b9de19b82b4406d8904cb937a466e8b.json"}}, {"family": "Hober", "given": "Sophia", "initials": "S", "orcid": "0000-0003-0605-8417", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a1bdfd8500c4dbea343132bc0d8e44c.json"}}, {"family": "Rostami", "given": "Elham", "initials": "E", "orcid": "0000-0003-1218-6247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e6b2f42c0714de792d6214a55d9bcea.json"}}, {"family": "Rasmusson", "given": "Annica", "initials": "A", "orcid": "0000-0002-7228-7755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2f3b6ac5c4e40f484add0f1fbfa17fa.json"}}, {"family": "Cunningham", "given": "Janet L", "initials": "JL", "orcid": "0000-0001-7876-7779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/724e76952d6c43fe9f97030bb8ed75f2.json"}}, {"family": "Havervall", "given": "Sebastian", "initials": "S"}, {"family": "Th\u00e5lin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-1345-6491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/584e7e091c0f41259bf2d98cdf713a91.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2024-10-17", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "8941", "issn-l": "2041-1723"}, "abstract": "Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at five time points over a 16-month period in 2020 and 2021 using proteome-wide and targeted protein and peptide arrays. Our results show that prevalent new-onset autoantibodies against a wide range of antigens emerged following SARS-CoV-2 infection in relation to pre-infectious baseline samples and remained elevated for at least 12 months. We found an increased prevalence of new-onset autoantibodies after severe COVID-19 and demonstrated associations between distinct new-onset autoantibodies and neuropsychiatric symptoms post-COVID-19. Using epitope mapping, we determined the main epitopes of selected new-onset autoantibodies, validated them in independent cohorts of neuro-COVID and pre-pandemic healthy controls, and identified sequence similarities suggestive of molecular mimicry between main epitopes and the conserved fusion peptide of the SARS-CoV-2 Spike glycoprotein. Our work describes the complexity and dynamics of the autoantibody repertoire emerging with COVID-19 and supports the need for continued analysis of the new-onset autoantibody repertoire to elucidate the mechanisms of the post-COVID-19 condition.", "doi": "10.1038/s41467-024-53356-5", "pmid": "39414823", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11484904"}, {"db": "pii", "key": "10.1038/s41467-024-53356-5"}], "notes": [], "created": "2026-09-23T08:48:31.192Z", "modified": "2026-09-23T08:48:31.444Z"}, {"entity": "publication", "iuid": "0285c6e526764c20a50fd2e2a8f2b168", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0285c6e526764c20a50fd2e2a8f2b168.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0285c6e526764c20a50fd2e2a8f2b168"}}, "title": "Three cases with chronic obsessive compulsive disorder report gains in wellbeing and function following rituximab treatment", "authors": [{"family": "Cunningham", "given": "Janet", "initials": "J", "orcid": "0000-0001-7876-7779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/724e76952d6c43fe9f97030bb8ed75f2.json"}}, {"family": "Gallwitz", "given": "Maike", "initials": "M"}, {"family": "Lindqvist", "given": "Isa", "initials": "I"}, {"family": "Mulder", "given": "Jan", "initials": "J", "orcid": "0000-0003-3717-5018", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/40ed8170792444b491519e499d51c434.json"}}, {"family": "Rasmusson", "given": "Annica", "initials": "A", "orcid": "0000-0002-7228-7755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2f3b6ac5c4e40f484add0f1fbfa17fa.json"}}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Hus\u00e9n", "given": "Evelina", "initials": "E"}, {"family": "Borin", "given": "Jesper", "initials": "J"}, {"family": "Spek", "given": "Peter van der", "initials": "Pvd", "orcid": "0000-0002-2203-0652", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f90048bcb296403596dee2b9a29de1dd.json"}}, {"family": "Sabbagh", "given": "Nour", "initials": "N"}, {"family": "Widgren", "given": "Anna", "initials": "A"}, {"family": "Bergquist", "given": "Jonas", "initials": "J"}, {"family": "Cervenka", "given": "Simon", "initials": "S"}, {"family": "Burman", "given": "Joachim", "initials": "J"}], "type": "posted-content", "published": "2024-01-12", "journal": {"issn-l": null}, "abstract": null, "doi": "10.21203/rs.3.rs-3398406/v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-09-23T14:50:12.283Z", "modified": "2026-09-23T14:50:12.358Z"}, {"entity": "publication", "iuid": "95dea53d0b674e2d99478128767d1f13", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/95dea53d0b674e2d99478128767d1f13.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/95dea53d0b674e2d99478128767d1f13"}}, "title": "Toll-like receptor 4 methylation grade is linked to depressive symptom severity.", "authors": [{"family": "Rasmusson", "given": "Annica J", "initials": "AJ", "orcid": "0000-0002-7228-7755", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2f3b6ac5c4e40f484add0f1fbfa17fa.json"}}, {"family": "Gallwitz", "given": "Maike", "initials": "M"}, {"family": "Soltanabadi", "given": "Bardia", "initials": "B", "orcid": "0000-0003-4827-5268", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17d5ab20b2e9415f83030d8ffa9f6199.json"}}, {"family": "Ciuculete", "given": "Diana M", "initials": "DM"}, {"family": "Mengel-From", "given": "Jonas", "initials": "J"}, {"family": "Christensen", "given": "Kaare", "initials": "K", "orcid": "0000-0002-5429-5292", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6d6f32bfc8d43f791f774fa79619abf.json"}}, {"family": "Nygaard", "given": "Marianne", "initials": "M", "orcid": "0000-0003-0703-2665", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1b2d8bb887e4f539b717ddb56b1a22b.json"}}, {"family": "Soerensen", "given": "Mette", "initials": "M", "orcid": "0000-0001-5268-3366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60881ef30f9e4d35b5ada85ecec642f5.json"}}, {"family": "Bostr\u00f6m", "given": "Adrian E", "initials": "AE"}, {"family": "Fredriksson", "given": "Robert", "initials": "R"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Mwinyi", "given": "Jessica", "initials": "J"}, {"family": "Czamara", "given": "Darina", "initials": "D", "orcid": "0000-0001-7381-904X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1f8ecca929c444391279db6aab323a7.json"}}, {"family": "Binder", "given": "Elisabeth B", "initials": "EB", "orcid": "0000-0001-7088-6618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41b5f214510f4e0f9d1508d553148a40.json"}}, {"family": "Schi\u00f6th", "given": "Helgi B", "initials": "HB"}, {"family": "Cunningham", "given": "Janet L", "initials": "JL", "orcid": "0000-0001-7876-7779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/724e76952d6c43fe9f97030bb8ed75f2.json"}}], "type": "journal article", "published": "2021-06-24", "journal": {"title": "Transl Psychiatry", "issn": "2158-3188", "volume": "11", "issue": "1", "pages": "371", "issn-l": "2158-3188"}, "abstract": "This study explores potential associations between the methylation of promoter-associated CpG sites of the toll-like receptor (TLR)-family, plasma levels of pro-inflammatory proteins and depressive symptoms in young female psychiatric patients. Ratings of depressive symptoms and blood samples were obtained from 92 young women seeking psychiatric care. Methylation of 32 promoter-associated CpG sites in TLR1 to TLR10 was analysed using the Illumina Infinium Methylation EPIC BeadChip. Expression levels of 91 inflammatory proteins were determined by proximity extension assay. Statistical correlations between depressive state, TLR1-10 methylation and inflammatory proteins were investigated. Four additional cohorts were studied to evaluate the generalizability of the findings. In the discovery cohort, methylation grade of cg05429895 (TLR4) in blood was inversely correlated with depressive symptoms score in young adults. After correction for multiple testing, plasma levels of macrophage inflammatory protein 1\u03b2 (MIP-1\u03b2/CCL4) were associated with both TLR4 methylation and depressive symptom severity. A similar inverse association between TLR4 methylation in blood and affective symptoms score was also found in a cohort of 148 both males and females (<40 years of age) from the Danish Twin Registry. These findings were not, however, replicated in three other external cohorts; which differed from the first two cohorts by a higher age and mixed ethnicities, thus limiting the generalizability of our findings. However, TLR4 methylation inversely correlated with TLR4 mRNA expression in the Danish Twin Study indicating a functional significance of methylation at this particular CpG. Higher depression scores in young Scandinavian adults was associated with decreased methylation of TLR4 in blood.", "doi": "10.1038/s41398-021-01481-w", "pmid": "34226490", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8257733"}, {"db": "pii", "key": "10.1038/s41398-021-01481-w"}], "notes": [], "created": "2026-09-23T11:53:02.212Z", "modified": "2026-09-23T11:53:02.505Z"}]}