{"entity": "researcher", "timestamp": "2026-09-25T06:23:52.391Z", "family": "Konopka", "given": "Paulina", "initials": "P", "orcid": "0000-0003-3568-8530", "affiliations": ["Clinical Research Center, Medical University of Bialystok, Bialystok, Poland.", "Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2e58b3d3c8247b08e7faa6705bcad7a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2e58b3d3c8247b08e7faa6705bcad7a"}}, "publications": [{"entity": "publication", "iuid": "df27115d57a64abc8455d357325d784c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/df27115d57a64abc8455d357325d784c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/df27115d57a64abc8455d357325d784c"}}, "title": "Common genetic variants near SLC2A2 and glycemic response to glimepiride in the GRADE comparative effectiveness clinical trial.", "authors": [{"family": "Li", "given": "Josephine H", "initials": "JH", "orcid": "0000-0003-2314-0914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/088795c9a08f4c7695b81a209b739802.json"}}, {"family": "Szczerbinski", "given": "Lukasz", "initials": "L", "orcid": "0000-0002-6201-0605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82b692823ae54bbfba619c32d87f265d.json"}}, {"family": "Tripputi", "given": "Mark", "initials": "M", "orcid": "0000-0002-5510-7310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/24d514a70ba747408d17f00809099e2e.json"}}, {"family": "Liu", "given": "Haiyin", "initials": "H"}, {"family": "Nam", "given": "Stella", "initials": "S", "orcid": "0000-0002-9049-2680", "researcher": {"href": 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"given": "Paulina", "initials": "P", "orcid": "0000-0003-3568-8530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2e58b3d3c8247b08e7faa6705bcad7a.json"}}, {"family": "Czajkowski", "given": "Marcin", "initials": "M", "orcid": "0000-0002-3967-1819", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cec120ba1cae4cbaa97849bed6bb3da5.json"}}, {"family": "Huerta-Chagoya", "given": "Alicia", "initials": "A", "orcid": "0000-0001-6218-3904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1282817aaac54b1da845392b7bd58a16.json"}}, {"family": "Vora", "given": "Maheak", "initials": "M", "orcid": "0000-0002-3248-9547", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f93c37513c346d9b95f192f8080dce7.json"}}, {"family": "Leong", "given": "Aaron", "initials": "A"}, {"family": "Meigs", "given": "James B", "initials": "JB", "orcid": "0000-0002-2439-2657", "researcher": 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"https://publications-affiliated.scilifelab.se/researcher/82a95b865979487494e2ed162560f936.json"}}, {"family": "Dawed", "given": "Adam Y", "initials": "AY"}, {"family": "Pearson", "given": "Ewan R", "initials": "ER", "orcid": "0000-0001-9237-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e27e9e47f1cc4a969268eb5a65b8045b.json"}}, {"family": "Satin", "given": "Leslie S", "initials": "LS", "orcid": "0000-0003-1355-8647", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/63a36d8403184889b1c86660df7c1153.json"}}, {"family": "den Hoed", "given": "Marcel", "initials": "M", "orcid": "0000-0001-8081-428X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1d3e34c06cff4446ad703cde901c5033.json"}}, {"family": "Kretowski", "given": "Adam", "initials": "A", "orcid": "0000-0002-4522-4978", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/262c99ab4ca5433ca26a746aae3ff432.json"}}, {"family": "Kahn", "given": "Steven E", "initials": "SE", "orcid": "0000-0001-7307-9002", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67767780e8ac4757808ccee52b2f8427.json"}}, {"family": "Younes", "given": "Naji", "initials": "N", "orcid": "0000-0002-8913-0340", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff311b44e78f4fb9a2ebb7b4d7f542d5.json"}}, {"family": "Mercader", "given": "Josep M", "initials": "JM", "orcid": "0000-0001-8494-3660", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6c7a41ea07f46f19ca5d6f442461bbd.json"}}, {"family": "Florez", "given": "Jose C", "initials": "JC", "orcid": "0000-0002-1730-9325", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0986a889b72a47068f6134b2567d1b2f.json"}}], "type": "journal article", "published": "2025-10-08", "journal": {"title": "medRxiv", "issn-l": null}, "abstract": "Optimizing second-line therapy for type 2 diabetes is challenging due to interindividual variability in response. We conducted a pharmacogenomic genome-wide association study (GWAS) in the Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness (GRADE) Study to identify genetic predictors of glycemic response to insulin glargine, glimepiride, liraglutide, and sitagliptin, when added to metformin in a diverse population. We identified 21 genome-wide significant loci associated with treatment response. rs1905505, a non-coding variant near SLC2A2, the gene encoding the glucose transporter GLUT2, was enriched in Africans/African Americans and conferred a 36% increased risk of treatment failure on glimepiride (p=4.83\u00d710). Carriers had impaired \u03b2-cell function, evidenced by a lower C-peptide index during OGTT, and diminished glucose-lowering response to an acute sulfonylurea challenge. Genetic manipulation in zebrafish confirmed that slc2a2 disruption attenuates the glucose-lowering effect of glimepiride. In conclusion, genetic variation influences glycemic response to medications, with SLC2A2 emerging as a key determinant of sulfonylurea response.\n\nNCT01794143.", "doi": "10.1101/2025.10.07.25336827", "pmid": "41282760", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12632647"}, {"db": "pii", "key": "2025.10.07.25336827"}, {"db": "ClinicalTrials.gov", "key": "NCT01794143"}], "notes": [], "created": "2026-09-23T15:51:48.104Z", "modified": "2026-09-23T15:51:48.901Z"}]}