{"entity": "researcher", "timestamp": "2026-10-01T12:34:03.808Z", "family": "Papadopoulos", "given": "Natalia", "initials": "N", "orcid": "0000-0001-5781-5524", "affiliations": ["Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.", "Science for Life Laboratory, Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c265a361c3604b8e8e761ae69897d754.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c265a361c3604b8e8e761ae69897d754"}}, "publications": [{"entity": "publication", "iuid": "991860699ebe4d5382ab412220dbb44c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/991860699ebe4d5382ab412220dbb44c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/991860699ebe4d5382ab412220dbb44c"}}, "title": "PDGFR\u03b2 translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.", "authors": [{"family": "Papadopoulos", "given": "Natalia", "initials": "N", "orcid": "0000-0001-5781-5524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c265a361c3604b8e8e761ae69897d754.json"}}, {"family": "Lennartsson", "given": "Johan", "initials": "J"}, {"family": "Heldin", "given": "Carl-Henrik", "initials": "CH", "orcid": "0000-0002-9508-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5bca6678f5eb4baf853fca6ed5f9b726.json"}}], "type": "journal article", "published": "2018-05-07", "journal": {"title": "J. Cell Biol.", "issn": "1540-8140", "volume": "217", "issue": "5", "pages": "1701-1717", "issn-l": "0021-9525"}, "abstract": "Translocation of full-length or fragments of receptors to the nucleus has been reported for several tyrosine kinase receptors. In this paper, we show that a fraction of full-length cell surface platelet-derived growth factor (PDGF) receptor \u03b2 (PDGFR\u03b2) accumulates in the nucleus at the chromatin and the nuclear matrix after ligand stimulation. Nuclear translocation of PDGFR\u03b2 was dependent on PDGF-BB-induced receptor dimerization, clathrin-mediated endocytosis, \u03b2-importin, and intact Golgi, occurring in both normal and cancer cells. In the nucleus, PDGFR\u03b2 formed ligand-inducible complexes with the tyrosine kinase Fer and its substrate, TATA element-modifying factor 1 (TMF-1). PDGF-BB stimulation decreased TMF-1 binding to the transcriptional regulator Brahma-related gene 1 (Brg-1) and released Brg-1 from the SWI-SNF chromatin remodeling complex. Moreover, knockdown of TMF-1 by small interfering RNA decreased nuclear translocation of PDGFR\u03b2 and caused significant up-regulation of the Brg-1/p53-regulated cell cycle inhibitor CDKN1A (encoding p21) without affecting PDGFR\u03b2-inducible immediate-early genes. In conclusion, nuclear interactions of PDGFR\u03b2 control proliferation by chromatin remodeling and regulation of p21 levels.", "doi": "10.1083/jcb.201706118", "pmid": "29545370", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5940298"}, {"db": "pii", "key": "jcb.201706118"}], "notes": [], "created": "2018-12-05T12:41:13.883Z", "modified": "2026-09-23T11:43:16.131Z"}]}