{"entity": "researcher", "timestamp": "2026-09-23T15:28:22.895Z", "family": "Behere", "given": "Anish", "initials": "A", "orcid": "0000-0002-2424-3475", "affiliations": ["Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c220e32442f343deb55eb3a1aa1865e0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c220e32442f343deb55eb3a1aa1865e0"}}, "publications": [{"entity": "publication", "iuid": "802b4d38eda945dea38c11481e23dd9f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/802b4d38eda945dea38c11481e23dd9f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/802b4d38eda945dea38c11481e23dd9f"}}, "title": "Idiopathic inflammatory myopathies lack neutralising autoantibodies to type- I, II and III interferons.", "authors": [{"family": "Behere", "given": "Anish", "initials": "A", "orcid": "0000-0002-2424-3475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c220e32442f343deb55eb3a1aa1865e0.json"}}, {"family": "Mildner", "given": "Hedvig", "initials": "H"}, {"family": "Peralta Garcia", "given": "Irene", "initials": "I"}, {"family": "P\u00e9rez Bucio", "given": "C\u00e9sar", "initials": "C"}, {"family": "Lundberg", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-6068-9212", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2891140c49d446dbd82c96857bcde73.json"}}, {"family": "Horuluoglu", "given": "Begum", "initials": "B"}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "journal article", "published": "2025-09-25", "journal": {"title": "RMD Open", "issn": "2056-5933", "volume": "11", "issue": "3", "issn-l": null}, "abstract": "To determine whether autoantibodies against interferons are present and play a role in disease modulation in idiopathic inflammatory myopathies (IIMs).\n\nWe screened for autoantibodies against a large number of interferons (IFNs) and other cytokines in a cross-sectional observational cohort of Swedish patients with anti-synthetase syndrome (n=51) and dermatomyositis (n=48), matched together with blood donors (n=100) from general population, using both planar and suspension-based multiplex assays. A single patient with autoimmune polyendocrine syndrome, type-1 (APS-1), known to harbour autoantibodies that neutralise type-I interferons, was included as a reference biological positive. The functional ability of autoantibodies to neutralise type-I interferons was tested in vitro, using an IFN-\u03b1/\u03b2 responsive cell reporter assay.\n\nThe initial screening of plasma samples indicated a repertoire of autoantibodies in IIM patients against a number of common myositis-specific and myositis-associated antigens. On screening for autoantibodies against type-I, II or III interferons, we did not find any evidence of anti-IFN autoantibodies being present in any of the IIM patient subgroups or the blood donors from general population. Additionally, none of the tested plasma samples, except the APS-1, exhibited neutralisation of physiological concentration IFN-\u03b12, further confirming a complete lack of functional autoantibodies against IFN-\u03b1 subtypes in this cohort.\n\nWe did not detect neutralising autoantibodies against IFN-\u03b1 and autoantibodies against other types of IFNs in a Swedish cohort of IIM patients. These findings contrast with the presence of autoantibodies against type-I IFNs in other systemic autoimmune diseases, such as systemic lupus erythematosus, characterised by type-I IFN overactivation.", "doi": "10.1136/rmdopen-2025-005836", "pmid": "40998521", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12481268"}, {"db": "pii", "key": "rmdopen-2025-005836"}], "notes": [], "created": "2026-09-23T12:35:45.217Z", "modified": "2026-09-23T12:35:45.283Z"}, {"entity": "publication", "iuid": "6c7e87bb497b4391a632f4c8dbcef1e5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6c7e87bb497b4391a632f4c8dbcef1e5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6c7e87bb497b4391a632f4c8dbcef1e5"}}, "title": "Evaluating IL1RA-Autoantibodies Across SARS-CoV-2-Related Diseases.", "authors": [{"family": "Behere", "given": "Anish", "initials": "A", "orcid": "0000-0002-2424-3475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c220e32442f343deb55eb3a1aa1865e0.json"}}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Cederholm", "given": "Axel", "initials": "A"}, {"family": "Cavalli", "given": "Marco", "initials": "M", "orcid": "0000-0003-1143-1431", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3104b875f2e459093b1e468ba4af556.json"}}, {"family": "Yalcinkaya", "given": "Ahmet", "initials": "A"}, {"family": "COVID\u2010HGE", "given": "", "initials": ""}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d106604b8ad84e67870302b906a94963.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Wadelius", "given": "Mia", "initials": "M"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "letter", "published": "2025-07-00", "journal": {"title": "Scand. J. Immunol.", "issn": "1365-3083", "volume": "102", "issue": "1", "pages": "e70039", "issn-l": "0300-9475"}, "abstract": null, "doi": "10.1111/sji.70039", "pmid": "40556349", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12188108"}], "notes": [], "created": "2026-09-23T12:30:53.363Z", "modified": "2026-09-23T12:30:53.473Z"}, {"entity": "publication", "iuid": "45cca395453640539d14003ca2081458", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/45cca395453640539d14003ca2081458.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/45cca395453640539d14003ca2081458"}}, "title": "No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines.", "authors": [{"family": "Yalcinkaya", "given": "Ahmet", "initials": "A", "orcid": "0000-0002-1172-3330", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d69855f99eec4f31a547fce683b47c16.json"}}, {"family": "Cavalli", "given": "Marco", "initials": "M"}, {"family": "Cederholm", "given": "Axel", "initials": "A", "orcid": "0009-0006-5973-9637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f21e794263354dd19a65d1aa0871a194.json"}}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M", "orcid": "0000-0003-0050-704X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0c18f520e34593865f7ed850f34a17.json"}}, {"family": "Behere", "given": "Anish", "initials": "A", "orcid": "0000-0002-2424-3475", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c220e32442f343deb55eb3a1aa1865e0.json"}}, {"family": "Mildner", "given": "Hedvig", "initials": "H", "orcid": "0009-0009-6636-2008", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/870312047ef04a25b26ac747dd514974.json"}}, {"family": "Lakshmikanth", "given": "Tadepally", "initials": "T", "orcid": "0000-0001-7256-5770", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/28e45f00f5f247389409f0411d412da1.json"}}, {"family": "Gonzalez", "given": "Laura", "initials": "L"}, {"family": "Mugabo", "given": "Constantin Habimana", "initials": "CH"}, {"family": "Johnsson", "given": "Anette", "initials": "A"}, {"family": "Ekwall", "given": "Olov", "initials": "O"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}, {"family": "Bensing", "given": "Sophie", "initials": "S"}, {"family": "Brodin", "given": "Petter", "initials": "P"}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Wadelius", "given": "Mia", "initials": "M", "orcid": "0000-0002-6368-2622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a663f51c194a8f8060b6fa54f11ac6.json"}}, {"family": "Landegren", "given": "Nils", "initials": "N"}], "type": "journal article", "published": "2024-02-22", "journal": {"title": "NPJ Vaccines", "issn": "2059-0105", "volume": "9", "issue": "1", "pages": "42", "issn-l": null}, "abstract": "Type I interferons act as gatekeepers against viral infection, and autoantibodies that neutralize these signaling molecules have been associated with COVID-19 severity and adverse reactions to the live-attenuated yellow fever vaccine. On this background, we sought to examine whether autoantibodies against type I interferons were associated with adverse events following COVID-19 vaccination. Our nationwide analysis suggests that type I interferon autoantibodies were not associated with adverse events after mRNA or viral-vector COVID-19 vaccines.", "doi": "10.1038/s41541-024-00829-9", "pmid": "38388530", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10883980"}, {"db": "pii", "key": "10.1038/s41541-024-00829-9"}], "notes": [], "created": "2026-09-23T12:56:40.668Z", "modified": "2026-09-23T12:56:40.806Z"}]}