{"entity": "researcher", "timestamp": "2026-08-20T21:15:15.306Z", "family": "Barbiera", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-2051-2359", "affiliations": ["Gynecologic Oncology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c18e2aab6af747439958edfa9be888a7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c18e2aab6af747439958edfa9be888a7"}}, "publications": [{"entity": "publication", "iuid": "5137acade2f14370b914614b3b1b44fa", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5137acade2f14370b914614b3b1b44fa.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5137acade2f14370b914614b3b1b44fa"}}, "title": "The PP2A-B55\u03b1 phosphatase is a master regulator of mitochondrial degradation and biogenesis.", "authors": [{"family": "Cianfanelli", "given": "Valentina", "initials": "V", "orcid": "0000-0002-3857-9463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecd317d35f4142febdd006e4c19ecd3b.json"}}, {"family": "Nanni", "given": "Monica", "initials": "M", "orcid": "0000-0001-5706-0053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09b0dc7e755640268eb404b8984fe701.json"}}, {"family": "Corr\u00e0", "given": "Samantha", "initials": "S", "orcid": "0000-0003-1985-6194", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/34aed5b4b7d14834bcbcd1550714f9ef.json"}}, {"family": "Mauri", "given": "Sofia", "initials": "S", "orcid": "0000-0003-3931-1490", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e0ea3075fda4ba18327bc96a9123f69.json"}}, {"family": "Sumpton", "given": "David", "initials": "D", "orcid": "0000-0002-9004-4079", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f3a17d1b74741f8bccfff7c0ad05b19.json"}}, {"family": "Lilla", "given": "Sergio", "initials": "S", "orcid": "0000-0003-3142-7640", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a5956d3819947df8122ec1601025bbc.json"}}, {"family": "De Cegli", "given": "Rossella", "initials": "R", "orcid": "0000-0002-8526-8692", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1269d7def39540659533698e1282ce13.json"}}, {"family": "Bordi", "given": "Matteo", "initials": "M", "orcid": "0000-0001-8207-8546", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c34176b2b1141f6a41d23f49de8e4ec.json"}}, {"family": "Milletti", "given": "Giacomo", "initials": "G", "orcid": "0000-0003-2391-342X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f829170c13433d95819874b6fa3952.json"}}, {"family": "Ferraina", "given": "Caterina", "initials": "C", "orcid": "0000-0002-3770-4437", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eb9f5ebe210040f78d03e3bc8503c727.json"}}, {"family": "Hall", "given": "Arnaldur", "initials": "A", "orcid": "0000-0001-6847-4438", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4c8a78056504735b11d15abd86dc46d.json"}}, {"family": "Petraroia", "given": "Michele", "initials": "M", "orcid": "0009-0000-0329-1155", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10cc6330b16e4a338e87c3a38ccb36da.json"}}, {"family": "Clausi", "given": "Valentina", "initials": "V", "orcid": "0009-0008-2662-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/027ce4a5d2f745b392ee0a6e92f65b5d.json"}}, {"family": "Giorda", "given": "Ezio", "initials": "E", "orcid": "0000-0002-5875-832X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6005bedf7cd44c678a5e50a999ba06dd.json"}}, {"family": "Scarsella", "given": "Marco", "initials": "M", "orcid": "0000-0002-3386-9664", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8fe29ee7e764f6bb29092e11f52c6f9.json"}}, {"family": "Barbiera", "given": "Alessandra", "initials": "A", "orcid": "0000-0002-2051-2359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c18e2aab6af747439958edfa9be888a7.json"}}, {"family": "Cadeddu", "given": "Giulia", "initials": "G", "orcid": "0000-0003-1841-8395", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c209292faee4904bda06ce017551fd8.json"}}, {"family": "Colasanti", "given": "Marco", "initials": "M", "orcid": "0000-0002-5752-4943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/479c78cbd64a455a9b7f5cbedd475fa0.json"}}, {"family": "Persichini", "given": "Tiziana", "initials": "T", "orcid": "0000-0001-8291-6706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d80e8c50c4f45b8b13eda46cbbc3067.json"}}, {"family": "Maeda", "given": "Kenji", "initials": "K", "orcid": "0000-0002-9080-5691", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9dc9c0792c6c44e29090a2683a73f884.json"}}, {"family": "Maya-Mendoza", "given": "Apolinar", "initials": "A", "orcid": "0000-0001-7452-9896", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8120d9952114478b9909d9906e0dd543.json"}}, {"family": "Bartek", "given": "Jiri", "initials": "J", "orcid": "0000-0003-2013-7525", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/288939950c0c4c6393d35c84e5128b5f.json"}}, {"family": "Di Malta", "given": "Chiara", "initials": "C", "orcid": "0000-0001-6524-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bef2e1eff2cf49f6ba6da220d8e76d2c.json"}}, {"family": "Locatelli", "given": "Franco", "initials": "F", "orcid": "0000-0002-7976-3654", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2687cc638c754f099e9a76deec1d8911.json"}}, {"family": "Zanivan", "given": "Sara", "initials": "S"}, {"family": "Ismail", "given": "Shehab", "initials": "S", "orcid": "0000-0002-4150-1077", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1587edc23d6043eb8c3be75259ef47e2.json"}}, {"family": "Ziviani", "given": "Elena", "initials": "E"}, {"family": "Cecconi", "given": "Francesco", "initials": "F", "orcid": "0000-0002-5614-4359", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1736eeb3ba3d4b0f80058b507487c5e1.json"}}], "type": "journal article", "published": "2025-10-03", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "11", "issue": "40", "pages": "eadw7376", "issn-l": "2375-2548"}, "abstract": "Mitochondrial homeostasis relies on a tight balance between mitochondrial biogenesis and degradation. Although mitophagy is one of the main pathways involved in the clearance of damaged or old mitochondria, its coordination with mitochondrial biogenesis is poorly characterized. Here, by unbiased approaches including last-generation liquid chromatography coupled to mass spectrometry and transcriptomics, we identify the protein phosphatase PP2A-B55\u03b1/PPP2R2A as a Parkin-dependent regulator of mitochondrial number. Upon mitochondrial damage, PP2A-B55\u03b1 determines the amplitude of mitophagy induction and execution by regulating both early and late mitophagy events. A few minutes after the insult, ULK1 is released from the inhibitory regulation of PP2A-B55\u03b1, whereas 2 to 4 hours later, PP2A-B55\u03b1 promotes the nuclear translocation of TFEB, the master regulator of autophagy and lysosome genes, to support mitophagy execution. Moreover, PP2A-B55\u03b1 controls a transcriptional program of mitochondrial biogenesis by stabilizing the Parkin substrate and PGC-1\u03b1 inhibitor PARIS. PP2A-B55\u03b1 targeting rescues neurodegenerative phenotypes in a fly model of Parkinson's disease, thus suggesting potential therapeutic application.", "doi": "10.1126/sciadv.adw7376", "pmid": "41042873", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12494018"}], "notes": [], "created": "2026-08-20T11:59:09.713Z", "modified": "2026-08-20T11:59:10.839Z"}]}