{"entity": "researcher", "timestamp": "2026-08-20T20:43:17.090Z", "family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "affiliations": ["Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569"}}, "publications": [{"entity": "publication", "iuid": "b4162b0e192e47f185b537a36028e435", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b4162b0e192e47f185b537a36028e435.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b4162b0e192e47f185b537a36028e435"}}, "title": "Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis.", "authors": [{"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L", "orcid": "0000-0003-0635-6377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d1c8d008d08491b9e40516ce0c5806a.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C", "orcid": "0000-0001-5327-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6a44fc40ff4b38a3b1da5cf2e8661e.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2025-02-00", "journal": {"title": "Amyotroph Lateral Scler Frontotemporal Degener", "issn": "2167-9223", "volume": "26", "issue": "1-2", "pages": "113-123", "issn-l": null}, "abstract": "To evaluate the prognostic potential of neurofilament medium chain (NfM) in CSF from patients with ALS and explore its relationship with the extensively studied neurofilament light chain (NfL) and phosphorylated heavy chain (pNfH).\n\nCSF levels of NfL, NfM, and pNfH were analyzed in 235 samples from patients with ALS, ALS mimics, and healthy controls in a well-characterized cohort from Karolinska ALS Clinical Research Center in Stockholm, Sweden. NfM levels were analyzed using an antibody-based suspension bead-array and NfL and pNfH levels were measured using ELISA. Clinical data, including ALS Revised Functional Rating Scale (ALSFRS-R), and survival outcomes were utilized for disease progression estimations.\n\nIncreased NfM levels were observed in patients with ALS compared with mimics and healthy controls. Similarly, higher NfM levels were found in fast compared with slow progressing patients for baseline and longitudinal progression when evaluating both total and subscores of ALSFRS-R. These findings were consistent with the results observed for NfL and pNfH. All three proteins, used individually as well as in combination, showed comparable performance when classifying fast vs slow progressing patients (AUCs 0.78-0.85). For all neurofilaments, higher survival probability was observed for patients with low CSF levels.\n\nBased on this cross-sectional study, the prognostic value provided by NfM aligns with the more established markers, NfL and pNfH. Additional investigations with independent cohorts and longitudinal studies are needed to further assess the potential added value of NfM.", "doi": "10.1080/21678421.2024.2428930", "pmid": "39575564", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T09:37:40.836Z", "modified": "2026-08-20T09:37:41.085Z"}, {"entity": "publication", "iuid": "bea27aac30214f489afdb3c8ba1ddcd2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/bea27aac30214f489afdb3c8ba1ddcd2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/bea27aac30214f489afdb3c8ba1ddcd2"}}, "title": "Cerebrospinal fluid levels of NfM in relation to NfL and pNfH as prognostic markers in amyotrophic lateral sclerosis", "authors": [{"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "\u00d6ijerstedt", "given": "Linn", "initials": "L", "orcid": "0000-0003-0635-6377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d1c8d008d08491b9e40516ce0c5806a.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C", "orcid": "0000-0001-5327-7204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6e6a44fc40ff4b38a3b1da5cf2e8661e.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "posted-content", "published": "2024-07-10", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.07.09.24310135", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:55:36.267Z", "modified": "2026-08-20T10:55:36.374Z"}, {"entity": "publication", "iuid": "7e607955637a4b4aafa78db842ae0bbb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7e607955637a4b4aafa78db842ae0bbb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7e607955637a4b4aafa78db842ae0bbb"}}, "title": "Addressing inter-individual variability in CSF levels of brain-derived proteins across neurodegenerative diseases", "authors": [{"family": "Mravinacov\u00e1", "given": "S\u00e1ra", "initials": "S"}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "de San Jos\u00e9", "given": "Nerea G\u00f3mez", "initials": "NG"}, {"family": "Anderl-Straub", "given": "Sarah", "initials": "S", "orcid": "0000-0003-1848-910X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1e48837666642b18a977bb8a8c39603.json"}}, {"family": "Diehl-Schmid", "given": "Janine", "initials": "J"}, {"family": "Fassbender", "given": "Klaus", "initials": "K"}, {"family": "Fliessbach", "given": "Klaus", "initials": "K"}, {"family": "Jahn", "given": "Holger", "initials": "H"}, {"family": "Kornhuber", "given": "Johannes", "initials": "J"}, {"family": "Landwehrmeyer", "given": "G Bernhard", "initials": "GB"}, {"family": "Lauer", "given": "Martin", "initials": "M"}, {"family": "Levin", "given": "Johannes", "initials": "J"}, {"family": "Ludolph", "given": "Albert C", "initials": "AC"}, {"family": "Prudlo", "given": "Johannes", "initials": "J"}, {"family": "Schneider", "given": "Anja", "initials": "A"}, {"family": "Schroeter", "given": "Matthias L", "initials": "ML"}, {"family": "Wiltfang", "given": "Jens", "initials": "J"}, {"family": "Steinacker", "given": "Petra", "initials": "P"}, {"family": "Otto", "given": "Markus", "initials": "M", "orcid": "0000-0003-4273-4267", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5bee470b0e4e45a2b553d849d8299e2f.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "posted-content", "published": "2024-05-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.05.27.24307739", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:54:55.969Z", "modified": "2026-08-20T10:54:56.092Z"}, {"entity": "publication", "iuid": "59b004c7df1d4131a8eedb6051b9167b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b"}}, "title": "Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.", "authors": [{"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c4a7070f339466690b40d63ad6ea769.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Markaki", "given": "Ioanna", "initials": "I", "orcid": "0000-0003-3328-5746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f31c405d780a4beeb64971dabd57cafd.json"}}, {"family": "Carvalho", "given": "Stephanie", "initials": "S"}, {"family": "Corvol", "given": "Jean-Christophe", "initials": "JC", "orcid": "0000-0001-7325-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81bf347acb7349dfa3d7c22483c1fba4.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "L\u00f6wenmark", "given": "Malin", "initials": "M"}, {"family": "Ingelsson", "given": "Martin", "initials": "M", "orcid": "0000-0001-5466-8370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9cdd74196957459fa3618c6bd2c35ff8.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B", "orcid": "0000-0001-6791-8893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0815ffb8b9404272a26b28cb11f001ba.json"}}, {"family": "Brosseron", "given": "Frederic", "initials": "F", "orcid": "0000-0003-3137-7516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8a371f4aaa4ba59389f30bd9349c1f.json"}}, {"family": "Heneka", "given": "Michael T", "initials": "MT", "orcid": "0000-0003-4996-1630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8da023abc6974d4582fe3c688a483950.json"}}, {"family": "Bosch", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-6094-0024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd5741747488412c9c8334a97e7302ad.json"}}, {"family": "Sanchez-Valle", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7750-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bba6a10e4cd4b0180ccc900d70fd869.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "8", "issue": "7", "pages": "1456-1470", "issn-l": "2328-9503"}, "abstract": "Decreased amyloid beta (A\u03b2) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.\n\nWe utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification.\n\nSix proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A\u03b242 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations.\n\nIn conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.", "doi": "10.1002/acn3.51402", "pmid": "34129723", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8283172"}], "notes": [], "created": "2026-08-20T06:27:18.835Z", "modified": "2026-08-20T06:27:19.431Z"}, {"entity": "publication", "iuid": "8f32b4a0feec426aa7a3b473b819c5db", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8f32b4a0feec426aa7a3b473b819c5db.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8f32b4a0feec426aa7a3b473b819c5db"}}, "title": "Publisher Correction: Altered perivascular fibroblast activity precedes ALS disease onset.", "authors": [{"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Skene", "given": "Nathan", "initials": "N"}, {"family": "Sanders", "given": "Folkert", "initials": "F"}, {"family": "Trusohamn", "given": "Marta", "initials": "M", "orcid": "0000-0002-0541-8903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/234e99cb31064ecd97ce20cd6bed0671.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J"}, {"family": "Szczepi\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Aksoylu", "given": "Inci Sevval", "initials": "IS"}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Ebarasi", "given": "Lwaki", "initials": "L"}, {"family": "Wouters", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5243-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f539b54a76a54f72a91cb8d32faf5f6e.json"}}, {"family": "Lehmann", "given": "Manuela", "initials": "M"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "von Gohren Antequera", "given": "Inti", "initials": "I"}, {"family": "Domaniku", "given": "Aylin", "initials": "A", "orcid": "0000-0002-7785-2143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95697e92a2ab473a822a823eb0f8b4c8.json"}}, {"family": "De Schaepdryver", "given": "Maxim", "initials": "M", "orcid": "0000-0003-2480-863X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d74bcbf7a0534626978de5911f54e9f8.json"}}, {"family": "De Vocht", "given": "Joke", "initials": "J"}, {"family": "Poesen", "given": "Koen", "initials": "K"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Anink", "given": "Jasper", "initials": "J"}, {"family": "Mijnsbergen", "given": "Caroline", "initials": "C"}, {"family": "Vergunst-Bosch", "given": "Hermieneke", "initials": "H"}, {"family": "H\u00fcbers", "given": "Annemarie", "initials": "A"}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "Rodriguez-Vieitez", "given": "Elena", "initials": "E"}, {"family": "Gilthorpe", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-6884-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b96eb721974441b2940f6f8a86ed8390.json"}}, {"family": "Hedlund", "given": "Eva", "initials": "E", "orcid": "0000-0001-6347-0075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb646c0222e24fd1807f19a915b5b0c7.json"}}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7558fb5ceba54b689244b4e771714b76.json"}}, {"family": "Aronica", "given": "Eleonora", "initials": "E"}, {"family": "Van Damme", "given": "Philip", "initials": "P", "orcid": "0000-0002-4010-2357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b455ddb4b88495fb728afc06b18e998.json"}}, {"family": "Ludolph", "given": "Albert", "initials": "A"}, {"family": "Veldink", "given": "Jan", "initials": "J", "orcid": "0000-0001-5572-9657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2a35cf75e024b2fbb2750dbdb0cfd9c.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Lewandowski", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-5935-0211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2707f71ea5b641318c3479efafbdf5bc.json"}}], "type": "published erratum", "published": "2021-07-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "27", "issue": "7", "pages": "1308", "issn-l": "1078-8956"}, "abstract": null, "doi": "10.1038/s41591-021-01414-6", "pmid": "34079107", "labels": [], "xrefs": [{"db": "pii", "key": "10.1038/s41591-021-01414-6"}], "notes": [], "created": "2026-08-20T09:01:58.367Z", "modified": "2026-08-20T09:01:58.485Z"}, {"entity": "publication", "iuid": "0b4b5765a54d4b25a1480c67a55d1154", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0b4b5765a54d4b25a1480c67a55d1154.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0b4b5765a54d4b25a1480c67a55d1154"}}, "title": "Altered perivascular fibroblast activity precedes ALS disease onset.", "authors": [{"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Skene", "given": "Nathan", "initials": "N"}, {"family": "Sanders", "given": "Folkert", "initials": "F"}, {"family": "Trusohamn", "given": "Marta", "initials": "M", "orcid": "0000-0002-0541-8903", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/234e99cb31064ecd97ce20cd6bed0671.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J"}, {"family": "Szczepi\u0144ska", "given": "Anna", "initials": "A"}, {"family": "Aksoylu", "given": "Inci Sevval", "initials": "IS"}, {"family": "L\u00f6nnerberg", "given": "Peter", "initials": "P"}, {"family": "Ebarasi", "given": "Lwaki", "initials": "L"}, {"family": "Wouters", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5243-6186", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f539b54a76a54f72a91cb8d32faf5f6e.json"}}, {"family": "Lehmann", "given": "Manuela", "initials": "M"}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "von Gohren Antequera", "given": "Inti", "initials": "I"}, {"family": "Domaniku", "given": "Aylin", "initials": "A", "orcid": "0000-0002-7785-2143", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/95697e92a2ab473a822a823eb0f8b4c8.json"}}, {"family": "De Schaepdryver", "given": "Maxim", "initials": "M", "orcid": "0000-0003-2480-863X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d74bcbf7a0534626978de5911f54e9f8.json"}}, {"family": "De Vocht", "given": "Joke", "initials": "J"}, {"family": "Poesen", "given": "Koen", "initials": "K"}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Anink", "given": "Jasper", "initials": "J"}, {"family": "Mijnsbergen", "given": "Caroline", "initials": "C"}, {"family": "Vergunst-Bosch", "given": "Hermieneke", "initials": "H"}, {"family": "H\u00fcbers", "given": "Annemarie", "initials": "A"}, {"family": "Kl\u00e4ppe", "given": "Ulf", "initials": "U", "orcid": "0000-0001-5832-038X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3939bb5c873241299ce82d2aec37457a.json"}}, {"family": "Rodriguez-Vieitez", "given": "Elena", "initials": "E"}, {"family": "Gilthorpe", "given": "Jonathan D", "initials": "JD", "orcid": "0000-0002-6884-4774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b96eb721974441b2940f6f8a86ed8390.json"}}, {"family": "Hedlund", "given": "Eva", "initials": "E", "orcid": "0000-0001-6347-0075", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb646c0222e24fd1807f19a915b5b0c7.json"}}, {"family": "Harris", "given": "Robert A", "initials": "RA", "orcid": "0000-0003-4990-509X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7558fb5ceba54b689244b4e771714b76.json"}}, {"family": "Aronica", "given": "Eleonora", "initials": "E"}, {"family": "Van Damme", "given": "Philip", "initials": "P", "orcid": "0000-0002-4010-2357", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b455ddb4b88495fb728afc06b18e998.json"}}, {"family": "Ludolph", "given": "Albert", "initials": "A"}, {"family": "Veldink", "given": "Jan", "initials": "J", "orcid": "0000-0001-5572-9657", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2a35cf75e024b2fbb2750dbdb0cfd9c.json"}}, {"family": "Ingre", "given": "Caroline", "initials": "C"}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Lewandowski", "given": "Sebastian A", "initials": "SA", "orcid": "0000-0002-5935-0211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2707f71ea5b641318c3479efafbdf5bc.json"}}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "27", "issue": "4", "pages": "640-646", "issn-l": "1078-8956"}, "abstract": "Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study we use an expression-weighted cell-type enrichment method to infer cell activity in spinal cord samples from patients with sporadic ALS and mouse models of this disease. Here we report that patients with sporadic ALS present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response. Notably, during the presymptomatic stage, perivascular fibroblast cells showed the strongest gene enrichments, and their marker proteins SPP1 and COL6A1 accumulated in enlarged perivascular spaces in patients with sporadic ALS. Moreover, in plasma of 574 patients with ALS from four independent cohorts, increased levels of SPP1 at disease diagnosis repeatedly predicted shorter survival with stronger effect than the established risk factors of bulbar onset or neurofilament levels in cerebrospinal fluid. We propose that the activity of the recently discovered perivascular fibroblast can predict survival of patients with ALS and provide a new conceptual framework to re-evaluate definitions of ALS etiology.", "doi": "10.1038/s41591-021-01295-9", "pmid": "33859435", "labels": [], "xrefs": [{"db": "mid", "key": "EMS151802"}, {"db": "pmc", "key": "PMC7613336"}, {"db": "pii", "key": "10.1038/s41591-021-01295-9"}, {"db": "figshare", "key": "10.6084/m9.figshare.11632794"}, {"db": "figshare", "key": "10.6084/m9.figshare.11635887"}, {"db": "figshare", "key": "10.6084/m9.figshare.11628891"}, {"db": "figshare", "key": "10.6084/m9.figshare.11628585"}, {"db": "figshare", "key": "10.6084/m9.figshare.14035616"}], "notes": [], "created": "2026-08-20T09:01:51.665Z", "modified": "2026-08-20T09:01:52.157Z"}, {"entity": "publication", "iuid": "7eeee9d1d2884e55b87d5c50ba3abbad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7eeee9d1d2884e55b87d5c50ba3abbad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7eeee9d1d2884e55b87d5c50ba3abbad"}}, "title": "Association of CSF proteins with tau and amyloid \u03b2 levels in asymptomatic 70-year-olds.", "authors": [{"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Sj\u00f6stedt", "given": "Evelina", "initials": "E", "orcid": "0000-0002-0327-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6fb5a1c88b44798144fd2de255fb00.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Zettergren", "given": "Anna", "initials": "A"}, {"family": "Kern", "given": "Silke", "initials": "S"}, {"family": "Skoog", "given": "Ingmar", "initials": "I"}, {"family": "Nilsson", "given": "Peter", "initials": "P"}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}], "type": "journal article", "published": "2021-03-02", "journal": {"title": "Alzheimers Res Ther", "issn": "1758-9193", "volume": "13", "issue": "1", "pages": "54", "issn-l": null}, "abstract": "Increased knowledge of the evolution of molecular changes in neurodegenerative disorders such as Alzheimer's disease (AD) is important for the understanding of disease pathophysiology and also crucial to be able to identify and validate disease biomarkers. While several biological changes that occur early in the disease development have already been recognized, the need for further characterization of the pathophysiological mechanisms behind AD still remains.\n\nIn this study, we investigated cerebrospinal fluid (CSF) levels of 104 proteins in 307 asymptomatic 70-year-olds from the H70 Gothenburg Birth Cohort Studies using a multiplexed antibody- and bead-based technology.\n\nThe protein levels were first correlated with the core AD CSF biomarker concentrations of total tau, phospho-tau and amyloid beta (A\u03b242) in all individuals. Sixty-three proteins showed significant correlations to either total tau, phospho-tau or A\u03b242. Thereafter, individuals were divided based on CSF A\u03b242/A\u03b240 ratio and Clinical Dementia Rating (CDR) score to determine if early changes in pathology and cognition had an effect on the correlations. We compared the associations of the analysed proteins with CSF markers between groups and found 33 proteins displaying significantly different associations for amyloid-positive individuals and amyloid-negative individuals, as defined by the CSF A\u03b242/A\u03b240 ratio. No differences in the associations could be seen for individuals divided by CDR score.\n\nWe identified a series of transmembrane proteins, proteins associated with or anchored to the plasma membrane, and proteins involved in or connected to synaptic vesicle transport to be associated with CSF biomarkers of amyloid and tau pathology in AD. Further studies are needed to explore these proteins' role in AD pathophysiology.", "doi": "10.1186/s13195-021-00789-5", "pmid": "33653397", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7923505"}, {"db": "pii", "key": "10.1186/s13195-021-00789-5"}], "notes": [], "created": "2026-08-20T12:22:13.883Z", "modified": "2026-08-20T12:23:59.358Z"}]}