{"entity": "researcher", "timestamp": "2026-09-23T15:36:07.327Z", "family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "affiliations": ["Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.", "Theme of Children's Health, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/c03e0a2905534e26b5a2a2b5de453872.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/c03e0a2905534e26b5a2a2b5de453872"}}, "publications": [{"entity": "publication", "iuid": "3a3a8ff693ed4aa88f61e02c39248a15", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3a3a8ff693ed4aa88f61e02c39248a15.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3a3a8ff693ed4aa88f61e02c39248a15"}}, "title": "Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF.", "authors": [{"family": "Kvedaraite", "given": "Egle", "initials": "E", "orcid": "0000-0001-5308-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/12e2bb98f9ea4186a3fc75703b205484.json"}}, {"family": "Lourda", "given": "Magda", "initials": "M", "orcid": "0000-0003-3155-1123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3b0f1d58b48430b8553aceb99998d40.json"}}, {"family": "Mouratidou", "given": "Natalia", "initials": "N"}, {"family": "D\u00fcking", "given": "Tim", "initials": "T", "orcid": "0000-0002-4347-7648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c4b1032e7a34102af444c74bf67dd59.json"}}, {"family": "Padhi", "given": "Avinash", "initials": "A"}, {"family": "Moll", "given": "Kirsten", "initials": "K"}, {"family": "Czarnewski", "given": "Paulo", "initials": "P"}, {"family": "Sinha", "given": "Indranil", "initials": "I", "orcid": "0000-0002-2513-5927", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83272c13da5c4ea6a8154656d53efb00.json"}}, {"family": "Xagoraris", "given": "Ioanna", "initials": "I"}, {"family": "Kokkinou", "given": "Efthymia", "initials": "E"}, {"family": "Damdimopoulos", "given": "Anastasios", "initials": "A"}, {"family": "Weigel", "given": "Whitney", "initials": "W"}, {"family": "Hartwig", "given": "Olga", "initials": "O", "orcid": "0000-0001-5016-5960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cbc793bf0f147558140e652a8d2cfa2.json"}}, {"family": "Santos", "given": "Telma E", "initials": "TE"}, {"family": "Soini", "given": "Tea", "initials": "T"}, {"family": "Van Acker", "given": "Aline", "initials": "A"}, {"family": "Rahkonen", "given": "Nelly", "initials": "N"}, {"family": "Flodstr\u00f6m Tullberg", "given": "Malin", "initials": "M", "orcid": "0000-0003-2685-2052", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/358926667b494e6d8cc544f34bc80c5e.json"}}, {"family": "Ringqvist", "given": "Emma", "initials": "E"}, {"family": "Buggert", "given": "Marcus", "initials": "M", "orcid": "0000-0003-0633-1719", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf1bb88eef764f8bb81bdd6d8a231113.json"}}, {"family": "Jorns", "given": "Carl", "initials": "C", "orcid": "0000-0001-7727-8113", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef68cb234b3141278a29a407ed988b32.json"}}, {"family": "Lindforss", "given": "Ulrik", "initials": "U"}, {"family": "Nordenvall", "given": "Caroline", "initials": "C"}, {"family": "Stamper", "given": "Christopher T", "initials": "CT"}, {"family": "Unnersj\u00f6-Jess", "given": "David", "initials": "D", "orcid": "0000-0002-4162-0973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/32d1982020d14121b558c26285b212ca.json"}}, {"family": "Akber", "given": "Mira", "initials": "M"}, {"family": "Nadisauskaite", "given": "Ruta", "initials": "R"}, {"family": "Jansson", "given": "Jessica", "initials": "J"}, {"family": "Vandamme", "given": "Niels", "initials": "N"}, {"family": "Sorini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-6803-8377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/652b92b02a9448179fb0bf7648ed30b9.json"}}, {"family": "Grundeken", "given": "Marijke Elise", "initials": "ME", "orcid": "0000-0001-6915-0339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/79de930c618c42bbae8e3c7729373d11.json"}}, {"family": "Rolandsdotter", "given": "Helena", "initials": "H"}, {"family": "Rassidakis", "given": "George", "initials": "G"}, {"family": "Villablanca", "given": "Eduardo J", "initials": "EJ", "orcid": "0000-0001-9522-9729", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c90ee0c3d1904ae0933efe3631a651e0.json"}}, {"family": "Idestr\u00f6m", "given": "Maja", "initials": "M"}, {"family": "Eulitz", "given": "Stefan", "initials": "S"}, {"family": "Arnell", "given": "Henrik", "initials": "H"}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J", "orcid": "0000-0002-1119-0976", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/33e4f7ea779c4b3382604de7ea259bc8.json"}}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c03e0a2905534e26b5a2a2b5de453872.json"}}, {"family": "Svensson", "given": "Mattias", "initials": "M", "orcid": "0000-0003-1695-7934", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f3cb4fb47f3c4be0a6d529a4d8382b82.json"}}], "type": "journal article", "published": "2024-02-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "1752", "issn-l": "2041-1723"}, "abstract": "Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142-/low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142-/low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation.", "doi": "10.1038/s41467-024-46076-3", "pmid": "38409190", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10897309"}, {"db": "pii", "key": "10.1038/s41467-024-46076-3"}], "notes": [], "created": "2026-09-23T09:04:49.642Z", "modified": "2026-09-23T09:04:50.297Z"}, {"entity": "publication", "iuid": "98929223c21f46d2b9ab716d0fcd7d3f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/98929223c21f46d2b9ab716d0fcd7d3f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/98929223c21f46d2b9ab716d0fcd7d3f"}}, "title": "Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.", "authors": [{"family": "Rudd", "given": "Sean G", "initials": "SG", "orcid": "0000-0002-4368-3855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d65643e96cfe4f3a98cf4f48225eac73.json"}}, {"family": "Tsesmetzis", "given": "Nikolaos", "initials": "N"}, {"family": "Sanjiv", "given": "Kumar", "initials": "K"}, {"family": "Paulin", "given": "Cynthia Bj", "initials": "CB"}, {"family": "Sandhow", "given": "Lakshmi", "initials": "L"}, {"family": "Kutzner", "given": "Juliane", "initials": "J"}, {"family": "Hed Myrberg", "given": "Ida", "initials": "I", "orcid": "0000-0002-8297-2238", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d753895b29ea4614831148c361688e2b.json"}}, {"family": "Bunten", "given": "Sarah S", "initials": "SS"}, {"family": "Axelsson", "given": "Hanna", "initials": "H", "orcid": "0000-0003-2365-1749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/affc5ee12a2d47b6a7f9ab3df049991e.json"}}, {"family": "Zhang", "given": "Si Min", "initials": "SM"}, {"family": "Rasti", "given": "Azita", "initials": "A"}, {"family": "M\u00e4kel\u00e4", "given": "Petri", "initials": "P"}, {"family": "Coggins", "given": "Si'Ana A", "initials": "SA"}, {"family": "Tao", "given": "Sijia", "initials": "S"}, {"family": "Suman", "given": "Sharda", "initials": "S"}, {"family": "Branca", "given": "Rui M", "initials": "RM"}, {"family": "Mermelekas", "given": "Georgios", "initials": "G"}, {"family": "Wiita", "given": "Elis\u00e9e", "initials": "E"}, {"family": "Lee", "given": "Sun", "initials": "S"}, {"family": "Walfridsson", "given": "Julian", "initials": "J"}, {"family": "Schinazi", "given": "Raymond F", "initials": "RF"}, {"family": "Kim", "given": "Baek", "initials": "B"}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Rassidakis", "given": "Georgios Z", "initials": "GZ"}, {"family": "Pokrovskaja Tamm", "given": "Katja", "initials": "K"}, {"family": "Warpman-Berglund", "given": "Ulrika", "initials": "U"}, {"family": "Heyman", "given": "Mats", "initials": "M"}, {"family": "Grand\u00e9r", "given": "Dan", "initials": "D"}, {"family": "Lehmann", "given": "S\u00f6ren", "initials": "S"}, {"family": "Lundb\u00e4ck", "given": "Thomas", "initials": "T"}, {"family": "Qian", "given": "Hong", "initials": "H"}, {"family": "Henter", "given": "Jan-Inge", "initials": "JI", "orcid": "0000-0002-0629-2126", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c03e0a2905534e26b5a2a2b5de453872.json"}}, {"family": "Schaller", "given": "Torsten", "initials": "T", "orcid": "0000-0001-9597-4112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/93d3003ec7854be68f4e38283bca1da0.json"}}, {"family": "Helleday", "given": "Thomas", "initials": "T", "orcid": "0000-0002-7384-092X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/385586c159494955a9a72c3381e3ad47.json"}}, {"family": "Herold", "given": "Nikolas", "initials": "N", "orcid": "0000-0001-9468-4543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/749eedaa5f69414aa315bb875eef9475.json"}}], "type": "journal article", "published": "2020-03-06", "journal": {"title": "EMBO Mol Med", "issn": "1757-4684", "volume": "12", "issue": "3", "pages": "e10419", "issn-l": "1757-4676"}, "abstract": "The deoxycytidine analogue cytarabine (ara-C) remains the backbone treatment of acute myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but must be combined with other chemotherapeutics to achieve cure. Yet, the underlying mechanism dictating synergistic efficacy of combination chemotherapy remains largely unknown. The dNTPase SAMHD1, which regulates dNTP homoeostasis antagonistically to ribonucleotide reductase (RNR), limits ara-C efficacy by hydrolysing the active triphosphate metabolite ara-CTP. Here, we report that clinically used inhibitors of RNR, such as gemcitabine and hydroxyurea, overcome the SAMHD1-mediated barrier to ara-C efficacy in primary blasts and mouse models of AML, displaying SAMHD1-dependent synergy with ara-C. We present evidence that this is mediated by dNTP pool imbalances leading to allosteric reduction of SAMHD1 ara-CTPase activity. Thus, SAMHD1 constitutes a novel biomarker for combination therapies of ara-C and RNR inhibitors with immediate consequences for clinical practice to improve treatment of AML.", "doi": "10.15252/emmm.201910419", "pmid": "31950591", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7059017"}], "notes": [], "created": "2026-09-23T09:19:01.523Z", "modified": "2026-09-23T09:19:01.659Z"}]}