{"entity": "researcher", "timestamp": "2026-08-20T20:49:42.934Z", "family": "Kater", "given": "Arnon", "initials": "A", "orcid": "0000-0003-3190-1891", "affiliations": ["Department of Hematology, Cancer Center Amsterdam and Lymphoma and Myeloma Center Amsterdam, The Netherlands, Amsterdam, Netherlands."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf8f235e28f2429dabfe12465a298e5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf8f235e28f2429dabfe12465a298e5b"}}, "publications": [{"entity": "publication", "iuid": "048922da2a384daa953047cd1a0fa998", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/048922da2a384daa953047cd1a0fa998"}}, "title": "Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study.", "authors": [{"family": "Visentin", "given": "Andrea", "initials": "A", "orcid": "0000-0003-0271-7200", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/10a25bb174034d55a6a2f0fccb036f02.json"}}, {"family": "Gaffo", "given": "Enrico", "initials": "E", "orcid": "0000-0001-6338-7677", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a30412a5d86429d99d9ab62bf7be0b2.json"}}, {"family": "F\u00fcrstenau", "given": "Moritz", "initials": "M", "orcid": "0000-0002-6593-0140", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4f3c1950a80040ada1cda908470910c9.json"}}, {"family": "Rogers", "given": "Kerry A", "initials": "KA"}, {"family": "Panagiotis", "given": "Baliakas", "initials": "B", "orcid": "0000-0002-5634-7156", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a31997db1ee4ef1aaff75e423b8ccfb.json"}}, {"family": "Cui", "given": "Chenghua", 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{"href": "https://publications-affiliated.scilifelab.se/researcher/f223eed5e0dc4decad48346341db0f6b.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Ghia", "given": "Paolo", "initials": "P", "orcid": "0000-0003-3750-7342", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/475d35f1a3c446819b2f24be819c2dee.json"}}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K", "orcid": "0000-0001-8529-640X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06f6107d6f774ee6acb2c66ecfcb90cc.json"}}, {"family": "Trentin", "given": "Livio", "initials": "L", "orcid": "0000-0003-1222-6149", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/820ab4c1a5534ada88d9c318fa8aa2e1.json"}}, {"family": "Bortoluzzi", "given": "Stefania", "initials": "S", "orcid": "0000-0001-8240-3070", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0831daa98b3b4ea980ccd20da78a22fb.json"}}], "type": "journal article", "published": "2025-12-00", "journal": {"title": "Leukemia", "issn": "1476-5551", "volume": "39", "issue": "12", "pages": "2957-2967", "issn-l": "0887-6924"}, "abstract": "In chronic lymphocytic leukemia (CLL), the role of complex karyotype (CK) for prognostic stratification remains a topic of debate, and the impact of specific cytogenetic abnormalities is still unclear. This study aims to investigate the clinical and biological features of CLL with t(14;19)(q32;q13) (tCLL) involving the BCL3 gene. Patients with tCLL were younger and more commonly presented unmutated IGHV gene, subset #8 stereotypy, trisomy of chromosome 12, and complex karyotype than other patients without t(14;19) (oCLL). The presence of t(14;19) was associated with a shorter time to treatment and overall survival compared to oCLL. Gene expression analysis revealed a unique transcriptome profile in tCLL, characterized by the upregulation of BCL3 and the activation of B-cell receptor, PI3K-Akt. Conversely, apoptosis-related pathways were suppressed in tCLL. While the BTK gene was upregulated, the BCL2L11 gene, coding for the pro-apoptotic protein BIM, was downregulated. Notably, patients with tCLL were characterized by a trend (p = 0.058) for a longer time to the next treatment with BTK inhibitors (BTKi) compared to those treated with a venetoclax-based (Ven-based) regimen. We underscore the adverse outcomes of tCLL, its distinct molecular features and gene expression patterns. Therefore, our data suggest that identifying tCLL could help tailor therapeutic approaches.", "doi": "10.1038/s41375-025-02755-8", "pmid": "40973766", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12634426"}, {"db": "pii", "key": "10.1038/s41375-025-02755-8"}], "notes": [], "created": "2026-08-20T08:47:27.388Z", "modified": "2026-08-20T08:47:52.757Z"}, {"entity": "publication", "iuid": "c465d839b28e46469b4d87962568750c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c465d839b28e46469b4d87962568750c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c465d839b28e46469b4d87962568750c"}}, "title": "Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact.", "authors": [{"family": "Baliakas", "given": "Panagiotis", "initials": "P"}, {"family": "Jeromin", "given": "Sabine", "initials": "S"}, {"family": "Iskas", "given": "Michalis", "initials": "M"}, {"family": "Puiggros", "given": "Anna", "initials": "A"}, {"family": "Plevova", "given": "Karla", "initials": "K"}, {"family": "Nguyen-Khac", "given": "Florence", "initials": "F"}, {"family": "Davis", "given": "Zadie", "initials": "Z"}, {"family": "Rigolin", "given": "Gian Matteo", "initials": "GM"}, {"family": "Visentin", "given": "Andrea", "initials": "A"}, {"family": "Xochelli", "given": "Aliki", "initials": "A"}, {"family": "Delgado", "given": "Julio", "initials": "J"}, {"family": "Baran-Marszak", "given": "Fanny", "initials": "F"}, {"family": "Stalika", "given": "Evangelia", "initials": "E"}, {"family": "Abrisqueta", "given": "Pau", "initials": "P"}, {"family": "Durechova", "given": "Kristina", "initials": "K"}, {"family": "Papaioannou", "given": "George", "initials": "G"}, {"family": "Eclache", "given": "Virginie", "initials": "V"}, {"family": "Dimou", "given": "Maria", "initials": "M"}, {"family": "Iliakis", "given": "Theodoros", "initials": "T"}, {"family": "Collado", "given": "Rosa", "initials": "R"}, {"family": "Doubek", "given": "Michael", "initials": "M"}, {"family": "Calasanz", "given": "M Jose", "initials": "MJ"}, {"family": "Ruiz-Xiville", "given": "Neus", "initials": "N"}, {"family": "Moreno", "given": "Carolina", "initials": "C"}, {"family": "Jarosova", "given": "Marie", "initials": "M"}, {"family": "Leeksma", "given": "Alexander C", "initials": "AC"}, {"family": "Panayiotidis", "given": "Panayiotis", "initials": "P"}, {"family": "Podgornik", "given": "Helena", "initials": "H", "orcid": "0000-0003-3752-2067", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebf5f82ee9df40889d9d20965db3fb8d.json"}}, {"family": "Cymbalista", "given": "Florence", "initials": "F"}, {"family": "Anagnostopoulos", "given": "Achilles", "initials": "A"}, {"family": "Trentin", "given": "Livio", "initials": "L"}, {"family": "Stavroyianni", "given": "Niki", "initials": "N"}, {"family": "Davi", "given": "Fred", "initials": "F"}, {"family": "Ghia", "given": "Paolo", "initials": "P"}, {"family": "Kater", "given": "Arnon P", "initials": "AP", "orcid": "0000-0003-3190-1891", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf8f235e28f2429dabfe12465a298e5b.json"}}, {"family": "Cuneo", "given": "Antonio", "initials": "A"}, {"family": "Pospisilova", "given": "Sarka", "initials": "S"}, {"family": "Espinet", "given": "Blanca", "initials": "B"}, {"family": "Athanasiadou", "given": "Anastasia", "initials": "A"}, {"family": "Oscier", "given": "David", "initials": "D"}, {"family": "Haferlach", "given": "Claudia", "initials": "C"}, {"family": "Stamatopoulos", "given": "Kostas", "initials": "K"}, {"family": "ERIC, the European Research Initiative on CLL", "given": "", "initials": ""}], "type": "journal article", "published": "2019-03-14", "journal": {"title": "Blood", "issn": "1528-0020", "volume": "133", "issue": "11", "pages": "1205-1216", "issn-l": "0006-4971"}, "abstract": "Recent evidence suggests that complex karyotype (CK) defined by the presence of \u22653 chromosomal aberrations (structural and/or numerical) identified by using chromosome-banding analysis (CBA) may be relevant for treatment decision-making in chronic lymphocytic leukemia (CLL). However, many challenges toward the routine clinical application of CBA remain. In a retrospective study of 5290 patients with available CBA data, we explored both clinicobiological associations and the clinical impact of CK in CLL. We found that patients with \u22655 abnormalities, defined as high-CK, exhibit uniformly dismal clinical outcomes, independently of clinical stage, TP53 aberrations (deletion of chromosome 17p and/or TP53 mutations [TP53abs]), and the expression of somatically hypermutated (M-CLL) or unmutated immunoglobulin heavy variable genes. Thus, they contrasted with CK cases with 3 or 4 aberrations (low-CK and intermediate-CK, respectively) who followed aggressive disease courses only in the presence of TP53abs. At the other end of the spectrum, patients with CK and +12,+19 displayed an exceptionally indolent profile. Building upon CK, TP53abs, and immunoglobulin heavy variable gene somatic hypermutation status, we propose a novel hierarchical model in which patients with high-CK exhibit the worst prognosis, whereas those with mutated CLL lacking CK or TP53abs, as well as CK with +12,+19, show the longest overall survival. Thus, CK should not be axiomatically considered unfavorable in CLL, representing a heterogeneous group with variable clinical behavior. High-CK with \u22655 chromosomal aberrations emerges as prognostically adverse, independent of other biomarkers. Prospective clinical validation is warranted before ultimately incorporating high-CK in risk stratification of CLL.", "doi": "10.1182/blood-2018-09-873083", "pmid": "30602617", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6509568"}, {"db": "pii", "key": "S0006-4971(20)42705-3"}], "notes": [], "created": "2026-08-20T12:17:26.475Z", "modified": "2026-08-20T12:17:26.564Z"}]}