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{"family": "Sofer", "given": "Tamar", "initials": "T"}, {"family": "Stricker", "given": "Bruno H", "initials": "BH"}, {"family": "Tiemeier", "given": "Henning", "initials": "H", "orcid": "0000-0002-4395-1397", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bed764abb33d4d9e8bcd05dd64379a7c.json"}}, {"family": "Vrijkotte", "given": "Tanja G M", "initials": "TGM"}, {"family": "Asselbergs", "given": "Folkert W", "initials": "FW", "orcid": "0000-0002-1692-8669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/181a8a467ca54344b574d248cc98f1d3.json"}}, {"family": "Brundel", "given": "Bianca J J M", "initials": "BJJM"}, {"family": "Heckbert", "given": "Susan R", "initials": "SR"}, {"family": "Whitsel", "given": "Eric A", "initials": "EA"}, {"family": "den Hoed", "given": "Marcel", "initials": "M"}, {"family": "Snieder", "given": "Harold", "initials": "H"}, {"family": "de Geus", "given": "Eco J C", "initials": "EJC"}], "type": "journal article", "published": "2017-06-14", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "8", "issue": null, "pages": "15805", "issn-l": "2041-1723"}, "abstract": "Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (-0.74<rg<-0.55) and blood pressure (-0.35<rg<-0.20). These findings provide clinically relevant biological insight into heritable variation in vagal heart rhythm regulation, with a key role for genetic variants (GNG11, RGS6) that influence G-protein heterotrimer action in GIRK-channel induced pacemaker membrane hyperpolarization.", "doi": "10.1038/ncomms15805", "pmid": "28613276", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5474732"}, {"db": "pii", "key": "ncomms15805"}], "notes": [], "created": "2018-12-05T10:22:30.073Z", "modified": "2026-09-23T07:25:56.913Z"}, {"entity": "publication", "iuid": "3319ed3faaa04b37904ac096febd0936", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3319ed3faaa04b37904ac096febd0936.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3319ed3faaa04b37904ac096febd0936"}}, "title": "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.", "authors": [{"family": "Justice", 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"Vestergaard", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3090-269X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2fa5c4f74894d6a833afd105ec72848.json"}}, {"family": "Vollenweider", "given": "Peter", "initials": "P"}, {"family": "Wareham", "given": "Nicholas J", "initials": "NJ"}, {"family": "Weir", "given": "David R", "initials": "DR"}, {"family": "Whitfield", "given": "John B", "initials": "JB"}, {"family": "Wilson", "given": "James F", "initials": "JF", "orcid": "0000-0001-5751-9178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/513b6983cc9d478ab9d81c2f21579961.json"}}, {"family": "Tyrrell", "given": "Jessica", "initials": "J"}, {"family": "Frayling", "given": "Timothy M", "initials": "TM"}, {"family": "Barroso", "given": "In\u00eas", "initials": "I"}, {"family": "Boehnke", "given": "Michael", "initials": "M"}, {"family": "Deloukas", "given": "Panagiotis", "initials": "P"}, {"family": "Fox", "given": "Caroline S", "initials": "CS"}, {"family": "Hirschhorn", "given": "Joel N", "initials": "JN"}, {"family": "Hunter", "given": "David J", "initials": "DJ"}, {"family": "Spector", "given": "Tim D", "initials": "TD"}, {"family": "Strachan", "given": "David P", "initials": "DP", "orcid": "0000-0001-7854-1366", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d43385a350914b0a843fb49008d108b0.json"}}, {"family": "van Duijn", "given": "Cornelia M", "initials": "CM"}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Mohlke", "given": "Karen L", "initials": "KL", "orcid": "0000-0001-6721-153X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fac0e041c56347fe98cef9ae8f004b67.json"}}, {"family": "Marchini", "given": "Jonathan", "initials": "J", "orcid": "0000-0003-0610-8322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a7d0d3e23a76434098fa7731ac294cd1.json"}}, {"family": "Loos", "given": "Ruth J F", "initials": "RJF"}, {"family": "Kilpel\u00e4inen", "given": "Tuomas O", "initials": "TO"}, {"family": "Liu", "given": "Ching-Ti", "initials": "CT", "orcid": "0000-0002-0703-0742", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0df836bc876845a6af66828561f24a27.json"}}, {"family": "Borecki", "given": "Ingrid B", "initials": "IB"}, {"family": "North", "given": "Kari E", "initials": "KE"}, {"family": "Cupples", "given": "L Adrienne", "initials": "LA"}], "type": "journal article", "published": "2017-04-26", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "8", "issue": null, "pages": "14977", "issn-l": "2041-1723"}, "abstract": "Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.", "doi": "10.1038/ncomms14977", "pmid": "28443625", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC5414044"}, {"db": "pii", "key": "ncomms14977"}], "notes": [], "created": "2018-12-05T09:47:57.139Z", "modified": "2026-09-23T06:42:25.568Z"}, {"entity": "publication", "iuid": "b252b094f4584c578bd9431f29eb03ae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b252b094f4584c578bd9431f29eb03ae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b252b094f4584c578bd9431f29eb03ae"}}, "title": "Novel genetic loci underlying human intracranial volume identified through genome-wide association.", "authors": [{"family": "Adams", "given": "Hieab H H", "initials": "HH", "orcid": "0000-0003-3687-2508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/946c17edd9c84330bf3b89cc6597c98c.json"}}, {"family": "Hibar", "given": "Derrek P", "initials": "DP"}, {"family": "Chouraki", "given": "Vincent", "initials": "V"}, {"family": "Stein", "given": "Jason L", "initials": "JL"}, {"family": "Nyquist", "given": "Paul A", "initials": "PA"}, {"family": "Renter\u00eda", "given": "Miguel E", "initials": "ME"}, {"family": "Trompet", "given": "Stella", "initials": "S"}, {"family": "Arias-Vasquez", "given": "Alejandro", "initials": "A"}, {"family": "Seshadri", "given": "Sudha", "initials": "S"}, {"family": "Desrivi\u00e8res", "given": "Sylvane", "initials": "S", "orcid": "0000-0002-9120-7060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9aa0e10e94a342f5a725a10d55d831ac.json"}}, {"family": "Beecham", "given": "Ashley H", "initials": "AH"}, {"family": "Jahanshad", "given": "Neda", "initials": "N"}, {"family": "Wittfeld", "given": "Katharina", "initials": "K"}, {"family": "Van der Lee", "given": "Sven J", "initials": "SJ", "orcid": "0000-0003-1606-8643", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b8444a73ec44d868978bbe982ee755c.json"}}, {"family": "Abramovic", "given": "Lucija", "initials": "L"}, {"family": "Alhusaini", "given": "Saud", "initials": "S"}, {"family": "Amin", "given": "Najaf", "initials": "N"}, {"family": "Andersson", "given": "Micael", "initials": "M"}, {"family": "Arfanakis", "given": "Konstantinos", "initials": "K"}, {"family": "Aribisala", "given": "Benjamin S", "initials": "BS"}, {"family": "Armstrong", "given": "Nicola J", "initials": "NJ", "orcid": "0000-0002-4477-293X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/870bc682be5e475385c92f0af73281fb.json"}}, {"family": "Athanasiu", "given": "Lavinia", "initials": "L"}, {"family": "Axelsson", "given": "Tomas", "initials": "T"}, {"family": "Beiser", "given": "Alexa", "initials": "A"}, {"family": "Bernard", "given": "Manon", "initials": "M"}, {"family": "Bis", "given": "Joshua C", "initials": "JC"}, {"family": "Blanken", "given": "Laura M E", "initials": "LM"}, {"family": "Blanton", "given": "Susan H", "initials": "SH"}, {"family": "Bohlken", "given": "Marc M", "initials": "MM"}, {"family": "Boks", "given": "Marco P", "initials": "MP", "orcid": "0000-0001-6163-7484", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9fea668ab0745209f8fe952dcf92ff0.json"}}, {"family": "Bralten", "given": "Janita", "initials": "J"}, {"family": "Brickman", "given": "Adam M", "initials": "AM"}, {"family": "Carmichael", "given": "Owen", "initials": "O"}, {"family": "Chakravarty", "given": "M Mallar", "initials": "MM"}, {"family": "Chauhan", "given": "Ganesh", "initials": "G"}, {"family": "Chen", "given": "Qiang", "initials": "Q"}, {"family": "Ching", "given": "Christopher R K", "initials": "CR"}, {"family": "Cuellar-Partida", "given": "Gabriel", "initials": "G"}, {"family": "Braber", "given": "Anouk Den", "initials": "AD"}, {"family": "Doan", "given": "Nhat Trung", "initials": "NT"}, {"family": "Ehrlich", "given": "Stefan", "initials": "S"}, {"family": "Filippi", "given": "Irina", "initials": "I"}, {"family": "Ge", "given": "Tian", "initials": "T"}, {"family": "Giddaluru", "given": "Sudheer", "initials": "S"}, {"family": "Goldman", "given": "Aaron L", "initials": "AL"}, {"family": "Gottesman", "given": "Rebecca F", "initials": "RF"}, {"family": "Greven", "given": "Corina U", "initials": "CU"}, {"family": "Grimm", "given": "Oliver", "initials": "O"}, {"family": "Griswold", "given": "Michael E", "initials": "ME"}, {"family": "Guadalupe", "given": "Tulio", "initials": "T"}, {"family": "Hass", "given": "Johanna", "initials": "J"}, {"family": "Haukvik", "given": "Unn K", "initials": "UK"}, {"family": "Hilal", "given": "Saima", "initials": "S"}, {"family": "Hofer", "given": "Edith", "initials": "E"}, {"family": "Hoehn", "given": "David", "initials": "D"}, {"family": "Holmes", "given": "Avram J", "initials": "AJ"}, {"family": "Hoogman", "given": "Martine", "initials": "M"}, {"family": "Janowitz", "given": "Deborah", "initials": "D"}, {"family": "Jia", "given": "Tianye", "initials": "T"}, {"family": "Kasperaviciute", "given": "Dalia", "initials": "D"}, {"family": "Kim", "given": "Sungeun", "initials": "S"}, {"family": "Klein", "given": "Marieke", "initials": "M", "orcid": "0000-0001-8784-5679", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b95dc08735d4c56b8b23af6090e614d.json"}}, {"family": "Kraemer", "given": "Bernd", "initials": "B"}, {"family": "Lee", "given": "Phil H", "initials": "PH", "orcid": "0000-0003-1770-3100", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/612eef5f4bbf4226b8282e9aac2fcc5b.json"}}, {"family": "Liao", "given": "Jiemin", "initials": "J"}, {"family": "Liewald", "given": "David C M", "initials": "DC", "orcid": "0000-0002-0544-7368", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48dce9b92862489b8cf51482fa3dcb7b.json"}}, {"family": "Lopez", "given": "Lorna M", "initials": "LM"}, {"family": "Luciano", "given": "Michelle", "initials": "M"}, {"family": "Macare", "given": "Christine", "initials": "C"}, {"family": "Marquand", "given": "Andre", "initials": "A"}, {"family": "Matarin", "given": "Mar", "initials": "M"}, {"family": "Mather", "given": "Karen A", "initials": "KA"}, {"family": "Mattheisen", "given": "Manuel", "initials": "M", "orcid": "0000-0002-8442-493X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc6a347bff244d59821f31a5aa0fd805.json"}}, {"family": "Mazoyer", "given": "Bernard", "initials": "B", "orcid": "0000-0003-0970-2837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/037390b4786845d4be6560d42d1f5206.json"}}, {"family": "McKay", "given": "David R", "initials": "DR"}, {"family": "McWhirter", "given": "Rebekah", "initials": "R"}, {"family": "Milaneschi", "given": "Yuri", "initials": "Y"}, {"family": "Mirza-Schreiber", "given": "Nazanin", "initials": "N"}, {"family": "Muetzel", "given": "Ryan L", "initials": "RL"}, {"family": "Maniega", "given": "Susana Mu\u00f1oz", "initials": "SM"}, {"family": "Nho", "given": "Kwangsik", "initials": "K"}, {"family": "Nugent", "given": "Allison C", "initials": "AC"}, {"family": "Loohuis", "given": "Loes M Olde", "initials": "LM", "orcid": "0000-0002-3327-7837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/07fa5bd9100641999f6bfaca8047844d.json"}}, {"family": "Oosterlaan", "given": "Jaap", "initials": "J"}, {"family": "Papmeyer", "given": "Martina", "initials": "M"}, {"family": "Pappa", "given": "Irene", "initials": "I"}, {"family": "Pirpamer", "given": "Lukas", "initials": "L"}, {"family": "Pudas", "given": "Sara", "initials": "S"}, {"family": "P\u00fctz", "given": "Benno", "initials": "B"}, {"family": "Rajan", "given": "Kumar B", "initials": "KB"}, {"family": "Ramasamy", "given": "Adaikalavan", "initials": "A"}, {"family": "Richards", "given": "Jennifer S", "initials": "JS"}, {"family": "Risacher", "given": "Shannon L", "initials": "SL"}, {"family": "Roiz-Santia\u00f1ez", "given": "Roberto", "initials": "R", "orcid": "0000-0002-5176-2983", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a14bf67140445b78d8459ac9f988df2.json"}}, {"family": "Rommelse", "given": "Nanda", "initials": "N"}, {"family": "Rose", "given": "Emma J", "initials": "EJ"}, {"family": "Royle", "given": "Natalie A", "initials": "NA"}, {"family": "Rundek", "given": "Tatjana", "initials": "T"}, {"family": "S\u00e4mann", "given": "Philipp G", "initials": "PG"}, {"family": "Satizabal", "given": "Claudia L", "initials": "CL", "orcid": "0000-0002-1115-4430", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a99feb4ad0e472b926ac0421af72e8d.json"}}, {"family": "Schmaal", "given": "Lianne", "initials": "L"}, {"family": "Schork", "given": "Andrew J", "initials": "AJ"}, {"family": "Shen", "given": "Li", "initials": "L", "orcid": "0000-0002-5443-0503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3c894b682ca4770a1c97f4243f4c4eb.json"}}, {"family": "Shin", "given": "Jean", "initials": "J"}, {"family": "Shumskaya", "given": "Elena", "initials": "E"}, {"family": "Smith", "given": "Albert V", "initials": "AV", "orcid": "0000-0003-1942-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51752e0d35a74befa66a65b95ceaad38.json"}}, {"family": "Sprooten", "given": "Emma", "initials": "E"}, {"family": "Strike", "given": "Lachlan T", "initials": "LT"}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "Thomson", "given": "Russell", "initials": "R"}, {"family": "Tordesillas-Gutierrez", "given": "Diana", "initials": "D"}, {"family": "Toro", "given": "Roberto", "initials": "R"}, {"family": "Trabzuni", "given": "Daniah", "initials": "D", "orcid": "0000-0003-4826-9570", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/75ee83bdbcee483ebdecdd04860e81d2.json"}}, {"family": "Vaidya", "given": "Dhananjay", "initials": "D"}, {"family": "Van der Grond", "given": "Jeroen", "initials": "J"}, {"family": "Van der Meer", "given": "Dennis", "initials": "D"}, {"family": "Van Donkelaar", "given": "Marjolein M J", "initials": "MM", "orcid": "0000-0002-9112-2307", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6c2650cac7f140fc8615352063830f2f.json"}}, {"family": "Van Eijk", "given": "Kristel R", "initials": "KR"}, {"family": "Van Erp", "given": "Theo G M", "initials": "TG", "orcid": "0000-0002-2465-2797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/496d84f2b39f425aa01f9b68c6cdeacd.json"}}, {"family": "Van Rooij", "given": "Daan", "initials": "D"}, {"family": "Walton", "given": "Esther", "initials": "E"}, {"family": "Westlye", "given": "Lars T", "initials": "LT", "orcid": "0000-0001-8644-956X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7e3ff3f70e6a482fbed8aa2637716570.json"}}, {"family": "Whelan", "given": "Christopher D", "initials": "CD"}, {"family": "Windham", "given": "Beverly G", "initials": "BG"}, {"family": "Winkler", "given": "Anderson M", "initials": "AM", "orcid": "0000-0002-4169-9781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f27a5caa67bd42fab244b372117baebc.json"}}, {"family": "Woldehawariat", "given": "Girma", "initials": "G"}, {"family": "Wolf", "given": "Christiane", "initials": "C"}, {"family": "Wolfers", "given": "Thomas", "initials": "T"}, {"family": "Xu", "given": "Bing", "initials": "B"}, {"family": "Yanek", "given": "Lisa R", "initials": "LR"}, {"family": "Yang", "given": "Jingyun", "initials": "J"}, {"family": "Zijdenbos", "given": "Alex", "initials": "A"}, {"family": "Zwiers", "given": "Marcel P", "initials": "MP"}, {"family": "Agartz", "given": "Ingrid", "initials": "I"}, {"family": "Aggarwal", "given": "Neelum T", "initials": "NT"}, {"family": "Almasy", "given": "Laura", "initials": "L"}, {"family": "Ames", "given": "David", "initials": "D"}, {"family": "Amouyel", "given": "Philippe", "initials": "P", "orcid": "0000-0001-9088-234X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9bc53ec75293497bab1ec0419c6e5800.json"}}, {"family": "Andreassen", "given": "Ole A", "initials": "OA", "orcid": "0000-0002-4461-3568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43ded34fa6ff40ea9bd47d222d9df745.json"}}, {"family": "Arepalli", "given": "Sampath", "initials": "S"}, {"family": "Assareh", 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"https://publications-affiliated.scilifelab.se/researcher/3067eab9389944518589b44ca208dcce.json"}}, {"family": "Weinberger", "given": "Daniel R", "initials": "DR"}, {"family": "Weiner", "given": "Michael W", "initials": "MW"}, {"family": "Wen", "given": "Wei", "initials": "W"}, {"family": "Westman", "given": "Eric", "initials": "E"}, {"family": "White", "given": "Tonya", "initials": "T"}, {"family": "Wong", "given": "Tien Y", "initials": "TY"}, {"family": "Wright", "given": "Clinton B", "initials": "CB"}, {"family": "Zielke", "given": "H Ronald", "initials": "HR"}, {"family": "Zonderman", "given": "Alan B", "initials": "AB"}, {"family": "Deary", "given": "Ian J", "initials": "IJ"}, {"family": "DeCarli", "given": "Charles", "initials": "C"}, {"family": "Schmidt", "given": "Helena", "initials": "H"}, {"family": "Martin", "given": "Nicholas G", "initials": "NG"}, {"family": "De Craen", "given": "Anton J M", "initials": "AJ"}, {"family": "Wright", "given": "Margaret J", "initials": "MJ"}, {"family": "Launer", "given": "Lenore J", "initials": "LJ"}, {"family": "Schumann", "given": "Gunter", "initials": "G"}, {"family": "Fornage", "given": "Myriam", "initials": "M"}, {"family": "Franke", "given": "Barbara", "initials": "B", "orcid": "0000-0003-4375-6572", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2321b3d7708a4c3d884b0875260cb5e0.json"}}, {"family": "Debette", "given": "St\u00e9phanie", "initials": "S"}, {"family": "Medland", "given": "Sarah E", "initials": "SE"}, {"family": "Ikram", "given": "M Arfan", "initials": "MA", "orcid": "0000-0003-0372-8585", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef9df12e0e6743f5a97d73c58e75443b.json"}}, {"family": "Thompson", "given": "Paul M", "initials": "PM"}], "type": "journal article", "published": "2016-12-00", "journal": {"title": "Nat. Neurosci.", "issn": "1546-1726", "volume": "19", "issue": "12", "pages": "1569-1582", "issn-l": "1097-6256"}, "abstract": "Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (\u03c1genetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.", "doi": "10.1038/nn.4398", "pmid": "27694991", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS822505"}, {"db": "pmc", "key": "PMC5227112"}, {"db": "pii", "key": "nn.4398"}], "notes": [], "created": "2018-12-05T09:19:05.917Z", "modified": "2026-09-23T06:40:19.435Z"}]}