{"entity": "researcher", "timestamp": "2026-08-26T23:02:33.740Z", "family": "J\u00f8rgensen", "given": "Anders P", "initials": "AP", "orcid": "0000-0002-1246-9194", "affiliations": ["Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, Pb. 4950 Nydalen, 0424 Oslo, Norway.", "Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Box 1072 Blindern, 0316 Oslo, Norway."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc5ad03de219408f8d8c71309d7e9466.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc5ad03de219408f8d8c71309d7e9466"}}, "publications": [{"entity": "publication", "iuid": "ba14291fe27d407ca35d423a0660be3f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ba14291fe27d407ca35d423a0660be3f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ba14291fe27d407ca35d423a0660be3f"}}, "title": "TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.", "authors": [{"family": "Sj\u00f6stedt", "given": "Evelina", "initials": "E", "orcid": "0000-0002-0327-7377", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ec6fb5a1c88b44798144fd2de255fb00.json"}}, {"family": "Kolnes", "given": "Anders J", "initials": "AJ", "orcid": "0000-0003-4607-9642", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/479aad69241d4c85964bb9f41945fbb9.json"}}, {"family": "Olarescu", "given": "Nicoleta C", "initials": "NC"}, {"family": "Mitsios", "given": "Nicholas", "initials": "N"}, {"family": "Hikmet", "given": "Feria", "initials": "F"}, {"family": "Sivertsson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "Lindskog", "given": "Cecilia", "initials": "C"}, {"family": "\u00d8ystese", "given": "Kristin A B", "initials": "KAB", "orcid": "0000-0002-3147-6007", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a67f26c2257d44a0a31d2f8d3a9e695b.json"}}, {"family": "J\u00f8rgensen", "given": "Anders P", "initials": "AP", "orcid": "0000-0002-1246-9194", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bc5ad03de219408f8d8c71309d7e9466.json"}}, {"family": "Bollerslev", "given": "Jens", "initials": "J"}, {"family": "Casar-Borota", "given": "Olivera", "initials": "O", "orcid": "0000-0001-7376-7331", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/be2f108c23f24ce6b661c0446eeb3134.json"}}], "type": "journal article", "published": "2020-12-31", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "13", "issue": "1", "issn-l": "2072-6694"}, "abstract": "Here, we report the investigation of transforming growth factor beta-receptor 3 like (TGFBR3L), an uncharacterised pituitary specific membrane protein, in non-neoplastic anterior pituitary gland and pituitary neuroendocrine tumours. A polyclonal antibody produced within the Human Protein Atlas project (HPA074356) was used for TGFBR3L staining and combined with SF1 and FSH for a 3-plex fluorescent protocol, providing more details about the cell lineage specificity of TGFBR3L expression. A cohort of 230 pituitary neuroendocrine tumours were analysed. In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. TGFBR3L immunostaining correlated positively to both FSH (R = 0.290) and LH (R = 0.390) immunostaining, and SSTR3 (R = 0.315). TGFBR3L correlated inversely to membranous E-cadherin staining (R = -0.351) and oestrogen receptor \u03b2 mRNA (R = -0.274). In conclusion, TGFBR3L is a novel pituitary gland specific protein, located in the membrane of gonadotroph cells in non-neoplastic anterior pituitary gland and in a subset of gonadotroph pituitary tumours.", "doi": "10.3390/cancers13010114", "pmid": "33396509", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7795056"}, {"db": "pii", "key": "cancers13010114"}], "notes": [], "created": "2026-08-21T13:01:33.704Z", "modified": "2026-08-21T13:01:33.906Z"}]}