{"entity": "researcher", "timestamp": "2026-08-20T21:35:01.408Z", "family": "Ivansson", "given": "Emma", "initials": "E", "orcid": "0000-0002-4630-1576", "affiliations": ["Department of Immunology, Genetics, and Pathology, Biomedical Center, SciLifeLab Uppsala, Uppsala University, SE-75108 Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbc77e3f9694f068f5f4c4eb1e11d88.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbc77e3f9694f068f5f4c4eb1e11d88"}}, "publications": [{"entity": "publication", "iuid": "186c17edb6a14a5b98db51bbd5a32346", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/186c17edb6a14a5b98db51bbd5a32346.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/186c17edb6a14a5b98db51bbd5a32346"}}, "title": "Data-driven analysis of a validated risk score for ovarian cancer identifies clinically distinct patterns during follow-up and treatment.", "authors": [{"family": "Enroth", "given": "Stefan", "initials": "S", "orcid": "0000-0002-5056-9137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae9be8ef3b1145239a4e0231e2a148cd.json"}}, {"family": "Ivansson", "given": "Emma", "initials": "E", "orcid": "0000-0002-4630-1576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbc77e3f9694f068f5f4c4eb1e11d88.json"}}, {"family": "Lindberg", "given": "Julia Hedlund", "initials": "JH"}, {"family": "Lycke", "given": "Maria", "initials": "M"}, {"family": "Bergman", "given": "Jessica", "initials": "J"}, {"family": "Reneland", "given": "Anna", "initials": "A"}, {"family": "St\u00e5lberg", "given": "Karin", "initials": "K", "orcid": "0000-0001-5527-8796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ca801fe1aba4d04a06eaf9f6e3407dd.json"}}, {"family": "Sundfeldt", "given": "Karin", "initials": "K"}, {"family": "Gyllensten", "given": "Ulf", "initials": "U", "orcid": "0000-0002-6316-3355", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/eacfdf2095e947e99ac45fe994261b72.json"}}], "type": "journal article", "published": "2022-10-01", "journal": {"title": "Commun Med (Lond)", "issn": "2730-664X", "volume": "2", "pages": "124", "issn-l": null}, "abstract": "Ovarian cancer is the eighth most common cancer among women and due to late detection prognosis is poor with an overall 5-year survival of 30-50%. Novel biomarkers are needed to reduce diagnostic surgery and enable detection of early-stage cancer by population screening. We have previously developed a risk score based on an 11-biomarker plasma protein assay to distinguish benign tumors (cysts) from malignant ovarian cancer in women with adnexal ovarian mass.\n\nProtein concentrations of 11 proteins were characterized in plasma from 1120 clinical samples with a custom version of the proximity extension assay. The performance of the assay was evaluated in terms of prediction accuracy based on receiver operating characteristics (ROC) and multiple hypothesis adjusted Fisher's Exact tests on achieved sensitivity and specificity.\n\nThe assay's performance is validated in two independent clinical cohorts with a sensitivity of 0.83/0.91 and specificity of 0.88/0.92. We also show that the risk score follows the clinical development and is reduced upon treatment, and increased with relapse and cancer progression. Data-driven modeling of the risk score patterns during a 2-year follow-up after diagnosis identifies four separate risk score trajectories linked to clinical development and survival. A Cox proportional hazard regression analysis of 5-year survival shows that at time of diagnosis the risk score is the second-strongest predictive variable for survival after tumor stage, whereas MUCIN-16 (CA-125) alone is not significantly predictive.\n\nThe robust performance of the biomarker assay across clinical cohorts and the correlation with clinical development indicates its usefulness both in the diagnostic work-up of women with adnexal ovarian mass and for predicting their clinical course.", "doi": "10.1038/s43856-022-00193-6", "pmid": "36196264", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9526736"}, {"db": "pii", "key": "193"}], "notes": [], "created": "2026-08-20T09:26:19.954Z", "modified": "2026-08-20T09:26:20.090Z"}, {"entity": "publication", "iuid": "c37c452543f54547a83fb9fcd40b5eef", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c37c452543f54547a83fb9fcd40b5eef.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c37c452543f54547a83fb9fcd40b5eef"}}, "title": "Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.", "authors": [{"family": "Letko", "given": "Anna", "initials": "A", "orcid": "0000-0002-6521-1285", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/73645c57be3244ddb773d7c72ff8c7e8.json"}}, {"family": "Minor", "given": "Katie M", "initials": "KM", "orcid": "0000-0002-5472-5088", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/898c5d6ebc9a41279b0be28ccd9babb6.json"}}, {"family": "Norton", "given": "Elaine M", "initials": "EM", "orcid": "0000-0001-9450-2893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5ae49124c2af4e73a83ea38640b5cc7c.json"}}, {"family": "Marinescu", "given": "Voichita D", "initials": "VD"}, {"family": "Dr\u00f6gem\u00fcller", "given": "Michaela", "initials": "M"}, {"family": "Ivansson", "given": "Emma", "initials": "E", "orcid": "0000-0002-4630-1576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bbbc77e3f9694f068f5f4c4eb1e11d88.json"}}, {"family": "Megquier", "given": "Kate", "initials": "K"}, {"family": "Noh", "given": "Hyun Ji", "initials": "HJ", "orcid": "0000-0002-6634-0599", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/159b936128f7496191354f9f06b88ffd.json"}}, {"family": "Starkey", "given": "Mike", "initials": "M"}, {"family": "Friedenberg", "given": "Steven G", "initials": "SG", "orcid": "0000-0002-7510-2322", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c530c0937b3d4df3a028905e6a2c7420.json"}}, {"family": "Lindblad-Toh", "given": "Kerstin", "initials": "K"}, {"family": "Mickelson", "given": "James R", "initials": "JR"}, {"family": "Dr\u00f6gem\u00fcller", "given": "Cord", "initials": "C", "orcid": "0000-0001-9773-522X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe49a28e95b3424594f4282277709507.json"}}], "type": "journal article", "published": "2021-12-09", "journal": {"title": "Genes (Basel)", "issn": "2073-4425", "volume": "12", "issue": "12", "issn-l": "2073-4425"}, "abstract": "Dogs represent a unique spontaneous cancer model. Osteosarcoma (OSA) is the most common primary bone tumor in dogs (OMIA 001441-9615), and strongly resembles human forms of OSA. Several large- to giant-sized dog breeds, including the Leonberger, have a greatly increased risk of developing OSA. We performed genome-wide association analysis with high-density imputed SNP genotype data from 273 Leonberger cases with a median age of 8.1 [3.1-13.5] years and 365 controls older than eight years. This analysis revealed significant associations at the CDKN2A/B gene locus on canine chromosome 11, mirroring previous findings in other dog breeds, such as the greyhound, that also show an elevated risk for OSA. Heritability (h2SNP) was determined to be 20.6% (SE = 0.08; p-value = 5.7 \u00d7 10-4) based on a breed prevalence of 20%. The 2563 SNPs across the genome accounted for nearly all the h2SNP of OSA, with 2183 SNPs of small effect, 316 SNPs of moderate effect, and 64 SNPs of large effect. As with many other cancers it is likely that regulatory, non-coding variants underlie the increased risk for cancer development. Our findings confirm a complex genetic basis of OSA, moderate heritability, and the crucial role of the CDKN2A/B locus leading to strong cancer predisposition in dogs. It will ultimately be interesting to study and compare the known genetic loci associated with canine OSA in human OSA.", "doi": "10.3390/genes12121964", "pmid": "34946912", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8700858"}, {"db": "pii", "key": "genes12121964"}], "notes": [], "created": "2026-08-20T13:40:52.421Z", "modified": "2026-08-20T13:40:52.630Z"}]}