{"entity": "researcher", "timestamp": "2026-08-20T21:01:32.380Z", "family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "affiliations": ["Department of Medical Sciences, Uppsala University Hospital, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf"}}, "publications": [{"entity": "publication", "iuid": "327b76ce89e14812bcff35c6b96d4942", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/327b76ce89e14812bcff35c6b96d4942.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/327b76ce89e14812bcff35c6b96d4942"}}, "title": "The association between the gut microbiome and 24-hour blood pressure measurements in the SCAPIS study", "authors": [{"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2023-12-09", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.12.08.23299598", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:50:52.048Z", "modified": "2026-08-20T10:50:52.175Z"}, {"entity": "publication", "iuid": "8af06b272b154fac9f50b3bc455e6b3e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8af06b272b154fac9f50b3bc455e6b3e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8af06b272b154fac9f50b3bc455e6b3e"}}, "title": "Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort.", "authors": [{"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF"}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G"}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-8298-539X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6a28f0ea6264c3893bbd362355ec85c.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Lin", "given": "Yi-Ting", "initials": "YT"}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-3873-7943", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13bd5f11f5cc4420a1c57183bb8323c9.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Pita", "given": "Sara", "initials": "S", "orcid": "0000-0002-5163-7306", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc61e356bdb84493813be139de58922a.json"}}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Ericson", "given": "Ulrika", "initials": "U"}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Ottosson", "given": "Filip", "initials": "F"}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Ericson", "given": "Dan", "initials": "D", "orcid": "0000-0003-0356-2351", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a89ea38f5bb6487abe6f6973a3886019.json"}}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B"}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1fa67d262984bccbb6b45e913a09393.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A", "orcid": "0000-0002-4098-7765", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/394a2f4dcf5847ce98e1c758f5c4d710.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "journal article", "published": "2023-08-08", "journal": {"title": "Circulation", "issn": "1524-4539", "volume": "148", "issue": "6", "pages": "459-472", "issn-l": "0009-7322"}, "abstract": "Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography-based measures of coronary atherosclerosis and to explore relevant clinical correlates.\n\nWe conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of fecal samples, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.\n\nThe mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcus oralis subsp oralis (P<1\u00d710-5). Associations were largely similar across coronary computed tomography angiography-based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malm\u00f6 Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid \u03b2-oxidation, and amino acid degradation were associated with coronary artery calcium score.\n\nThis study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.", "doi": "10.1161/CIRCULATIONAHA.123.063914", "pmid": "37435755", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10399955"}], "notes": [], "created": "2026-08-20T12:16:07.214Z", "modified": "2026-08-20T12:16:07.530Z"}, {"entity": "publication", "iuid": "39bcafc7c8f4498b8a39ae492dc30f85", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/39bcafc7c8f4498b8a39ae492dc30f85.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/39bcafc7c8f4498b8a39ae492dc30f85"}}, "title": "ACCELEROMETER-BASED SEDENTARY BEHAVIOUR AND PHYSICAL ACTIVITY ARE ASSOCIATED WITH THE GUT MICROBIOTA IN 8507 INDIVIDUALS FROM THE POPULATION-BASED SCAPIS", "authors": [{"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Ekblom-Bak", "given": "Elin", "initials": "E", "orcid": "0000-0002-3901-7833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1db422e63016471ca7e9a2030d77d727.json"}}, {"family": "Ekblom", "given": "\u00d6rjan", "initials": "\u00d6", "orcid": "0000-0001-6058-4982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2ef59def17c34c159bf2b7ad7b358a44.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S"}, {"family": "Ericson", "given": "Ulrika", "initials": "U", "orcid": "0000-0003-4629-4318", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f7a231a3bc84f2d99732325be9c92ad.json"}}, {"family": "Arvidsson", "given": "Daniel", "initials": "D", "orcid": "0000-0002-3112-5434", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ddce14555f514266bf1be0bbae23f4ce.json"}}, {"family": "B\u00f6rjesson", "given": "Mats", "initials": "M"}, {"family": "Johanson", "given": "Peter J", "initials": "PJ"}, {"family": "Smith", "given": "J Gustav", "initials": "JG"}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2023-06-04", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.06.01.23290817", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:46:18.098Z", "modified": "2026-08-20T10:46:18.388Z"}, {"entity": "publication", "iuid": "4f9deae374214a88a69da30b419575ba", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4f9deae374214a88a69da30b419575ba.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4f9deae374214a88a69da30b419575ba"}}, "title": "Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women.", "authors": [{"family": "Mendham", "given": "Amy E", "initials": "AE", "orcid": "0000-0002-1959-6698", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1301a064a29a4b2ea6634ca93e51bacc.json"}}, {"family": "Micklesfield", "given": "Lisa K", "initials": "LK", "orcid": "0000-0002-4994-0779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af359e74210340d793d9897f052631ae.json"}}, {"family": "Karpe", "given": "Fredrik", "initials": "F"}, {"family": "Kengne", "given": "Andre Pascal", "initials": "AP"}, {"family": "Chikowore", "given": "Tinashe", "initials": "T", "orcid": "0000-0002-6743-751X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef254d9fea24464aae64d30bf69f50cf.json"}}, {"family": "Kufe", "given": "Clement N", "initials": "CN", "orcid": "0000-0001-6599-7284", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfaeb816aab946d6be4b301b6126b493.json"}}, {"family": "Masemola", "given": "Maphoko", "initials": "M", "orcid": "0000-0002-4398-9061", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d5756cbd12b48fd9e45e42fb2354b99.json"}}, {"family": "Crowther", "given": "Nigel J", "initials": "NJ", "orcid": "0000-0002-5766-1745", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84e127dfcc594326ba56a580bbdc9292.json"}}, {"family": "Norris", "given": "Shane A", "initials": "SA", "orcid": "0000-0001-7124-3788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/74e0dddf0b3847b6bb0eb7146cab2b50.json"}}, {"family": "Olsson", "given": "Tommy", "initials": "T", "orcid": "0000-0001-7768-1076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3298ba8b0d34ce681e9e4fec588dc49.json"}}, {"family": "Elmst\u00e5hl", "given": "S\u00f6lve", "initials": "S", "orcid": "0000-0001-7153-5414", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/186fe3792fe645a882402a364d8f94e1.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Goedecke", "given": "Julia H", "initials": "JH"}], "type": "journal article", "published": "2023-01-00", "journal": {"title": "Diabetologia", "issn": "1432-0428", "volume": "66", "issue": "1", "pages": "174-189", "issn-l": "0012-186X"}, "abstract": "Using a targeted proteomics approach, we aimed to identify and validate circulating proteins associated with impaired glucose metabolism (IGM) and type 2 diabetes in a Black South African cohort. In addition, we assessed sex-specific associations between the validated proteins and pathophysiological pathways of type 2 diabetes.\n\nThis cross-sectional study included Black South African men (n=380) and women (n=375) who were part of the Middle-Aged Soweto Cohort (MASC). Dual-energy x-ray absorptiometry was used to determine fat mass and visceral adipose tissue, and fasting venous blood samples were collected for analysis of glucose, insulin and C-peptide and for targeted proteomics, measuring a total of 184 pre-selected protein biomarkers. An OGTT was performed on participants without diabetes, and peripheral insulin sensitivity (Matsuda index), HOMA-IR, basal insulin clearance, insulin secretion (C-peptide index) and beta cell function (disposition index) were estimated. Participants were classified as having normal glucose tolerance (NGT; n=546), IGM (n=116) or type 2 diabetes (n=93). Proteins associated with dysglycaemia (IGM or type 2 diabetes) in the MASC were validated in the Swedish EpiHealth cohort (NGT, n=1706; impaired fasting glucose, n=550; type 2 diabetes, n=210).\n\nWe identified 73 proteins associated with dysglycaemia in the MASC, of which 34 were validated in the EpiHealth cohort. Among these validated proteins, 11 were associated with various measures of insulin dynamics, with the largest number of proteins being associated with HOMA-IR. In sex-specific analyses, IGF-binding protein 2 (IGFBP2) was associated with lower HOMA-IR in women (coefficient -0.35; 95% CI -0.44, -0.25) and men (coefficient -0.09; 95% CI -0.15, -0.03). Metalloproteinase inhibitor 4 (TIMP4) was associated with higher insulin secretion (coefficient 0.05; 95% CI 0.001, 0.11; p for interaction=0.025) and beta cell function (coefficient 0.06; 95% CI 0.02, 0.09; p for interaction=0.013) in women only. In contrast, a stronger positive association between IGFBP2 and insulin sensitivity determined using an OGTT (coefficient 0.38; 95% CI 0.27, 0.49) was observed in men (p for interaction=0.004). A posteriori analysis showed that the associations between TIMP4 and insulin dynamics were not mediated by adiposity. In contrast, most of the associations between IGFBP2 and insulin dynamics, except for insulin secretion, were mediated by either fat mass index or visceral adipose tissue in men and women. Fat mass index was the strongest mediator between IGFBP2 and insulin sensitivity (total effect mediated 40.7%; 95% CI 37.0, 43.6) and IGFBP2 and HOMA-IR (total effect mediated 39.1%; 95% CI 31.1, 43.5) in men.\n\nWe validated 34 proteins that were associated with type 2 diabetes, of which 11 were associated with measures of type 2 diabetes pathophysiology such as peripheral insulin sensitivity and beta cell function. This study highlights biomarkers that are similar between cohorts of different ancestry, with different lifestyles and sociodemographic profiles. The African-specific biomarkers identified require validation in African cohorts to identify risk markers and increase our understanding of the pathophysiology of type 2 diabetes in African populations.", "doi": "10.1007/s00125-022-05788-1", "pmid": "36114877", "labels": [], "xrefs": [{"db": "pii", "key": "10.1007/s00125-022-05788-1"}], "notes": [], "created": "2026-08-20T06:38:54.837Z", "modified": "2026-08-20T06:38:55.186Z"}, {"entity": "publication", "iuid": "53dc2332a9ca4907bdcfdb318e887e97", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/53dc2332a9ca4907bdcfdb318e887e97.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/53dc2332a9ca4907bdcfdb318e887e97"}}, "title": "Obstructive sleep apnea is associated with specific gut microbiota species and functions in the population-based Swedish CardioPulmonary bioImage Study (SCAPIS)", "authors": [{"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Theorell-Hagl\u00f6w", "given": "Jenny", "initials": "J", "orcid": "0000-0003-2819-2799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdbe4f0179eb46f890bbcc54805cf291.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Holm", "given": "Jacob Bak", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "Henrik Bj\u00f8rn", "initials": "HB", "orcid": "0000-0003-2281-5713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f42a7caf34014b1186783a3662375dd0.json"}}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Benedict", "given": "Christian", "initials": "C", "orcid": "0000-0002-8911-4068", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4754abd3a35249109dfe62d79808cf23.json"}}, {"family": "Cedernaes", "given": "Jonathan", "initials": "J", "orcid": "0000-0002-9052-8372", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af9c0c50c8dc475daf410655475ea64d.json"}}, {"family": "Koskiniemi", "given": "Sanna", "initials": "S", "orcid": "0000-0002-3275-0936", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cd05acc7311e433abf784f6e96841941.json"}}, {"family": "Phillipson", "given": "Mia", "initials": "M", "orcid": "0000-0002-2387-0266", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/265c9b3e11de4fcaa270a0eb20faf65c.json"}}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J", "orcid": "0000-0003-2247-8454", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e1b8ae02d2949acaa8c2e18349b33a1.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G", "orcid": "0000-0003-4289-5722", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d414b3352a4540a68227ca7eec73cfa6.json"}}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G", "orcid": "0000-0002-8618-9152", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5faed1571d4742588095acc83e631dfc.json"}}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J", "orcid": "0000-0002-6933-4637", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/292b3ce479bf480487f49dc793084f22.json"}}, {"family": "Kennedy", "given": "Beatrice", "initials": "B", "orcid": "0000-0002-0066-4814", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb88fcd6bead49978b129dffe779d8a0.json"}}, {"family": "Lindberg", "given": "Eva", "initials": "E", "orcid": "0000-0002-8552-4510", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fc99a1fb25c4bd98a45beb18e300aa2.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2022-06-14", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.06.10.22276241", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:11:44.910Z", "modified": "2026-08-20T10:11:45.181Z"}, {"entity": "publication", "iuid": "6288d2088a5f4c98937d224c432a65b9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6288d2088a5f4c98937d224c432a65b9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6288d2088a5f4c98937d224c432a65b9"}}, "title": "Streptococcus species abundance in the gut is linked to subclinical coronary atherosclerosis in 8973 participants from the SCAPIS cohort", "authors": [{"family": "Sayols-Baixeras", "given": "Sergi", "initials": "S", "orcid": "0000-0002-1181-6262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13c5c3ffbe8f4ffda8cabbf2d0664906.json"}}, {"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "J\u00f6nsson", "given": "Daniel", "initials": "D"}, {"family": "Hammar", "given": "Ulf", "initials": "U", "orcid": "0000-0001-8367-5000", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b833fa7c77f542aabd5b04f4d9c02afd.json"}}, {"family": "Lin", "given": "Yi Ting", "initials": "YT", "orcid": "0000-0002-5833-0040", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36368cfa632140839b84bc166dd09b1a.json"}}, {"family": "Ahmad", "given": "Shafqat", "initials": "S", "orcid": "0000-0002-1914-5248", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/edbc11d091084a2392a8dfc062f070e8.json"}}, {"family": "Nguyen", "given": "Diem", "initials": "D", "orcid": "0000-0002-9680-5772", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b12f13041f343e19fd4566678181b69.json"}}, {"family": "Varotsis", "given": "Georgios", "initials": "G", "orcid": "0000-0002-3320-2448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a30a9d8a223487a955992023a18658e.json"}}, {"family": "Pita", "given": "Sara", "initials": "S"}, {"family": "Nielsen", "given": "Nynne", "initials": "N"}, {"family": "Eklund", "given": "Aron C", "initials": "AC", "orcid": "0000-0003-0861-1001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee40b4fbb47f4d80ab454cdc064e1ea3.json"}}, {"family": "Holm", "given": "Jacob B", "initials": "JB", "orcid": "0000-0003-1756-0875", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27bea3fb86174b0da08cbaf68820ae98.json"}}, {"family": "Nielsen", "given": "H Bj\u00f8rn", "initials": "HB"}, {"family": "Ericson", "given": "Ulrika", "initials": "U"}, {"family": "Brunkwall", "given": "Louise", "initials": "L"}, {"family": "Ottosson", "given": "Filip", "initials": "F", "orcid": "0000-0002-8312-3545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f18bcbc718e74439b675ea98e23a0e99.json"}}, {"family": "Larsson", "given": "Anna", "initials": "A"}, {"family": "Ericson", "given": "Dan", "initials": "D"}, {"family": "Klinge", "given": "Bj\u00f6rn", "initials": "B", "orcid": "0000-0003-2100-2446", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/af7e26452d9f4f6b959164c5933db734.json"}}, {"family": "Nilsson", "given": "Peter M", "initials": "PM", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1fa67d262984bccbb6b45e913a09393.json"}}, {"family": "Malinovschi", "given": "Andrei", "initials": "A"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Bergstr\u00f6m", "given": "G\u00f6ran", "initials": "G"}, {"family": "Sundstr\u00f6m", "given": "Johan", "initials": "J"}, {"family": "\u00c4rnl\u00f6v", "given": "Johan", "initials": "J"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Smith", "given": "J Gustav", "initials": "JG", "orcid": "0000-0001-6285-9935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98819c1b9e814b4388cfadc32b1f4e73.json"}}, {"family": "Orho-Melander", "given": "Marju", "initials": "M", "orcid": "0000-0002-3578-2503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09f3f572ea914566930761d3dcf189b0.json"}}, {"family": "Fall", "given": "Tove", "initials": "T", "orcid": "0000-0003-2071-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7dbbd468e6da4727b69333ade942c071.json"}}], "type": "posted-content", "published": "2022-05-25", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.05.25.22275561", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:11:25.774Z", "modified": "2026-08-20T10:11:25.964Z"}, {"entity": "publication", "iuid": "3255bdad045e4a328bad0e00eadf8d3d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3255bdad045e4a328bad0e00eadf8d3d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3255bdad045e4a328bad0e00eadf8d3d"}}, "title": "Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study.", "authors": [{"family": "Baldanzi", "given": "Gabriel", "initials": "G", "orcid": "0000-0003-3962-3953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0f55bfbbb6304ebc91c13c1ddefa0c42.json"}}, {"family": "Hammar", "given": "Ulf", "initials": "U"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Lindberg", "given": "Eva", "initials": "E"}, {"family": "Lind", "given": "Lars", "initials": "L", "orcid": "0000-0003-2335-8542", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb72ba22274c49dfb8a1cc5f607b1cdf.json"}}, {"family": "Elmst\u00e5hl", "given": "S\u00f6lve", "initials": "S"}, {"family": "Theorell-Hagl\u00f6w", "given": "Jenny", "initials": "J", "orcid": "0000-0003-2819-2799", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bdbe4f0179eb46f890bbcc54805cf291.json"}}], "type": "journal article", "published": "2022-02-14", "journal": {"title": "Sleep", "issn": "1550-9109", "volume": "45", "issue": "2", "issn-l": "0161-8105"}, "abstract": "Individuals with evening chronotype have a higher risk of cardiovascular and metabolic disorders, although the underlying mechanisms are not well understood. In a population-based cohort, we aimed to investigate the association between chronotype and 242 circulating proteins from three panels of established or candidate biomarkers of cardiometabolic processes.\n\nIn 2,471 participants (49.7% men, mean age 61.2 \u00b1 8.4 SD years) from the EpiHealth cohort, circulating proteins were analyzed with a multiplex proximity extension technique. Participants self-reported their chronotype on a five-level scale from extreme morning to extreme evening chronotype. With the intermediate chronotype set as the reference, each protein was added as the dependent variable in a series of linear regression models adjusted for confounders. Next, the chronotype coefficients were jointly tested and the resulting p-values adjusted for multiple testing using a false discovery rate (5%). For the associations identified, we then analyzed the marginal effect of each chronotype category.\n\nWe identified 17 proteins associated with chronotype. Evening chronotype was positively associated with proteins previously linked to insulin resistance and cardiovascular risk, namely retinoic acid receptor protein 2, fatty acid-binding protein adipocyte, tissue-type plasminogen activator, and plasminogen activator inhibitor 1 (PAI-1). Additionally, PAI-1 was inversely associated with the extreme morning chronotype.\n\nIn this population-based study, proteins previously related to cardiometabolic risk were elevated in the evening chronotypes. These results may guide future research in the relation between chronotype and cardiometabolic disorders.", "doi": "10.1093/sleep/zsab226", "pmid": "34480568", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8842133"}, {"db": "pii", "key": "6364133"}], "notes": [], "created": "2026-08-20T09:51:48.464Z", "modified": "2026-08-20T09:51:48.577Z"}, {"entity": "publication", "iuid": "1bdae64c008244cd8ad1d2488fa9e21d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/1bdae64c008244cd8ad1d2488fa9e21d"}}, "title": "An online atlas of human plasma metabolite signatures of gut microbiome composition", "authors": [{"family": "Dekkers", "given": "Koen F", "initials": "KF", "orcid": "0000-0002-4074-7235", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c290d03c7bbf457abdd06a151e3650fe.json"}}, {"family": 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