{"entity": "researcher", "timestamp": "2026-10-16T12:04:28.827Z", "family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "affiliations": ["Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6, Lund University, 222 42 Lund, Sweden.", "Department of Neurology, Sk\u00e5ne University Hospital, Lund University, 211 84 Lund, Sweden.", "Wallenberg Center for Molecular Medicine, Lund University, 22184 Lund, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a"}}, "publications": [{"entity": "publication", "iuid": "8e6e53c611e44004b1a4297c1c1d4b94", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e6e53c611e44004b1a4297c1c1d4b94.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e6e53c611e44004b1a4297c1c1d4b94"}}, "title": "Reference proteins to improve Core 1 and Core 2 Alzheimer's disease CSF and plasma biomarkers.", "authors": [{"family": "Karlsson", "given": "Linda", "initials": "L", "orcid": "0000-0002-0630-772X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ead4d76d56ff439ba30689e7dfe3aae2.json"}}, {"family": "Janelidze", "given": "Shorena", "initials": "S"}, {"family": "Barth\u00e9lemy", "given": "Nicolas R", "initials": "NR"}, {"family": "Horie", "given": "Kanta", "initials": "K", "orcid": "0000-0001-7736-2614", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a39cbb87fbd940fe830fef9c5d1ad9d5.json"}}, {"family": "Therriault", "given": "Joseph", "initials": "J", "orcid": "0000-0002-7826-4781", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ead8a0c5abeb4021b67de72780349675.json"}}, {"family": "Gaetani", "given": "Lorenzo", "initials": "L"}, {"family": "Bellomo", "given": "Giovanni", "initials": "G"}, {"family": "Schindler", "given": "Suzanne E", "initials": "SE"}, {"family": "Vogel", "given": "Jacob", "initials": "J"}, {"family": "Arvidsson", "given": "Ida", "initials": "I"}, {"family": "\u00c5str\u00f6m", "given": "Kalle", "initials": "K"}, {"family": "Gordon", "given": "Brian A", "initials": "BA", "orcid": "0000-0003-2109-2955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d260cb618f240bc839bdb8b607c5418.json"}}, {"family": "Raji", "given": "Cyrus A", "initials": "CA"}, {"family": "Benzinger", "given": "Tammie L S", "initials": "TLS"}, {"family": "Morris", "given": "John C", "initials": "JC", "orcid": "0000-0003-2967-9662", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0daa367529d419e868dcacfb8bd68c8.json"}}, {"family": "Nilsson", "given": "Johanna", "initials": "J", "orcid": "0000-0002-2856-6060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d57bafbf656a49e3987d6917b48493ab.json"}}, {"family": "Brinkmalm", "given": "Ann", "initials": "A"}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Salvad\u00f3", "given": "Gemma", "initials": "G", "orcid": "0000-0002-5210-9230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3b7599000404d618d84b389ba47f19a.json"}}, {"family": "Pichet Binette", "given": "Alexa", "initials": "A"}, {"family": "Di Filippo", "given": "Massimiliano", "initials": "M", "orcid": "0000-0002-2645-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88e41f7a4f234f6e911ca591d87daa17.json"}}, {"family": "Parnetti", "given": "Lucilla", "initials": "L"}, {"family": "Rosa-Neto", "given": "Pedro", "initials": "P", "orcid": "0000-0001-9116-1376", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aada749a4ab6404a9954fd902f5560fd.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K"}, {"family": "Bateman", "given": "Randall J", "initials": "RJ", "orcid": "0000-0002-7729-1702", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0dd2354822ab40feacbdd2168370d582.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2026-04-07", "journal": {"title": "Brain", "issn": "1460-2156", "volume": "149", "issue": "4", "pages": "1153-1167", "issn-l": "0006-8950"}, "abstract": "Concentration-based fluid biomarkers represent an informative and cost-effective way to detect and monitor Alzheimer's disease (AD) pathology. However, non-AD-related interindividual variation in biofluids can also affect biomarker concentrations. Here, we investigated whether normalization of CSF and plasma biomarkers to reference proteins, such as amyloid-\u03b240 (A\u03b240) and non-phosphorylated mid-region tau (np-tau), improves their robustness and reliability of representing AD pathology load. Using the Swedish BioFINDER-2 cohort [n = 1702, 50.7% male, mean (standard deviation) age 68.4 (12.2) years], we compared the associations between tau/A\u03b2-PET load and fluid biomarkers alone versus biomarkers in a ratio with a reference protein (A\u03b240 or np-tau) in univariate linear regression models. Fluid biomarkers included CSF and plasma measures of p-tau217, p-tau181, p-tau205, np-tau181-190, np-tau195-210, np-tau212-221, A\u03b242 and A\u03b240; CSF MTBR-tau243, SNAP-25, neurogranin, YKL-40 and sTREM2; and plasma eMTBR-tau243. Biomarkers were measured with mass spectrometry assays and/or immunoassays. In addition, we performed validation and extended analyses, comparing, for example, group-level diagnostic differences and longitudinal biomarker trajectories, in three independent prospective cohorts [BioFINDER-1, Knight Alzheimer Disease Research Center (ADRC) and Translational Biomarkers in Aging and Dementia (TRIAD)] and in an Italian multiple sclerosis cohort. CSF A\u03b240 normalization significantly strengthened the associations of several core CSF AD biomarkers, including CSF MTBR-tau243, p-tau isoforms and synaptic biomarkers, with tau-PET (\u0394R2 = 0.064-0.24) and A\u03b2-PET (\u0394R2 = 0.016-0.28). Normalization to CSF np-tau mainly improved concordance with A\u03b2-PET (\u0394R2 = -0.0059 to 0.19). The strongest association with tau-PET was observed for MTBR-tau243/A\u03b240 (R2 = 0.78, compared with 0.65 for non-normalized MTBR-tau243), and with A\u03b2-PET for p-tau217/np-tau (R2 = 0.65, compared with 0.46 for non-normalized p-tau217). Plasma biomarker associations with tau-PET improved when using normalization to plasma A\u03b240 or np-tau (\u0394R2 = 0.004-0.14), with the strongest effect for eMTBR-tau243/np-tau (R2 = 0.72 versus 0.60). Associations with A\u03b2-PET were enhanced with np-tau normalization (\u0394R2 = 0.018-0.16, strongest for p-tau217/np-tau: R2 = 0.62 versus 0.53). The results were replicated in Knight ADRC and TRIAD. Furthermore, longitudinal analyses showed that A\u03b240 normalization typically reduced interindividual rather than intra-individual variability over time. Normalization did not enhance group-level differences in inflammatory CSF biomarkers in AD, nor did it improve biomarker associations in the multiple sclerosis cohort. In conclusion, normalization of CSF and plasma biomarkers to reference proteins, such as A\u03b240 or np-tau, enhances their association with brain tau and A\u03b2 pathology, making already high-performing AD fluid biomarkers even more accurate.", "doi": "10.1093/brain/awaf375", "pmid": "41051312", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC13058454"}, {"db": "pii", "key": "8275810"}], "notes": [], "created": "2026-10-01T08:28:47.583Z", "modified": "2026-10-01T08:28:47.783Z"}, {"entity": "publication", "iuid": "41296afe1fb94394af66909057750160", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/41296afe1fb94394af66909057750160"}}, "title": "Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer's Disease.", "authors": [{"family": "Anij\u00e4rv", "given": "Toomas Erik", "initials": "TE", "orcid": "0000-0002-3650-4230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/478837ec8fef4a8d9d4b39e088049614.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Pichet Binette", "given": "Alexa", "initials": "A", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Behjat", "given": "Harry H", "initials": "HH", "orcid": "0000-0001-6729-6801", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5d1b40c4a8342eb841754961f1b3593.json"}}, {"family": "Rittmo", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-5075-0166", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f46afd59d3a44a18a35c560c3d2e37f3.json"}}, {"family": "Karlsson", "given": "Linda", "initials": "L", "orcid": "0000-0002-0630-772X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ead4d76d56ff439ba30689e7dfe3aae2.json"}}, {"family": "Ahmadi", "given": "Khazar", "initials": "K", "orcid": "0000-0002-3371-6211", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5295cea5ead34b96a887d4055ccd659b.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Alzheimer\u2019s Disease Neuroimaging Initiative", "given": "", "initials": ""}, {"family": "van Westen", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8649-9874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38afd81dca574f4a9884a1ce97b78e50.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E"}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Spotorno", "given": "Nicola", "initials": "N", "orcid": "0000-0001-5404-8788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4851c8ec84264207bdf67c2fd04643da.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-09-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "8232", "issn-l": "2041-1723"}, "abstract": "The distribution of tau pathology in Alzheimer's disease (AD) shows remarkable inter-individual heterogeneity, including hemispheric asymmetry. However, the factors driving this asymmetry remain poorly understood. Here we explore whether tau asymmetry is linked to i) reduced inter-hemispheric brain connectivity (potentially restricting tau spread), or ii) asymmetry in amyloid-beta (A\u03b2) distribution (indicating greater hemisphere-specific vulnerability to AD pathology). We include 452 participants from the Swedish BioFINDER-2 cohort with evidence of both A\u03b2 pathology (CSF A\u03b242/40 or neocortical A\u03b2-PET) and tau pathology (temporal tau-PET), categorising them as left asymmetric (n = 102), symmetric (n = 306), or right asymmetric (n = 44) based on temporal lobe tau-PET uptake distribution. We assess edge-wise inter-hemispheric functional (RSfMRI; n = 318) and structural connectivity (dMRI; n = 352) but find no association between tau asymmetry and connectivity. In contrast, we observe a strong association between tau and A\u03b2 laterality patterns based on PET uptake (n = 233; \u03b2 = 0.632, p < 0.001), which we replicate in three independent cohorts (n = 234; \u03b2 = 0.535, p < 0.001). In a longitudinal A\u03b2-positive sample, we show that baseline A\u03b2 asymmetry predicts progression of tau laterality over time (n = 289; \u03b2 = 0.025, p = 0.028). These findings suggest that tau asymmetry is not associated with a weaker inter-hemispheric connectivity but might reflect hemispheric differences in vulnerability to A\u03b2 pathology, underscoring the role of regional vulnerability in determining the distribution of AD pathology.", "doi": "10.1038/s41467-025-63564-2", "pmid": "40913038", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12413461"}, {"db": "pii", "key": "10.1038/s41467-025-63564-2"}], "notes": [], "created": "2026-08-21T11:50:12.353Z", "modified": "2026-10-01T08:24:55.333Z"}, {"entity": "publication", "iuid": "8e16e41a05b84805851dcab40b6d2049", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8e16e41a05b84805851dcab40b6d2049.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8e16e41a05b84805851dcab40b6d2049"}}, "title": "Proteomic signatures of the APOE \u03b54 and APOE \u03b52 genetic variants and Alzheimer's disease.", "authors": [{"family": "Lu", "given": "Lina", "initials": "L", "orcid": "0000-0001-9395-242X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2067c4e87b804659b8aee8603d3848e0.json"}}, {"family": "Binette", "given": "Alexa Pichet", "initials": "AP", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Hristovska", "given": "Ines", "initials": "I"}, {"family": "Janelidze", "given": "Shorena", "initials": "S"}, {"family": "Smets", "given": "Bart", "initials": "B"}, {"family": "Mayoral", "given": "Irene Cumplido", "initials": "IC", "orcid": "0000-0002-1967-7025", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5486c50f78d9419484fb75d726dffb3e.json"}}, {"family": "Vasanthakumar", "given": "Aparna", "initials": "A"}, {"family": "Milkovich", "given": "Britney", "initials": "B"}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Krish", "given": "Varsha", "initials": "V"}, {"family": "Imam", "given": "Farhad", "initials": "F"}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Vogel", "given": "Jacob", "initials": "J"}, {"family": "Stomrud", "given": "Erik", "initials": "E", "orcid": "0000-0002-0841-5580", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac36a615800c40b98d64369cb029497c.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}], "type": "journal article", "published": "2025-08-25", "journal": {"title": "medRxiv", "issn-l": null}, "abstract": "The \u03b54 and \u03b52 alleles of the Apolipoprotein E (APOE) gene confer opposite genetic risks for Alzheimer's disease (AD), but their underlying molecular mechanisms remain poorly characterized in humans. To resolve this, we systematically profiled APOE-associated proteomic alterations across five cohorts-including the Global Neurodegeneration Proteomics Consortium (GNPC), BioFINDER-2, the Alzheimer's Disease Neuroimaging Initiative (ADNI), the Parkinson's Progression Markers Initiative (PPMI), and UK Biobank (UKB)-using SomaLogic and OLINK platforms in plasma and cerebrospinal fluid (CSF) from over 10,000 individuals. Using GNPC (plasma SomaLogic, N=4,045), we mapped a comprehensive APOE-protein network and applied mediation modeling to classify genotype-related signals as upstream mediators, downstream consequences, or APOE-specific changes. We then leveraged CSF beta-amyloid (A\u03b2) biomarker data from BioFINDER-2 (plasma SomaLogic, N=1,421) to improve temporal resolution and isolate early, A\u03b2-independent proteomic programs. In the A\u03b2- individuals, APOE4 was linked to cell cycle and chromatin remodeling, while APOE2 was associated with mitochondrial regulation and DNA repair. Mediation analyses nominated proteins such as S100A13, TBCA, SPC25 for APOE4, and APOB, SNAP23 for APOE2 as candidate upstream effectors, supported by CSF validation (ADNI, SomaLogic, N=666), brain transcriptomic co-expression, and AD GWAS colocalization. Longitudinal CSF data from PPMI confirmed the temporal stability of several APOE-associated proteins. Cross-platform comparisons (UKB plasma OLINK, N=4,820, and BF2 CSF OLINK, N=1,475) revealed matrix- and assay-specific heterogeneity, underscoring challenges in reproducibility. Together, our results delineate allele-specific, temporally structured proteomic signatures that precede AD pathology, offering insight into APOE-driven molecular pathways and potential therapeutic targets for early intervention.", "doi": "10.1101/2025.08.04.25332945", "pmid": "40799961", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12340876"}, {"db": "pii", "key": "2025.08.04.25332945"}], "notes": [], "created": "2026-10-01T08:34:37.305Z", "modified": "2026-10-01T08:34:37.445Z"}, {"entity": "publication", "iuid": "c889c9fd45524086a24104f2fd3095a2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c889c9fd45524086a24104f2fd3095a2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c889c9fd45524086a24104f2fd3095a2"}}, "title": "The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging.", "authors": [{"family": "Imam", "given": "Farhad", "initials": "F", "orcid": "0000-0003-2854-2568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4b307d7379c43498446d995e26ef596.json"}}, {"family": "Saloner", "given": "Rowan", "initials": "R", "orcid": "0000-0002-1351-6183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23de862940594622a28cb1e1c78b4447.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Krish", "given": "Varsha", "initials": "V"}, {"family": "Abdel-Azim", "given": "Gamal", "initials": "G"}, {"family": "Ali", "given": "Muhammad", "initials": "M", "orcid": "0000-0002-1399-6631", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21caa67549d64397bee640897fb7b8b3.json"}}, {"family": "An", "given": "Lijun", "initials": "L", "orcid": "0000-0003-1030-4625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06744ec5a4ad4223b88038071e7b1dbf.json"}}, {"family": "Anastasi", "given": "Federica", "initials": "F", "orcid": "0000-0002-9304-5421", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05157ef2d97e4ae2aae53ec63e57e70a.json"}}, {"family": "Bennett", "given": "David", "initials": "D"}, {"family": "Pichet Binette", "given": "Alexa", "initials": "A"}, {"family": "Boxer", "given": "Adam L", "initials": "AL", "orcid": "0000-0002-1215-5064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9d03c29ef924cb8a15db8c1c890740f.json"}}, {"family": "Bringmann", "given": "Martin", "initials": "M", "orcid": "0000-0003-4289-7605", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a60e477edb034243b1005cb36e6d7883.json"}}, {"family": "Burns", "given": "Jeffrey M", "initials": "JM", "orcid": "0000-0001-7609-8954", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5f760a3e79d41d992e947dcb0dabd24.json"}}, {"family": "Cruchaga", "given": "Carlos", "initials": "C", "orcid": "0000-0002-0276-2899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9c0207f812f48c1bfd0918169154508.json"}}, {"family": "Dage", "given": "Jeff L", "initials": "JL"}, {"family": "Farinas", "given": "Amelia", "initials": "A", "orcid": "0000-0002-6697-8883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a92edf26e6cc4ef8be8024386777a2d7.json"}}, {"family": "Ferrucci", "given": "Luigi", "initials": "L"}, {"family": "Finney", "given": "Caitlin A", "initials": "CA", "orcid": "0000-0002-9357-8316", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9b9fb68aab72477bbeea74dd557f6c02.json"}}, {"family": "Frasier", "given": "Mark", "initials": "M"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Hohman", "given": "Timothy J", "initials": "TJ", "orcid": "0000-0002-3377-7014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/802e920731d54ac0b061d28139a57be1.json"}}, {"family": "Johnson", "given": "Erik C B", "initials": "ECB", "orcid": "0000-0002-0604-2944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e0f475a90b6a4b13a0d74e2c2cd593a5.json"}}, {"family": "Kivimaki", "given": "Mika", "initials": "M", "orcid": "0000-0002-4699-5627", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/59d7f4b1a8f8464eba40b0abe733aae9.json"}}, {"family": "Korologou-Linden", "given": "Roxanna", "initials": "R"}, {"family": "Ruiz Laza", "given": "Agustin", "initials": "A", "orcid": "0000-0003-2633-2495", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/35d7238129b14df1af8c2f808945ace1.json"}}, {"family": "Levey", "given": "Allan I", "initials": "AI", "orcid": "0000-0002-3153-502X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5bac26ce6a9b4ba38ed01518c742747e.json"}}, {"family": "Liepelt-Scarfone", "given": "Inga", "initials": "I"}, {"family": "Lu", "given": "Lina", "initials": "L"}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Middleton", "given": "Lefkos T", "initials": "LT", "orcid": "0000-0002-2176-403X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dcbe479f467442ea9ba5482cc5a99bd2.json"}}, {"family": "Nho", "given": "Kwangsik", "initials": "K"}, {"family": "Oh", "given": "Hamilton Se-Hwee", "initials": "HS"}, {"family": "Petersen", "given": "Ronald C", "initials": "RC"}, {"family": "Reiman", "given": "Eric M", "initials": "EM", "orcid": "0000-0002-0705-3696", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0282bd2bddad4e539605aa663f3ee79d.json"}}, {"family": "Robinson", "given": "Oliver", "initials": "O", "orcid": "0000-0002-4735-0468", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9532ceaa97eb4526b5b9446ac72747da.json"}}, {"family": "Rothstein", "given": "Jeffrey D", "initials": "JD"}, {"family": "Saykin", "given": "Andrew J", "initials": "AJ", "orcid": "0000-0002-1376-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9b775d178844c869a3b9655fa204121.json"}}, {"family": "Shvetcov", "given": "Artur", "initials": "A"}, {"family": "Slawson", "given": "Chad", "initials": "C", "orcid": "0000-0002-6886-4847", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dbb39b9ae8c246a9a899114ab9327248.json"}}, {"family": "Smets", "given": "Bart", "initials": "B"}, {"family": "Su\u00e1rez-Calvet", "given": "Marc", "initials": "M"}, {"family": "Tijms", "given": "Betty M", "initials": "BM", "orcid": "0000-0002-2612-1797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/803d2e2311394c50b47c43c5f6a4c425.json"}}, {"family": "Timmers", "given": "Maarten", "initials": "M"}, {"family": "Vieira", "given": "Fernando", "initials": "F", "orcid": "0000-0003-2996-6418", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dac955f7e8784d43956f81d2bb54555d.json"}}, {"family": "Vilor-Tejedor", "given": "Natalia", "initials": "N"}, {"family": "Visser", "given": "Pieter Jelle", "initials": "PJ"}, {"family": "Walker", "given": "Keenan A", "initials": "KA", "orcid": "0000-0002-5989-9853", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d3c771604ad24c5b98db69b514f30592.json"}}, {"family": "Winchester", "given": "Laura M", "initials": "LM"}, {"family": "Wyss-Coray", "given": "Tony", "initials": "T", "orcid": "0000-0001-5893-0831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6ad3115d413a4a46ad05465b15306b21.json"}}, {"family": "Yang", "given": "Chengran", "initials": "C", "orcid": "0000-0003-4577-5590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f11aa3f425634c9cb9bf2c30752376c5.json"}}, {"family": "Bose", "given": "Niranjan", "initials": "N", "orcid": "0000-0002-1301-7827", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/03a544bbd61f48efa4ff0fc7d1578d5a.json"}}, {"family": "Lovestone", "given": "Simon", "initials": "S"}, {"family": "Global Neurodegeneration Proteomics Consortium (GNPC)", "given": "", "initials": ""}], "type": "journal article", "published": "2025-08-00", "journal": {"title": "Nat. Med.", "issn": "1546-170X", "volume": "31", "issue": "8", "pages": "2556-2566", "issn-l": "1078-8956"}, "abstract": "More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions. High-dimensional molecular studies in biofluids ('omics') offer promise for scalable biomarker discovery, but challenges in assembling large, diverse datasets hinder progress. To address this, the Global Neurodegeneration Proteomics Consortium (GNPC)-a public-private partnership-established one of the world's largest harmonized proteomic datasets. It includes approximately 250 million unique protein measurements from multiple platforms from more than 35,000 biofluid samples (plasma, serum and cerebrospinal fluid) contributed by 23 partners, alongside associated clinical data spanning Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). This dataset is accessible to GNPC members via the Alzheimer's Disease Data Initiative's AD Workbench, a secure cloud-based environment, and will be available to the wider research community on 15 July 2025. Here we present summary analyses of the plasma proteome revealing disease-specific differential protein abundance and transdiagnostic proteomic signatures of clinical severity. Furthermore, we describe a robust plasma proteomic signature of APOE \u03b54 carriership, reproducible across AD, PD, FTD and ALS, as well as distinct patterns of organ aging across these conditions. This work demonstrates the power of international collaboration, data sharing and open science to accelerate discovery in neurodegeneration research.", "doi": "10.1038/s41591-025-03834-0", "pmid": "40665048", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12353841"}, {"db": "pii", "key": "10.1038/s41591-025-03834-0"}], "notes": [], "created": "2026-08-20T09:02:07.394Z", "modified": "2026-09-23T07:36:31.248Z"}, {"entity": "publication", "iuid": "5f981cbb10d5403baea20853de7d39ad", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5f981cbb10d5403baea20853de7d39ad.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5f981cbb10d5403baea20853de7d39ad"}}, "title": "Benchmarking the AI-based diagnostic potential of plasma proteomics for neurodegenerative disease in 17,170 people.", "authors": [{"family": "An", "given": "Lijun", "initials": "L", "orcid": "0000-0003-1030-4625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06744ec5a4ad4223b88038071e7b1dbf.json"}}, {"family": "Pichet-Binette", "given": "Alexa", "initials": "A", "orcid": "0000-0001-5218-3337", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f0967b7b694bcf96e30a051a5bbe9a.json"}}, {"family": "Hristovska", "given": "Ines", "initials": "I"}, {"family": "Vilkaite", "given": "Gabriele", "initials": "G", "orcid": "0009-0009-6985-4307", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc705f5708ae447ea1ebd6a3a0bd73cf.json"}}, {"family": "Yu", "given": "Xiao", "initials": "X", "orcid": "0009-0006-6760-4134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49c14c0be1f2486bb835dd3090785268.json"}}, {"family": "Smets", "given": "Bart", "initials": "B"}, {"family": "Saloner", "given": "Rowan", "initials": "R", "orcid": "0000-0002-1351-6183", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/23de862940594622a28cb1e1c78b4447.json"}}, {"family": "Tasaki", "given": "Shinya", "initials": "S", "orcid": "0000-0003-3656-7394", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/741c7fb0f6044af6a9cae7b128972b10.json"}}, {"family": "Xu", "given": "Ying", "initials": "Y"}, {"family": "Krish", "given": "Varsha", "initials": "V"}, {"family": "Imam", "given": "Farhad", "initials": "F", "orcid": "0000-0003-2854-2568", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4b307d7379c43498446d995e26ef596.json"}}, {"family": "Janelidze", "given": "Shorena", "initials": "S", "orcid": "0000-0003-2869-8378", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3e2ab428bdc42838f5af521a4d8b862.json"}}, {"family": "van Westen", "given": "Danielle", "initials": "D", "orcid": "0000-0001-8649-9874", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/38afd81dca574f4a9884a1ce97b78e50.json"}}, {"family": "Global Neurodegeneration Proteomics Consortium (GNPC)", "given": "", "initials": ""}, {"family": "Stomrud", "given": "Erik", "initials": "E", "orcid": "0000-0002-0841-5580", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac36a615800c40b98d64369cb029497c.json"}}, {"family": "Whelan", "given": "Christopher D", "initials": "CD", "orcid": "0000-0003-0308-5583", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/172a710cb4974f168783a34e02eca6ee.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}], "type": "journal article", "published": "2025-07-01", "journal": {"title": "medRxiv", "issn-l": null}, "abstract": "Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathological diagnosis are not available for most neurodegenerative neuropathologies. Here, we present ProtAIDe-Dx, a deep joint-learning model trained on 17,170 patients and controls that uses plasma proteomics to provide simultaneous probabilistic diagnosis across six conditions associated with dementia in aging. ProtAIDe-Dx achieves cross-validated balanced classification accuracy of 69%-96% and AUCs > 79% across all conditions. The model's diagnostic probabilities highlighted subgroups of patients with co-pathologies, and were associated with pathology-specific biomarkers in an external sample, even among cognitively unimpaired people. Model interpretation revealed a suite of protein networks marking shared and specific biological processes across diseases, and identified novel and previously described proteins discriminating each diagnosis. ProtAIDe-Dx significantly improved biomarker-based differential diagnosis in a memory clinic sample, pinpointing proteins leading to diagnostic decisions at an individual level. Together, this work highlights the promise of plasma proteomics to improve patient-level diagnostic work-up with a single blood draw.", "doi": "10.1101/2025.06.27.25330344", "pmid": "40630573", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12236936"}, {"db": "pii", "key": "2025.06.27.25330344"}], "notes": [], "created": "2026-08-20T11:06:20.965Z", "modified": "2026-09-23T14:28:43.092Z"}, {"entity": "publication", "iuid": "0c2cac650bae4d76b8be915a0ddc508f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/0c2cac650bae4d76b8be915a0ddc508f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/0c2cac650bae4d76b8be915a0ddc508f"}}, "title": "Brain network dynamics determine tau presence while regional vulnerability governs tau load in Alzheimer\u2019s disease", "authors": [{"family": "Xiao", "given": "Yu", "initials": "Y", "orcid": "0009-0006-6760-4134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49c14c0be1f2486bb835dd3090785268.json"}}, {"family": "Spotorno", "given": "Nicola", "initials": "N", "orcid": "0000-0001-5404-8788", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4851c8ec84264207bdf67c2fd04643da.json"}}, {"family": "An", "given": "Lijun", "initials": "L", "orcid": "0000-0003-1030-4625", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06744ec5a4ad4223b88038071e7b1dbf.json"}}, {"family": "Bazinet", "given": "Vincent", "initials": "V", "orcid": "0000-0001-6693-9641", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bf7315c0afaa444dab889dc98142cfc1.json"}}, {"family": "Hansen", "given": "Justine Y", "initials": "JY", "orcid": "0000-0003-3142-7480", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb0fa058a43d40329e061d621d305b06.json"}}, {"family": "Strandberg", "given": "Olof", "initials": "O"}, {"family": "Shafiei", "given": "Golia", "initials": "G", "orcid": "0000-0002-2036-5571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a248c7067e0487e90ef72448bb7fd1c.json"}}, {"family": "Behjat", "given": "Harry H", "initials": "HH", "orcid": "0000-0001-6729-6801", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5d1b40c4a8342eb841754961f1b3593.json"}}, {"family": "Funck", "given": "Thomas", "initials": "T", "orcid": "0000-0002-8925-9830", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0069b039d56940928b8785a6a68d5eda.json"}}, {"family": "Salvad\u00f3", "given": "Gemma", "initials": "G", "orcid": "0000-0002-5210-9230", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3b7599000404d618d84b389ba47f19a.json"}}, {"family": "Stomrud", "given": "Erik", "initials": "E", "orcid": "0000-0002-0841-5580", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac36a615800c40b98d64369cb029497c.json"}}, {"family": "Smith", "given": "Ruben", "initials": "R", "orcid": "0000-0001-7147-0112", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9c69d9e76c884720afe20ce34b2c4d81.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Mattsson-Carlgren", "given": "Niklas", "initials": "N", "orcid": "0000-0002-8885-7724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bb26ae59b2a04f369c5ebc2f2375195a.json"}}, {"family": "Palomero-Gallagher", "given": "Nicola", "initials": "N", "orcid": "0000-0003-4463-8578", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cb2e20b61c594a2cbb69ebac77b193cc.json"}}, {"family": "Dagher", "given": "Alain", "initials": "A", "orcid": "0000-0002-0945-5779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/642c0c268b8a447784b84ad589d0ba7f.json"}}, {"family": "Misic", "given": "Bratislav", "initials": "B", "orcid": "0000-0003-0307-2862", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6cba1b095bd43b2b9a44cbd57fac573.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}], "type": "posted-content", "published": "2025-04-23", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.04.17.648358", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-10-01T08:31:00.151Z", "modified": "2026-10-01T08:31:00.421Z"}, {"entity": "publication", "iuid": "9d9906f7aee144eeab4a77c395e2c6ff", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/9d9906f7aee144eeab4a77c395e2c6ff.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/9d9906f7aee144eeab4a77c395e2c6ff"}}, "title": "Hemispheric Asymmetry of Tau Pathology is Related to Asymmetric Amyloid Deposition in Alzheimer\u2019s Disease", "authors": [{"family": "Anij\u00e4rv", "given": "T E", "initials": "TE", "orcid": "0000-0002-3650-4230", "researcher": {"href": 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{"family": "Heneka", "given": "Michael T", "initials": "MT"}, {"family": "Wagner", "given": "Michael", "initials": "M"}, {"family": "D\u00fczel", "given": "Emrah", "initials": "E", "orcid": "0000-0002-0139-5388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83a4ff611c18448295e1e6d449d8c8fc.json"}}, {"family": "Jessen", "given": "Frank", "initials": "F"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}, {"family": "Berron", "given": "David", "initials": "D", "orcid": "0000-0003-1558-1883", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7a3f4829ce644c23a65a4c13359f17fe.json"}}], "type": "journal article", "published": "2024-07-05", "journal": {"title": "Brain", "issn": "1460-2156", "volume": "147", "issue": "7", "pages": "2400-2413", "issn-l": "0006-8950"}, "abstract": "Memory clinic patients are a heterogeneous population representing various aetiologies of pathological ageing. It is not known whether divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean \u00b1 standard deviation, age = 70.67 \u00b1 6.07 years, 52% females). Participants were cognitively unimpaired (n = 285) or fulfilled diagnostic criteria for subjective cognitive decline (n = 342), mild cognitive impairment (n = 118) or dementia of the Alzheimer's type (n = 68). Atrophy subtypes were compared in baseline demographics, fluid Alzheimer's disease biomarker levels, the Preclinical Alzheimer Cognitive Composite (PACC-5) as well as episodic memory and executive functioning. PACC-5 trajectories over up to 240 weeks were examined. To test whether baseline atrophy subtype and stage predicted clinical trajectories before manifest cognitive impairment, we analysed PACC-5 trajectories and mild cognitive impairment conversion rates of cognitively unimpaired participants and those with subjective cognitive decline. Limbic-predominant and hippocampal-sparing atrophy subtypes were identified. Limbic-predominant atrophy initially affected the medial temporal lobes, followed by further temporal regions and, finally, the remaining cortical regions. At baseline, this subtype was related to older age, more pathological Alzheimer's disease biomarker levels, APOE \u03b54 carriership and an amnestic cognitive impairment. Hippocampal-sparing atrophy initially occurred outside the temporal lobe, with the medial temporal lobe spared up to advanced atrophy stages. This atrophy pattern also affected individuals with positive Alzheimer's disease biomarkers and was associated with more generalized cognitive impairment. Limbic-predominant atrophy, in all participants and in only unimpaired participants, was linked to more negative longitudinal PACC-5 slopes than observed in participants without or with hippocampal-sparing atrophy and increased the risk of mild cognitive impairment conversion. SuStaIn modelling was repeated in a sample from the Swedish BioFINDER-2 cohort. Highly similar atrophy progression patterns and associated cognitive profiles were identified. Cross-cohort model generalizability, at both the subject and the group level, was excellent, indicating reliable performance in previously unseen data. The proposed model is a promising tool for capturing heterogeneity among older adults at early at-risk states for Alzheimer's disease in applied settings. The implementation of atrophy subtype- and stage-specific end points might increase the statistical power of pharmacological trials targeting early Alzheimer's disease.", "doi": "10.1093/brain/awae118", "pmid": "38654513", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11224599"}, {"db": "pii", "key": "7657064"}], "notes": [], "created": "2025-03-19T11:17:08.204Z", "modified": "2025-03-19T11:19:16.050Z"}]}