{"entity": "researcher", "timestamp": "2026-07-20T22:32:18.659Z", "family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75"}}, "publications": [{"entity": "publication", "iuid": "e7a3d3b826e941a788bbd2dd4d7dd16d", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e7a3d3b826e941a788bbd2dd4d7dd16d.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e7a3d3b826e941a788bbd2dd4d7dd16d"}}, "title": "Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems.", "authors": [{"family": "Tjakra", "given": "Marco", "initials": "M", "orcid": "0000-0003-2266-4011", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a5cb334519c3421db6078ea3f25e1a08.json"}}, {"family": "Chakrapeesirisuk", "given": "Nopdanai", "initials": "N"}, {"family": "Jacobson", "given": "Magdalena", "initials": "M"}, {"family": "Sellin", "given": "Mikael E", "initials": "ME"}, {"family": "Eriksson", "given": "Jens", "initials": "J"}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}], "type": "journal article", "published": "2025-07-07", "journal": {"title": "Mol. Pharm.", "issn": "1543-8392", "volume": "22", "issue": "7", "pages": "4032-4045", "issn-l": "1543-8384"}, "abstract": "Development of oral drug delivery systems that penetrate the colonic mucus remains challenging. Artificial models of porcine colonic mucus have been developed that mimic the rheology and viscosity of the native mucus and its contents of mucins, protein, and lipids. However, they are less representative with regard to the zeta potential, a factor of importance for charged molecules and particles. This study therefore aimed to improve the existing porcine artificial colonic mucus model by exchanging the polymer backbone (used for viscosity) to more closely mimic the charge of porcine native colonic mucus. Polymers studied were poly(acrylic acid), hydroxyethylcellulose, sodium hyaluronate, sodium alginate, and pectin. The resulting porcine artificial colonic mucus was assayed for apparent viscosity, storage modulus, pH, water content, zeta potential, and pore size. The two best-performing polymers (poly(acrylic acid) and hydroxyethylcellulose) were then assayed with diffusion of FITC-dextran, particle tracking of nanoparticles, and binding of FITC-dextran and contrasted to data generated in porcine native colonic mucus (PNCM). Of the two polymers, PACM based on HEC generated zeta potential and binding kinetics similar to those of PNCM. We conclude that the choice of polymer in PACMs is critical for improving their use in drug development. The extensive characterization of the PACMs further points toward the importance of complementary techniques to determine rheological characteristics, mesh, and pore size.", "doi": "10.1021/acs.molpharmaceut.5c00298", "pmid": "40492464", "labels": {"Mikael Sellin": null, "SciLifeLab Fellow": null, "Alexandra Teleki": null}, "xrefs": [{"db": "pmc", "key": "PMC12239078"}], "notes": [], "created": "2025-11-17T07:45:56.922Z", "modified": "2025-11-27T18:51:32.698Z"}, {"entity": "publication", "iuid": "a8006e7784d64011a073c55b8d64d3a3", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a8006e7784d64011a073c55b8d64d3a3.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a8006e7784d64011a073c55b8d64d3a3"}}, "title": "Intrinsic lipolysis rate for systematic design of lipid-based formulations", "authors": [{"family": "Jacobsen", "given": "Ann Christin", "initials": "AC", "orcid": "0000-0003-2636-979X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc3e2954e95f43d28d1869aefaf1eca7.json"}}, {"family": "Kabedev", "given": "Aleksei", "initials": "A", "orcid": "0000-0003-3429-3713", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7ade1054e7d44ba9a80ce1e5d0d6f487.json"}}, {"family": "Sinko", "given": "Patrick D", "initials": "PD", "orcid": "0000-0002-0304-7918", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/285648e8eb90406da692a0a8528c8f5f.json"}}, {"family": "Palm", "given": "Johan E", "initials": "JE"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}], "type": "journal-article", "published": "2023-05-00", "journal": {"title": "Drug Deliv. and Transl. Res.", "issn": "2190-393X", "volume": "13", "issue": "5", "pages": "1288-1304", "issn-l": null}, "abstract": null, "doi": "10.1007/s13346-022-01246-y", "pmid": "36209313", "labels": {"SciLifeLab Fellow": null, "Alexandra Teleki": null}, "xrefs": [], "notes": [], "created": "2022-12-01T20:55:12.479Z", "modified": "2023-06-16T12:58:05.942Z"}, {"entity": "publication", "iuid": "842f5e3273af43e3a5a52fb26ac1ed5e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/842f5e3273af43e3a5a52fb26ac1ed5e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/842f5e3273af43e3a5a52fb26ac1ed5e"}}, "title": "Hyperthermia-Induced In Situ Drug Amorphization by Superparamagnetic Nanoparticles in Oral Dosage Forms", "authors": [{"family": "Ansari", "given": "Shaquib Rahman", "initials": "SR", "orcid": "0000-0003-3710-405X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d50cab7c722144d185a212d83600d80b.json"}}, {"family": "Hempel", "given": "Nele Johanna", "initials": "NJ"}, {"family": "Asad", "given": "Shno", "initials": "S"}, {"family": "Svedlindh", "given": "Peter", "initials": "P", "orcid": "0000-0002-3049-6831", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b0341fe5a8e2404f89e556908fdeca81.json"}}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}, {"family": "L\u00f6bmann", "given": "Korbinian", "initials": "K", "orcid": "0000-0002-8710-6347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed940056bb8248468f21964dba464f49.json"}}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}], "type": "journal-article", "published": "2022-05-18", "journal": {"title": "ACS Appl Mater Interfaces", "issn": "1944-8244", "volume": "14", "issue": "19", "pages": "21978-21988", "issn-l": null}, "abstract": null, "doi": "10.1021/acsami.2c03556", "pmid": null, "labels": {"SciLifeLab Fellow": null, "Alexandra Teleki": null}, "xrefs": [], "notes": [], "created": "2022-12-01T20:52:30.424Z", "modified": "2022-12-01T20:52:30.520Z"}, {"entity": "publication", "iuid": "3b3d67a12c7a4e9c9dcd0b1c008ac981", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/3b3d67a12c7a4e9c9dcd0b1c008ac981.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/3b3d67a12c7a4e9c9dcd0b1c008ac981"}}, "title": "Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet", "authors": [{"family": "Hempel", "given": "Nele Johanna", "initials": "NJ", "orcid": "0000-0002-1021-6898", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/817e99f5b11f4c768e493ed7d614367f.json"}}, {"family": "Merkl", "given": "Padryk", "initials": "P", "orcid": "0000-0002-8922-3774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ef9f5d07bdb442c88ea767812cbfc8ca.json"}}, {"family": "Asad", "given": "Shno", "initials": "S", "orcid": "0000-0002-0589-546X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d6ea98db2a3c499d9d95dc2d9c686648.json"}}, {"family": "Knopp", "given": "Matthias Manne", "initials": "MM"}, {"family": "Berthelsen", "given": "Ragna", "initials": "R", "orcid": "0000-0002-5992-9688", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe9efdd81a854ca8929fa01d240935cb.json"}}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}, {"family": "Sotiriou", "given": "Georgios A", "initials": "GA", "orcid": "0000-0001-5040-620X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f4b529432ad344308c9529badf192efd.json"}}, {"family": "L\u00f6bmann", "given": "Korbinian", "initials": "K", "orcid": "0000-0002-8710-6347", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed940056bb8248468f21964dba464f49.json"}}], "type": "journal-article", "published": "2021-06-07", "journal": {"title": "Mol. Pharmaceutics", "issn": "1543-8384", "volume": "18", "issue": "6", "pages": "2254-2262", "issn-l": "1543-8384"}, "abstract": "Poor aqueous drug solubility represents a major challenge in oral drug delivery. A novel approach to overcome this challenge is drug amorphization inside a tablet, that is, on-demand drug amorphization. The amorphous form is a thermodynamically instable, disordered solid-state with increased dissolution rate and solubility compared to its crystalline counterpart. During on-demand drug amorphization, the drug molecularly disperses into a polymer to form an amorphous solid at elevated temperatures inside a tablet. This study investigates, for the first time, the utilization of photothermal plasmonic nanoparticles for on-demand drug amorphization as a new pharmaceutical application. For this, near-IR photothermal plasmonic nanoparticles were tableted together with a crystalline drug (celecoxib) and a polymer (polyvinylpyrrolidone). The tablets were subjected to a near-IR laser at different intensities and durations to study the rate of drug amorphization under each condition. During laser irradiation, the plasmonic nanoparticles homogeneously heated the tablet. The temperature was directly related to the rate and degree of amorphization. Exposure times as low as 180 s at 1.12 W cm-2 laser intensity with only 0.25 wt % plasmonic nanoparticles and up to 50 wt % drug load resulted in complete drug amorphization. Therefore, near-IR photothermal plasmonic nanoparticles are promising excipients for on-demand drug amorphization with laser irradiation.", "doi": "10.1021/acs.molpharmaceut.1c00077", "pmid": "33951909", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [], "notes": [], "created": "2021-12-14T23:40:08.341Z", "modified": "2025-12-04T17:06:45.849Z"}, {"entity": "publication", "iuid": "f9cf70dd6e9a47c8a0c9e14ed0a3f8e1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f9cf70dd6e9a47c8a0c9e14ed0a3f8e1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f9cf70dd6e9a47c8a0c9e14ed0a3f8e1"}}, "title": "3D-printing of solid lipid tablets from emulsion gels", "authors": [{"family": "Johannesson", "given": "Jenny", "initials": "J"}, {"family": "Khan", "given": "Jamal", "initials": "J"}, {"family": "Hubert", "given": "Madlen", "initials": "M"}, {"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}], "type": "journal-article", "published": "2021-03-00", "journal": {"title": "Int J Pharm", "issn": "0378-5173", "volume": "597", "pages": "120304", "issn-l": null}, "abstract": "Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need for personalized medicines. Most research to date has focused on printing of polymeric-based drug delivery systems at high temperatures. Furthermore, oral formulation development is continuously challenged by the large number of poorly water-soluble drugs, which require more advanced enabling formulations to improve oral bioavailability. In this work, we used semi-solid extrusion (SSE) printing of emulsion gels with three types of emulsified lipid-based formulations (LBFs) to produce solid lipid tablets incorporating the poorly water-soluble drug, fenofibrate. Tablets were successfully 3D-printed from emulsion gels using SSE at room temperature, making the methodology particularly useful for thermolabile compounds. The tablets were well-defined in mass and disintegrated rapidly (<15 min). Importantly, the oil droplet size reconstituted after dispersion of the tablets and subsequent lipid digestion was similar to traditional liquid LBFs. This work demonstrates the successful use of SSE for fabricating solid lipid tablets based on emulsion gels. The method is further promising for on demand production of personalized dosage forms, necessary for flexible dosage adjustment in e.g., pediatric patients, when poorly water-soluble compounds constitute the core of the therapy.", "doi": "10.1016/j.ijpharm.2021.120304", "pmid": "33540029", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "S0378-5173(21)00108-3"}], "notes": [], "created": "2021-12-14T23:39:45.150Z", "modified": "2025-12-04T17:05:56.843Z"}, {"entity": "publication", "iuid": "5dba39f1e92245769428f523bfa87f92", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5dba39f1e92245769428f523bfa87f92.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5dba39f1e92245769428f523bfa87f92"}}, "title": "Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media.", "authors": [{"family": "Teleki", "given": "Alexandra", "initials": "A", "orcid": "0000-0001-6514-8960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fe98cb60a304a5aa33e24401fcd8af6.json"}}, {"family": "Nylander", "given": "Olivia", "initials": "O"}, {"family": "Bergstr\u00f6m", "given": "Christel A S", "initials": "CAS", "orcid": "0000-0002-8917-2612", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bae48739770b4614bc6f64eab574dd75.json"}}], "type": "journal article", "published": "2020-05-28", "journal": {"title": "Pharmaceutics", "issn": "1999-4923", "issn-l": null, "volume": "12", "issue": "6", "pages": "493"}, "abstract": "The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine. Here, we developed a robust method for rapid, medium throughput screening of IDR and established the largest IDR dataset in open literature to date that can be used for pharmaceutical computational modeling. Eighteen compounds with diverse physicochemical properties were studied in both fasted and fed state simulated intestinal fluids. Dissolution profiles were measured in small-scale experimental assays using compound suspensions or discs. IDR measurements were not solely linked to API solubility in either dissolution media. Multivariate data analysis revealed that IDR strongly depends on compound partitioning into bile salt and phospholipid micelles in the simulated intestinal fluids, a process that in turn is governed by API lipophilicity, hydrophobicity, and ionization.", "doi": "10.3390/pharmaceutics12060493", "pmid": "32481718", "labels": {"Alexandra Teleki": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "pharmaceutics12060493"}, {"db": "pmc", "key": "PMC7356998"}], "notes": [], "created": "2020-11-30T21:39:19.046Z", "modified": "2022-11-04T11:32:14.941Z"}]}