{"entity": "researcher", "timestamp": "2026-10-13T19:57:53.393Z", "family": "Kim", "given": "Peter Geon", "initials": "PG", "orcid": "0000-0002-8716-8759", "affiliations": ["Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA.", "Broad Institute of Harvard and MIT, Cambridge, MA."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/bab07a767447416fa8e4004c6cbe7b7f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/bab07a767447416fa8e4004c6cbe7b7f"}}, "publications": [{"entity": "publication", "iuid": "ec7c5372a6954d0186cb4fa27ef713d9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ec7c5372a6954d0186cb4fa27ef713d9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ec7c5372a6954d0186cb4fa27ef713d9"}}, "title": "Clonal haematopoiesis and risk of chronic liver disease.", "authors": [{"family": "Wong", "given": "Waihay J", "initials": "WJ", "orcid": "0000-0003-2023-6590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a4e1a5be5c54646ab5881bc338bf6cd.json"}}, {"family": "Emdin", "given": "Connor", "initials": "C"}, {"family": "Bick", "given": "Alexander G", "initials": "AG"}, {"family": "Zekavat", "given": "Seyedeh M", "initials": "SM", "orcid": "0000-0003-4026-8944", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6234b31f08e442a9b71a711ec7b1147a.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A"}, {"family": "Pirruccello", "given": "James P", "initials": "JP", "orcid": "0000-0001-6088-4037", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60d2e9f23cce41f5b1f40ce0f010e9d9.json"}}, {"family": "Dichtel", "given": "Laura", "initials": "L"}, {"family": "Griffin", "given": "Gabriel", "initials": "G"}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Gibson", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0002-3700-5310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ce9f64755e483496f8c28a76a2a1ff.json"}}, {"family": "Kovalcik", "given": "Veronica", "initials": "V"}, {"family": "Lin", "given": "Amy E", "initials": "AE"}, {"family": "McConkey", "given": "Marie E", "initials": "ME"}, {"family": "Vromman", "given": "Amelie", "initials": "A", "orcid": "0000-0002-1724-2095", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c5297e9d22b24ac7beaab07f94c6d1f7.json"}}, {"family": "Sellar", "given": "Rob S", "initials": "RS"}, {"family": "Kim", "given": "Peter G", "initials": "PG", "orcid": "0000-0002-8716-8759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bab07a767447416fa8e4004c6cbe7b7f.json"}}, {"family": "Agrawal", "given": "Mridul", "initials": "M"}, {"family": "Weinstock", "given": "Joshua", "initials": "J", "orcid": "0000-0001-7013-1899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2501ed5d8a4e43d488e7267e58ad68cd.json"}}, {"family": "Long", "given": "Michelle T", "initials": "MT", "orcid": "0000-0001-6131-3981", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3d2425beb9d4716a378684bbf3817f3.json"}}, {"family": "Yu", "given": "Bing", "initials": "B"}, {"family": "Banerjee", "given": "Rajarshi", "initials": "R"}, {"family": "Nicholls", "given": "Rowan C", "initials": "RC", "orcid": "0000-0002-3311-4974", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9861d98d104414aa96c7646418b04e7.json"}}, {"family": "Dennis", "given": "Andrea", "initials": "A"}, {"family": "Kelly", "given": "Matt", "initials": "M", "orcid": "0000-0002-5834-635X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1f150673cd0427ea54c82ecadd62a15.json"}}, {"family": "Loh", "given": "Po-Ru", "initials": "PR", "orcid": "0000-0001-5542-9064", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ace35329adf34fc6a3ea3d31c880d5c2.json"}}, {"family": "McCarroll", "given": "Steve", "initials": "S", "orcid": "0000-0002-6954-8184", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bde6c6c1092647c090d29dae413b2073.json"}}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Vasan", "given": "Ramachandran S", "initials": "RS", "orcid": "0000-0001-7357-5970", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22de41f77ce541d09a9b04aa59de33f7.json"}}, {"family": "Jaiswal", "given": "Siddhartha", "initials": "S", "orcid": "0000-0002-9597-0477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1901e08f989434fb01dfa17b0a85470.json"}}, {"family": "Johnson", "given": "Andrew D", "initials": "AD", "orcid": "0000-0001-6369-5178", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b268f8da3f247ba90dc37ea73d93c2f.json"}}, {"family": "Chung", "given": "Raymond T", "initials": "RT"}, {"family": "Corey", "given": "Kathleen", "initials": "K"}, {"family": "Levy", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1843-8724", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57605ba755d44792ab87cf14114ec757.json"}}, {"family": "Ballantyne", "given": "Christie", "initials": "C", "orcid": "0000-0002-6432-1730", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/27dc5297c262410bad3bbb66a488d4b4.json"}}, {"family": "NHLBI TOPMed Hematology Working Group", "given": "", "initials": ""}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}], "type": "journal article", "published": "2023-04-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "616", "issue": "7958", "pages": "747-754", "issn-l": "0028-0836"}, "abstract": "Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P < 0.001). Individuals with CHIP were more likely to demonstrate liver inflammation and fibrosis detectable by magnetic resonance imaging compared to those without CHIP (odds ratio = 1.74, 95% CI [1.16, 2.60]; P = 0.007). To assess potential causality, Mendelian randomization analyses showed that genetic predisposition to CHIP was associated with a greater risk of chronic liver disease (odds ratio = 2.37, 95% CI [1.57, 3.6]; P < 0.001). In a dietary model of non-alcoholic steatohepatitis, mice transplanted with Tet2-deficient haematopoietic cells demonstrated more severe liver inflammation and fibrosis. These effects were mediated by the NLRP3 inflammasome and increased levels of expression of downstream inflammatory cytokines in Tet2-deficient macrophages. In summary, clonal haematopoiesis is associated with an elevated risk of liver inflammation and chronic liver disease progression through an aberrant inflammatory response.", "doi": "10.1038/s41586-023-05857-4", "pmid": "37046084", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "mid", "key": "NIHMS1912281"}, {"db": "pmc", "key": "PMC10405350"}, {"db": "pii", "key": "10.1038/s41586-023-05857-4"}], "notes": [], "created": "2023-11-20T11:39:32.404Z", "modified": "2023-11-20T11:39:32.756Z"}, {"entity": "publication", "iuid": "52464b798110423d9a8e29770cfa84a5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/52464b798110423d9a8e29770cfa84a5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/52464b798110423d9a8e29770cfa84a5"}}, "title": "Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.", "authors": [{"family": "Kim", "given": "Peter Geon", "initials": "PG", "orcid": "0000-0002-8716-8759", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bab07a767447416fa8e4004c6cbe7b7f.json"}}, {"family": "Niroula", "given": "Abhishek", "initials": "A", "orcid": "0000-0002-5904-0635", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/05df7afc7a494ba5af8a378e5ffa53f0.json"}}, {"family": "Shkolnik", "given": "Veronica", "initials": "V", "orcid": "0000-0002-9043-1503", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/509e4c48124649a29675f21de034504f.json"}}, {"family": "McConkey", "given": "Marie", "initials": "M", "orcid": "0000-0002-9500-018X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e5174577207f4e46b75a2f0170e76ff3.json"}}, {"family": "Lin", "given": "Amy E", "initials": "AE", "orcid": "0000-0001-6723-5443", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6d80e192e27498b9c63898e7136af68.json"}}, {"family": "S\u0142abicki", "given": "Miko\u0142aj", "initials": "M", "orcid": "0000-0001-6317-9296", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98e216db96f944ffb3f32454b487a4d0.json"}}, {"family": "Kemp", "given": "John P", "initials": "JP", "orcid": "0000-0002-9105-2249", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/97d7ab51837846cca8a4ec1fac0bc462.json"}}, {"family": "Bick", "given": "Alexander", "initials": "A", "orcid": "0000-0001-5824-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2da5a35a4984921b19dfafe64cea2de.json"}}, {"family": "Gibson", "given": "Christopher J", "initials": "CJ", "orcid": "0000-0002-3700-5310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/71ce9f64755e483496f8c28a76a2a1ff.json"}}, {"family": "Griffin", "given": "Gabriel", "initials": "G", "orcid": "0000-0002-4042-6757", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f6153204e19d4660b640dc4467605973.json"}}, {"family": "Sekar", "given": "Aswin", "initials": "A", "orcid": "0000-0003-0406-0935", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2cff21c3699340a3a10c13447b59c7ff.json"}}, {"family": "Brooks", "given": "Daniel J", "initials": "DJ", "orcid": "0000-0001-7408-9851", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/89eefb6cb22245a3a0cb94e93efc0eb3.json"}}, {"family": "Wong", "given": "Waihay J", "initials": "WJ", "orcid": "0000-0003-2023-6590", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a4e1a5be5c54646ab5881bc338bf6cd.json"}}, {"family": "Cohen", "given": "Drew N", "initials": "DN", "orcid": "0000-0001-5263-4409", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d561a8c372244aa95e1a9b1ed82c4d7.json"}}, {"family": "Uddin", "given": "Md Mesbah", "initials": "MM", "orcid": "0000-0003-1846-0411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42f1ac7010c34ba997a3fd9e56c6a56a.json"}}, {"family": "Shin", "given": "Wesley J", "initials": "WJ", "orcid": "0000-0003-0627-0821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/961f875b160341b6b31afa58a8f47680.json"}}, {"family": "Pirruccello", "given": "James", "initials": "J", "orcid": "0000-0001-6088-4037", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/60d2e9f23cce41f5b1f40ce0f010e9d9.json"}}, {"family": "Tsai", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0001-5868-2305", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1030f0fcd7a749d4862319fd5d7e6a9f.json"}}, {"family": "Agrawal", "given": "Mridul", "initials": "M", "orcid": "0000-0002-5455-2543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a2e1aab434af4a05a350e2be61ae5e4f.json"}}, {"family": "Kiel", "given": "Douglas P", "initials": "DP", "orcid": "0000-0001-8474-0310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f10765c4b3a3446bb420c81ffee3f0f7.json"}}, {"family": "Bouxsein", "given": "Mary L", "initials": "ML", "orcid": "0000-0002-7027-7414", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c547e0d1028464b8cb407e45d9e1596.json"}}, {"family": "Richards", "given": "J Brent", "initials": "JB", "orcid": "0000-0002-3746-9086", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed87dd6607bd4dcdbc150d5432ebfb05.json"}}, {"family": "Evans", "given": "David M", "initials": "DM", "orcid": "0000-0003-0663-4621", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd3b234756eb4580804c61705bf72d5c.json"}}, {"family": "Wein", "given": "Marc N", "initials": "MN", "orcid": "0000-0002-6015-8147", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13ba103bbb2940978d471e36ab3e4787.json"}}, {"family": "Charles", "given": "Julia F", "initials": "JF", "orcid": "0000-0002-5875-314X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/878a909b8f214e20b88bbc4916b957a4.json"}}, {"family": "Jaiswal", "given": "Siddhartha", "initials": "S", "orcid": "0000-0002-9597-0477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a1901e08f989434fb01dfa17b0a85470.json"}}, {"family": "Natarajan", "given": "Pradeep", "initials": "P", "orcid": "0000-0001-8402-7435", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe8bd48c61c047cd8e61c35d9e9ac650.json"}}, {"family": "Ebert", "given": "Benjamin L", "initials": "BL", "orcid": "0000-0003-0197-5451", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/56e4f1c53a4348e2b0ceb44a38850a17.json"}}], "type": "journal article", "published": "2021-12-06", "journal": {"title": "J. Exp. Med.", "issn": "1540-9538", "volume": "218", "issue": "12", "issn-l": "0022-1007"}, "abstract": "Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hematopoiesis of indeterminate potential (CHIP). Analyzing exome sequencing data from the UK Biobank, we found CHIP to be associated with increased incident osteoporosis diagnoses and decreased bone mineral density. In murine models, hematopoietic-specific mutations in Dnmt3a, the most commonly mutated gene in CHIP, decreased bone mass via increased osteoclastogenesis. Dnmt3a-/- demethylation opened chromatin and altered activity of inflammatory transcription factors. Bone loss was driven by proinflammatory cytokines, including Irf3-NF-\u03baB-mediated IL-20 expression from Dnmt3a mutant macrophages. Increased osteoclastogenesis due to the Dnmt3a mutations was ameliorated by alendronate or IL-20 neutralization. These results demonstrate a novel source of osteoporosis-inducing inflammation.", "doi": "10.1084/jem.20211872", "pmid": "34698806", "labels": {"Abhishek Niroula": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC8552148"}, {"db": "pii", "key": "212724"}], "notes": [], "created": "2023-11-20T11:28:02.188Z", "modified": "2023-11-20T11:28:03.284Z"}]}