{"entity": "researcher", "timestamp": "2026-09-30T01:02:34.978Z", "family": "Wright", "given": "Galen E B", "initials": "GEB", "orcid": "0000-0003-2415-7339", "affiliations": ["Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.", "British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.", "Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba835e4dce8440b480c6e8ab980b77b0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba835e4dce8440b480c6e8ab980b77b0"}}, "publications": [{"entity": "publication", "iuid": "4d5901dbcd4348daa8c85c8f8945dabb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/4d5901dbcd4348daa8c85c8f8945dabb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/4d5901dbcd4348daa8c85c8f8945dabb"}}, "title": "Common variation near IRF6 is associated with IFN-\u03b2-induced liver injury in multiple sclerosis.", "authors": [{"family": "Kowalec", "given": "Kaarina", "initials": "K"}, {"family": "Wright", "given": "Galen E B", "initials": "GEB", "orcid": "0000-0003-2415-7339", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ba835e4dce8440b480c6e8ab980b77b0.json"}}, {"family": "Dr\u00f6gem\u00f6ller", "given": "Britt I", "initials": "BI", "orcid": "0000-0002-3348-5855", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57e3e42631ae4552a386d0d105e48639.json"}}, {"family": "Aminkeng", "given": "Folefac", "initials": "F"}, {"family": "Bhavsar", "given": "Amit P", "initials": "AP"}, {"family": "Kingwell", "given": "Elaine", "initials": "E"}, {"family": "Yoshida", "given": "Eric M", "initials": "EM"}, {"family": "Traboulsee", "given": "Anthony", "initials": "A"}, {"family": "Marrie", "given": "Ruth Ann", "initials": "RA"}, {"family": "Kremenchutzky", "given": "Marcelo", "initials": "M"}, {"family": "Campbell", "given": "Trudy L", "initials": "TL"}, {"family": "Duquette", "given": "Pierre", "initials": "P"}, {"family": "Chalasani", "given": "Naga", "initials": "N"}, {"family": "Wadelius", "given": "Mia", "initials": "M", "orcid": "0000-0002-6368-2622", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1a663f51c194a8f8060b6fa54f11ac6.json"}}, {"family": "Hallberg", "given": "P\u00e4r", "initials": "P"}, {"family": "Xia", "given": "Zongqi", "initials": "Z"}, {"family": "De Jager", "given": "Philip L", "initials": "PL", "orcid": "0000-0002-8057-2505", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4684858b1fd74dab972859106e0e50a0.json"}}, {"family": "Denny", "given": "Joshua C", "initials": "JC"}, {"family": "Davis", "given": "Mary F", "initials": "MF"}, {"family": "Ross", "given": "Colin J D", "initials": "CJD"}, {"family": "Tremlett", "given": "Helen", "initials": "H", "orcid": "0000-0001-5804-2535", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e885cbe51def496aa35ad882105f4de5.json"}}, {"family": "Carleton", "given": "Bruce C", "initials": "BC"}], "type": "journal article", "published": "2018-08-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "50", "issue": "8", "pages": "1081-1085", "issn-l": "1061-4036"}, "abstract": "Multiple sclerosis (MS) is a disease of the central nervous system treated with disease-modifying therapies, including the biologic, interferon-\u03b2 (IFN-\u03b2). Up to 60% of IFN-\u03b2-exposed MS patients develop abnormal biochemical liver test results1,2, and 1 in 50 experiences drug-induced liver injury3. Since genomic variation contributes to other forms of drug-induced liver injury4,5, we aimed to identify biomarkers of IFN-\u03b2-induced liver injury using a two-stage genome-wide association study. The rs2205986 variant, previously linked to differential expression of IRF6, surpassed genome-wide significance in the combined two-stage analysis (P = 2.3 \u00d7 10-8, odds ratio = 8.3, 95% confidence interval = 3.6-19.2). Analysis of an independent cohort of IFN-\u03b2-treated MS patients identified via electronic medical records showed that rs2205986 was also associated with increased peak levels of aspartate aminotransferase (P = 7.6 \u00d7 10-5) and alkaline phosphatase (P = 4.9 \u00d7 10-4). We show that these findings may be applicable to predicting IFN-\u03b2-induced liver injury, offering insight into its safer use.", "doi": "10.1038/s41588-018-0168-y", "pmid": "30013178", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1021645"}, {"db": "pmc", "key": "PMC6513312"}, {"db": "pii", "key": "10.1038/s41588-018-0168-y"}], "notes": [], "created": "2019-01-17T13:56:55.215Z", "modified": "2026-09-23T10:18:17.508Z"}]}