{"entity": "researcher", "timestamp": "2026-09-23T15:13:20.092Z", "family": "Canouil", "given": "Micka\u00ebl", "initials": "M", "orcid": "0000-0002-3396-4549", "affiliations": ["CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9723d3bb47949d0a498ebd7dabe9f16.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9723d3bb47949d0a498ebd7dabe9f16"}}, "publications": [{"entity": "publication", "iuid": "c0440b2a8e2a4b789e260513c6890a8e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/c0440b2a8e2a4b789e260513c6890a8e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/c0440b2a8e2a4b789e260513c6890a8e"}}, "title": "Elevated circulating follistatin associates with an increased risk of type 2 diabetes.", "authors": [{"family": "Wu", "given": "Chuanyan", "initials": "C"}, {"family": "Born\u00e9", "given": "Yan", "initials": "Y"}, {"family": "Gao", "given": "Rui", "initials": "R"}, {"family": "L\u00f3pez Rodriguez", "given": "Maykel", "initials": "M"}, {"family": "Roell", "given": "William C", "initials": "WC"}, {"family": "Wilson", "given": "Jonathan M", "initials": "JM", "orcid": "0000-0002-8648-600X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6dc6efaca3254878bf64aca0d4e00fb3.json"}}, {"family": "Regmi", "given": "Ajit", "initials": "A"}, {"family": "Luan", "given": "Cheng", "initials": "C"}, {"family": "Aly", "given": "Dina Mansour", "initials": "DM"}, {"family": "Peter", "given": "Andreas", "initials": "A"}, {"family": "Machann", "given": "J\u00fcrgen", "initials": "J", "orcid": "0000-0002-4458-5886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7848a54c233f4c1f8807e286b4638f1d.json"}}, {"family": "Staiger", "given": "Harald", "initials": "H"}, {"family": "Fritsche", "given": "Andreas", "initials": "A"}, {"family": "Birkenfeld", "given": "Andreas L", "initials": "AL", "orcid": "0000-0003-1407-9023", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1b638068c1784dd3866b4f2d57399113.json"}}, {"family": "Tao", "given": "Rongya", "initials": "R"}, {"family": "Wagner", "given": "Robert", "initials": "R", "orcid": "0000-0002-6120-0191", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/208155a0ed8148efaf27a83cacf74f0e.json"}}, {"family": "Canouil", "given": "Micka\u00ebl", "initials": "M", "orcid": "0000-0002-3396-4549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9723d3bb47949d0a498ebd7dabe9f16.json"}}, {"family": "Hong", "given": "Mun-Gwan", "initials": "MG", "orcid": "0000-0001-8603-8293", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d12504acae5c4f31b83f75c3d7786cd4.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Ahlqvist", "given": "Emma", "initials": "E", "orcid": "0000-0002-6513-2384", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e8f6fb443ea34629a88f3d9fc2d0c340.json"}}, {"family": "Kaikkonen", "given": "Minna U", "initials": "MU", "orcid": "0000-0001-6294-0979", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e50bf7cdd8c844248aefd8d28ec9c6db.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-5652-8459", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c1fa67d262984bccbb6b45e913a09393.json"}}, {"family": "Shore", "given": "Angela C", "initials": "AC", "orcid": "0000-0003-3039-308X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f021ad781f3e4337b970da02f3e2a266.json"}}, {"family": "Khan", "given": "Faisel", "initials": "F"}, {"family": "Natali", "given": "Andrea", "initials": "A"}, {"family": "Melander", "given": "Olle", "initials": "O"}, {"family": "Orho-Melander", "given": "Marju", "initials": "M"}, {"family": "Nilsson", "given": "Jan", "initials": "J", "orcid": "0000-0002-9752-7479", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/52452489c5c2437999e7538771a9f038.json"}}, {"family": "H\u00e4ring", "given": "Hans-Ulrich", "initials": "HU"}, {"family": "Renstr\u00f6m", "given": "Erik", "initials": "E"}, {"family": "Wollheim", "given": "Claes B", "initials": "CB"}, {"family": "Engstr\u00f6m", "given": "Gunnar", "initials": "G"}, {"family": "Weng", "given": "Jianping", "initials": "J"}, {"family": "Pearson", "given": "Ewan R", "initials": "ER"}, {"family": "Franks", "given": "Paul W", "initials": "PW", "orcid": "0000-0002-0520-7604", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8263a26f474946de8b61a2080051d37b.json"}}, {"family": "White", "given": "Morris F", "initials": "MF"}, {"family": "Duffin", "given": "Kevin L", "initials": "KL"}, {"family": "Vaag", "given": "Allan Arthur", "initials": "AA"}, {"family": "Laakso", "given": "Markku", "initials": "M", "orcid": "0000-0002-3394-7749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81c631c24b2e4c479ac6976eab7b1e88.json"}}, {"family": "Stefan", "given": "Norbert", "initials": "N", "orcid": "0000-0002-2186-9595", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/236ffb6614de4a1995590dd28cf0b738.json"}}, {"family": "Groop", "given": "Leif", "initials": "L", "orcid": "0000-0002-0187-3263", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b549c1ef49648bf81c481bc88857552.json"}}, {"family": "De Marinis", "given": "Yang", "initials": "Y", "orcid": "0000-0002-8081-2142", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a19579820e5a40ad86f7787c6d703ec8.json"}}], "type": "journal article", "published": "2021-11-10", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "12", "issue": "1", "pages": "6486", "issn-l": "2041-1723"}, "abstract": "The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04-1.47, p < 0.05) during 19-year follow-up (n = 4060, Sweden); and 1.31 (CI: 1.09-1.58, p < 0.01) during 4-year follow-up (n = 883, Finland). High circulating follistatin associates with adipose tissue insulin resistance and non-alcoholic fatty liver disease (n = 210, Germany). In human adipocytes, follistatin dose-dependently increases free fatty acid release. In genome-wide association study (GWAS), variation in the glucokinase regulatory protein gene (GCKR) associates with plasma follistatin levels (n = 4239, Sweden; n = 885, UK, Italy and Sweden) and GCKR regulates follistatin secretion in hepatocytes in vitro. Our findings suggest that GCKR regulates follistatin secretion and that elevated circulating follistatin associates with an increased risk of T2D by inducing adipose tissue insulin resistance.", "doi": "10.1038/s41467-021-26536-w", "pmid": "34759311", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8580990"}, {"db": "pii", "key": "10.1038/s41467-021-26536-w"}], "notes": [], "created": "2026-09-23T08:37:16.137Z", "modified": "2026-09-23T08:37:16.782Z"}, {"entity": "publication", "iuid": "e3153b7609ad4515bbdda959618c46ed", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e3153b7609ad4515bbdda959618c46ed.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e3153b7609ad4515bbdda959618c46ed"}}, "title": "A catalog of genetic loci associated with kidney function from analyses of a million individuals.", "authors": [{"family": "Wuttke", "given": "Matthias", "initials": "M", "orcid": "0000-0003-3420-5082", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f2f154153f941cb98907f8d3e454281.json"}}, {"family": "Li", "given": "Yong", "initials": "Y", "orcid": "0000-0003-2651-8791", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fe899ba2a29e4ec3ad81ef8027f8326e.json"}}, {"family": "Li", "given": "Man", "initials": "M", "orcid": "0000-0002-3839-0281", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5436bf44eb30448d8ff5b2d9216500f5.json"}}, {"family": "Sieber", "given": "Karsten B", "initials": "KB"}, {"family": "Feitosa", "given": "Mary F", "initials": "MF", "orcid": "0000-0002-0933-2410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c6683f293db41d0a275a94b6a9e0af4.json"}}, {"family": "Gorski", "given": "Mathias", "initials": "M"}, {"family": "Tin", "given": "Adrienne", "initials": "A", "orcid": "0000-0002-4207-5866", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d0c7ca063aad427da7db8a96ea1937da.json"}}, {"family": "Wang", "given": "Lihua", "initials": "L"}, {"family": "Chu", "given": "Audrey Y", "initials": "AY"}, {"family": "Hoppmann", "given": "Anselm", "initials": "A"}, {"family": "Kirsten", "given": "Holger", "initials": "H", "orcid": "0000-0002-3126-7950", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/31231fe89b45443496f0f08e7ab94fcc.json"}}, {"family": "Giri", "given": "Ayush", "initials": "A", "orcid": "0000-0002-7786-4670", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/424e945c81e14434a13205bdd2e986ac.json"}}, {"family": "Chai", "given": "Jin-Fang", "initials": "JF"}, {"family": "Sveinbjornsson", "given": "Gardar", "initials": "G"}, {"family": "Tayo", "given": "Bamidele O", "initials": "BO"}, {"family": "Nutile", "given": "Teresa", "initials": "T"}, {"family": "Fuchsberger", "given": "Christian", "initials": "C"}, {"family": "Marten", "given": "Jonathan", "initials": "J", "orcid": "0000-0001-6916-2014", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5e99ac6161834a3dac9641e3443ecdd6.json"}}, {"family": "Cocca", "given": "Massimiliano", "initials": "M", "orcid": "0000-0002-1127-7596", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d19d2cc833046b69aad74182469aa98.json"}}, {"family": "Ghasemi", "given": "Sahar", "initials": "S"}, {"family": "Xu", "given": "Yizhe", "initials": "Y"}, {"family": "Horn", "given": "Katrin", "initials": "K"}, {"family": "Noce", "given": "Damia", "initials": "D"}, {"family": "van der Most", "given": "Peter J", "initials": "PJ", "orcid": "0000-0001-8450-3518", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aab1c835d9be4682b250164838d5b4ec.json"}}, {"family": "Sedaghat", "given": "Sanaz", "initials": "S"}, {"family": "Yu", "given": "Zhi", "initials": "Z"}, {"family": 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"initials": "G", "orcid": "0000-0002-9936-946X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fd7f7623d67e44a8a7b2a7a701d9ab67.json"}}, {"family": "Boehnke", "given": "Michael", "initials": "M", "orcid": "0000-0002-6442-7754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e36dfed05bd94a1588f0ad628a9e39c5.json"}}, {"family": "Boerwinkle", "given": "Eric", "initials": "E"}, {"family": "Boissel", "given": "Mathilde", "initials": "M", "orcid": "0000-0001-5719-8749", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7e3c665c13442e489bfac88082ee6b9.json"}}, {"family": "Bottinger", "given": "Erwin P", "initials": "EP"}, {"family": "Boutin", "given": "Thibaud S", "initials": "TS", "orcid": "0000-0003-4754-1675", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e1bd612393744c13993ed8cfac3f4710.json"}}, {"family": "Brenner", "given": "Hermann", "initials": "H"}, {"family": "Brumat", "given": "Marco", "initials": "M"}, {"family": "Burkhardt", "given": "Ralph", "initials": "R", "orcid": "0000-0003-1924-1202", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a585b2b608074d5e8011d3da9f061294.json"}}, {"family": "Butterworth", "given": "Adam S", "initials": "AS", "orcid": "0000-0002-6915-9015", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88842023860148bb8d155b5c18db72a8.json"}}, {"family": "Campana", "given": "Eric", "initials": "E"}, {"family": "Campbell", "given": "Archie", "initials": "A", "orcid": "0000-0003-0198-5078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0727bde0027c4a8a9d2737bb486f1bad.json"}}, {"family": "Campbell", "given": "Harry", "initials": "H"}, {"family": "Canouil", "given": "Micka\u00ebl", "initials": "M", "orcid": "0000-0002-3396-4549", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9723d3bb47949d0a498ebd7dabe9f16.json"}}, {"family": "Carroll", "given": "Robert J", "initials": "RJ"}, {"family": "Catamo", "given": "Eulalia", "initials": "E"}, {"family": "Chambers", "given": "John C", "initials": "JC"}, {"family": "Chee", "given": "Miao-Ling", "initials": "ML"}, {"family": "Chee", "given": "Miao-Li", "initials": "ML"}, {"family": "Chen", "given": "Xu", "initials": "X", "orcid": "0000-0002-7299-3238", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4e440b72e0f47079dadf74bfd661448.json"}}, {"family": "Cheng", "given": "Ching-Yu", "initials": "CY"}, {"family": "Cheng", "given": "Yurong", "initials": "Y"}, {"family": "Christensen", "given": "Kaare", "initials": "K", "orcid": "0000-0002-5429-5292", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e6d6f32bfc8d43f791f774fa79619abf.json"}}, {"family": "Cifkova", "given": "Renata", "initials": "R"}, {"family": "Ciullo", "given": "Marina", "initials": "M"}, {"family": "Concas", "given": "Maria Pina", "initials": "MP", "orcid": "0000-0003-3598-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8c79d01fcc34ff7a13aa5162d8d465c.json"}}, {"family": "Cook", "given": "James P", "initials": "JP"}, {"family": "Coresh", "given": "Josef", "initials": "J", "orcid": "0000-0002-4598-0669", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e26609ab79774b89a8d85a1a3634dac5.json"}}, {"family": "Corre", "given": "Tanguy", "initials": "T"}, {"family": "Sala", "given": "Cinzia Felicita", "initials": "CF"}, {"family": "Cusi", "given": "Daniele", "initials": "D"}, {"family": "Danesh", "given": "John", "initials": "J"}, {"family": "Daw", "given": "E Warwick", "initials": "EW"}, {"family": "de Borst", "given": "Martin H", "initials": "MH", "orcid": "0000-0002-4127-8733", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5261982a3d1b40f38a8fef1e6f112e4c.json"}}, {"family": "De Grandi", "given": "Alessandro", "initials": "A"}, {"family": "de Mutsert", "given": "Ren\u00e9e", "initials": "R"}, {"family": "de Vries", "given": "Aiko P J", "initials": "APJ"}, {"family": "Degenhardt", "given": "Frauke", "initials": "F"}, {"family": "Delgado", "given": "Graciela", "initials": "G"}, {"family": "Demirkan", "given": "Ayse", "initials": "A"}, {"family": "Di Angelantonio", "given": "Emanuele", "initials": "E"}, {"family": "Dittrich", "given": "Katalin", "initials": "K"}, {"family": "Divers", "given": "Jasmin", "initials": "J"}, {"family": "Dorajoo", "given": "Rajkumar", "initials": "R", "orcid": "0000-0001-6608-2051", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2274574c011f4509935dfc60954447ce.json"}}, {"family": "Eckardt", "given": "Kai-Uwe", "initials": "KU"}, {"family": "Ehret", "given": "Georg", "initials": "G", "orcid": "0000-0002-5730-0675", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fe0233af4614b8b870be7bb90772368.json"}}, {"family": "Elliott", "given": "Paul", "initials": "P", "orcid": "0000-0002-7511-5684", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f380d322e67841e7b47ff3202991c1c4.json"}}, {"family": "Endlich", "given": "Karlhans", "initials": "K"}, {"family": "Evans", "given": "Michele K", "initials": "MK"}, {"family": "Felix", "given": "Janine F", "initials": "JF", "orcid": "0000-0002-9801-5774", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c51a2653326d4a14997c39b147ba1be1.json"}}, {"family": "Foo", "given": "Valencia Hui Xian", "initials": "VHX"}, {"family": "Franco", "given": "Oscar H", "initials": "OH"}, {"family": "Franke", "given": "Andre", "initials": "A", "orcid": "0000-0003-1530-5811", "researcher": {"href": 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"Snieder", "given": "Harold", "initials": "H"}, {"family": "Stefansson", "given": "Kari", "initials": "K", "orcid": "0000-0003-1676-864X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9edf80871ac84e76a4d1316fc7079d7d.json"}}, {"family": "Hung", "given": "Adriana M", "initials": "AM", "orcid": "0000-0002-3203-1608", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c9c6d7e42fd4f1bb64e93c1660a6010.json"}}, {"family": "Heid", "given": "Iris M", "initials": "IM"}, {"family": "Scholz", "given": "Markus", "initials": "M", "orcid": "0000-0002-4059-1779", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5283e0dd4ad745938042b3fb48fcb73d.json"}}, {"family": "Teumer", "given": "Alexander", "initials": "A", "orcid": "0000-0002-8309-094X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1a40a959d1b8480cb8268e00f77a0449.json"}}, {"family": "K\u00f6ttgen", "given": "Anna", "initials": "A", "orcid": "0000-0002-4671-3714", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed83f5aa153f40169b9975b5c4360653.json"}}, {"family": "Pattaro", "given": "Cristian", "initials": "C", "orcid": "0000-0002-4119-0109", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8c7ff447060429da7904b26ea8b1d4b.json"}}], "type": "journal article", "published": "2019-06-00", "journal": {"title": "Nat. Genet.", "issn": "1546-1718", "volume": "51", "issue": "6", "pages": "957-972", "issn-l": "1061-4036"}, "abstract": "Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.", "doi": "10.1038/s41588-019-0407-x", "pmid": "31152163", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1038587"}, {"db": "pmc", "key": "PMC6698888"}, {"db": "pii", "key": "10.1038/s41588-019-0407-x"}], "notes": [], "created": "2026-09-22T19:59:34.302Z", "modified": "2026-09-22T19:59:35.870Z"}]}