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Methods", "issn": "1548-7105", "volume": "22", "issue": "4", "pages": "641-645", "issn-l": "1548-7091"}, "abstract": "In the Big Data era, a change of paradigm in the use of molecular dynamics is required. Trajectories should be stored under FAIR (findable, accessible, interoperable and reusable) requirements to favor its reuse by the community under an open science paradigm.", "doi": "10.1038/s41592-025-02635-0", "pmid": "40175561", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2081560"}, {"db": "pmc", "key": "PMC12950262"}, {"db": "pii", "key": "10.1038/s41592-025-02635-0"}], "notes": [], "created": "2026-08-20T09:03:25.648Z", "modified": "2026-08-20T09:03:27.707Z"}, {"entity": "publication", "iuid": "b6189b5801bb417783640d54af89c9ae", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b6189b5801bb417783640d54af89c9ae.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b6189b5801bb417783640d54af89c9ae"}}, "title": "3D genomics across the tree of life reveals condensin II as a determinant of architecture type.", "authors": [{"family": "Hoencamp", "given": "Claire", "initials": "C", "orcid": "0000-0003-2047-4724", 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{"href": "https://publications-affiliated.scilifelab.se/researcher/6f92ed61662349f9820c15c180c8984c.json"}}, {"family": "Nel-Themaat", "given": "Liesl", "initials": "L"}, {"family": "Behringer", "given": "Richard R", "initials": "RR"}, {"family": "Kaur", "given": "Parwinder", "initials": "P", "orcid": "0000-0003-0201-0766", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b238dcbbacde4a09aac2d02747b25e81.json"}}, {"family": "Medema", "given": "Ren\u00e9 H", "initials": "RH"}, {"family": "van Steensel", "given": "Bas", "initials": "B", "orcid": "0000-0002-0284-0404", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e68726cff15040be923aeb6ff0740d20.json"}}, {"family": "de Wit", "given": "Elzo", "initials": "E", "orcid": "0000-0003-2883-1415", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/800bcbd5f60849f6b796c359f23ae844.json"}}, {"family": "Onuchic", "given": "Jos\u00e9 N", "initials": "JN", "orcid": "0000-0002-9448-0388", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b9592fa9f1b54a29b87e4c89c420ed53.json"}}, {"family": "Di Pierro", "given": "Michele", "initials": "M", "orcid": "0000-0002-2889-2632", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f9859e3415cc408c86b7705912044bfd.json"}}, {"family": "Lieberman Aiden", "given": "Erez", "initials": "E", "orcid": "0000-0003-0634-6486", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4b90000755b4e5587ca5115331c1207.json"}}, {"family": "Rowland", "given": "Benjamin D", "initials": "BD", "orcid": "0000-0002-0694-8463", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67f8361527604d88b1491cbadacab26e.json"}}], "type": "journal article", "published": "2021-05-28", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "372", "issue": "6545", "pages": "984-989", "issn-l": "0036-8075"}, "abstract": "We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.", "doi": "10.1126/science.abe2218", "pmid": "34045355", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1704706"}, {"db": "pmc", "key": "PMC8172041"}, {"db": "pii", "key": "372/6545/984"}], "notes": [], "created": "2026-08-20T11:59:25.344Z", "modified": "2026-08-20T11:59:27.055Z"}]}