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"given": "Vivien", "initials": "V", "orcid": "0000-0002-4020-824X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9eccfef230a0494d87395d92b9618fb5.json"}}], "type": "journal article", "published": "2024-03-00", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "383", "issue": "6686", "pages": "eadh4059", "issn-l": "0036-8075"}, "abstract": "We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre-\u03b1 T cell receptor (pre-TCR\u03b1) expression. Low circulating naive \u03b1\u03b2 T cell counts at birth persisted over time, with normal memory \u03b1\u03b2 and high \u03b3\u03b4 T cell counts. Their TCR\u03b1 repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue \u03b1\u03b2 T cell development. Only a minority of these individuals were sick, with infection, lymphoproliferation, and/or autoimmunity. We also report that 1 in 4000 individuals from the Middle East and South Asia are homozygous for a common hypomorphic PTCRA variant. They had normal circulating naive \u03b1\u03b2 T cell counts but high \u03b3\u03b4 T cell counts. Although residual pre-TCR\u03b1 expression drove the differentiation of more \u03b1\u03b2 T cells, autoimmune conditions were more frequent in these patients compared with the general population.", "doi": "10.1126/science.adh4059", "pmid": "38422122", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1972302"}, {"db": "pmc", "key": "PMC10958617"}], "notes": [], "created": "2026-08-20T11:59:36.719Z", "modified": "2026-08-20T11:59:39.340Z"}, {"entity": "publication", "iuid": "5a193f7f67d64f559b8b7072b952af38", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5a193f7f67d64f559b8b7072b952af38.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5a193f7f67d64f559b8b7072b952af38"}}, "title": "Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq.", "authors": [{"family": "Vazquez", "given": "Sara E", "initials": "SE", "orcid": "0000-0002-0601-7001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49153fe797f842ae9518fd57c97d8d52.json"}}, {"family": "Mann", "given": "Sabrina A", "initials": "SA", "orcid": "0000-0002-4970-1073", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2be93b26537412788df5818630bce69.json"}}, {"family": "Bodansky", "given": "Aaron", "initials": "A", "orcid": "0000-0001-8943-8233", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e914c6ceb1e4302b74175621c93e118.json"}}, {"family": "Kung", "given": "Andrew F", "initials": "AF"}, {"family": "Quandt", "given": "Zoe", "initials": "Z"}, {"family": "Ferr\u00e9", "given": "Elise M N", "initials": "EMN"}, {"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Liu", "given": "Jamin", "initials": "J"}, {"family": "Mitchell", "given": "Anthea", "initials": "A"}, {"family": "Proekt", "given": "Irina", "initials": "I"}, {"family": "Yu", "given": "David", "initials": "D"}, {"family": "Mandel-Brehm", "given": "Caleigh", "initials": "C"}, {"family": "Wang", "given": "Chung-Yu", "initials": "CY"}, {"family": "Miao", "given": "Brenda", "initials": "B", "orcid": "0000-0002-3393-9837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/665396bf406645248aea5d60ded9c416.json"}}, {"family": "Sowa", "given": "Gavin", "initials": "G", "orcid": "0000-0002-2089-8116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3ffc3bfa15f4477809a7fa6bf9e67f3.json"}}, {"family": "Zorn", "given": "Kelsey", "initials": "K"}, {"family": "Chan", "given": "Alice Y", "initials": "AY"}, {"family": "Tagi", "given": "Veronica M", "initials": "VM"}, {"family": "Shimizu", "given": "Chisato", "initials": "C"}, {"family": "Tremoulet", "given": "Adriana", "initials": "A"}, {"family": "Lynch", "given": "Kara", "initials": "K"}, {"family": "Wilson", "given": "Michael R", "initials": "MR", "orcid": "0000-0002-8705-5084", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9a673f794cf47218701cf478c4099f7.json"}}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}, {"family": "Dobbs", "given": "Kerry", "initials": "K", "orcid": "0000-0002-3432-3137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ceabb8518334a3d81676cf0ca204b58.json"}}, {"family": "Delmonte", "given": "Ottavia M", "initials": "OM"}, {"family": "Bacchetta", "given": "Rosa", "initials": "R"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Burns", "given": "Jane C", "initials": "JC"}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL"}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Torgerson", "given": "Troy R", "initials": "TR", "orcid": "0000-0003-3489-5036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6100dc10f4f74550ac61e40619a04813.json"}}, {"family": "Anderson", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-3093-4758", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a3782bf0dc24d309281bd1841ebb08a.json"}}, {"family": "DeRisi", "given": "Joseph L", "initials": "JL", "orcid": "0000-0002-4611-9205", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6898c7e43dd34fa3a0da1b240a0417a2.json"}}], "type": "journal article", "published": "2022-10-27", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "11", "issn-l": "2050-084X"}, "abstract": "Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood forms of immune dysregulation. Despite several successful implementations of PhIP-seq for autoantigen discovery, including our previous work (Vazquez et al., 2020), current protocols are inherently difficult to scale to accommodate large cohorts of cases and importantly, healthy controls. Here, we develop and validate a high throughput extension of PhIP-seq in various etiologies of autoimmune and inflammatory diseases, including APS1, IPEX, RAG1/2 deficiency, Kawasaki disease (KD), multisystem inflammatory syndrome in children (MIS-C), and finally, mild and severe forms of COVID-19. We demonstrate that these scaled datasets enable machine-learning approaches that result in robust prediction of disease status, as well as the ability to detect both known and novel autoantigens, such as prodynorphin (PDYN) in APS1 patients, and intestinally expressed proteins BEST4 and BTNL8 in IPEX patients. Remarkably, BEST4 antibodies were also found in two patients with RAG1/2 deficiency, one of whom had very early onset IBD. Scaled PhIP-seq examination of both MIS-C and KD demonstrated rare, overlapping antigens, including CGNL1, as well as several strongly enriched putative pneumonia-associated antigens in severe COVID-19, including the endosomal protein EEA1. Together, scaled PhIP-seq provides a valuable tool for broadly assessing both rare and common autoantigen overlap between autoimmune diseases of varying origins and etiologies.", "doi": "10.7554/eLife.78550", "pmid": "36300623", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9711525"}, {"db": "pii", "key": "78550"}, {"db": "Dryad", "key": "10.5061/dryad.qfttdz0k4"}], "notes": [], "created": "2026-08-20T13:54:36.168Z", "modified": "2026-08-20T13:54:36.797Z"}, {"entity": "publication", "iuid": "70e3ad9ee72a49c795f06a5d9572988c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/70e3ad9ee72a49c795f06a5d9572988c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/70e3ad9ee72a49c795f06a5d9572988c"}}, "title": "Author response: Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq", "authors": [{"family": "Vazquez", "given": "Sara E", "initials": "SE", "orcid": "0000-0002-0601-7001", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49153fe797f842ae9518fd57c97d8d52.json"}}, {"family": "Mann", "given": "Sabrina A", "initials": "SA", "orcid": "0000-0002-4970-1073", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f2be93b26537412788df5818630bce69.json"}}, {"family": "Bodansky", "given": "Aaron", "initials": "A", "orcid": "0000-0001-8943-8233", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0e914c6ceb1e4302b74175621c93e118.json"}}, {"family": "Kung", "given": "Andrew F", "initials": "AF"}, {"family": "Quandt", "given": "Zoe", "initials": "Z"}, {"family": "Ferr\u00e9", "given": "Elise MN", "initials": "EM"}, {"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Bastard", "given": "Paul", "initials": "P"}, {"family": "Zhang", "given": "Shen Ying", "initials": "SY"}, {"family": "Liu", "given": "Jamin", "initials": "J"}, {"family": "Mitchell", "given": "Anthea", "initials": "A"}, {"family": "Proekt", "given": "Irina", "initials": "I"}, {"family": "Yu", "given": "David", "initials": "D"}, {"family": "Mandel-Brehm", "given": "Caleigh", "initials": "C"}, {"family": "Wang", "given": "Chung Yu", "initials": "CY"}, {"family": "Miao", "given": "Brenda", "initials": "B", "orcid": "0000-0002-3393-9837", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/665396bf406645248aea5d60ded9c416.json"}}, {"family": "Sowa", "given": "Gavin", "initials": "G", "orcid": "0000-0002-2089-8116", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c3ffc3bfa15f4477809a7fa6bf9e67f3.json"}}, {"family": "Zorn", "given": "Kelsey", "initials": "K"}, {"family": "Chan", "given": "Alice Y", "initials": "AY"}, {"family": "Tagi", "given": "Veronica M", "initials": "VM"}, {"family": "Shimizu", "given": "Chisato", "initials": "C"}, {"family": "Tremoulet", "given": "Adriana", "initials": "A"}, {"family": "Lynch", "given": "Kara", "initials": "K"}, {"family": "Wilson", "given": "Michael R", "initials": "MR", "orcid": "0000-0002-8705-5084", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c9a673f794cf47218701cf478c4099f7.json"}}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}, {"family": "Dobbs", "given": "Kerry", "initials": "K", "orcid": "0000-0002-3432-3137", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4ceabb8518334a3d81676cf0ca204b58.json"}}, {"family": "Delmonte", "given": "Ottavia M", "initials": "OM"}, {"family": "Bacchetta", "given": "Rosa", "initials": "R"}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD"}, {"family": "Burns", "given": "Jane C", "initials": "JC"}, {"family": "Casanova", "given": "Jean Laurent", "initials": "JL"}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Torgerson", "given": "Troy R", "initials": "TR", "orcid": "0000-0003-3489-5036", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6100dc10f4f74550ac61e40619a04813.json"}}, {"family": "Anderson", "given": "Mark S", "initials": "MS", "orcid": "0000-0002-3093-4758", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a3782bf0dc24d309281bd1841ebb08a.json"}}, {"family": "DeRisi", "given": "Joseph L", "initials": "JL", "orcid": "0000-0002-4611-9205", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6898c7e43dd34fa3a0da1b240a0417a2.json"}}], "type": "peer-review", "published": "2022-09-22", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.78550.sa2", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:54:38.817Z", "modified": "2026-08-20T13:54:38.923Z"}, {"entity": "publication", "iuid": "650246f643f34db2a3ca461cb6740c53", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/650246f643f34db2a3ca461cb6740c53.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/650246f643f34db2a3ca461cb6740c53"}}, "title": "A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.", "authors": [{"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Ishii", "given": "Norito", "initials": "N", "orcid": "0000-0002-1199-6611", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/510d3f97277d4d9dae7b5645a3eae5df.json"}}, {"family": "Aranda-Guill\u00e9n", "given": "Maribel", "initials": "M", "orcid": "0000-0003-0050-704X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1c0c18f520e34593865f7ed850f34a17.json"}}, {"family": "Gunnarsson", "given": "H\u00f6r\u00f0ur Ingi", "initials": "HI"}, {"family": "Sardh", "given": "Fabian", "initials": "F"}, {"family": "Hallgren", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "St\u00e5hle", "given": "Mona", "initials": "M", "orcid": "0000-0002-3916-9343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51d5039a78a4471d879d9159ae862a12.json"}}, {"family": "Hagforsen", "given": "Eva", "initials": "E"}, {"family": "Bradley", "given": "Maria", "initials": "M", "orcid": "0000-0001-7192-5041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/469e5ac8c9a34e538e477b772bd83ead.json"}}, {"family": "Edqvist", "given": "Per-Henrik D", "initials": "PD", "orcid": "0000-0002-8330-0134", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5219527c2dc6480da474f3c47dff9318.json"}}, {"family": "Pont\u00e9n", "given": "Fredrik", "initials": "F", "orcid": "0000-0003-0703-3940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f5294424542413c9ba4432c839c2b63.json"}}, {"family": "M\u00e4kitie", "given": "Outi", "initials": "O", "orcid": "0000-0002-4547-001X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/79b7b7154e694a85b1498dd78fe370c0.json"}}, {"family": "Eidsmo", "given": "Liv", "initials": "L"}, {"family": "Norl\u00e9n", "given": "Lars", "initials": "L"}, {"family": "Achour", "given": "Adnane", "initials": "A", "orcid": "0000-0003-0432-710X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/65fba324156a4fcbafbe636e642587a9.json"}}, {"family": "Dahlbom", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0560-9275", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aec88dbb6f8946d3b841a64083918ec9.json"}}, {"family": "Korponay-Szab\u00f3", "given": "Ilma", "initials": "I", "orcid": "0000-0003-0554-2629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4a26fdc4f1ee450b9369daee14accef7.json"}}, {"family": "Agardh", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1435-1234", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/233900b2f8ed45828493bd305291abf0.json"}}, {"family": "Alimohammadi", "given": "Mohammad", "initials": "M", "orcid": "0000-0001-5937-1963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fcc0aab3164a451ca01cb9b2b7493148.json"}}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Hashimoto", "given": "Takashi", "initials": "T", "orcid": "0000-0002-0144-3255", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8edf83e7ea8f40bc80434031352b3c4c.json"}}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Proc. Natl. Acad. Sci. U.S.A.", "issn": "1091-6490", "volume": "118", "issue": "51", "issn-l": "0027-8424"}, "abstract": "Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglutaminase 1 (TGM1) as a member of a protein family prone to autoimmune attack. By screening sera from patients with various acquired skin disorders, we identified seropositive subjects with the blistering mucocutaneous disease paraneoplastic pemphigus. Validation in further subjects confirmed TGM1 autoantibodies as a 55% sensitive and 100% specific marker for paraneoplastic pemphigus. This gene-centric approach leverages the wealth of data available for human genes and may prove generally applicable for biomarker discovery in autoimmune diseases.", "doi": "10.1073/pnas.2100687118", "pmid": "34911754", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8713791"}, {"db": "pii", "key": "2100687118"}], "notes": [], "created": "2026-08-20T09:30:57.213Z", "modified": "2026-08-20T09:30:57.722Z"}, {"entity": "publication", "iuid": "050e6f424a234d3ab5face7cda58b935", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/050e6f424a234d3ab5face7cda58b935.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/050e6f424a234d3ab5face7cda58b935"}}, "title": "Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.", "authors": [{"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Smith", "given": "Gustav", "initials": "G"}, {"family": "Ferre", "given": "Elise M N", "initials": "EMN", "orcid": "0000-0002-3285-7768", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/224d21056bde4f0288e965318dea6cd3.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5fe1b70e79d48b1bc07ceeec842c3a3.json"}}, {"family": "Sharon", "given": "Donald", "initials": "D"}, {"family": "Snyder", "given": "Michael", "initials": "M"}, {"family": "Lionakis", "given": "Michail", "initials": "M"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}], "type": "journal article", "published": "2019-06-27", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "8", "issn-l": "2050-084X"}, "abstract": "The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.", "doi": "10.7554/eLife.43578", "pmid": "31244471", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6597240"}, {"db": "pii", "key": "43578"}], "notes": [], "created": "2026-08-20T13:52:42.493Z", "modified": "2026-08-20T13:52:42.635Z"}, {"entity": "publication", "iuid": "64c59ee5394a413682ea9eacce3738a5", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/64c59ee5394a413682ea9eacce3738a5.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/64c59ee5394a413682ea9eacce3738a5"}}, "title": "Author response: Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'", "authors": [{"family": "Landegren", "given": "Nils", "initials": "N", "orcid": "0000-0002-6163-9540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6765f1617f51434baf93e4683965f03a.json"}}, {"family": "Rosen", "given": "Lindsey B", "initials": "LB"}, {"family": "Freyhult", "given": "Eva", "initials": "E"}, {"family": "Eriksson", "given": "Daniel", "initials": "D", "orcid": "0000-0001-5473-3312", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8847907a59147cf95d312afa115a3d3.json"}}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Smith", "given": "Gustav", "initials": "G"}, {"family": "Ferre", "given": "Elise M N", "initials": "EMN", "orcid": "0000-0002-3285-7768", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/224d21056bde4f0288e965318dea6cd3.json"}}, {"family": "Brodin", "given": "Petter", "initials": "P", "orcid": "0000-0002-8103-0046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5fe1b70e79d48b1bc07ceeec842c3a3.json"}}, {"family": "Sharon", "given": "Donald", "initials": "D"}, {"family": "Snyder", "given": "Michael", "initials": "M"}, {"family": "Lionakis", "given": "Michail", "initials": "M"}, {"family": "Anderson", "given": "Mark", "initials": "M"}, {"family": "K\u00e4mpe", "given": "Olle", "initials": "O", "orcid": "0000-0001-6091-9914", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/48f52710708f4b3291e5b5a4eefca8f5.json"}}], "type": "peer-review", "published": "2019-05-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.7554/elife.43578.018", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T13:52:44.648Z", "modified": "2026-08-20T13:52:44.689Z"}]}