{"entity": "researcher", "timestamp": "2026-08-20T20:57:51.614Z", "family": "Cianciotti", "given": "Beatrice Claudia", "initials": "BC", "orcid": "0000-0002-1337-5915", "affiliations": ["IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation, and Infectious Diseases, Experimental Hematology Unit, via Olgettina 60, Milan 20132, Italy."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b80a1fa9b2d14bfe8ba9e3103fe581d6.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b80a1fa9b2d14bfe8ba9e3103fe581d6"}}, "publications": [{"entity": "publication", "iuid": "8dbdd622a6684fc09a07dc19fa3bf37f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8dbdd622a6684fc09a07dc19fa3bf37f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8dbdd622a6684fc09a07dc19fa3bf37f"}}, "title": "Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR.", "authors": [{"family": "Manfredi", "given": "Francesco", "initials": "F", "orcid": "0000-0003-2409-944X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f8173a6adb74503a2c2636bc7cd6187.json"}}, {"family": "Stasi", "given": "Lorena", "initials": "L", "orcid": "0000-0001-8044-2295", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/103e396d7f714d0eadf42ae463e23006.json"}}, {"family": "Buonanno", "given": "Silvia", "initials": "S"}, {"family": "Marzuttini", "given": "Francesca", "initials": "F"}, {"family": "Noviello", "given": "Maddalena", "initials": "M"}, {"family": "Mastaglio", "given": "Sara", "initials": "S"}, {"family": "Abbati", "given": "Danilo", "initials": "D", "orcid": "0000-0001-8517-7937", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cf52edec41c48e7a085130d6a0f538a.json"}}, {"family": "Potenza", "given": "Alessia", "initials": "A", "orcid": "0000-0003-0298-7315", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5c2f5b34a8444def99ed10d6922b29b2.json"}}, {"family": "Balestrieri", "given": "Chiara", "initials": "C", "orcid": "0000-0001-7362-3530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c720c467b1714e78bd49b928d1df4717.json"}}, {"family": "Cianciotti", "given": "Beatrice Claudia", "initials": "BC", "orcid": "0000-0002-1337-5915", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b80a1fa9b2d14bfe8ba9e3103fe581d6.json"}}, {"family": "Tassi", "given": "Elena", "initials": "E", "orcid": "0000-0002-2921-8666", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/650c1981b70b4dbf866d21221e0d18b7.json"}}, {"family": "Feola", "given": "Sara", "initials": "S", "orcid": "0000-0002-4012-4310", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81e8d2f15fcf4e1aabf7b5a41a977f3f.json"}}, {"family": "Toffalori", "given": "Cristina", "initials": "C", "orcid": "0000-0002-8313-3057", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/41008f14a9b94192a9cacd2ab0710976.json"}}, {"family": "Punta", "given": "Marco", "initials": "M", "orcid": "0000-0002-0050-0676", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/083075f454224bf1a13724e85cf2bf7c.json"}}, {"family": "Magnani", "given": "Zulma", "initials": "Z", "orcid": "0000-0001-7612-6097", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8b56dd0945ff4ebf941b8c1ed107378c.json"}}, {"family": "Camisa", "given": "Barbara", "initials": "B", "orcid": "0000-0002-3867-2457", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9f967aca004f41e59f1e8e182851d732.json"}}, {"family": "Tiziano", "given": "Elena", "initials": "E", "orcid": "0000-0002-1794-4265", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3818be60d8a34864943b9697aa4e11bd.json"}}, {"family": "Lupo-Stanghellini", "given": "Maria Teresa", "initials": "MT"}, {"family": "Branca", "given": "Rui Mamede", "initials": "RM", "orcid": "0000-0003-3890-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f557cf4f7ed402c8843173ab0bbef04.json"}}, {"family": "Lehti\u00f6", "given": "Janne", "initials": "J", "orcid": "0000-0002-8100-9562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/561efcf32e2648c8a10fee692fc4e908.json"}}, {"family": "Sikanen", "given": "Tiina M", "initials": "TM", "orcid": "0000-0002-0788-1301", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ee477a2ee578421c889c078b35324ce5.json"}}, {"family": "Haapala", "given": "Markus J", "initials": "MJ", "orcid": "0000-0001-7828-8663", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2241723f3734c5390b4fa4014563668.json"}}, {"family": "Cerullo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0003-4901-3796", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d46c756e18bb49268b98a75a5234664a.json"}}, {"family": "Casucci", "given": "Monica", "initials": "M", "orcid": "0000-0003-4500-9060", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a0f5a535676445f5b871cfffd7d98560.json"}}, {"family": "Vago", "given": "Luca", "initials": "L", "orcid": "0000-0003-4247-3175", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4e307dc8f3774bbfa97926dd1d1464d1.json"}}, {"family": "Ciceri", "given": "Fabio", "initials": "F", "orcid": "0000-0003-0873-0123", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9631c85f2abe41ecb26c2b96f662c19c.json"}}, {"family": "Bonini", "given": "Chiara", "initials": "C", "orcid": "0000-0002-0772-1674", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/72025c797fe74a749bb9b5945a1c4cc1.json"}}, {"family": "Ruggiero", "given": "Eliana", "initials": "E", "orcid": "0000-0002-2954-8278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/58dd81c18e944546b46ad24074911897.json"}}], "type": "journal article", "published": "2023-12-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "9", "issue": "48", "pages": "eadg8014", "issn-l": "2375-2548"}, "abstract": "To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic stem cell transplant, we typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens (TAAs) in 39 consecutive transplanted patients, for 1 year after transplant. We showed that TAA-specific T cells circulated in 90% of patients but display a limited effector function associated to an exhaustion phenotype, particularly in the subgroup of patients deemed to relapse, where exhausted stem cell memory T cells accumulated. Accordingly, cancer-specific cytolytic functions were relevant only when the TAA-specific T cell receptors (TCRs) were transferred into healthy, genome-edited T cells. We then exploited trogocytosis and ligandome-on-chip technology to unveil the specificities of tumor-specific TCRs retrieved from the exhausted T cell pool. Overall, we showed that harnessing circulating TAA-specific and exhausted T cells allow to isolate TCRs against TAAs and previously not described acute myeloid leukemia antigens, potentially relevant for T cell-based cancer immunotherapy.", "doi": "10.1126/sciadv.adg8014", "pmid": "38039364", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10691777"}], "notes": [], "created": "2026-08-20T11:58:45.183Z", "modified": "2026-08-20T11:58:46.172Z"}]}