{"entity": "researcher", "timestamp": "2026-08-20T21:16:33.268Z", "family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "affiliations": ["Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580"}}, "publications": [{"entity": "publication", "iuid": "37c2811b51fb490f9f9abeff181e0d6a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/37c2811b51fb490f9f9abeff181e0d6a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/37c2811b51fb490f9f9abeff181e0d6a"}}, "title": "Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis", "authors": [{"family": "Sreenivasan", "given": "Akshai Parakkal", "initials": "AP", "orcid": "0000-0002-7293-6487", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d98ac49d150e4d0781be908a2e496e2d.json"}}, {"family": "Vaivade", "given": "Aina", "initials": "A", "orcid": "0000-0002-1608-2130", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a71aa2d44ff4999a3972954002973ad.json"}}, {"family": "Noui", "given": "Yassine", "initials": "Y", "orcid": "0000-0002-0513-7546", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bd1fb37b6823494e8541aee6a0592f7d.json"}}, {"family": "Khoonsari", "given": "Payam Emami", "initials": "PE", "orcid": "0000-0002-4137-5517", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f0f1758926845329c02b1ee8164ce60.json"}}, {"family": "Burman", "given": "Joachim", "initials": "J", "orcid": "0000-0002-7045-1806", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3335e3bfaf346699df4986234aa065c.json"}}, {"family": "Spjuth", "given": "Ola", "initials": "O", "orcid": "0000-0002-8083-2864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c192389f99d4801b91f3350e07dfb9e.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}], "type": "posted-content", "published": "2024-03-02", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.03.01.24303566", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:52:26.215Z", "modified": "2026-08-20T10:52:26.446Z"}, {"entity": "publication", "iuid": "59b004c7df1d4131a8eedb6051b9167b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b"}}, "title": "Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.", "authors": [{"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c4a7070f339466690b40d63ad6ea769.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Markaki", "given": "Ioanna", "initials": "I", "orcid": "0000-0003-3328-5746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f31c405d780a4beeb64971dabd57cafd.json"}}, {"family": "Carvalho", "given": "Stephanie", "initials": "S"}, {"family": "Corvol", "given": "Jean-Christophe", "initials": "JC", "orcid": "0000-0001-7325-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81bf347acb7349dfa3d7c22483c1fba4.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "L\u00f6wenmark", "given": "Malin", "initials": "M"}, {"family": "Ingelsson", "given": "Martin", "initials": "M", "orcid": "0000-0001-5466-8370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9cdd74196957459fa3618c6bd2c35ff8.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B", "orcid": "0000-0001-6791-8893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0815ffb8b9404272a26b28cb11f001ba.json"}}, {"family": "Brosseron", "given": "Frederic", "initials": "F", "orcid": "0000-0003-3137-7516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8a371f4aaa4ba59389f30bd9349c1f.json"}}, {"family": "Heneka", "given": "Michael T", "initials": "MT", "orcid": "0000-0003-4996-1630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8da023abc6974d4582fe3c688a483950.json"}}, {"family": "Bosch", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-6094-0024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd5741747488412c9c8334a97e7302ad.json"}}, {"family": "Sanchez-Valle", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7750-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bba6a10e4cd4b0180ccc900d70fd869.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "8", "issue": "7", "pages": "1456-1470", "issn-l": "2328-9503"}, "abstract": "Decreased amyloid beta (A\u03b2) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.\n\nWe utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification.\n\nSix proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A\u03b242 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations.\n\nIn conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.", "doi": "10.1002/acn3.51402", "pmid": "34129723", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8283172"}], "notes": [], "created": "2026-08-20T06:27:18.835Z", "modified": "2026-08-20T06:27:19.431Z"}, {"entity": "publication", "iuid": "aa227408ea8f4d6eb6553056600daf1a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/aa227408ea8f4d6eb6553056600daf1a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/aa227408ea8f4d6eb6553056600daf1a"}}, "title": "Approaches for Containerized Scientific Workflows in Cloud Environments with Applications in Life Science", "authors": [{"family": "Spjuth", "given": "Ola", "initials": "O", "orcid": "0000-0002-8083-2864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c192389f99d4801b91f3350e07dfb9e.json"}}, {"family": "Capuccini", "given": "Marco", "initials": "M"}, {"family": "Carone", "given": "Matteo", "initials": "M"}, {"family": "Larsson", "given": "Anders", "initials": "A"}, {"family": "Schaal", "given": "Wesley", "initials": "W"}, {"family": "Novella", "given": "Jon Ander", "initials": "JA"}, {"family": "Stein", "given": "Oliver", "initials": "O"}, {"family": "Ekmefjord", "given": "Morgan", "initials": "M"}, {"family": "Di Tommaso", "given": "Paolo", "initials": "P"}, {"family": "Floden", "given": "Evan", "initials": "E"}, {"family": "Notredame", "given": "Cedric", "initials": "C"}, {"family": "Moreno", "given": "Pablo", "initials": "P"}, {"family": "Emami Khoonsari", "given": "Payam", "initials": "P"}, {"family": "Herman", "given": "Stephanie", "initials": "S"}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Lampa", "given": "Samuel", "initials": "S", "orcid": "0000-0001-6740-9212", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3a4d1f6d7ea24907a74784d421d7143d.json"}}], "type": "posted-content", "published": "2020-01-31", "journal": {"issn-l": null}, "abstract": null, "doi": "10.20944/preprints202001.0378.v1", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T12:56:28.491Z", "modified": "2026-08-20T12:56:28.520Z"}, {"entity": "publication", "iuid": "986f18cf8de7492ebb0027ca1f43d7e2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/986f18cf8de7492ebb0027ca1f43d7e2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/986f18cf8de7492ebb0027ca1f43d7e2"}}, "title": "Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing\u207bRemitting Multiple Sclerosis.", "authors": [{"family": "Herman", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-9382-3273", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/021db99abbc64339b7c0d6048e3f2ce1.json"}}, {"family": "\u00c5kerfeldt", "given": "Torbj\u00f6rn", "initials": "T"}, {"family": "Spjuth", "given": "Ola", "initials": "O", "orcid": "0000-0002-8083-2864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c192389f99d4801b91f3350e07dfb9e.json"}}, {"family": "Burman", "given": "Joachim", "initials": "J"}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}], "type": "journal article", "published": "2019-01-24", "journal": {"title": "Cells", "issn": "2073-4409", "volume": "8", "issue": "2", "issn-l": "2073-4409"}, "abstract": "To better understand the pathophysiological differences between secondary progressive multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify potential biomarkers of disease progression, we applied high-resolution mass spectrometry (HRMS) to investigate the metabolome of cerebrospinal fluid (CSF). The biochemical differences were determined using partial least squares discriminant analysis (PLS-DA) and connected to biochemical pathways as well as associated to clinical and radiological measures. Tryptophan metabolism was significantly altered, with perturbed levels of kynurenate, 5-hydroxytryptophan, 5-hydroxyindoleacetate, and N-acetylserotonin in SPMS patients compared with RRMS and controls. SPMS patients had altered kynurenine compared with RRMS patients, and altered indole-3-acetate compared with controls. Regarding the pyrimidine metabolism, SPMS patients had altered levels of uridine and deoxyuridine compared with RRMS and controls, and altered thymine and glutamine compared with RRMS patients. Metabolites from the pyrimidine metabolism were significantly associated with disability, disease activity and brain atrophy, making them of particular interest for understanding the disease mechanisms and as markers of disease progression. Overall, these findings are of importance for the characterization of the molecular pathogenesis of SPMS and support the hypothesis that the CSF metabolome may be used to explore changes that occur in the transition between the RRMS and SPMS pathologies.", "doi": "10.3390/cells8020084", "pmid": "30678351", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6406712"}, {"db": "pii", "key": "cells8020084"}], "notes": [], "created": "2026-08-20T13:40:11.597Z", "modified": "2026-08-20T13:40:11.698Z"}, {"entity": "publication", "iuid": "25845e2b830647a29b1b095fa3fbf8e9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/25845e2b830647a29b1b095fa3fbf8e9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/25845e2b830647a29b1b095fa3fbf8e9"}}, "title": "Container-based bioinformatics with Pachyderm", "authors": [{"family": "Novella", "given": "Jon Ander", "initials": "JA", "orcid": "0000-0002-2187-5426", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/19f8d27fd16f43a8aebcd2795bc82b6e.json"}}, {"family": "Khoonsari", "given": "Payam Emami", "initials": "PE", "orcid": "0000-0002-4137-5517", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3f0f1758926845329c02b1ee8164ce60.json"}}, {"family": "Herman", "given": "Stephanie", "initials": "S", "orcid": "0000-0001-9382-3273", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/021db99abbc64339b7c0d6048e3f2ce1.json"}}, {"family": "Whitenack", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1155-8889", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dbbae6dade3f485eb0f4c332ad5ded63.json"}}, {"family": "Capuccini", "given": "Marco", "initials": "M", "orcid": "0000-0002-4851-759X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d7bae1f40b274e1c87db5d9dd3785dd5.json"}}, {"family": "Burman", "given": "Joachim", "initials": "J", "orcid": "0000-0002-7045-1806", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e3335e3bfaf346699df4986234aa065c.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Spjuth", "given": "Ola", "initials": "O", "orcid": "0000-0002-8083-2864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c192389f99d4801b91f3350e07dfb9e.json"}}], "type": "posted-content", "published": "2018-04-18", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/299032", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:09:59.390Z", "modified": "2026-08-20T11:09:59.653Z"}]}