{"entity": "researcher", "timestamp": "2026-09-30T03:45:20.828Z", "family": "Hedin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-4921-8516", "affiliations": ["Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.", "Division of Gastroenterology, Medical Unit Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7c7dee0eb4c416582a8f27ccf6ea089.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7c7dee0eb4c416582a8f27ccf6ea089"}}, "publications": [{"entity": "publication", "iuid": "7863866f956a453fac0aa6c5b88e978f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7863866f956a453fac0aa6c5b88e978f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7863866f956a453fac0aa6c5b88e978f"}}, "title": "Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing.", "authors": [{"family": "Mazzurana", "given": "Luca", "initials": "L"}, {"family": "Czarnewski", "given": "Paulo", "initials": "P", "orcid": "0000-0001-8150-4021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/501677a1262c438aa4077b205bb39a72.json"}}, {"family": "Jonsson", "given": "Viktor", "initials": "V"}, {"family": "Wigge", "given": "Leif", "initials": "L"}, {"family": "Ringn\u00e9r", "given": "Markus", "initials": "M", "orcid": "0000-0001-5469-8940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/949fda08083846abae1c0ee20e6bceb1.json"}}, {"family": "Williams", "given": "Teresa C", "initials": "TC"}, {"family": "Ravindran", "given": "Avinash", "initials": "A"}, {"family": "Bj\u00f6rklund", "given": "\u00c5sa K", "initials": "\u00c5K", "orcid": "0000-0003-2224-7090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1cfd05eeb19640eea44f996699f998f0.json"}}, {"family": "S\u00e4fholm", "given": "Jesper", "initials": "J"}, {"family": "Nilsson", "given": "Gunnar", "initials": "G"}, {"family": "Dahl\u00e9n", "given": "Sven-Erik", "initials": "SE"}, {"family": "Orre", "given": "Ann-Charlotte", "initials": "AC"}, {"family": "Al-Ameri", "given": "Mamdoh", "initials": "M"}, {"family": "H\u00f6\u00f6g", "given": "Charlotte", "initials": "C"}, {"family": "Hedin", "given": "Charlotte", "initials": "C", "orcid": "0000-0002-4921-8516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7c7dee0eb4c416582a8f27ccf6ea089.json"}}, {"family": "Szczegielniak", "given": "Sylwester", "initials": "S"}, {"family": "Almer", "given": "Sven", "initials": "S", "orcid": "0000-0001-9334-1821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/21a9f11211fd440bb56b53bbac790a1d.json"}}, {"family": "Mj\u00f6sberg", "given": "Jenny", "initials": "J"}], "type": "journal article", "published": "2021-05-00", "journal": {"title": "Cell Res.", "issn": "1748-7838", "volume": "31", "issue": "5", "pages": "554-568", "issn-l": "1001-0602"}, "abstract": "The impact of the microenvironment on innate lymphoid cell (ILC)-mediated immunity in humans remains largely unknown. Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ ILCs across four human tissues. Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs, and signatures of tissue-residency, activation and modified metabolism in colon and lung ILCs. Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident na\u00efve ILCs to a spectrum of mature ILC subsets. In the lung we identified both CRTH2+ and CRTH2- ILC2 with lung-specific signatures, which could be recapitulated by alarmin-exposure of circulating ILC2. Finally, we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells, revealing a subset of potentially immature ILCs with TCR-\u03b4 rearrangement. Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans, with implications for disease.", "doi": "10.1038/s41422-020-00445-x", "pmid": "33420427", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8089104"}, {"db": "pii", "key": "10.1038/s41422-020-00445-x"}], "notes": [], "created": "2026-09-23T06:48:27.531Z", "modified": "2026-09-23T06:48:27.705Z"}]}