{"entity": "researcher", "timestamp": "2026-09-08T10:05:25.871Z", "family": "Strage", "given": "Emma M", "initials": "EM", "orcid": "0000-0003-4731-2960", "affiliations": ["Department of Clinical Sciences, University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden.", "Clinical Pathology Laboratory, University Animal Hospital, Swedish University of Agricultural Sciences, Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b775c2827e984a0482a341ec0d3fedee.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b775c2827e984a0482a341ec0d3fedee"}}, "publications": [{"entity": "publication", "iuid": "57ca3bf6eb0841859bb41db9f54f1b09", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/57ca3bf6eb0841859bb41db9f54f1b09.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/57ca3bf6eb0841859bb41db9f54f1b09"}}, "title": "Effect of insulin treatment on circulating insulin-like growth factor I and IGF-binding proteins in cats with diabetes mellitus.", "authors": [{"family": "Strage", "given": "Emma M", "initials": "EM", "orcid": "0000-0003-4731-2960", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b775c2827e984a0482a341ec0d3fedee.json"}}, {"family": "Sundberg", "given": "M\u00e5rten", "initials": "M"}, {"family": "Holst", "given": "Bodil S", "initials": "BS"}, {"family": "Andersson Franko", "given": "Mikael", "initials": "M"}, {"family": "Ramstr\u00f6m", "given": "Margareta", "initials": "M"}, {"family": "Fall", "given": "Tove", "initials": "T"}, {"family": "Lewitt", "given": "Moira", "initials": "M"}], "type": "journal article", "published": "2018-09-00", "journal": {"title": "J. Vet. Intern. Med.", "issn": "1939-1676", "volume": "32", "issue": "5", "pages": "1579-1590", "issn-l": "0891-6640"}, "abstract": "Insulin-like growth factor-I (IGF-I) is used to screen for acromegaly in diabetic cats. In humans, most circulating IGF-I forms ternary complexes (TC) with IGF-binding protein (IGFBP-3) and an acid-labile subunit. Compared to humans, the amount of TC in cats is more variable. Insulin-like growth factor-I concentrations are reported to increase during insulin treatment, more rapidly in cats achieving remission.\n\nTo investigate (i) factors associated with circulating IGF-I concentrations, including IGFBP-profiles (ii) effect of insulin treatment on IGF-I concentrations and (iii) IGF-I as prognostic marker of diabetes mellitus remission.\n\nThirty-one privately owned diabetic cats of which 24 were followed 1 year, and 13 healthy cats.\n\nProspective study. Serum insulin, IGF-I, glucose, and fructosamine concentrations were measured. IGF-binding forms were determined by chromatography in 14 diabetic and 13 healthy cats; and IGF-I, IGF-II, IGFBP-3, and IGFBP-5 by mass spectrometry in 3 cats achieving remission.\n\nInsulin-like growth factor-I median (interquartile range) before start of insulin treatment was 300 (160-556) ng/mL. Insulin-like growth factor-I was positively associated with TC (P < .0001) and endogenous insulin (P = .005) and negatively associated with fructosamine (P < .0001). Median IGF-I was higher 2-4 weeks after start of insulin treatment compared with baseline (300 versus 670 ng/mL, P = .0001) and predicted future remission (P = .046). In cats that went into remission, the amount of TC and IGFBP-3 increased, suggesting increase in IGF-I is dependent on TC formation.\n\nInsulin treatment should be accounted for when interpreting IGF-I in diabetic cats. Insulin-like growth factor-I 2-4 weeks after initiation of insulin treatment shows promise as prognostic marker for remission in diabetic cats.", "doi": "10.1111/jvim.15243", "pmid": "30112786", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6189377"}], "notes": [], "created": "2026-08-20T11:18:42.919Z", "modified": "2026-08-20T11:18:43.046Z"}]}