{"entity": "researcher", "timestamp": "2026-09-23T21:52:45.525Z", "family": "Ulfstedt", "given": "Johan Mattsson", "initials": "JM", "orcid": "0000-0003-0682-7394", "affiliations": ["Experimental and Clinical Oncology, Department of Immunology, Genetics and Pathology, Uppsala University, SE-752 36 Uppsala, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6e14c2d59bc4f41a6ed41612d99fab9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6e14c2d59bc4f41a6ed41612d99fab9"}}, "publications": [{"entity": "publication", "iuid": "754b280f4ae843e198bd71791fa6cc73", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/754b280f4ae843e198bd71791fa6cc73.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/754b280f4ae843e198bd71791fa6cc73"}}, "title": "Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue.", "authors": [{"family": "Gholiha", "given": "Alex Reza", "initials": "AR", "orcid": "0000-0002-3393-1106", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d47518bd66114a30a8f52de713203cf1.json"}}, {"family": "Hollander", "given": "Peter", "initials": "P", "orcid": "0000-0002-0226-5681", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e41d94e388844c40a3f467fbee197a0b.json"}}, {"family": "L\u00f6f", "given": "Liza", "initials": "L"}, {"family": "Larsson", "given": "Anders", "initials": "A", "orcid": "0000-0003-3161-0402", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5b44e49c49f644cfa3348bcc4bb0080f.json"}}, {"family": "Hashemi", "given": "Jamileh", "initials": "J"}, {"family": "Ulfstedt", "given": "Johan Mattsson", "initials": "JM", "orcid": "0000-0003-0682-7394", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b6e14c2d59bc4f41a6ed41612d99fab9.json"}}, {"family": "Molin", "given": "Daniel", "initials": "D"}, {"family": "Amini", "given": "Rose-Marie", "initials": "RM"}, {"family": "Freyhult", "given": "Eva", "initials": "E", "orcid": "0000-0003-0226-1047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13486bb11790445fa37f592a42e6a7ed.json"}}, {"family": "Kamali-Moghaddam", "given": "Masood", "initials": "M"}, {"family": "Enblad", "given": "Gunilla", "initials": "G"}], "type": "journal article", "published": "2021-12-21", "journal": {"title": "Cancers (Basel)", "issn": "2072-6694", "volume": "14", "issue": "1", "issn-l": "2072-6694"}, "abstract": "In classical Hodgkin Lymphoma (cHL), immunoediting via protein signaling is key to evading tumor surveillance. We aimed to identify immune-related proteins that distinguish diagnostic cHL tissues (=diagnostic tumor lysates, n = 27) from control tissues (reactive lymph node lysates, n = 30). Further, we correlated our findings with the proteome plasma profile between cHL patients (n = 26) and healthy controls (n = 27). We used the proximity extension assay (PEA) with the OlinkTM multiplex Immuno-Oncology panel, consisting of 92 proteins. Univariate, multivariate-adjusted analysis and Benjamini-Hochberg's false discovery testing (=Padj) were performed to detect significant discrepancies. Proteins distinguishing cHL cases from controls were more numerous in plasma (30 proteins) than tissue (17 proteins), all Padj < 0.05. Eight of the identified proteins in cHL tissue (PD-L1, IL-6, CCL17, CCL3, IL-13, MMP12, TNFRS4, and LAG3) were elevated in both cHL tissues and cHL plasma compared with control samples. Six proteins distinguishing cHL tissues from controls tissues were significantly correlated to PD-L1 expression in cHL tissue (IL-6, MCP-2, CCL3, CCL4, GZMB, and IFN-gamma, all p \u22640.05). In conclusion, this study introduces a distinguishing proteomic profile in cHL tissue and potential immune-related markers of pathophysiological relevance.", "doi": "10.3390/cancers14010009", "pmid": "35008176", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8750205"}, {"db": "pii", "key": "cancers14010009"}], "notes": [], "created": "2026-09-23T12:11:13.593Z", "modified": "2026-09-23T12:11:13.695Z"}]}