{"entity": "researcher", "timestamp": "2026-08-20T20:35:35.819Z", "family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "affiliations": [], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42"}}, "publications": [{"entity": "publication", "iuid": "8f211faff1b34845bac63030e2ac437a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/8f211faff1b34845bac63030e2ac437a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/8f211faff1b34845bac63030e2ac437a"}}, "title": "Loss of Y chromosome in Alzheimer's patients co-occurs with somatic mutations beyond CHIP drivers.", "authors": [{"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d6d15c10afd4e9fb2b0a3f4488e0293.json"}}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D"}, {"family": "Horbacz", "given": "Monika", "initials": "M"}, {"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54cc533c598a45b69b437489a3e82a6a.json"}}, {"family": "Dr\u0119\u017cek-Chy\u0142a", "given": "Kinga", "initials": "K"}, {"family": "Koszy\u0144ski", "given": "Miko\u0142aj", "initials": "M"}, {"family": "Davies", "given": "Hanna", "initials": "H"}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42.json"}}, {"family": "W\u00f3jcik-Zalewska", "given": "Magdalena", "initials": "M"}, {"family": "Klich-R\u0105czka", "given": "Alicja", "initials": "A", "orcid": "0000-0002-9311-0078", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1769068b00f047a1a9acfc40da1697ce.json"}}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "Ingelsson", "given": "Martin", "initials": "M"}, {"family": "Bukowska-Strakova", "given": "Karolina", "initials": "K", "orcid": "0000-0001-9181-439X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b51ac8fa49c64b9eb451c3eea6ca9420.json"}}, {"family": "W\u0119glarczyk", "given": "Kazimierz", "initials": "K"}, {"family": "Siedlar", "given": "Maciej", "initials": "M", "orcid": "0000-0002-3904-5412", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4e3fe27b0244d56b31c564e6cc85ccc.json"}}, {"family": "Baran", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Ry\u015b", "given": "Janusz", "initials": "J"}, {"family": "Piotrowski", "given": "Arkadiusz", "initials": "A"}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64588db686e244778a885aebaa19c2c2.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9bc35062e3496785fe8ea665861ed2.json"}}], "type": "journal article", "published": "2026-02-00", "journal": {"title": "Life Sci. Alliance", "issn": "2575-1077", "volume": "9", "issue": "2", "issn-l": null}, "abstract": "Loss of Y chromosome (LOY) and clonal hematopoiesis of indeterminate potential (CHIP) are common age-related events with implications for aging and Alzheimer disease (AD). LOY is linked to increased AD risk, whereas CHIP may be protective, and their co-occurrence remains unclear. We conducted whole-exome sequencing of CD4+ T cells, NK cells, and myeloid cells from AD patients and controls exhibiting LOY or retention of Y chromosome. We identified 39 variants in known myeloid and lymphoid driver genes, with up to 35% co-occurring with LOY in the same clone. In addition, we detected 192 unknown drivers of clonal hematopoiesis, enriched in AD-LOY individuals (odds ratio 4.8, P = 0.041). In myeloid cells, total driver burden correlated with LOY (\u03c1 = 0.52, P = 0.00041). These results indicate that LOY is a primary driver of clonal hematopoiesis in AD, seeding myeloid clones that accumulate unknown driver variants, whereas most canonical CHIP mutations arise independently. Our study reveals distinct, partially overlapping clonal architectures for LOY and CHIP and highlights LOY-driven myeloid expansion as a contributor to AD pathogenesis.", "doi": "10.26508/lsa.202503533", "pmid": "41371958", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12696397"}, {"db": "pii", "key": "9/2/e202503533"}, {"db": "Dataset DOI", "key": "https://ega-archive.org/ EGAS00001008234"}], "notes": [], "created": "2026-08-20T13:03:59.493Z", "modified": "2026-08-20T13:03:59.673Z"}, {"entity": "publication", "iuid": "a3c601bbf5d74e7f8eb79f9ef36a79d7", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a3c601bbf5d74e7f8eb79f9ef36a79d7.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a3c601bbf5d74e7f8eb79f9ef36a79d7"}}, "title": "Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genes", "authors": [{"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d6d15c10afd4e9fb2b0a3f4488e0293.json"}}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D", "orcid": "0000-0002-2451-4386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a442a33fd38643c59ea730364d9ba8fd.json"}}, {"family": "Horbacz", "given": "Monika", "initials": "M", "orcid": "0000-0003-1644-2957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebc9e942f42f447ea2e53323b168b892.json"}}, {"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54cc533c598a45b69b437489a3e82a6a.json"}}, {"family": "Dr\u0119\u017cek-Chy\u0142a", "given": "Kinga", "initials": "K"}, {"family": "Koszy\u0144ski", "given": "Miko\u0142aj", "initials": "M"}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/888e384e2507499bbff9971cfa5f2370.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42.json"}}, {"family": "W\u00f3jcik-Zalewska", "given": "Magdalena", "initials": "M"}, {"family": "Klich-R\u0105czka", "given": "Alicja", "initials": "A"}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "Ingelsson", "given": "Martin", "initials": "M"}, {"family": "Bukowska-Strakova", "given": "Karolina", "initials": "K", "orcid": "0000-0001-9181-439X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b51ac8fa49c64b9eb451c3eea6ca9420.json"}}, {"family": "W\u0119glarczyk", "given": "Kazimierz", "initials": "K", "orcid": "0000-0001-5255-5436", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1728ac70db484e2da0b8d5ca776ecadf.json"}}, {"family": "Siedlar", "given": "Maciej", "initials": "M", "orcid": "0000-0002-3904-5412", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e4e3fe27b0244d56b31c564e6cc85ccc.json"}}, {"family": "Baran", "given": "Jaros\u0142aw", "initials": "J", "orcid": "0000-0003-1787-1972", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e2b438855cd94e93b9051b10f1023b06.json"}}, {"family": "Ry\u015b", "given": "Janusz", "initials": "J"}, {"family": "Piotrowski", "given": "Arkadiusz", "initials": "A"}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64588db686e244778a885aebaa19c2c2.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9bc35062e3496785fe8ea665861ed2.json"}}], "type": "posted-content", "published": "2025-06-06", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.06.05.25329040", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:06:02.678Z", "modified": "2026-08-20T11:06:02.918Z"}, {"entity": "publication", "iuid": "b337514cf8d343d1b5543e030bf28efb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b337514cf8d343d1b5543e030bf28efb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b337514cf8d343d1b5543e030bf28efb"}}, "title": "Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases", "authors": [{"family": "W\u00f3jcik", "given": "Magdalena", "initials": "M", "orcid": "0000-0001-5475-8448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d86767e0cd24959b141c46b72052a89.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42.json"}}, {"family": "Mohammadi", "given": "Elyas", "initials": "E", "orcid": "0000-0002-3352-2572", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e61ec5ae19ac4229b370d7d1328702ed.json"}}, {"family": "Mattisson", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4456-9667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55ab3f88462844d9884e8787bd46236a.json"}}, {"family": "Dr\u0119\u017cek-Chy\u0142a", "given": "Kinga", "initials": "K"}, {"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d6d15c10afd4e9fb2b0a3f4488e0293.json"}}, {"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54cc533c598a45b69b437489a3e82a6a.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/888e384e2507499bbff9971cfa5f2370.json"}}, {"family": "Chojnowska", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-5571-6618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62c056bcb8d64949b3cae6753ceee075.json"}}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0002-2788-5254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f34db06bf7ea4a698e4227ae6c9ecf80.json"}}, {"family": "Bie\u0144kowski", "given": "Micha\u0142", "initials": "M"}, {"family": "Jankowski", "given": "Micha\u0142", "initials": "M"}, {"family": "Rostkowska", "given": "Olga", "initials": "O"}, {"family": "Hellmann", "given": "Andrzej", "initials": "A"}, {"family": "P\u0119ksa", "given": "Rafa\u0142", "initials": "R"}, {"family": "Kowalski", "given": "Jacek", "initials": "J"}, {"family": "Zdrenka", "given": "Marek", "initials": "M"}, {"family": "Kobiela", "given": "Jarek", "initials": "J"}, {"family": "Zegarski", "given": "Wojciech", "initials": "W"}, {"family": "Biernat", "given": "Wojciech", "initials": "W"}, {"family": "Szylberg", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Remiszewski", "given": "Piotr", "initials": "P"}, {"family": "Mieczkowski", "given": "Jakub", "initials": "J", "orcid": "0000-0002-2091-012X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1f3a661ef734ec6bbe55e6969eedc80.json"}}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64588db686e244778a885aebaa19c2c2.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9bc35062e3496785fe8ea665861ed2.json"}}], "type": "posted-content", "published": "2023-06-22", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.06.17.23289722", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:46:50.936Z", "modified": "2026-08-20T10:46:51.154Z"}, {"entity": "publication", "iuid": "e04ea176416641e8b843478f4c6082e0", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/e04ea176416641e8b843478f4c6082e0.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/e04ea176416641e8b843478f4c6082e0"}}, "title": "Loss of Y in leukocytes as a risk factor for critical COVID-19 in men", "authors": [{"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54cc533c598a45b69b437489a3e82a6a.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/888e384e2507499bbff9971cfa5f2370.json"}}, {"family": "Sarkisyan", "given": "Daniil", "initials": "D", "orcid": "0000-0002-2451-4386", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a442a33fd38643c59ea730364d9ba8fd.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42.json"}}, {"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d6d15c10afd4e9fb2b0a3f4488e0293.json"}}, {"family": "W\u00f3jcik", "given": "Magdalena", "initials": "M"}, {"family": "Horbacz", "given": "Monika", "initials": "M", "orcid": "0000-0003-1644-2957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebc9e942f42f447ea2e53323b168b892.json"}}, {"family": "J\u0105kalski", "given": "Marcin", "initials": "M", "orcid": "0000-0002-5481-9148", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e56aebb0edf0484398c3a929ff862b9d.json"}}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0002-2788-5254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f34db06bf7ea4a698e4227ae6c9ecf80.json"}}, {"family": "Westholm", "given": "Jakub O", "initials": "JO", "orcid": "0000-0002-6849-6220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/966341b184974f0f81c34e36cadd74e0.json"}}, {"family": "Smialowska", "given": "Agata", "initials": "A"}, {"family": "Wierzba", "given": "Karol", "initials": "K", "orcid": "0000-0003-1257-4047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/49ab57f2616a46ac8075d3c3f5920142.json"}}, {"family": "Naluai", "given": "\u00c5sa Torinsson", "initials": "\u00c5T", "orcid": "0000-0002-0504-6492", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/617363307f184ff7ba99f746898ddd30.json"}}, {"family": "Jern", "given": "Niklas", "initials": "N"}, {"family": "Andersson", "given": "Lars Magnus", "initials": "LM", "orcid": "0000-0002-9203-5969", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a83b0fb848b4ba8ad2d9a3d8f28e544.json"}}, {"family": "J\u00e4rhult", "given": "Josef D", "initials": "JD", "orcid": "0000-0002-7075-1059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d08e178bd3d4e0895ba6e9e933fa020.json"}}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64588db686e244778a885aebaa19c2c2.json"}}, {"family": "Janson", "given": "Eva Tiensuu", "initials": "ET", "orcid": "0000-0002-1649-4880", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/457db2e5e73945eea80e42e5892bab07.json"}}, {"family": "Rubertsson", "given": "Sten", "initials": "S"}, {"family": "Lipcsey", "given": "Mikl\u00f3s", "initials": "M", "orcid": "0000-0002-1976-4129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ecca73b0185443c3ba74f354a424ac38.json"}}, {"family": "Gissl\u00e9n", "given": "Magnus", "initials": "M", "orcid": "0000-0002-2357-1020", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ea6bdcb8fbaf4b4ca4cae2e09e02ecaf.json"}}, {"family": "Hultstr\u00f6m", "given": "Michael", "initials": "M", "orcid": "0000-0003-4675-1099", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b71550d499b489d9db0592164460c21.json"}}, {"family": "Frithiof", "given": "Robert", "initials": "R", "orcid": "0000-0003-2278-7951", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/da36700cbbc94948bce995cef6b0af2f.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9bc35062e3496785fe8ea665861ed2.json"}}], "type": "posted-content", "published": "2022-01-19", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2022.01.19.22269521", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:09:14.053Z", "modified": "2026-08-20T10:09:14.650Z"}]}