{"entity": "researcher", "timestamp": "2026-09-27T17:30:29.671Z", "family": "Mehtonen", "given": "Juha", "initials": "J", "orcid": "0000-0003-0554-4667", "affiliations": ["Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4af88e8707748aa9261c81f55a43e10.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4af88e8707748aa9261c81f55a43e10"}}, "publications": [{"entity": "publication", "iuid": "a80e0144ed3146d78a3cf5657063c2cc", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a80e0144ed3146d78a3cf5657063c2cc.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a80e0144ed3146d78a3cf5657063c2cc"}}, "title": "Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia.", "authors": [{"family": "Gr\u00f6nroos", "given": "Toni", "initials": "T"}, {"family": "M\u00e4kinen", "given": "Artturi", "initials": "A"}, {"family": "Laukkanen", "given": "Saara", "initials": "S"}, {"family": "Mehtonen", "given": "Juha", "initials": "J", "orcid": "0000-0003-0554-4667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4af88e8707748aa9261c81f55a43e10.json"}}, {"family": "Nikkil\u00e4", "given": "Atte", "initials": "A"}, {"family": "Oksa", "given": "Laura", "initials": "L"}, {"family": "Rounioja", "given": "Samuli", "initials": "S"}, {"family": "Marincevic-Zuniga", "given": "Yanara", "initials": "Y"}, {"family": "Nordlund", "given": "Jessica", "initials": "J"}, {"family": "Pohjolainen", "given": "Virva", "initials": "V"}, {"family": "Paavonen", "given": "Timo", "initials": "T"}, {"family": "Hein\u00e4niemi", "given": "Merja", "initials": "M"}, {"family": "Lohi", "given": "Olli", "initials": "O"}], "type": "journal article", "published": "2020-02-06", "journal": {"title": "Sci Rep", "issn": "2045-2322", "volume": "10", "issue": "1", "pages": "2043", "issn-l": "2045-2322"}, "abstract": "Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.", "doi": "10.1038/s41598-020-58970-z", "pmid": "32029838", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7005266"}, {"db": "pii", "key": "10.1038/s41598-020-58970-z"}], "notes": [], "created": "2026-09-23T12:02:25.790Z", "modified": "2026-09-23T12:02:25.861Z"}]}