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"", "initials": ""}, {"family": "COVID-STORM Clinicians", "given": "", "initials": ""}, {"family": "Imagine COVID Group", "given": "", "initials": ""}, {"family": "French COVID Cohort Study Group", "given": "", "initials": ""}, {"family": "Milieu Int\u00e9rieur Consortium", "given": "", "initials": ""}, {"family": "CoV-Contact Cohort", "given": "", "initials": ""}, {"family": "Amsterdam UMC Covid-19 Biobank", "given": "", "initials": ""}, {"family": "COVID Human Genetic Effort", "given": "", "initials": ""}, {"family": "Tsang", "given": "John S", "initials": "JS", "orcid": "0000-0003-3186-3047", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/274e51d6e6f24512a177604add810d4b.json"}}, {"family": "Goldbach-Mansky", "given": "Raphaela", "initials": "R", "orcid": "0000-0001-7865-5769", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06ab2f730fca45fb8dce02dafc811d37.json"}}, {"family": "Kisand", "given": "Kai", "initials": "K", "orcid": "0000-0002-5426-4648", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd7352f8a0254478add242528188ffdc.json"}}, {"family": "Lionakis", "given": "Michail S", "initials": "MS"}, {"family": "Puel", "given": "Anne", "initials": "A", "orcid": "0000-0003-2603-0323", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d106604b8ad84e67870302b906a94963.json"}}, {"family": "Zhang", "given": "Shen-Ying", "initials": "SY"}, {"family": "Holland", "given": "Steven M", "initials": "SM", "orcid": "0000-0003-3207-5464", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b90f9be3102e4cf4894e11bdad4c0d5f.json"}}, {"family": "Gorochov", "given": "Guy", "initials": "G"}, {"family": "Jouanguy", "given": "Emmanuelle", "initials": "E", "orcid": "0000-0002-7358-9157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/de52d6ee013c4d18888fed695f547f54.json"}}, {"family": "Rice", "given": "Charles M", "initials": "CM"}, {"family": "Cobat", "given": "Aur\u00e9lie", "initials": "A", "orcid": "0000-0001-7209-6257", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55186a4757e7417389f415061b59ab5c.json"}}, {"family": "Notarangelo", "given": "Luigi D", "initials": "LD", "orcid": "0000-0002-8335-0262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c24b272de580450caee36c6e772b6bc6.json"}}, {"family": "Abel", "given": "Laurent", "initials": "L", "orcid": "0000-0001-7016-6493", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/80da2e422a014973a981c891c6c38070.json"}}, {"family": "Su", "given": "Helen C", "initials": "HC", "orcid": "0000-0002-5582-9110", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c4d439536e38409595738548b17c7871.json"}}, {"family": "Casanova", "given": "Jean-Laurent", "initials": "JL", "orcid": "0000-0002-7782-4169", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/264335517ad94440b23a027fe66f767d.json"}}], "type": "journal article", "published": "2020-10-23", "journal": {"title": "Science (New York, N.Y.)", "issn": "1095-9203", "volume": "370", "issue": "6515", "issn-l": "0036-8075"}, "abstract": "Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-\u03c9 (IFN-\u03c9) (13 patients), against the 13 types of IFN-\u03b1 (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.", "doi": "10.1126/science.abd4585", "pmid": "32972996", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1668509"}, {"db": "pmc", "key": "PMC7857397"}, {"db": "pii", "key": "science.abd4585"}], "notes": [], "created": "2026-08-21T12:23:22.474Z", "modified": "2026-08-21T12:23:24.271Z"}]}