{"entity": "researcher", "timestamp": "2026-08-25T09:43:05.813Z", "family": "Kohda", "given": "Daisuke", "initials": "D", "orcid": "0000-0001-8234-3776", "affiliations": ["RIKEN SPring-8 Center, Sayo, Hyogo, 679-5148, Japan.", "Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582, Japan."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b304f490dc0e4dfba592705cc1d02b41.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b304f490dc0e4dfba592705cc1d02b41"}}, "publications": [{"entity": "publication", "iuid": "5628c35354a1426083bfad6a0d5b1e71", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5628c35354a1426083bfad6a0d5b1e71.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5628c35354a1426083bfad6a0d5b1e71"}}, "title": "Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7.", "authors": [{"family": "Hanawa-Suetsugu", "given": "Kyoko", "initials": "K"}, {"family": "Itoh", "given": "Yuzuru", "initials": "Y"}, {"family": "Ab Fatah", "given": "Maisarah", "initials": "M"}, {"family": "Nishimura", "given": "Tamako", "initials": "T"}, {"family": "Takemura", "given": "Kazuhiro", "initials": "K"}, {"family": "Takeshita", "given": "Kohei", "initials": "K"}, {"family": "Kubota", "given": "Satoru", "initials": "S"}, {"family": "Miyazaki", "given": "Naoyuki", "initials": "N"}, {"family": "Wan Mohamad Noor", "given": "Wan Nurul Izzati", "initials": "WNI"}, {"family": "Inaba", "given": "Takehiko", "initials": "T"}, {"family": "Nguyen", "given": "Nhung Thi Hong", "initials": "NTH"}, {"family": "Hamada-Nakahara", "given": "Sayaka", "initials": "S"}, {"family": "Oono-Yakura", "given": "Kayoko", "initials": "K"}, {"family": "Tachikawa", "given": "Masashi", "initials": "M"}, {"family": "Iwasaki", "given": "Kenji", "initials": "K", "orcid": "0000-0002-3808-8904", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3971e190c21c496aa07878b70d6b2fa3.json"}}, {"family": "Kohda", "given": "Daisuke", "initials": "D", "orcid": "0000-0001-8234-3776", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b304f490dc0e4dfba592705cc1d02b41.json"}}, {"family": "Yamamoto", "given": "Masaki", "initials": "M"}, {"family": "Kitao", "given": "Akio", "initials": "A", "orcid": "0000-0002-5221-0806", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1855bd6075b7497f8b0e286975a6a34f.json"}}, {"family": "Shimada", "given": "Atsushi", "initials": "A", "orcid": "0000-0002-4108-770X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/42708bf3df1e48b1b929a2b855c5a097.json"}}, {"family": "Suetsugu", "given": "Shiro", "initials": "S", "orcid": "0000-0002-4612-0628", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/11a5123425804e6cb0333efea399b3e3.json"}}], "type": "journal article", "published": "2019-10-18", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "10", "issue": "1", "pages": "4763", "issn-l": "2041-1723"}, "abstract": "Phagocytosis is a cellular process for internalization of micron-sized large particles including pathogens. The Bin-Amphiphysin-Rvs167 (BAR) domain proteins, including the FCH-BAR (F-BAR) domain proteins, impose specific morphologies on lipid membranes. Most BAR domain proteins are thought to form membrane invaginations or protrusions by assembling into helical submicron-diameter filaments, such as on clathrin-coated pits, caveolae, and filopodia. However, the mechanism by which BAR domain proteins assemble into micron-scale phagocytic cups was unclear. Here, we show that the two-dimensional sheet-like assembly of Growth Arrest-Specific 7 (GAS7) plays a critical role in phagocytic cup formation in macrophages. GAS7 has the F-BAR domain that possesses unique hydrophilic loops for two-dimensional sheet formation on flat membranes. Super-resolution microscopy reveals the similar assemblies of GAS7 on phagocytic cups and liposomes. The mutations of the loops abolishes both the membrane localization of GAS7 and phagocytosis. Thus, the sheet-like assembly of GAS7 plays a significant role in phagocytosis.", "doi": "10.1038/s41467-019-12738-w", "pmid": "31628328", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC6802115"}, {"db": "pii", "key": "10.1038/s41467-019-12738-w"}], "notes": [], "created": "2026-08-21T11:48:25.300Z", "modified": "2026-08-21T11:48:25.504Z"}]}