{"entity": "researcher", "timestamp": "2026-06-08T11:45:34.416Z", "family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "affiliations": ["Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.", "Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC, Canada."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2a049a261eb46c79066a817f5cd4d5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2a049a261eb46c79066a817f5cd4d5b"}}, "publications": [{"entity": "publication", "iuid": "b436447782154e4d8b72068ac6711bfb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b436447782154e4d8b72068ac6711bfb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b436447782154e4d8b72068ac6711bfb"}}, "title": "PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.", "authors": [{"family": "Cikes", "given": "Domagoj", "initials": "D", "orcid": "0000-0003-0350-5672", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/04b1713531d24e25aff51715d7d0f4cf.json"}}, {"family": "Elsayad", "given": "Kareem", "initials": "K"}, {"family": "Sezgin", "given": "Erdinc", "initials": "E", "orcid": "0000-0002-4915-388X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f7bd3619c7fd48318bc4c1e7a9910df8.json"}}, {"family": "Koitai", "given": "Erika", "initials": "E", "orcid": "0000-0002-1370-2955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/638ff8aa9fbd4074bcfb37df52229f1d.json"}}, {"family": "Torma", "given": "Ferenc", "initials": "F", "orcid": "0000-0003-1331-8643", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ba5ed9f5d944a179cf0c9a203b68cd3.json"}}, {"family": "Orthofer", "given": "Michael", "initials": "M"}, {"family": "Yarwood", "given": "Rebecca", "initials": "R"}, {"family": "Heinz", "given": "Leonhard X", "initials": "LX"}, {"family": "Sedlyarov", "given": "Vitaly", "initials": "V"}, {"family": "Miranda", "given": "Nasser Darwish", "initials": "ND", "orcid": "0000-0002-8821-8236", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9fae2cac17074f359f28a4b206f235af.json"}}, {"family": "Taylor", "given": "Adrian", "initials": "A"}, {"family": "Grapentine", "given": "Sophie", "initials": "S", "orcid": "0000-0003-2307-4363", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c99aa24130ed4da5a00cb19b6627d5a9.json"}}, {"family": "Al-Murshedi", "given": "Fathiya", "initials": "F"}, {"family": "Abot", "given": "Anne", "initials": "A"}, {"family": "Weidinger", "given": "Adelheid", "initials": "A", "orcid": "0000-0002-2759-211X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7eb7308571dd458ab5bac42a7e7eab5c.json"}}, {"family": "Kutchukian", "given": "Candice", "initials": "C", "orcid": "0000-0003-1142-7109", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2af15deffb674ad4811f7818c7e577e3.json"}}, {"family": "Sanchez", "given": "Colline", "initials": "C"}, {"family": "Cronin", "given": "Shane J F", "initials": "SJF"}, {"family": "Novatchkova", "given": "Maria", "initials": "M"}, {"family": "Kavirayani", "given": "Anoop", "initials": "A", "orcid": "0000-0003-3874-3101", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fc3b7fff03cb470da6d0e79c2deb63dd.json"}}, {"family": "Schuetz", "given": "Thomas", "initials": "T", "orcid": "0000-0001-9211-8345", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/15449a6aa73040d9a015a9593508e39a.json"}}, {"family": "Haubner", "given": "Bernhard", "initials": "B"}, {"family": "Haas", "given": "Lisa", "initials": "L"}, {"family": "Hagelkruys", "given": "Astrid", "initials": "A", "orcid": "0000-0003-3015-4038", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4b00dea21d446c0af4c0cd542d24907.json"}}, {"family": "Jackowski", "given": "Suzanne", "initials": "S"}, {"family": "Kozlov", "given": "Andrey V", "initials": "AV", "orcid": "0000-0002-0834-4997", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/67c0a307da9a448a958fd90e0a8be55f.json"}}, {"family": "Jacquemond", "given": "Vincent", "initials": "V", "orcid": "0000-0003-4944-270X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a82711608ac14246825a8729909ef65e.json"}}, {"family": "Knauf", "given": "Claude", "initials": "C", "orcid": "0000-0001-5213-5378", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c2d6169ca6f44289baaa9b0a4df0d882.json"}}, {"family": "Superti-Furga", "given": "Giulio", "initials": "G", "orcid": "0000-0002-0570-1768", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfdf094156594f40a3900cbaadefa817.json"}}, {"family": "Rullman", "given": "Eric", "initials": "E", "orcid": "0000-0003-2854-7262", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4cfc8153e584034b3334e727c6bade4.json"}}, {"family": "Gustafsson", "given": "Thomas", "initials": "T"}, {"family": "McDermot", "given": "John", "initials": "J"}, {"family": "Lowe", "given": "Martin", "initials": "M"}, {"family": "Radak", "given": "Zsolt", "initials": "Z"}, {"family": "Chamberlain", "given": "Jeffrey S", "initials": "JS", "orcid": "0000-0001-5299-0059", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5bb089d221e408a8298d85391081588.json"}}, {"family": "Bakovic", "given": "Marica", "initials": "M"}, {"family": "Banka", "given": "Siddharth", "initials": "S", "orcid": "0000-0002-8527-2210", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/491aecbac6094f10be801a6a7803fd8f.json"}}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2a049a261eb46c79066a817f5cd4d5b.json"}}], "type": "journal article", "published": "2023-03-00", "journal": {"title": "Nat Metab", "issn": "2522-5812", "volume": "5", "issue": "3", "pages": "495-515", "issn-l": "2522-5812"}, "abstract": "Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective treatments for muscle diseases, represents an important goal in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency in PCYT2 causes a severe disease with failure to thrive and progressive weakness. pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the participant phenotypes, with failure to thrive, progressive muscle weakness and accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing. Thus, PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.", "doi": "10.1038/s42255-023-00766-2", "pmid": "36941451", "labels": {"SciLifeLab Fellow": null, "Erdinc Sezgin": null}, "xrefs": [{"db": "pii", "key": "10.1038/s42255-023-00766-2"}], "notes": [], "created": "2023-05-26T17:17:58.946Z", "modified": "2023-05-26T17:17:59.492Z"}, {"entity": "publication", "iuid": "35e363745bf14c1683bd43d4f1cb7fc9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/35e363745bf14c1683bd43d4f1cb7fc9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/35e363745bf14c1683bd43d4f1cb7fc9"}}, "title": "JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality.", "authors": [{"family": "Stebbing", "given": "Justin", "initials": "J", "orcid": "0000-0002-1117-6947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e9eebab9fdf44e5aa4da8938cca0495c.json"}}, {"family": "S\u00e1nchez Nievas", "given": "Gin\u00e9s", "initials": "G", "orcid": "0000-0003-3910-2955", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/540ff73318544abf8debbaee9eda693a.json"}}, {"family": "Falcone", "given": "Marco", "initials": "M"}, {"family": "Youhanna", "given": "Sonia", "initials": "S", "orcid": "0000-0002-9376-8478", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dfdfa956ff3d4fe5b1b7dd88970bb727.json"}}, {"family": "Richardson", "given": "Peter", "initials": "P"}, {"family": "Ottaviani", "given": "Silvia", "initials": "S", "orcid": "0000-0002-8830-9947", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f27e3810fbca4532b8ff56c179d4a40a.json"}}, {"family": "Shen", "given": "Joanne X", "initials": "JX"}, {"family": "Sommerauer", "given": "Christian", "initials": "C", "orcid": "0000-0001-7132-7172", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1fdc4a7e8f774940b9982c40ead59c30.json"}}, {"family": "Tiseo", "given": "Giusy", "initials": "G"}, {"family": "Ghiadoni", "given": "Lorenzo", "initials": "L"}, {"family": "Virdis", "given": "Agostino", "initials": "A"}, {"family": "Monzani", "given": "Fabio", "initials": "F", "orcid": "0000-0003-1676-098X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7f361ef1109c4eccb7874bdc3aa9831e.json"}}, {"family": "Rizos", "given": "Luis Romero", "initials": "LR"}, {"family": "Forfori", "given": "Francesco", "initials": "F", "orcid": "0000-0001-8201-8076", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b5e51f042c064bb8bf4f332ef8dcf899.json"}}, {"family": "Avenda\u00f1o C\u00e9spedes", "given": "Almudena", "initials": "A"}, {"family": "De Marco", "given": "Salvatore", "initials": "S", "orcid": "0000-0002-5013-0220", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98a811cc243449b692e9170c55d56492.json"}}, {"family": "Carrozzi", "given": "Laura", "initials": "L"}, {"family": "Lena", "given": "Fabio", "initials": "F", "orcid": "0000-0002-4920-9898", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/08fdb95eae5947ffa9fbacca12ba98ce.json"}}, {"family": "S\u00e1nchez-Jurado", "given": "Pedro Manuel", "initials": "PM"}, {"family": "Lacerenza", "given": "Leonardo Gianluca", "initials": "LG", "orcid": "0000-0002-9315-1654", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/51206a0726174ea3b72cb2b634930f4b.json"}}, {"family": "Cesira", "given": "Nencioni", "initials": "N", "orcid": "0000-0002-9133-8562", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e46e0717d98f45408b5583057f784395.json"}}, {"family": "Caldevilla Bernardo", "given": "David", "initials": "D", "orcid": "0000-0002-4836-3738", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3f5484fbf6a4553ae1fb72d136a0426.json"}}, {"family": "Perrella", "given": "Antonio", "initials": "A"}, {"family": "Niccoli", "given": "Laura", "initials": "L"}, {"family": "M\u00e9ndez", "given": "Lourdes S\u00e1ez", "initials": "LS"}, {"family": "Matarrese", "given": "Daniela", "initials": "D", "orcid": "0000-0002-3479-4545", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/486bf8ddb0f44bdf8126a9f3fa2e83ca.json"}}, {"family": "Goletti", "given": "Delia", "initials": "D", "orcid": "0000-0001-8360-4376", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/219892d2b99e4373ab9f032ec9dbdb45.json"}}, {"family": "Tan", "given": "Yee-Joo", "initials": "YJ", "orcid": "0000-0002-2278-4497", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e989fe0c53e0487aa10011145da77055.json"}}, {"family": "Monteil", "given": "Vanessa", "initials": "V", "orcid": "0000-0002-2652-5695", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3551c6819d784178ac36f8c7018f8c2f.json"}}, {"family": "Dranitsaris", "given": "George", "initials": "G"}, {"family": "Cantini", "given": "Fabrizio", "initials": "F"}, {"family": "Farcomeni", "given": "Alessio", "initials": "A", "orcid": "0000-0002-7104-5826", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/09910d63c6914f43b146a70ec7e1bcbc.json"}}, {"family": "Dutta", "given": "Shuchismita", "initials": "S", "orcid": "0000-0002-2109-5411", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c5f08d6f22d4f39a0465d8ed00ad3c0.json"}}, {"family": "Burley", "given": "Stephen K", "initials": "SK"}, {"family": "Zhang", "given": "Haibo", "initials": "H", "orcid": "0000-0002-1714-3038", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/db6a93087dbf4ef3b352ca326cbb39f7.json"}}, {"family": "Pistello", "given": "Mauro", "initials": "M", "orcid": "0000-0003-0908-6253", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/13075d00e97c41c4a09de956fd4af03f.json"}}, {"family": "Li", "given": "William", "initials": "W", "orcid": "0000-0003-3344-1403", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8a26a8c8ad0c4fb2a03f541eac672081.json"}}, {"family": "Romero", "given": "Marta Mas", "initials": "MM"}, {"family": "Andr\u00e9s Pretel", "given": "Fernando", "initials": "F"}, {"family": "Sim\u00f3n-Talero", "given": "Rafaela S\u00e1nchez", "initials": "RS"}, {"family": "Garc\u00eda-Molina", "given": "Rafael", "initials": "R", "orcid": "0000-0003-3498-1049", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6b449b3a7f0c4e97bb9e509d4da63f73.json"}}, {"family": "Kutter", "given": "Claudia", "initials": "C", "orcid": "0000-0002-8047-0058", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a4c9dcde56304ab2a99bb1032e4ce834.json"}}, {"family": "Felce", "given": "James H", "initials": "JH", "orcid": "0000-0001-5531-9244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/83072d8b6e004d5e882cb040635f3695.json"}}, {"family": "Nizami", "given": "Zehra F", "initials": "ZF", "orcid": "0000-0003-3308-3247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/199f60462af84cf484b2e97dbef17c0a.json"}}, {"family": "Miklosi", "given": "Andras G", "initials": "AG"}, {"family": "Penninger", "given": "Josef M", "initials": "JM", "orcid": "0000-0002-8194-3777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b2a049a261eb46c79066a817f5cd4d5b.json"}}, {"family": "Menichetti", "given": "Francesco", "initials": "F"}, {"family": "Mirazimi", "given": "Ali", "initials": "A"}, {"family": "Abizanda", "given": "Pedro", "initials": "P", "orcid": "0000-0002-4707-2963", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9d26407840a842759235b984e726bcaa.json"}}, {"family": "Lauschke", "given": "Volker M", "initials": "VM", "orcid": "0000-0002-1140-6204", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/82048d4da61547d08aa9d2bb3bae12dd.json"}}], "type": "journal article", "published": "2021-01-00", "journal": {"title": "Sci Adv", "issn": "2375-2548", "issn-l": "2375-2548", "volume": "7", "issue": "1", "pages": null}, "abstract": "Using AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age, 81 years). An additional 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-\u03b12 increases ACE2 expression and SARS-CoV-2 infectivity in parenchymal cells by greater than fivefold. RNA-seq reveals gene response signatures associated with platelet activation, fully inhibited by baricitinib. Using viral load quantifications and superresolution microscopy, we found that baricitinib exerts activity rapidly through the inhibition of host proteins (numb-associated kinases), uniquely among antivirals. This reveals mechanistic actions of a Janus kinase-1/2 inhibitor targeting viral entry, replication, and the cytokine storm and is associated with beneficial outcomes including in severely ill elderly patients, data that incentivize further randomized controlled trials.", "doi": "10.1126/sciadv.abe4724", "pmid": "33187978", "labels": {"Claudia Kutter": null, "SciLifeLab Fellow": null}, "xrefs": [{"db": "pii", "key": "sciadv.abe4724"}, {"db": "pmc", "key": "PMC7775747"}], "notes": [], "created": "2020-11-30T17:48:04.500Z", "modified": "2022-11-04T11:32:13.866Z"}]}