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"given": "Jaime", "initials": "J"}, {"family": "Beheshti", "given": "Afshin", "initials": "A", "orcid": "0000-0003-4643-531X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88d9eb73d9834a79ab05e6ee30708fba.json"}}], "type": "journal article", "published": "2024-08-00", "journal": {"title": "Nature", "issn": "1476-4687", "volume": "632", "issue": "8027", "pages": "995-1008", "issn-l": "0028-0836"}, "abstract": "The recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a 'second space age'. This era is also poised to leverage, for the first time, modern tools and methods of molecular biology and precision medicine, thus enabling precision aerospace medicine for the crews. The applications of these biomedical technologies and algorithms are diverse, and encompass multi-omic, single-cell and spatial biology tools to investigate human and microbial responses to spaceflight. Additionally, they extend to the development of new imaging techniques, real-time cognitive assessments, physiological monitoring and personalized risk profiles tailored for astronauts. Furthermore, these technologies enable advancements in pharmacogenomics, as well as the identification of novel spaceflight biomarkers and the development of corresponding countermeasures. In this Perspective, we highlight some of the recent biomedical research from the National Aeronautics and Space Administration, Japan Aerospace Exploration Agency, European Space Agency and other space agencies, and detail the entrance of the commercial spaceflight sector (including SpaceX, Blue Origin, Axiom and Sierra Space) into aerospace medicine and space biology, the first aerospace medicine biobank, and various upcoming missions that will utilize these tools to ensure a permanent human presence beyond low Earth orbit, venturing out to other planets and moons.", "doi": "10.1038/s41586-024-07586-8", "pmid": "38862027", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS2102169"}, {"db": "pmc", "key": "PMC12366838"}, {"db": "pii", "key": "10.1038/s41586-024-07586-8"}], "notes": [], "created": "2026-08-20T08:58:52.919Z", "modified": "2026-08-20T08:58:54.336Z"}, {"entity": "publication", "iuid": "a8ffb32cf7e34413952539e2e209dc79", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/a8ffb32cf7e34413952539e2e209dc79.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/a8ffb32cf7e34413952539e2e209dc79"}}, "title": "Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse Outcomes", "authors": [{"family": "Andreou", "given": "Maria", "initials": "M", "orcid": "0000-0002-2197-597X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a049e2ddeb954bdba0767cd9e757d8ee.json"}}, {"family": "J\u0105kalski", "given": "Marcin", "initials": "M", "orcid": "0000-0002-5481-9148", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e56aebb0edf0484398c3a929ff862b9d.json"}}, {"family": "Duzowska", "given": "Katarzyna", "initials": "K"}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64588db686e244778a885aebaa19c2c2.json"}}, {"family": "Kostecka", "given": "Anna", "initials": "A", "orcid": "0000-0001-5705-0795", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/155382b49119451eac0270139acfd2aa.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/888e384e2507499bbff9971cfa5f2370.json"}}, {"family": "Horbacz", "given": "Monika", "initials": "M", "orcid": "0000-0003-1644-2957", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ebc9e942f42f447ea2e53323b168b892.json"}}, {"family": "\u0141awrynowicz", "given": "Urszula", "initials": "U", "orcid": "0000-0001-6272-5603", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b81a86d909cb426882b5db05b52c09e6.json"}}, {"family": "Chojnowska", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-5571-6618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62c056bcb8d64949b3cae6753ceee075.json"}}, {"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54cc533c598a45b69b437489a3e82a6a.json"}}, {"family": "Jankau", "given": "Jerzy", "initials": "J"}, {"family": "\u015arutek", "given": "Ewa", "initials": "E"}, {"family": "Las-Jankowska", "given": "Manuela", "initials": "M"}, {"family": "Ba\u0142a", "given": "Dariusz", "initials": "D"}, {"family": "Hoffman", "given": "Jacek", "initials": "J"}, {"family": "Hartman", "given": "Johan", "initials": "J"}, {"family": "P\u0119ksa", "given": "Rafa\u0142", "initials": "R"}, {"family": "Skokowski", "given": "Jaros\u0142aw", "initials": "J"}, {"family": "Jankowski", "given": "Micha\u0142", "initials": "M"}, {"family": "Szylberg", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Zegarski", "given": "Wojciech", "initials": "W"}, {"family": "Nowikiewicz", "given": "Magdalena", "initials": "M"}, {"family": "Nowikiewicz", "given": "Tomasz", "initials": "T"}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9bc35062e3496785fe8ea665861ed2.json"}}, {"family": "Mieczkowski", "given": "Jakub", "initials": "J", "orcid": "0000-0002-2091-012X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1f3a661ef734ec6bbe55e6969eedc80.json"}}, {"family": "Piotrowski", "given": "Arkadiusz", "initials": "A", "orcid": "0000-0002-0823-0607", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9e64d7b68df2421f9456085fa4a41467.json"}}], "type": "posted-content", "published": "2024-02-08", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2024.02.07.579074", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:52:08.806Z", "modified": "2026-08-20T10:52:08.997Z"}, {"entity": "publication", "iuid": "b337514cf8d343d1b5543e030bf28efb", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b337514cf8d343d1b5543e030bf28efb.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b337514cf8d343d1b5543e030bf28efb"}}, "title": "Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases", "authors": [{"family": "W\u00f3jcik", "given": "Magdalena", "initials": "M", "orcid": "0000-0001-5475-8448", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6d86767e0cd24959b141c46b72052a89.json"}}, {"family": "Juhas", "given": "Ulana", "initials": "U", "orcid": "0000-0001-8393-5845", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b60a9482cdc4494aaed35243e04fbc42.json"}}, {"family": "Mohammadi", "given": "Elyas", "initials": "E", "orcid": "0000-0002-3352-2572", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e61ec5ae19ac4229b370d7d1328702ed.json"}}, {"family": "Mattisson", "given": "Jonas", "initials": "J", "orcid": "0000-0002-4456-9667", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/55ab3f88462844d9884e8787bd46236a.json"}}, {"family": "Dr\u0119\u017cek-Chy\u0142a", "given": "Kinga", "initials": "K"}, {"family": "Rychlicka-Buniowska", "given": "Edyta", "initials": "E", "orcid": "0000-0001-8050-2489", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3d6d15c10afd4e9fb2b0a3f4488e0293.json"}}, {"family": "Bruhn-Olszewska", "given": "Bo\u017cena", "initials": "B", "orcid": "0000-0003-2141-0247", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/54cc533c598a45b69b437489a3e82a6a.json"}}, {"family": "Davies", "given": "Hanna", "initials": "H", "orcid": "0000-0002-6289-3815", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/888e384e2507499bbff9971cfa5f2370.json"}}, {"family": "Chojnowska", "given": "Katarzyna", "initials": "K", "orcid": "0000-0002-5571-6618", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/62c056bcb8d64949b3cae6753ceee075.json"}}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P", "orcid": "0000-0002-2788-5254", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f34db06bf7ea4a698e4227ae6c9ecf80.json"}}, {"family": "Bie\u0144kowski", "given": "Micha\u0142", "initials": "M"}, {"family": "Jankowski", "given": "Micha\u0142", "initials": "M"}, {"family": "Rostkowska", "given": "Olga", "initials": "O"}, {"family": "Hellmann", "given": "Andrzej", "initials": "A"}, {"family": "P\u0119ksa", "given": "Rafa\u0142", "initials": "R"}, {"family": "Kowalski", "given": "Jacek", "initials": "J"}, {"family": "Zdrenka", "given": "Marek", "initials": "M"}, {"family": "Kobiela", "given": "Jarek", "initials": "J"}, {"family": "Zegarski", "given": "Wojciech", "initials": "W"}, {"family": "Biernat", "given": "Wojciech", "initials": "W"}, {"family": "Szylberg", "given": "\u0141ukasz", "initials": "\u0141"}, {"family": "Remiszewski", "given": "Piotr", "initials": "P"}, {"family": "Mieczkowski", "given": "Jakub", "initials": "J", "orcid": "0000-0002-2091-012X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1f3a661ef734ec6bbe55e6969eedc80.json"}}, {"family": "Filipowicz", "given": "Natalia", "initials": "N", "orcid": "0000-0002-9673-2649", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/64588db686e244778a885aebaa19c2c2.json"}}, {"family": "Dumanski", "given": "Jan P", "initials": "JP", "orcid": "0000-0002-1489-1452", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cc9bc35062e3496785fe8ea665861ed2.json"}}], "type": "posted-content", "published": "2023-06-22", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.06.17.23289722", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:46:50.936Z", "modified": "2026-08-20T10:46:51.154Z"}, {"entity": "publication", "iuid": "f062326b8cb24c5fa961bac68ae34a5b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f062326b8cb24c5fa961bac68ae34a5b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f062326b8cb24c5fa961bac68ae34a5b"}}, "title": "Size matters: the impact of nucleus size on results from spatial transcriptomics.", "authors": [{"family": "Mohammadi", "given": "Elyas", "initials": "E"}, {"family": "Chojnowska", "given": "Katarzyna", "initials": "K"}, {"family": "Bie\u0144kowski", "given": "Micha\u0142", "initials": "M"}, {"family": "Kostecka", "given": "Anna", "initials": "A"}, {"family": "Koczkowska", "given": "Magdalena", "initials": "M"}, {"family": "\u017bmijewski", "given": "Micha\u0142 A", "initials": "MA"}, {"family": "J\u0105kalski", "given": "Marcin", "initials": "M"}, {"family": "Ingelsson", "given": "Martin", "initials": "M"}, {"family": "Filipowicz", "given": "Natalia", "initials": "N"}, {"family": "Olszewski", "given": "Pawe\u0142", "initials": "P"}, {"family": "Davies", "given": "Hanna", "initials": "H"}, {"family": "Wierzbicka", "given": "Justyna M", "initials": "JM"}, {"family": "Hyman", "given": "Bradley T", "initials": "BT"}, {"family": "Dumanski", "given": "Jan P", "initials": "JP"}, {"family": "Piotrowski", "given": "Arkadiusz", "initials": "A"}, {"family": "Mieczkowski", "given": "Jakub", "initials": "J", "orcid": "0000-0002-2091-012X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b1f3a661ef734ec6bbe55e6969eedc80.json"}}], "type": "journal article", "published": "2023-04-21", "journal": {"title": "J Transl Med", "issn": "1479-5876", "volume": "21", "issue": "1", "pages": "270", "issn-l": "1479-5876"}, "abstract": "Visium Spatial Gene Expression (ST) is a method combining histological spatial information with transcriptomics profiles directly from tissue sections. The use of spatial information has made it possible to discover new modes of gene expression regulations. However, in the ST experiment, the nucleus size of cells may exceed the thickness of a tissue slice. This may, in turn, negatively affect comprehensive capturing the transcriptomics profile in a single slice, especially for tissues having large differences in the size of nuclei.\n\nHere, we defined the effect of Consecutive Slices Data Integration (CSDI) on unveiling accurate spot clustering and deconvolution of spatial transcriptomic spots in human postmortem brains. By considering the histological information as reference, we assessed the improvement of unsupervised clustering and single nuclei RNA-seq and ST data integration before and after CSDI.\n\nApart from the escalated number of defined clusters representing neuronal layers, the pattern of clusters in consecutive sections was concordant only after CSDI. Besides, the assigned cell labels to spots matches the histological pattern of tissue sections after CSDI.\n\nCSDI can be applied to investigate consecutive sections studied with ST in the human cerebral cortex, avoiding misinterpretation of spot clustering and annotation, increasing accuracy of cell recognition as well as improvement in uncovering the layers of grey matter in the human brain.", "doi": "10.1186/s12967-023-04129-z", "pmid": "37081484", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10120157"}, {"db": "pii", "key": "10.1186/s12967-023-04129-z"}], "notes": [], "created": "2026-08-20T12:20:55.740Z", "modified": "2026-08-20T12:20:55.782Z"}]}