{"entity": "researcher", "timestamp": "2026-08-20T21:02:19.134Z", "family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "affiliations": ["Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38"}}, "publications": [{"entity": "publication", "iuid": "2ba3b04b1f1d452faa4d842bc7873152", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2ba3b04b1f1d452faa4d842bc7873152.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2ba3b04b1f1d452faa4d842bc7873152"}}, "title": "Revealing molecular determinants of ligand efficacy and affinity at the D 2 dopamine receptor through molecular dynamics simulations", "authors": [{"family": "Chen", "given": "Yue", "initials": "Y"}, {"family": "Kahlous", "given": "Nour Aldin", "initials": "NA", "orcid": "0000-0002-7744-1491", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ed14cfbd31384338928150f4a97aee16.json"}}, {"family": "Saarinen", "given": "Marcus", "initials": "M", "orcid": "0000-0001-9019-8396", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7fad8ab6acf406d940ae2af691a07a3.json"}}, {"family": "Conesa", "given": "Sergio Perez", "initials": "SP", "orcid": "0000-0003-1951-2543", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/656db9d5b4eb4e9892dc39f0914b54a6.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Delemotte", "given": "Lucie", "initials": "L", "orcid": "0000-0002-0828-3899", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/87eaf619d7bd487ebdbe68c46b827e66.json"}}, {"family": "Carlsson", "given": "Jens", "initials": "J", "orcid": "0000-0003-4623-2977", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/792c1cd4aca248dc94b967115ffa82df.json"}}], "type": "posted-content", "published": "2025-04-03", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.03.30.646192", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:01:59.013Z", "modified": "2026-08-20T11:01:59.102Z"}, {"entity": "publication", "iuid": "dafbc8d8e2b3458384f7fbd1a1b7611b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/dafbc8d8e2b3458384f7fbd1a1b7611b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/dafbc8d8e2b3458384f7fbd1a1b7611b"}}, "title": "Met-ID: An Open-Source Software for Comprehensive Annotation of Multiple On-Tissue Chemical Modifications in MALDI-MSI", "authors": [{"family": "Bj\u00e4rterot", "given": "Patrik", "initials": "P", "orcid": "0000-0002-4350-5530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a958cde39e9471881c0282f9d62f39c.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R", "orcid": "0000-0001-9484-0921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76faa76e9dc445a3bbb1f470e9d33a23.json"}}, {"family": "Vallianatou", "given": "Theodosia", "initials": "T", "orcid": "0000-0002-1477-7756", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4374524ab2c14bd9ae46f904144dea63.json"}}, {"family": "Kaya", "given": "Ibrahim", "initials": "I", "orcid": "0000-0003-3345-5602", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/43885795cb254e2cba6fe8b538fbfaef.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "K\u00e4ll", "given": "Lukas", "initials": "L", "orcid": "0000-0001-5689-9797", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4464f2bf868498fa6d149a4a6d60e8b.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}], "type": "posted-content", "published": "2025-01-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2025.01.24.634674", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T11:00:40.199Z", "modified": "2026-08-20T11:00:40.313Z"}, {"entity": "publication", "iuid": "853228a414e14910b40095bc20ee75dd", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/853228a414e14910b40095bc20ee75dd.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/853228a414e14910b40095bc20ee75dd"}}, "title": "Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.", "authors": [{"family": "Kotliar", "given": "Ilana B", "initials": "IB", "orcid": "0000-0001-9533-4828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9066d33009cd4504a71287b07b54848e.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b84a8aa3e3b4439bb0b3a9fabdebcb70.json"}}, {"family": "Dahl", "given": "Leo", "initials": "L", "orcid": "0000-0003-1492-3052", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f357e135f9e43999d78db11ae5f0f40.json"}}, {"family": "Chen", "given": "Yuanhuang", "initials": "Y", "orcid": "0000-0001-7404-5170", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/127d5bd92dc249bca07717402dee4006.json"}}, {"family": "Saarinen", "given": "Marcus", "initials": "M"}, {"family": "Ceraudo", "given": "Emilie", "initials": "E", "orcid": "0000-0001-6563-9751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1f8126992cd4ae9afc3852054d93270.json"}}, {"family": "Dodig-Crnkovi\u0107", "given": "Tea", "initials": "T", "orcid": "0000-0002-2875-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5365873ed6a7463485fb44550a4826ec.json"}}, {"family": "Uhl\u00e9n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Sakmar", "given": "Thomas P", "initials": "TP", "orcid": "0000-0002-2836-8953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff78d726542d46a4984572ea8fed0931.json"}}], "type": "journal article", "published": "2024-08-02", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "10", "issue": "31", "pages": "eado9959", "issn-l": "2375-2548"}, "abstract": "Receptor activity-modifying proteins (RAMPs) form complexes with G protein-coupled receptors (GPCRs) and may regulate their cellular trafficking and pharmacology. RAMP interactions have been identified for about 50 GPCRs, but only a few GPCR-RAMP complexes have been studied in detail. To elucidate a comprehensive GPCR-RAMP interactome, we created a library of 215 dual epitope-tagged (DuET) GPCRs representing all GPCR subfamilies and coexpressed each GPCR with each of the three RAMPs. Screening the GPCR-RAMP pairs with customized multiplexed suspension bead array (SBA) immunoassays, we identified 122 GPCRs that showed strong evidence for interaction with at least one RAMP. We screened for interactions in three cell lines and found 23 endogenously expressed GPCRs that formed complexes with RAMPs. Mapping the GPCR-RAMP interactome expands the current system-wide functional characterization of RAMP-interacting GPCRs to inform the design of selective therapeutics targeting GPCR-RAMP complexes.", "doi": "10.1126/sciadv.ado9959", "pmid": "39083597", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11290489"}], "notes": [], "created": "2026-08-20T11:58:48.742Z", "modified": "2026-08-20T11:58:48.924Z"}, {"entity": "publication", "iuid": "d258c9592d164cf2bda6526b2c87966c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d258c9592d164cf2bda6526b2c87966c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d258c9592d164cf2bda6526b2c87966c"}}, "title": "Expanding the GPCR-RAMP interactome.", "authors": [{"family": "Kotliar", "given": "Ilana B", "initials": "IB", "orcid": "0000-0001-9533-4828", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9066d33009cd4504a71287b07b54848e.json"}}, {"family": "Bendes", "given": "Annika", "initials": "A", "orcid": "0000-0001-9329-2353", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b84a8aa3e3b4439bb0b3a9fabdebcb70.json"}}, {"family": "Dahl", "given": "Leo", "initials": "L", "orcid": "0000-0003-1492-3052", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8f357e135f9e43999d78db11ae5f0f40.json"}}, {"family": "Chen", "given": "Yuanhuang", "initials": "Y", "orcid": "0000-0001-7404-5170", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/127d5bd92dc249bca07717402dee4006.json"}}, {"family": "Saarinen", "given": "Marcus", "initials": "M", "orcid": "0000-0001-9019-8396", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e7fad8ab6acf406d940ae2af691a07a3.json"}}, {"family": "Ceraudo", "given": "Emilie", "initials": "E", "orcid": "0000-0001-6563-9751", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1f8126992cd4ae9afc3852054d93270.json"}}, {"family": "Dodig-Crnkovi\u0107", "given": "Tea", "initials": "T", "orcid": "0000-0002-2875-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5365873ed6a7463485fb44550a4826ec.json"}}, {"family": "Uhle'n", "given": "Mathias", "initials": "M", "orcid": "0000-0002-4858-8056", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9ea446aa574042a295d5f69437402f76.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Schwenk", "given": "Jochen M", "initials": "JM", "orcid": "0000-0001-8141-8449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/022e140799b6466ea123319c3d70c76e.json"}}, {"family": "Sakmar", "given": "Thomas P", "initials": "TP", "orcid": "0000-0002-2836-8953", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ff78d726542d46a4984572ea8fed0931.json"}}], "type": "preprint", "published": "2023-11-23", "journal": {"title": "bioRxiv", "issn": "2692-8205", "issn-l": null}, "abstract": "Receptor activity-modifying proteins (RAMPs) can form complexes with G protein-coupled receptors (GPCRs) and regulate their cellular trafficking and pharmacology. RAMP interactions have been identified for about 50 GPCRs, but only a few GPCR-RAMP complexes have been studied in detail. To elucidate a complete interactome between GPCRs and the three RAMPs, we developed a customized library of 215 Dual Epitope-Tagged (DuET) GPCRs representing all GPCR subfamilies. Using a multiplexed suspension bead array (SBA) assay, we identified 122 GPCRs that showed strong evidence for interaction with at least one RAMP. We screened for native interactions in three cell lines and found 23 GPCRs that formed complexes with RAMPs. Mapping the GPCR-RAMP interactome expands the current system-wide functional characterization of RAMP-interacting GPCRs to inform the design of selective GPCR-targeted therapeutics.", "doi": "10.1101/2023.11.22.568247", "pmid": "38045268", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10690247"}, {"db": "pii", "key": "2023.11.22.568247"}], "notes": [], "created": "2026-08-20T10:50:30.835Z", "modified": "2026-08-20T10:50:31.027Z"}, {"entity": "publication", "iuid": "93bba24e1e8247789d1eca1dc8e97bb8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/93bba24e1e8247789d1eca1dc8e97bb8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/93bba24e1e8247789d1eca1dc8e97bb8"}}, "title": "Cortex-wide topography of 1/f-exponent in Parkinson's disease.", "authors": [{"family": "Helson", "given": "Pascal", "initials": "P", "orcid": "0000-0002-2877-3705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ee66ee661c64a4a89df82afceff2e11.json"}}, {"family": "Lundqvist", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1593-2559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06fbc4c5ba644ef4b6ebeb1cc39c7f08.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Vinding", "given": "Mikkel C", "initials": "MC", "orcid": "0000-0002-7954-2886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaff4ee9c23497ba518325c7997701b.json"}}, {"family": "Kumar", "given": "Arvind", "initials": "A"}], "type": "journal article", "published": "2023-07-13", "journal": {"title": "NPJ Parkinsons Dis", "issn": "2373-8057", "volume": "9", "issue": "1", "pages": "109", "issn-l": null}, "abstract": "Parkinson's disease (PD) is a progressive and debilitating brain disorder. Besides the characteristic movement-related symptoms, the disease also causes decline in sensory and cognitive processing. The extent of symptoms and brain-wide projections of neuromodulators such as dopamine suggest that many brain regions are simultaneously affected in PD. To characterise brain-wide disease-related changes in neuronal function, we analysed resting state magnetoencephalogram (MEG) from two groups: PD patients and healthy controls. Besides standard spectral analysis, we quantified the aperiodic components (\u03ba, \u03bb) of the neural activity by fitting a power law \u03ba/f\u03bb - f is the frequency, \u03ba and \u03bb are the fitting parameters-to the MEG power spectrum and studied its relationship with age and Unified Parkinson's Disease Rating Scale (UPDRS). Consistent with previous results, the most significant spectral changes were observed in the high theta/low-alpha band (7-10 Hz) in all brain regions. Furthermore, analysis of the aperiodic part of the spectrum showed that in all but frontal regions \u03bb was significantly larger in PD patients than in control subjects. Our results indicate that PD is associated with significant changes in aperiodic activity across the whole neocortex. Surprisingly, even early sensory areas showed a significantly larger \u03bb in patients than in healthy controls. Moreover, \u03bb was not affected by the Levodopa medication. Finally, \u03bb was positively correlated with patient age but not with UPDRS-III. Because \u03bb is closely associated with excitation-inhibition balance, our results propose new hypotheses about neural correlates of PD in cortical networks.", "doi": "10.1038/s41531-023-00553-6", "pmid": "37438362", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10338503"}, {"db": "pii", "key": "10.1038/s41531-023-00553-6"}], "notes": [], "created": "2026-08-20T08:54:37.789Z", "modified": "2026-08-20T08:54:37.957Z"}, {"entity": "publication", "iuid": "43dd478910cd4608833943ade088205f", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/43dd478910cd4608833943ade088205f.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/43dd478910cd4608833943ade088205f"}}, "title": "Spatial Multimodal Analysis of Transcriptomes and Metabolomes in Tissues", "authors": [{"family": "Vicari", "given": "Marco", "initials": "M", "orcid": "0000-0002-3042-6278", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7c1ea4f9a5cf48a6ace7cf53c6334548.json"}}, {"family": "Mirzazadeh", "given": "Reza", "initials": "R", "orcid": "0000-0003-0554-080X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cf9cc546c2e48b7a63ca6d236639fe1.json"}}, {"family": "Nilsson", "given": "Anna", "initials": "A"}, {"family": "Shariatgorji", "given": "Reza", "initials": "R", "orcid": "0000-0001-9484-0921", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/76faa76e9dc445a3bbb1f470e9d33a23.json"}}, {"family": "Bj\u00e4rterot", "given": "Patrik", "initials": "P", "orcid": "0000-0002-4350-5530", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0a958cde39e9471881c0282f9d62f39c.json"}}, {"family": "Larsson", "given": "Ludvig", "initials": "L", "orcid": "0000-0003-4209-2911", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/36ad34c94b64432ab74d61fbc6d16905.json"}}, {"family": "Lee", "given": "Hower", "initials": "H", "orcid": "0000-0002-8781-3623", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3fd12772d55148518ab8944c401d3820.json"}}, {"family": "Nilsson", "given": "Mats", "initials": "M", "orcid": "0000-0001-9985-0387", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3311155f09a64b4f88d673da2a40627b.json"}}, {"family": "Foyer", "given": "Julia", "initials": "J"}, {"family": "Ekvall", "given": "Markus", "initials": "M", "orcid": "0000-0001-6942-0458", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18a639299c9b4970ab7be3d5f08723e9.json"}}, {"family": "Czarnewski", "given": "Paulo", "initials": "P", "orcid": "0000-0001-8150-4021", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/501677a1262c438aa4077b205bb39a72.json"}}, {"family": "Zhang", "given": "Xiaoqun", "initials": "X"}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Andr\u00e9n", "given": "Per E", "initials": "PE", "orcid": "0000-0002-4062-7743", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f1dd27e8b238475383983480e10099f6.json"}}, {"family": "Lundeberg", "given": "Joakim", "initials": "J", "orcid": "0000-0003-4313-1601", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d9fa47767cd14ef2b9528c8b998cf095.json"}}], "type": "posted-content", "published": "2023-01-27", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.01.26.525195", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:43:33.199Z", "modified": "2026-08-20T10:43:33.457Z"}, {"entity": "publication", "iuid": "fd2dcf41e7b849259a479369ec513c93", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/fd2dcf41e7b849259a479369ec513c93.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/fd2dcf41e7b849259a479369ec513c93"}}, "title": "Cortex-wide topography of 1/f-exponent in Parkinson\u2019s disease", "authors": [{"family": "Helson", "given": "Pascal", "initials": "P", "orcid": "0000-0002-2877-3705", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0ee66ee661c64a4a89df82afceff2e11.json"}}, {"family": "Lundqvist", "given": "Daniel", "initials": "D", "orcid": "0000-0003-1593-2559", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/06fbc4c5ba644ef4b6ebeb1cc39c7f08.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Vinding", "given": "Mikkel C", "initials": "MC", "orcid": "0000-0002-7954-2886", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ccaff4ee9c23497ba518325c7997701b.json"}}, {"family": "Kumar", "given": "Arvind", "initials": "A", "orcid": "0000-0002-8044-9195", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf2fe30252074acb8d09f88f6c9b55f3.json"}}], "type": "posted-content", "published": "2023-01-20", "journal": {"issn-l": null}, "abstract": null, "doi": "10.1101/2023.01.19.524792", "pmid": null, "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T10:43:31.079Z", "modified": "2026-08-20T10:43:31.221Z"}, {"entity": "publication", "iuid": "59b004c7df1d4131a8eedb6051b9167b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/59b004c7df1d4131a8eedb6051b9167b"}}, "title": "Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.", "authors": [{"family": "Bergstr\u00f6m", "given": "Sofia", "initials": "S", "orcid": "0000-0003-2910-4754", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/552414173f564ce4b813e107812f446d.json"}}, {"family": "Remnest\u00e5l", "given": "Julia", "initials": "J", "orcid": "0000-0002-3908-6476", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0122e5bb49d3421696fcbb64f99eea41.json"}}, {"family": "Yousef", "given": "Jamil", "initials": "J", "orcid": "0000-0001-5915-1258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0c4a7070f339466690b40d63ad6ea769.json"}}, {"family": "Olofsson", "given": "Jennie", "initials": "J", "orcid": "0000-0002-8593-9089", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0dc7102e4f24b2a9d3f1251fe80f569.json"}}, {"family": "Markaki", "given": "Ioanna", "initials": "I", "orcid": "0000-0003-3328-5746", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f31c405d780a4beeb64971dabd57cafd.json"}}, {"family": "Carvalho", "given": "Stephanie", "initials": "S"}, {"family": "Corvol", "given": "Jean-Christophe", "initials": "JC", "orcid": "0000-0001-7325-0199", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/81bf347acb7349dfa3d7c22483c1fba4.json"}}, {"family": "Kultima", "given": "Kim", "initials": "K", "orcid": "0000-0002-0680-1410", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b7dd4024d15a43a4a2395315af99d580.json"}}, {"family": "Kilander", "given": "Lena", "initials": "L"}, {"family": "L\u00f6wenmark", "given": "Malin", "initials": "M"}, {"family": "Ingelsson", "given": "Martin", "initials": "M", "orcid": "0000-0001-5466-8370", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9cdd74196957459fa3618c6bd2c35ff8.json"}}, {"family": "Blennow", "given": "Kaj", "initials": "K", "orcid": "0000-0002-1890-4193", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/57f920b41aab42f0a43a32bbe34035b2.json"}}, {"family": "Zetterberg", "given": "Henrik", "initials": "H", "orcid": "0000-0003-3930-4354", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/18365a2ea4ec4ca2baeb657cd1c8bd8f.json"}}, {"family": "Nellg\u00e5rd", "given": "Bengt", "initials": "B", "orcid": "0000-0001-6791-8893", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0815ffb8b9404272a26b28cb11f001ba.json"}}, {"family": "Brosseron", "given": "Frederic", "initials": "F", "orcid": "0000-0003-3137-7516", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2d8a371f4aaa4ba59389f30bd9349c1f.json"}}, {"family": "Heneka", "given": "Michael T", "initials": "MT", "orcid": "0000-0003-4996-1630", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8da023abc6974d4582fe3c688a483950.json"}}, {"family": "Bosch", "given": "Beatriz", "initials": "B", "orcid": "0000-0002-6094-0024", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dd5741747488412c9c8334a97e7302ad.json"}}, {"family": "Sanchez-Valle", "given": "Raquel", "initials": "R", "orcid": "0000-0001-7750-896X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2bba6a10e4cd4b0180ccc900d70fd869.json"}}, {"family": "M\u00e5nberg", "given": "Anna", "initials": "A", "orcid": "0000-0002-0056-1313", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/1ccc9581865849c285b687a4670bbf2b.json"}}, {"family": "Svenningsson", "given": "Per", "initials": "P", "orcid": "0000-0001-6727-3802", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b01bbacfa24e4b9794734bf1121d1c38.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}], "type": "journal article", "published": "2021-07-00", "journal": {"title": "Ann Clin Transl Neurol", "issn": "2328-9503", "volume": "8", "issue": "7", "pages": "1456-1470", "issn-l": "2328-9503"}, "abstract": "Decreased amyloid beta (A\u03b2) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.\n\nWe utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification.\n\nSix proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A\u03b242 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations.\n\nIn conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.", "doi": "10.1002/acn3.51402", "pmid": "34129723", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8283172"}], "notes": [], "created": "2026-08-20T06:27:18.835Z", "modified": "2026-08-20T06:27:19.431Z"}]}