{"entity": "researcher", "timestamp": "2026-08-22T07:49:53.442Z", "family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "affiliations": ["Department of Medical Biochemistry and Biophysics, Division of Medical Inflammation Research, Karolinska Institute, Stockholm, Stockholm County, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438"}}, "publications": [{"entity": "publication", "iuid": "b08136ee77f24b80bcc3baba86390e5c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/b08136ee77f24b80bcc3baba86390e5c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/b08136ee77f24b80bcc3baba86390e5c"}}, "title": "Comparative Analysis of Salivary and Serum Inflammatory Mediator Profiles in Patients With Rheumatoid Arthritis and Periodontitis.", "authors": [{"family": "Fei", "given": "Carina", "initials": "C", "orcid": "0009-0009-1355-0574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8803763f26784bc7a2e57189ffede5bf.json"}}, {"family": "Eriksson", "given": "Kaja", "initials": "K", "orcid": "0000-0002-9490-8540", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0d39119dc8a64c1383a831b68b53924a.json"}}, {"family": "Fei", "given": "Guozhong", "initials": "G"}, {"family": "Delgado Zambrano", "given": "Luis Fernando", "initials": "LF", "orcid": "0000-0001-7850-5285", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6cc1ff30e43d44a9b495d7c9b71198f6.json"}}, {"family": "Syed", "given": "Shigufta", "initials": "S"}, {"family": "Lindstr\u00f6m", "given": "Caroline", "initials": "C"}, {"family": "Ericson", "given": "Martina", "initials": "M"}, {"family": "Mohammadi", "given": "Mehrad", "initials": "M", "orcid": "0009-0006-0907-6046", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c7404d6fae574afeacb5fc81a7add542.json"}}, {"family": "Tsilingaridis", "given": "Georgios", "initials": "G", "orcid": "0000-0001-5361-5840", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/bfc2da9a9e0943399f9157acf3bd89f2.json"}}, {"family": "Guenifi", "given": "Amel", "initials": "A"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}, {"family": "Jansson", "given": "Leif", "initials": "L", "orcid": "0000-0001-5923-5777", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/613c58c53d7f4958868f74ddcb487100.json"}}, {"family": "Yucel-Lindberg", "given": "T\u00fclay", "initials": "T", "orcid": "0000-0003-0129-8809", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/314bbc7c0b64452b961dc73448494cf5.json"}}], "type": "journal article", "published": "2025-03-20", "journal": {"title": "Mediators Inflamm.", "issn": "1466-1861", "volume": "2025", "pages": "7739833", "issn-l": "0962-9351"}, "abstract": "Background: Periodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory conditions, characterized by dysregulated immune response and excessive production of inflammatory mediators. The oral disease PD is triggered by periodontal pathogens, leading to the destruction of tissues surrounding the teeth, whereas RA is a systemic autoimmune disease primarily affecting the joints. The objective of this study was to investigate the prevalence of PD and map the profile of salivary and serum inflammatory mediators of patients with RA, with respect to periodontal severity (PD stage II and PD stage III/IV). Methods: For this cross-sectional cohort study, 62 patients diagnosed with RA were recruited. All participants underwent a full-mouth dental examination. Levels of various inflammatory mediators, including tumor necrosis factor (TNF) superfamily proteins, interferon (IFN) family proteins, regulatory T cell (Treg) cytokines, and matrix metalloproteinases were determined in saliva and serum samples from each participant using a human inflammation multiplex immunoassay panel. Results: In the current RA cohort, all participants were diagnosed with PD, of which 35.5% were classified as PD stage II and 64.5% as PD stages III/IV. Inflammatory mediator levels were significantly higher in both saliva and serum samples from patients with RA and PD stages III/IV, compared to those with RA and stage II within the same cohort. These included higher serum levels of sCD30, IL-10, IL-19, osteopontin and elevated salivary levels of BAFF/TNFSF13B and IFN-\u03b12. Additionally, APRIL/TNFSF13 levels were increased in both saliva and serum. Conclusions: Among the studied patients with RA, the majority exhibited severe PD (stage III/IV), underscoring the importance of periodontal prophylaxis and treatment for this group of patients. Higher levels of inflammatory mediators were observed in both saliva and serum in those with PD stages III/IV, suggesting a potential link between the severity of PD and systemic inflammation in RA. Further research is needed to explore the clinical implications of these findings.", "doi": "10.1155/mi/7739833", "pmid": "40151315", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC11949604"}], "notes": [], "created": "2026-08-21T12:28:28.695Z", "modified": "2026-08-21T12:28:29.004Z"}, {"entity": "publication", "iuid": "6538516184c34387bbd73b670be1f443", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/6538516184c34387bbd73b670be1f443"}}, "title": "NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.", "authors": [{"family": "Linge", "given": "Petrus", "initials": "P", "orcid": "0000-0001-8906-2715", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c83a8ed6a2ac4711b0465b6dfbcabcc9.json"}}, {"family": "Arve", "given": "Sabine", "initials": "S", "orcid": "0000-0002-3347-5550", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d063b42c4af42efbba4afb26b9a9fd3.json"}}, {"family": "Olsson", "given": "Lina M", "initials": "LM"}, {"family": "Leonard", "given": "Dag", "initials": "D"}, {"family": "Sj\u00f6wall", "given": "Christopher", "initials": "C", "orcid": "0000-0003-0900-2048", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a9fcc24622ec440bac6996072cceea0e.json"}}, {"family": "Frodlund", "given": "Martina", "initials": "M"}, {"family": "Gunnarsson", "given": "Iva", "initials": "I"}, {"family": "Svenungsson", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3396-3244", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2c44ebd4f33e46a1862877bce94be05b.json"}}, {"family": "Tyd\u00e9n", "given": "Helena", "initials": "H"}, {"family": "J\u00f6nsen", "given": "Andreas", "initials": "A"}, {"family": "Kahn", "given": "Robin", "initials": "R", "orcid": "0000-0002-3167-1179", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/17ecdb4f26a648ba9ee080bb72a86c82.json"}}, {"family": "Johansson", "given": "\u00c5sa", "initials": "\u00c5"}, {"family": "R\u00f6nnblom", "given": "Lars", "initials": "L"}, {"family": "Holmdahl", "given": "Rikard", "initials": "R", "orcid": "0000-0002-4969-2576", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aef6264212044f46a28c24d5fc147438.json"}}, {"family": "Bengtsson", "given": "Anders", "initials": "A"}], "type": "journal article", "published": "2020-02-00", "journal": {"title": "Ann. Rheum. Dis.", "issn": "1468-2060", "volume": "79", "issue": "2", "pages": "254-261", "issn-l": "0003-4967"}, "abstract": "\u200bOBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). This study aimed at characterising NCF1-339 effects on neutrophil extracellular trap (NET) formation, type I interferon activity and antibody profile in patients with SLE. \u200bMETHODS: Neutrophil NET-release pathways (n=31), serum interferon (n=141) and finally antibody profiles (n=305) were investigated in SLE subjects from Lund, genotyped for NCF1-339. Then, 1087 SLE subjects from the rheumatology departments of four Swedish SLE centres, genotyped for NCF1-339, were clinically characterised to validate these findings. \u200bRESULTS: Compared with patients with normal-ROS NCF1-339 genotypes, neutrophils from patients with SLE with low-ROS NCF1-339 genotypes displayed impaired NET formation (p<0.01) and increased dependence on mitochondrial ROS (p<0.05). Low-ROS patients also had increased frequency of high serum interferon activity (80% vs 21.4%, p<0.05) and positivity for anti-\u03b22 glycoprotein I (p<0.01) and anticardiolipin antibodies (p<0.05) but were not associated with other antibodies. We confirmed an over-representation of having any antiphospholipid antibody, OR 1.40 (95% CI 1.01 to 1.95), anti-\u03b22 glycoprotein I, OR 1.82 (95% CI 1.02 to 3.24) and the antiphospholipid syndrome (APS), OR 1.74 (95% CI 1.19 to 2.55) in all four cohorts (n=1087). \u200bCONCLUSIONS: The NCF1-339 SNP mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of NETs in SLE, allowing dependence on mitochondrial ROS. Unexpectedly, we revealed a striking connection between the ROS deficient NCF1-339 genotypes and the presence of phospholipid antibodies and APS.", "doi": "10.1136/annrheumdis-2019-215820", "pmid": "31704719", "labels": [], "xrefs": [{"db": "pii", "key": "S0003-4967(24)01509-7"}], "notes": [], "created": "2026-08-21T12:25:45.018Z", "modified": "2026-08-21T12:25:45.336Z"}]}