{"entity": "researcher", "timestamp": "2026-09-23T15:39:05.259Z", "family": "Holmgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-2656-1864", "affiliations": ["Therapeutic Immune Design, Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institute, 171 76 Stockholm, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae381ba7a9624e0c9361a56bcf2fea74.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae381ba7a9624e0c9361a56bcf2fea74"}}, "publications": [{"entity": "publication", "iuid": "f558da18bac541259b0db98a200aca1e", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/f558da18bac541259b0db98a200aca1e.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/f558da18bac541259b0db98a200aca1e"}}, "title": "Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis.", "authors": [{"family": "Thomas", "given": "Olivia G", "initials": "OG", "orcid": "0000-0002-2011-1344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa20c46e0931406cafb75381f1fbabb8.json"}}, {"family": "Bronge", "given": "Mattias", "initials": "M", "orcid": "0000-0002-1258-3982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf585179ce31448a90a9b6b585214637.json"}}, {"family": "Tengvall", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0424-3571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8f6227041cc44b1bd163c99956bba78.json"}}, {"family": "Akpinar", "given": "Birce", "initials": "B"}, {"family": "Nilsson", "given": "Ola B", "initials": "OB"}, {"family": "Holmgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-2656-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae381ba7a9624e0c9361a56bcf2fea74.json"}}, {"family": "Hessa", "given": "Tara", "initials": "T"}, {"family": "Gafvelin", "given": "Guro", "initials": "G", "orcid": "0000-0003-1618-4011", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d527debbb4246ddb4d35dd6b0903028.json"}}, {"family": "Khademi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-0801-1444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22f8dcc673264db484e284e484bc7311.json"}}, {"family": "Alfredsson", "given": "Lars", "initials": "L", "orcid": "0000-0003-1688-6697", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3066044ee78743db8fbd2a94e24059cf.json"}}, {"family": "Martin", "given": "Roland", "initials": "R", "orcid": "0000-0002-0982-1329", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c05061445fcc4a5997a39a38cabcb3a3.json"}}, {"family": "Guerreiro-Cacais", "given": "Andr\u00e9 Ortlieb", "initials": "AO", "orcid": "0000-0002-4561-2823", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c2ecf483cb7442b9de5c99dcc11c1a5.json"}}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H", "orcid": "0000-0003-4882-7624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b91c9201b4d64b5b8d000d1f89e53be6.json"}}, {"family": "Olsson", "given": "Tomas", "initials": "T", "orcid": "0000-0002-2938-1877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2003b9ba415e422fa27b0c7fdce9497f.json"}}, {"family": "Kockum", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0867-4726", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/044ff0f987a642c7aa2aef33fe1d7ecd.json"}}], "type": "journal article", "published": "2023-05-19", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "9", "issue": "20", "pages": "eadg3032", "issn-l": "2375-2548"}, "abstract": "Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which and Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between Epstein-Barr nuclear antigen 1 (EBNA1) and alpha-crystallin B (CRYAB), we examined antibody reactivity to EBNA1 and CRYAB peptide libraries in 713 persons with MS (pwMS) and 722 matched controls (Con). Antibody response to CRYAB amino acids 7 to 16 was associated with MS (OR = 2.0), and combination of high EBNA1 responses with CRYAB positivity markedly increased disease risk (OR = 9.0). Blocking experiments revealed antibody cross-reactivity between the homologous EBNA1 and CRYAB epitopes. Evidence for T cell cross-reactivity was obtained in mice between EBNA1 and CRYAB, and increased CRYAB and EBNA1 CD4+ T cell responses were detected in natalizumab-treated pwMS. This study provides evidence for antibody cross-reactivity between EBNA1 and CRYAB and points to a similar cross-reactivity in T cells, further demonstrating the role of EBV adaptive immune responses in MS development.", "doi": "10.1126/sciadv.adg3032", "pmid": "37196088", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC10191428"}], "notes": [], "created": "2026-09-23T07:29:43.761Z", "modified": "2026-09-23T07:29:44.164Z"}, {"entity": "publication", "iuid": "19f1838c0542481484e93214d3cd6b42", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/19f1838c0542481484e93214d3cd6b42.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/19f1838c0542481484e93214d3cd6b42"}}, "title": "Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.", "authors": [{"family": "Bronge", "given": "Mattias", "initials": "M", "orcid": "0000-0002-1258-3982", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/cf585179ce31448a90a9b6b585214637.json"}}, {"family": "H\u00f6gelin", "given": "Klara Asplund", "initials": "KA"}, {"family": "Thomas", "given": "Olivia G", "initials": "OG", "orcid": "0000-0002-2011-1344", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa20c46e0931406cafb75381f1fbabb8.json"}}, {"family": "Ruhrmann", "given": "Sabrina", "initials": "S"}, {"family": "Carvalho-Queiroz", "given": "Claudia", "initials": "C"}, {"family": "Nilsson", "given": "Ola B", "initials": "OB"}, {"family": "Kaiser", "given": "Andreas", "initials": "A"}, {"family": "Zeitelhofer", "given": "Manuel", "initials": "M"}, {"family": "Holmgren", "given": "Erik", "initials": "E", "orcid": "0000-0002-2656-1864", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae381ba7a9624e0c9361a56bcf2fea74.json"}}, {"family": "Linnerbauer", "given": "Mathias", "initials": "M", "orcid": "0000-0002-5528-5141", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7caf4ce60f6441089c2df1a02e4379b6.json"}}, {"family": "Adzemovic", "given": "Milena Z", "initials": "MZ"}, {"family": "Hellstr\u00f6m", "given": "Cecilia", "initials": "C", "orcid": "0000-0003-0880-5375", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2a4f6cc50f094d36a281821ca78821a0.json"}}, {"family": "Jelcic", "given": "Ivan", "initials": "I", "orcid": "0000-0002-6187-7098", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3317b07cac4b4d3d8a8bba30a02506db.json"}}, {"family": "Liu", "given": "Hao", "initials": "H", "orcid": "0000-0001-6572-2870", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8fd3a1e88f8b4363950aedfe5fe07383.json"}}, {"family": "Nilsson", "given": "Peter", "initials": "P", "orcid": "0000-0002-4657-8532", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3db33fa3edb94febb8be7927a16838d0.json"}}, {"family": "Hillert", "given": "Jan", "initials": "J", "orcid": "0000-0002-7386-6732", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6f661fc2c98a4568a0fae89601b64f33.json"}}, {"family": "Brundin", "given": "Lou", "initials": "L", "orcid": "0000-0003-4408-7817", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/285bd0f3b11147c2a547a3239ea5f226.json"}}, {"family": "Fink", "given": "Katharina", "initials": "K"}, {"family": "Kockum", "given": "Ingrid", "initials": "I", "orcid": "0000-0002-0867-4726", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/044ff0f987a642c7aa2aef33fe1d7ecd.json"}}, {"family": "Tengvall", "given": "Katarina", "initials": "K", "orcid": "0000-0003-0424-3571", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b8f6227041cc44b1bd163c99956bba78.json"}}, {"family": "Martin", "given": "Roland", "initials": "R"}, {"family": "Tegel", "given": "Hanna", "initials": "H", "orcid": "0000-0002-7067-9173", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/7b9de19b82b4406d8904cb937a466e8b.json"}}, {"family": "Gr\u00e4slund", "given": "Torbj\u00f6rn", "initials": "T", "orcid": "0000-0002-5391-600X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/afff2431691348539334ab0e86158505.json"}}, {"family": "Al Nimer", "given": "Faiez", "initials": "F", "orcid": "0000-0003-0937-5995", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/00758cc3da934cdbb9cb00c1df4b700f.json"}}, {"family": "Guerreiro-Cacais", "given": "Andr\u00e9 Ortlieb", "initials": "AO", "orcid": "0000-0002-4561-2823", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c2ecf483cb7442b9de5c99dcc11c1a5.json"}}, {"family": "Khademi", "given": "Mohsen", "initials": "M", "orcid": "0000-0003-0801-1444", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/22f8dcc673264db484e284e484bc7311.json"}}, {"family": "Gafvelin", "given": "Guro", "initials": "G", "orcid": "0000-0003-1618-4011", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/4d527debbb4246ddb4d35dd6b0903028.json"}}, {"family": "Olsson", "given": "Tomas", "initials": "T", "orcid": "0000-0002-2938-1877", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2003b9ba415e422fa27b0c7fdce9497f.json"}}, {"family": "Gr\u00f6nlund", "given": "Hans", "initials": "H", "orcid": "0000-0003-4882-7624", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b91c9201b4d64b5b8d000d1f89e53be6.json"}}], "type": "journal article", "published": "2022-04-29", "journal": {"title": "Sci Adv", "issn": "2375-2548", "volume": "8", "issue": "17", "pages": "eabn1823", "issn-l": "2375-2548"}, "abstract": "Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS), in which pathological T cells, likely autoimmune, play a key role. Despite its central importance, the autoantigen repertoire remains largely uncharacterized. Using a novel in vitro antigen delivery method combined with the Human Protein Atlas library, we screened for T cell autoreactivity against 63 CNS-expressed proteins. We identified four previously unreported autoantigens in MS: fatty acid-binding protein 7, prokineticin-2, reticulon-3, and synaptosomal-associated protein 91, which were verified to induce interferon-\u03b3 responses in MS in two cohorts. Autoreactive profiles were heterogeneous, and reactivity to several autoantigens was MS-selective. Autoreactive T cells were predominantly CD4+ and human leukocyte antigen-DR restricted. Mouse immunization induced antigen-specific responses and CNS leukocyte infiltration. This represents one of the largest systematic efforts to date in the search for MS autoantigens, demonstrates the heterogeneity of autoreactive profiles, and highlights promising targets for future diagnostic tools and immunomodulatory therapies in MS.", "doi": "10.1126/sciadv.abn1823", "pmid": "35476434", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9045615"}], "notes": [], "created": "2026-09-23T08:48:17.478Z", "modified": "2026-09-23T08:48:17.929Z"}]}