{"entity": "researcher", "timestamp": "2026-09-09T09:46:37.759Z", "family": "Barkhof", "given": "Frederik", "initials": "F", "orcid": "0000-0003-3543-3706", "affiliations": ["Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Center, location VUmc, Amsterdam, The Netherlands.", "Amsterdam Neuroscience, Brain imaging, Amsterdam, The Netherlands.", "Institutes of Neurology & Healthcare Engineering, University College London, London, UK."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192"}}, "publications": [{"entity": "publication", "iuid": "d5e68a98d6c94abb9646df1e1a48dec1", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/d5e68a98d6c94abb9646df1e1a48dec1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/d5e68a98d6c94abb9646df1e1a48dec1"}}, "title": "Two-step detection of Lewy body pathology via smell-function testing and CSF \u03b1-synuclein seed amplification.", "authors": [{"family": "Mastenbroek", "given": "Sophie E", "initials": "SE", "orcid": "0009-0006-2759-9588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9732ea66d3d9402f9cb1b1a3e9b34fc8.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Caldera", "given": "Serena", "initials": "S"}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Adler", "given": "Charles H", "initials": "CH"}, {"family": "Vargiu", "given": "Claudia Marina", "initials": "CM", "orcid": "0009-0009-2921-6829", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3c57306acd0a4f36a786bd7452ce821a.json"}}, {"family": "Palmqvist", "given": "Sebastian", "initials": "S", "orcid": "0000-0002-9267-1930", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6fbd05e87cfb4057a1a7e41d9fb94aef.json"}}, {"family": "Barkhof", "given": "Frederik", "initials": "F", "orcid": "0000-0003-3543-3706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192.json"}}, {"family": "Parchi", "given": "Piero", "initials": "P", "orcid": "0000-0002-9444-9524", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a3f20dbf9b984aec85c74d9aea2eac69.json"}}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2025-08-05", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "16", "issue": "1", "pages": "7182", "issn-l": "2041-1723"}, "abstract": "Cerebrospinal fluid (CSF) \u03b1-synuclein (\u03b1-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with confirmatory CSF \u03b1-syn SAA testing only in individuals with reduced smell, for predicting postmortem LBP status. Among 358 autopsied participants, the two-step workflow predicted brain LBP with high accuracy overall (94%), and within clinical subgroups (clinical parkinsonism=95%; clinical Alzheimer's disease [AD]=94%; clinically unimpaired [CU]=93%). It reduced the need for confirmatory CSF testing by 43% overall (23% clinical parkinsonism; 35% clinical AD; 80% CU). In an independent in vivo cohort (N=1209), the workflow predicted CSF \u03b1-syn SAA status with 79% accuracy and reduced CSF testing by 26%. This approach may reduce invasive CSF testing, alleviating patient burden and lowering healthcare costs.", "doi": "10.1038/s41467-025-62458-7", "pmid": "40764485", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12325632"}, {"db": "pii", "key": "10.1038/s41467-025-62458-7"}], "notes": [], "created": "2026-08-20T08:54:03.905Z", "modified": "2026-08-20T08:54:04.105Z"}, {"entity": "publication", "iuid": "07ddd2fbfa834fd29a1a0a9a83c4fcf2", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/07ddd2fbfa834fd29a1a0a9a83c4fcf2.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/07ddd2fbfa834fd29a1a0a9a83c4fcf2"}}, "title": "Disease progression modelling reveals heterogeneity in trajectories of Lewy-type \u03b1-synuclein pathology.", "authors": [{"family": "Mastenbroek", "given": "Sophie E", "initials": "SE", "orcid": "0009-0006-2759-9588", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9732ea66d3d9402f9cb1b1a3e9b34fc8.json"}}, {"family": "Vogel", "given": "Jacob W", "initials": "JW", "orcid": "0000-0001-6394-9940", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d2ad5af780c245da9b59a8c80a0b00ff.json"}}, {"family": "Collij", "given": "Lyduine E", "initials": "LE", "orcid": "0000-0001-6263-1762", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/6612222d48fd4bdcaa7c091d38efcc2b.json"}}, {"family": "Serrano", "given": "Geidy E", "initials": "GE"}, {"family": "Tremblay", "given": "C\u00e9cilia", "initials": "C"}, {"family": "Young", "given": "Alexandra L", "initials": "AL", "orcid": "0000-0002-7772-781X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/d8a71365a32a4f4da1a29a925e5334c3.json"}}, {"family": "Arce", "given": "Richard A", "initials": "RA"}, {"family": "Shill", "given": "Holly A", "initials": "HA"}, {"family": "Driver-Dunckley", "given": "Erika D", "initials": "ED"}, {"family": "Mehta", "given": "Shyamal H", "initials": "SH"}, {"family": "Belden", "given": "Christine M", "initials": "CM"}, {"family": "Atri", "given": "Alireza", "initials": "A"}, {"family": "Choudhury", "given": "Parichita", "initials": "P"}, {"family": "Barkhof", "given": "Frederik", "initials": "F", "orcid": "0000-0003-3543-3706", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/adc9cefa2eb14e599fa41988ea003192.json"}}, {"family": "Adler", "given": "Charles H", "initials": "CH"}, {"family": "Ossenkoppele", "given": "Rik", "initials": "R", "orcid": "0000-0003-1584-7477", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9486d27ddd1b4b6485fa3ca10e0f3d82.json"}}, {"family": "Beach", "given": "Thomas G", "initials": "TG"}, {"family": "Hansson", "given": "Oskar", "initials": "O", "orcid": "0000-0001-8467-7286", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9292115deece4d9fafc8a02d4a430707.json"}}], "type": "journal article", "published": "2024-06-15", "journal": {"title": "Nat Commun", "issn": "2041-1723", "volume": "15", "issue": "1", "pages": "5133", "issn-l": "2041-1723"}, "abstract": "Lewy body (LB) diseases, characterized by the aggregation of misfolded \u03b1-synuclein proteins, exhibit notable clinical heterogeneity. This may be due to variations in accumulation patterns of LB neuropathology. Here we apply a data-driven disease progression model to regional neuropathological LB density scores from 814 brain donors with Lewy pathology. We describe three inferred trajectories of LB pathology that are characterized by differing clinicopathological presentation and longitudinal antemortem clinical progression. Most donors (81.9%) show earliest pathology in the olfactory bulb, followed by accumulation in either limbic (60.8%) or brainstem (21.1%) regions. The remaining donors (18.1%) initially exhibit abnormalities in brainstem regions. Early limbic pathology is associated with Alzheimer's disease-associated characteristics while early brainstem pathology is associated with progressive motor impairment and substantial LB pathology outside of the brain. Our data provides evidence for heterogeneity in the temporal spread of LB pathology, possibly explaining some of the clinical disparities observed in Lewy body disease.", "doi": "10.1038/s41467-024-49402-x", "pmid": "38879548", "labels": {"Jacob W Vogel": null, "DDLS Fellow": null}, "xrefs": [{"db": "pmc", "key": "PMC11180185"}, {"db": "pii", "key": "10.1038/s41467-024-49402-x"}], "notes": [], "created": "2025-03-19T11:17:02.737Z", "modified": "2025-03-19T11:19:08.814Z"}]}