{"entity": "researcher", "timestamp": "2026-08-20T20:29:27.452Z", "family": "Asghari", "given": "S Mohsen", "initials": "SM", "orcid": "0000-0002-0782-6687", "affiliations": ["Institute of Biochemistry and Biophysics, University of Tehran 1411713135 Iran."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac9c9f456f864ea8a12c770f006e015b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac9c9f456f864ea8a12c770f006e015b"}}, "publications": [{"entity": "publication", "iuid": "ec3dfa5fdd304ee69c72676da5559f23", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/ec3dfa5fdd304ee69c72676da5559f23.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/ec3dfa5fdd304ee69c72676da5559f23"}}, "title": "Noscapine-bile acid hybrids as novel anticancer agents.", "authors": [{"family": "Babanezhad Harikandei", "given": "Kosar", "initials": "K", "orcid": "0000-0001-9631-4191", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3360cee87a2241ba80d6de1a3c245498.json"}}, {"family": "Salehi", "given": "Peyman", "initials": "P", "orcid": "0000-0001-5774-3372", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/271052d3acf145d0aaf6392456efd7b3.json"}}, {"family": "Hasanpour", "given": "Zahra", "initials": "Z", "orcid": "0000-0002-2286-3574", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/2e704a3d403a4679a33df4240a0793b6.json"}}, {"family": "Bararjanian", "given": "Morteza", "initials": "M"}, {"family": "Kim", "given": "Wonghee", "initials": "W"}, {"family": "Asghari", "given": "S Mohsen", "initials": "SM", "orcid": "0000-0002-0782-6687", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac9c9f456f864ea8a12c770f006e015b.json"}}, {"family": "Mardinoglu", "given": "Adil", "initials": "A", "orcid": "0000-0002-4254-6090", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ca58bf2d214047e0ae5e38a42a0f2808.json"}}], "type": "journal article", "published": "2025-08-29", "journal": {"title": "RSC Med Chem", "issn": "2632-8682", "volume": "16", "issue": "11", "pages": "5511-5533", "issn-l": null}, "abstract": "Twenty novel noscapinoid-triterpene conjugate derivatives were designed and synthesized. Four noscapine derivatives (as secondary amine) and five bile acids were applied for the synthesis of a diverse library. The synthetic compounds were evaluated for their antiproliferative activity against PC3, A549, HepG2, Caki-1, U138MG, and MRC5. This study identified eight potent cytotoxic agents (7e-7i, 7k, 7m, and 7o) possessing more than 80% cell viability. Compounds 7e and 7f exhibited the highest cytotoxic activity against Caki-1 with IC50 values of 260 nM and 350 nM, respectively. Western blot analysis results indicated that the eight hit compounds decreased the \u03b1-tubulin and \u03b2-actin levels in A549 cells, and further cellular assays on A549 demonstrated that 7e and 7f significantly inhibited cell migration, induced pronounced G1 cell-cycle arrest (with 7f also showing a minor G2/M increase) and triggered marked apoptosis, with 7e showing the strongest pro-apoptotic effect.", "doi": "10.1039/d5md00570a", "pmid": "40980425", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12447841"}, {"db": "pii", "key": "d5md00570a"}], "notes": [], "created": "2026-08-20T09:28:12.090Z", "modified": "2026-08-20T09:28:12.309Z"}]}