{"entity": "researcher", "timestamp": "2026-08-22T08:30:49.758Z", "family": "Katayama", "given": "Shintaro", "initials": "S", "orcid": "0000-0001-7581-5157", "affiliations": ["Folkh\u00e4lsan Research Center, Helsinki, Finland.", "Stem Cells and Metabolism Research Program, Research Programs Unit, University of Helsinki, Finland.", "Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac94aab19cbd48d4970404f0d2b2e2ac.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac94aab19cbd48d4970404f0d2b2e2ac"}}, "publications": [{"entity": "publication", "iuid": "7cd543caec524bfdba4d14eafc53a33b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/7cd543caec524bfdba4d14eafc53a33b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/7cd543caec524bfdba4d14eafc53a33b"}}, "title": "Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity.", "authors": [{"family": "Altm\u00e4e", "given": "Signe", "initials": "S", "orcid": "0000-0002-0708-1865", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/dc13b857bcd94874b57dc0c24b7ba8bc.json"}}, {"family": "Plaza-Florido", "given": "Abel", "initials": "A", "orcid": "0000-0002-5374-3129", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/0af8876e633441c1b97f9a27257770cf.json"}}, {"family": "Esteban", "given": "Francisco J", "initials": "FJ", "orcid": "0000-0002-7135-2973", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b4fcb4c772424f7cac26c1108c6b5109.json"}}, {"family": "Anguita-Ruiz", "given": "Augusto", "initials": "A", "orcid": "0000-0001-6888-1041", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/483eff615b1e41cc9ca443a1952e101d.json"}}, {"family": "Krjut\u0161kov", "given": "Kaarel", "initials": "K", "orcid": "0000-0003-1297-1464", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/591c90e9fa694e7295d0a5f94d95cbc1.json"}}, {"family": "Katayama", "given": "Shintaro", "initials": "S", "orcid": "0000-0001-7581-5157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac94aab19cbd48d4970404f0d2b2e2ac.json"}}, {"family": "Einarsdottir", "given": "Elisabet", "initials": "E", "orcid": "0000-0003-3101-2285", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ae255687b53f4926b4cb9ad06dcf6edc.json"}}, {"family": "Kere", "given": "Juha", "initials": "J", "orcid": "0000-0003-1974-0271", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/5d26c0765a7349cca1abe211339e8f33.json"}}, {"family": "Radom-Aizik", "given": "Shlomit", "initials": "S"}, {"family": "Ortega", "given": "Francisco B", "initials": "FB", "orcid": "0000-0003-2001-1121", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/283e1e112bc046bc8e79d9ce7cad14ab.json"}}], "type": "randomized controlled trial", "published": "2024-02-00", "journal": {"title": "Am J Hum Biol", "issn": "1520-6300", "volume": "36", "issue": "2", "pages": "e23983", "issn-l": null}, "abstract": "The current knowledge about the molecular mechanisms underlying the health benefits of exercise is still limited, especially in childhood. We set out to investigate the effects of a 20-week exercise intervention on whole-blood transcriptome profile (RNA-seq) in children with overweight/obesity.\n\nTwenty-four children (10.21 \u00b1 1.33 years, 46% girls) with overweight/obesity, were randomized to either a 20-week exercise program (intervention group; n = 10), or to a no-exercise control group (n = 14). Whole-blood transcriptome profile was analyzed using RNA-seq by STRT technique with GlobinLock technology.\n\nFollowing the 20-week exercise intervention program, 161 genes were differentially expressed between the exercise and the control groups among boys, and 121 genes among girls (p-value <0.05), while after multiple correction, no significant difference between exercise and control groups persisted in gene expression profiles (FDR >0.05). Genes enriched in GO processes and molecular pathways showed different immune response in boys (antigen processing and presentation, infections, and T cell receptor complex) and in girls (Fc epsilon RI signaling pathway) (FDR <0.05).\n\nThese results suggest that 20-week exercise intervention program alters the molecular pathways involved in immune processes in children with overweight/obesity.", "doi": "10.1002/ajhb.23983", "pmid": "37715654", "labels": [], "xrefs": [{"db": "mid", "key": "NIHMS1937628"}, {"db": "pmc", "key": "PMC11482632"}], "notes": [], "created": "2026-08-21T10:59:44.632Z", "modified": "2026-08-21T10:59:45.516Z"}, {"entity": "publication", "iuid": "93bf55aab8f0402098e52556fc43a32b", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/93bf55aab8f0402098e52556fc43a32b.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/93bf55aab8f0402098e52556fc43a32b"}}, "title": "Nasal upregulation of CST1 in dog-sensitised children with severe allergic airway disease.", "authors": [{"family": "K\u00e4ck", "given": "Ulrika", "initials": "U"}, {"family": "Einarsdottir", "given": "Elisabet", "initials": "E"}, {"family": "van Hage", "given": "Marianne", "initials": "M"}, {"family": "Asarnoj", "given": "Anna", "initials": "A"}, {"family": "James", "given": "Anna", "initials": "A"}, {"family": "Nopp", "given": "Anna", "initials": "A"}, {"family": "Krjut\u0161kov", "given": "Kaarel", "initials": "K"}, {"family": "Katayama", "given": "Shintaro", "initials": "S", "orcid": "0000-0001-7581-5157", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac94aab19cbd48d4970404f0d2b2e2ac.json"}}, {"family": "Kere", "given": "Juha", "initials": "J"}, {"family": "Lilja", "given": "Gunnar", "initials": "G"}, {"family": "S\u00f6derh\u00e4ll", "given": "Cilla", "initials": "C", "orcid": "0000-0002-8397-3080", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8e8f600e345a433291e43231c9f4d243.json"}}, {"family": "Konradsen", "given": "Jon R", "initials": "JR"}], "type": "journal article", "published": "2021-04-00", "journal": {"title": "ERJ Open Res", "issn": "2312-0541", "volume": "7", "issue": "2", "issn-l": null}, "abstract": "The clinical presentation of children sensitised to dog dander varies from asymptomatic to severe allergic airway disease, but the genetic mechanisms underlying these differences are not clear. The objective of the present study was to investigate nasal transcriptomic profiles associated with dog dander sensitisation in school children and to reveal clinical symptoms related with these profiles.\n\nRNA was extracted from nasal epithelial cell brushings of children sensitised to dog dander and healthy controls. Blood sample analyses included IgE against dog dander, dog allergen molecules, other airborne and food allergens, basophil activation and white blood cell counts. Clinical history of asthma and rhinitis was recorded, and lung function was assessed (spirometry, methacholine provocation and exhaled nitric oxide fraction).\n\nThe most overexpressed gene in children sensitised to dog dander compared to healthy controls was CST1, coding for Cystatin 1. A cluster of these children with enhanced CST1 expression showed lower forced expiratory volume in 1 s, increased bronchial hyperreactivity, pronounced eosinophilia and higher basophil allergen threshold sensitivity compared with other children sensitised to dog dander. In addition, multi-sensitisation to lipocalins was more common in this group.\n\nOverexpression of CST1 is associated with more severe allergic airway disease in children sensitised to dog dander. CST1 is thus a possible biomarker of the severity of allergic airway disease and a possible therapeutic target for the future treatment of airborne allergy.", "doi": "10.1183/23120541.00917-2020", "pmid": "33898616", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC8053908"}, {"db": "pii", "key": "00917-2020"}], "notes": [], "created": "2026-08-21T12:33:43.463Z", "modified": "2026-08-21T12:33:43.567Z"}]}