{"entity": "researcher", "timestamp": "2026-08-20T21:05:33.824Z", "family": "Govender", "given": "Kimberleigh B", "initials": "KB", "orcid": "0000-0003-2372-5365", "affiliations": ["Catalysis and Peptide Research Unit, University of KwaZulu-Natal Durban 4001 South Africa govenderthav@icloud.com naickert1@ukzn.ac.za +27 312601845."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac4af1fdc8014145b709012f09fad215.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac4af1fdc8014145b709012f09fad215"}}, "publications": [{"entity": "publication", "iuid": "5ee73cdf9e7c4df0b2f1e52549cff3a8", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/5ee73cdf9e7c4df0b2f1e52549cff3a8.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/5ee73cdf9e7c4df0b2f1e52549cff3a8"}}, "title": "Development and in vitro evaluation of 1,4,7-triazacyclononane-coupled \u03b2-lactams against metallo-\u03b2-lactamase producing bacteria.", "authors": [{"family": "Shungube", "given": "Mbongeni", "initials": "M"}, {"family": "Reddy", "given": "Nakita", "initials": "N", "orcid": "0000-0003-4428-2241", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/8c720c72b0734659b2cc966792015076.json"}}, {"family": "Ghazi", "given": "Terisha", "initials": "T"}, {"family": "Govender", "given": "Kimberleigh B", "initials": "KB", "orcid": "0000-0003-2372-5365", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ac4af1fdc8014145b709012f09fad215.json"}}, {"family": "Singh", "given": "Ravesh", "initials": "R"}, {"family": "Kajee", "given": "Afsana", "initials": "A"}, {"family": "Chuturgoon", "given": "Anil", "initials": "A", "orcid": "0000-0003-4649-4133", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/3af870f9207f43e5ae3b802495214724.json"}}, {"family": "Kruger", "given": "Hendrik G", "initials": "HG", "orcid": "0000-0003-0606-2053", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/88f669867879452ca86ab92c27fd285c.json"}}, {"family": "Arvidsson", "given": "Per I", "initials": "PI", "orcid": "0000-0002-9453-6812", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/84789ce64d004c83919336cdf43c903e.json"}}, {"family": "Tiwari", "given": "Dileep", "initials": "D"}, {"family": "Govender", "given": "Thavendran", "initials": "T"}, {"family": "Naicker", "given": "Tricia", "initials": "T", "orcid": "0000-0002-7134-6258", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/f5b1b1625e8c43859647736baa3e83d9.json"}}], "type": "journal article", "published": "2025-07-04", "journal": {"title": "RSC Adv.", "issn": "2046-2069", "volume": "15", "issue": "29", "pages": "23427-23440", "issn-l": "2046-2069"}, "abstract": "Antimicrobial resistance (AMR) is a critical global issue, particularly against \u03b2-lactam antibiotics, which comprise over 60% of prescriptions. Metallo-\u03b2-lactamases (MBLs) are especially concerning as they inactivate nearly all \u03b2-lactams, except monobactams. Unlike serine-\u03b2-lactamases (SBLs), for which inhibitors exist, there are no clinically approved MBL inhibitors; only taniborbactam is in pre-registration. This study introduces eight new MBL inhibitors (13a-f, 14a-b), designed using a 1,4,7-triazacyclononane (NO3PY) chelator linked to a \u03b2-lactam. These inhibitors restored the efficacy of meropenem, reducing its minimum inhibitory concentration (MIC) against MBL-expressing pathogens to <2 mg L-1. Time-kill assays confirmed bactericidal activity, with this series being non-toxic and highly specific, these compounds hold promising potential as MBL inhibitors.", "doi": "10.1039/d5ra01842k", "pmid": "40626067", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC12230942"}, {"db": "pii", "key": "d5ra01842k"}], "notes": [], "created": "2026-08-20T09:28:15.994Z", "modified": "2026-08-20T09:28:16.135Z"}]}