{"entity": "researcher", "timestamp": "2026-08-20T21:01:47.120Z", "family": "Gonzalez", "given": "Javier Martin", "initials": "JM", "orcid": "0000-0002-7075-6028", "affiliations": ["Transgenic Core Facility, University of Copenhagen, Copenhagen, Denmark."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab8b43b5ce7a42cab1e49b292bfd8090.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab8b43b5ce7a42cab1e49b292bfd8090"}}, "publications": [{"entity": "publication", "iuid": "2824f391d83f4d4e877d2d083e93702a", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/2824f391d83f4d4e877d2d083e93702a.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/2824f391d83f4d4e877d2d083e93702a"}}, "title": "ATR expands embryonic stem cell fate potential in response to replication stress.", "authors": [{"family": "Atashpaz", "given": "Sina", "initials": "S", "orcid": "0000-0003-0566-5629", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c8836292554646f8b1db4da6fb341107.json"}}, {"family": "Samadi Shams", "given": "Sara", "initials": "S", "orcid": "0000-0002-1697-9343", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/c0769a0706764b6f85f3949e31f73d36.json"}}, {"family": "Gonzalez", "given": "Javier Martin", "initials": "JM", "orcid": "0000-0002-7075-6028", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/ab8b43b5ce7a42cab1e49b292bfd8090.json"}}, {"family": "Sebesty\u00e9n", "given": "Endre", "initials": "E", "orcid": "0000-0001-5470-2161", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/a6cad94788f84d2d8ce3e18f7dd21d68.json"}}, {"family": "Arghavanifard", "given": "Negar", "initials": "N", "orcid": "0000-0003-3039-7603", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/98744fc5a644426b80f96f5fafd8daca.json"}}, {"family": "Gnocchi", "given": "Andrea", "initials": "A", "orcid": "0000-0003-3290-9449", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/e402b4ef8af042308ca805bb2d739c6a.json"}}, {"family": "Albers", "given": "Eliene", "initials": "E"}, {"family": "Minardi", "given": "Simone", "initials": "S", "orcid": "0000-0001-7303-3821", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/9a6733b6b3734030a4a0bbfa059a6ba3.json"}}, {"family": "Faga", "given": "Giovanni", "initials": "G"}, {"family": "Soffientini", "given": "Paolo", "initials": "P"}, {"family": "Allievi", "given": "Elisa", "initials": "E"}, {"family": "Cancila", "given": "Valeria", "initials": "V"}, {"family": "Bachi", "given": "Angela", "initials": "A"}, {"family": "Fern\u00e1ndez-Capetillo", "given": "\u00d3scar", "initials": "\u00d3"}, {"family": "Tripodo", "given": "Claudio", "initials": "C"}, {"family": "Ferrari", "given": "Francesco", "initials": "F"}, {"family": "L\u00f3pez-Contreras", "given": "Andr\u00e9s Joaquin", "initials": "AJ"}, {"family": "Costanzo", "given": "Vincenzo", "initials": "V", "orcid": "0000-0002-2920-9508", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/fa58e20a668c49b2ba09a935b2f3c74f.json"}}], "type": "journal article", "published": "2020-03-12", "journal": {"title": "Elife", "issn": "2050-084X", "volume": "9", "issn-l": "2050-084X"}, "abstract": "Unrepaired DNA damage during embryonic development can be potentially inherited by a large population of cells. However, the quality control mechanisms that minimize the contribution of damaged cells to developing embryos remain poorly understood. Here, we uncovered an ATR- and CHK1-mediated transcriptional response to replication stress (RS) in mouse embryonic stem cells (ESCs) that induces genes expressed in totipotent two-cell (2C) stage embryos and 2C-like cells. This response is mediated by Dux, a multicopy retrogene defining the cleavage-specific transcriptional program in placental mammals. In response to RS, DUX triggers the transcription of 2C-like markers such as murine endogenous retrovirus-like elements (MERVL) and Zscan4. This response can also be elicited by ETAA1-mediated ATR activation in the absence of RS. ATR-mediated activation of DUX requires GRSF1-dependent post-transcriptional regulation of Dux mRNA. Strikingly, activation of ATR expands ESCs fate potential by extending their contribution to both embryonic and extra-embryonic tissues. These findings define a novel ATR dependent pathway involved in maintaining genome stability in developing embryos by controlling ESCs fate in response to RS.", "doi": "10.7554/eLife.54756", "pmid": "32163370", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC7067586"}, {"db": "pii", "key": "54756"}], "notes": [], "created": "2026-08-20T13:53:02.980Z", "modified": "2026-08-20T13:53:03.158Z"}]}