{"entity": "researcher", "timestamp": "2026-08-20T20:49:51.234Z", "family": "Nasiri", "given": "Rohollah", "initials": "R", "orcid": "0000-0002-8245-692X", "affiliations": ["AIMES, Center for the Advancement of Integrated Medical and Engineering Sciences, Department of Neuroscience, Karolinska Institute, Solnav\u00e4gen 9/B8, Solna, 171 65, Sweden.", "Division of Nanobiotechnology, Department of Protein Science, KTH Royal Institute of Technology, Tomtebodav\u00e4gen 23a, Solna, 171 65, Sweden."], "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaecdaea25fc438e937adfea37188ae1.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaecdaea25fc438e937adfea37188ae1"}}, "publications": [{"entity": "publication", "iuid": "71734534a2814d04b69dd990d234cdc9", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/71734534a2814d04b69dd990d234cdc9.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/71734534a2814d04b69dd990d234cdc9"}}, "title": "Metabolic Assessment of Human Induced Pluripotent Stem Cells-Derived Astrocytes and Fetal Primary Astrocytes: Lactate and Glucose Turnover.", "authors": [{"family": "Matthiesen", "given": "Isabelle", "initials": "I"}, {"family": "Nasiri", "given": "Rohollah", "initials": "R", "orcid": "0000-0002-8245-692X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaecdaea25fc438e937adfea37188ae1.json"}}, {"family": "Tamashiro Orrego", "given": "Alessandra", "initials": "A"}, {"family": "Winkler", "given": "Thomas E", "initials": "TE", "orcid": "0000-0002-2331-4833", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/851879d753574f5a80716e94dcc24590.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2022-10-08", "journal": {"title": "Biosensors (Basel)", "issn": "2079-6374", "volume": "12", "issue": "10", "issn-l": null}, "abstract": "Astrocytes represent one of the main cell types in the brain and play a crucial role in brain functions, including supplying the energy demand for neurons. Moreover, they are important regulators of metabolite levels. Glucose uptake and lactate production are some of the main observable metabolic actions of astrocytes. To gain insight into these processes, it is essential to establish scalable and functional sources for in vitro studies of astrocytes. In this study, we compared the metabolic turnover of glucose and lactate in astrocytes derived from human induced pluripotent stem cell (hiPSC)-derived Astrocytes (hiAstrocytes) as a scalable astrocyte source to human fetal astrocytes (HFAs). Using a user-friendly, commercial flow-based biosensor, we could verify that hiAstrocytes are as glycogenic as their fetal counterparts, but their normalized metabolic turnover is lower. Specifically, under identical culture conditions in a defined media, HFAs have 2.3 times higher levels of lactate production compared to hiAstrocytes. In terms of glucose, HFAs have 2.1 times higher consumption levels than hiAstrocytes at 24 h. Still, as we describe their glycogenic phenotype, our study demonstrates the use of hiAstrocytes and flow-based biosensors for metabolic studies of astrocyte function.", "doi": "10.3390/bios12100839", "pmid": "36290976", "labels": [], "xrefs": [{"db": "pmc", "key": "PMC9599592"}, {"db": "pii", "key": "bios12100839"}], "notes": [], "created": "2026-08-20T13:39:00.656Z", "modified": "2026-08-20T13:39:00.766Z"}, {"entity": "publication", "iuid": "33f710b9a5f849e2a369165c234cdc6c", "links": {"self": {"href": "https://publications-affiliated.scilifelab.se/publication/33f710b9a5f849e2a369165c234cdc6c.json"}, "display": {"href": "https://publications-affiliated.scilifelab.se/publication/33f710b9a5f849e2a369165c234cdc6c"}}, "title": "Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces.", "authors": [{"family": "Kavand", "given": "Hanie", "initials": "H", "orcid": "0000-0002-9144-0065", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/b084b9302f774b03ab553d66d4fbbc66.json"}}, {"family": "Nasiri", "given": "Rohollah", "initials": "R", "orcid": "0000-0002-8245-692X", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/aaecdaea25fc438e937adfea37188ae1.json"}}, {"family": "Herland", "given": "Anna", "initials": "A", "orcid": "0000-0002-5002-2537", "researcher": {"href": "https://publications-affiliated.scilifelab.se/researcher/367ed0d139fe4136808b62ee61baa4f0.json"}}], "type": "journal article", "published": "2022-04-00", "journal": {"title": "Adv. Mater. Weinheim", "issn": "1521-4095", "volume": "34", "issue": "17", "pages": "e2107876", "issn-l": "0935-9648"}, "abstract": "Advanced in vitro cell culture systems or microphysiological systems (MPSs), including microfluidic organ-on-a-chip (OoC), are breakthrough technologies in biomedicine. These systems recapitulate features of human tissues outside of the body. They are increasingly being used to study the functionality of different organs for applications such as drug evolutions, disease modeling, and precision medicine. Currently, developers and endpoint users of these in vitro models promote how they can replace animal models or even be a better ethically neutral and humanized alternative to study pathology, physiology, and pharmacology. Although reported models show a remarkable physiological structure and function compared to the conventional 2D cell culture, they are almost exclusively based on standard passive polymers or glass with none or minimal real-time stimuli and readout capacity. The next technology leap in reproducing in vivo-like functionality and real-time monitoring of tissue function could be realized with advanced functional materials and devices. This review describes the currently reported electronic and optical advanced materials for sensing and stimulation of MPS models. In addition, an overview of multi-sensing for Body-on-Chip platforms is given. Finally, one gives the perspective on how advanced functional materials could be integrated into in vitro systems to precisely mimic human physiology.", "doi": "10.1002/adma.202107876", "pmid": "34913206", "labels": [], "xrefs": [], "notes": [], "created": "2026-08-20T06:27:56.504Z", "modified": "2026-08-20T06:27:56.653Z"}]}